[{"date_published":"2017-11-02T00:00:00Z","type":"journal_article","oa":1,"publication_identifier":{"issn":["1934-5909"]},"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.stem.2017.08.012"}],"publication":"Cell Stem Cell","month":"11","oa_version":"Published Version","language":[{"iso":"eng"}],"keyword":["Cell Biology","Genetics","Molecular Medicine"],"external_id":{"pmid":["28919367"]},"date_updated":"2022-07-18T08:33:07Z","citation":{"ieee":"T. Toda <i>et al.</i>, “Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells,” <i>Cell Stem Cell</i>, vol. 21, no. 5. Elsevier, p. 618–634.e7, 2017.","chicago":"Toda, Tomohisa, Jonathan Y. Hsu, Sara B. Linker, Lauren Hu, Simon T. Schafer, Jerome Mertens, Filipe V. Jacinto, Martin Hetzer, and Fred H. Gage. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>.","apa":"Toda, T., Hsu, J. Y., Linker, S. B., Hu, L., Schafer, S. T., Mertens, J., … Gage, F. H. (2017). Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>","ama":"Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. 2017;21(5):618-634.e7. doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>","ista":"Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer M, Gage FH. 2017. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 21(5), 618–634.e7.","mla":"Toda, Tomohisa, et al. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>, vol. 21, no. 5, Elsevier, 2017, p. 618–634.e7, doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>.","short":"T. Toda, J.Y. Hsu, S.B. Linker, L. Hu, S.T. Schafer, J. Mertens, F.V. Jacinto, M. Hetzer, F.H. Gage, Cell Stem Cell 21 (2017) 618–634.e7."},"year":"2017","abstract":[{"text":"Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes. Binding of Nup153 to gene promoters or transcriptional end sites correlates with increased or decreased gene expression, respectively, and inhibiting Nup153 expression alters open chromatin configurations at its target genes, disrupts genomic localization of Sox2, and promotes differentiation in vitro and a gliogenic fate switch in vivo. Together, these findings reveal that nuclear structural proteins may exert bimodal transcriptional effects to control cell fate.","lang":"eng"}],"doi":"10.1016/j.stem.2017.08.012","day":"02","extern":"1","volume":21,"author":[{"full_name":"Toda, Tomohisa","last_name":"Toda","first_name":"Tomohisa"},{"full_name":"Hsu, Jonathan Y.","first_name":"Jonathan Y.","last_name":"Hsu"},{"full_name":"Linker, Sara B.","first_name":"Sara B.","last_name":"Linker"},{"last_name":"Hu","first_name":"Lauren","full_name":"Hu, Lauren"},{"full_name":"Schafer, Simon T.","first_name":"Simon T.","last_name":"Schafer"},{"last_name":"Mertens","first_name":"Jerome","full_name":"Mertens, Jerome"},{"full_name":"Jacinto, Filipe V.","last_name":"Jacinto","first_name":"Filipe V."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W"},{"first_name":"Fred H.","last_name":"Gage","full_name":"Gage, Fred H."}],"issue":"5","pmid":1,"_id":"11067","scopus_import":"1","title":"Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells","intvolume":"        21","publication_status":"published","date_created":"2022-04-07T07:46:12Z","article_processing_charge":"No","page":"618-634.e7","quality_controlled":"1","article_type":"original","publisher":"Elsevier"},{"extern":"1","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":19,"date_published":"2016-08-16T00:00:00Z","type":"journal_article","date_updated":"2021-01-12T08:12:00Z","citation":{"ieee":"C. Rolando <i>et al.</i>, “Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB,” <i>Cell Stem Cell</i>, vol. 19, no. 5. Elsevier, pp. 653–662, 2016.","chicago":"Rolando, Chiara, Andrea Erni, Alice Grison, Robert J Beattie, Anna Engler, Paul J. Gokhale, Marta Milo, Thomas Wegleiter, Sebastian Jessberger, and Verdon Taylor. “Multipotency of Adult Hippocampal NSCs in Vivo Is Restricted by Drosha/NFIB.” <i>Cell Stem Cell</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">https://doi.org/10.1016/j.stem.2016.07.003</a>.","apa":"Rolando, C., Erni, A., Grison, A., Beattie, R. J., Engler, A., Gokhale, P. J., … Taylor, V. (2016). Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">https://doi.org/10.1016/j.stem.2016.07.003</a>","ama":"Rolando C, Erni A, Grison A, et al. Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB. <i>Cell Stem Cell</i>. 2016;19(5):653-662. doi:<a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">10.1016/j.stem.2016.07.003</a>","ista":"Rolando C, Erni A, Grison A, Beattie RJ, Engler A, Gokhale PJ, Milo M, Wegleiter T, Jessberger S, Taylor V. 2016. Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB. Cell Stem Cell. 19(5), 653–662.","mla":"Rolando, Chiara, et al. “Multipotency of Adult Hippocampal NSCs in Vivo Is Restricted by Drosha/NFIB.” <i>Cell Stem Cell</i>, vol. 19, no. 5, Elsevier, 2016, pp. 653–62, doi:<a href=\"https://doi.org/10.1016/j.stem.2016.07.003\">10.1016/j.stem.2016.07.003</a>.","short":"C. Rolando, A. Erni, A. Grison, R.J. Beattie, A. Engler, P.J. Gokhale, M. Milo, T. Wegleiter, S. Jessberger, V. Taylor, Cell Stem Cell 19 (2016) 653–662."},"year":"2016","doi":"10.1016/j.stem.2016.07.003","day":"16","publication_identifier":{"issn":["1934-5909"]},"language":[{"iso":"eng"}],"page":"653-662","quality_controlled":"1","article_type":"original","publisher":"Elsevier","author":[{"full_name":"Rolando, Chiara","last_name":"Rolando","first_name":"Chiara"},{"full_name":"Erni, Andrea","first_name":"Andrea","last_name":"Erni"},{"full_name":"Grison, Alice","last_name":"Grison","first_name":"Alice"},{"id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8483-8753","full_name":"Beattie, Robert J","first_name":"Robert J","last_name":"Beattie"},{"last_name":"Engler","first_name":"Anna","full_name":"Engler, Anna"},{"full_name":"Gokhale, Paul J.","first_name":"Paul J.","last_name":"Gokhale"},{"last_name":"Milo","first_name":"Marta","full_name":"Milo, Marta"},{"last_name":"Wegleiter","first_name":"Thomas","full_name":"Wegleiter, Thomas"},{"full_name":"Jessberger, Sebastian","last_name":"Jessberger","first_name":"Sebastian"},{"first_name":"Verdon","last_name":"Taylor","full_name":"Taylor, Verdon"}],"issue":"5","_id":"7141","publication":"Cell Stem Cell","month":"08","title":"Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB","intvolume":"        19","publication_status":"published","oa_version":"None","article_processing_charge":"No","date_created":"2019-11-28T13:09:09Z"},{"scopus_import":"1","pmid":1,"_id":"11079","issue":"6","author":[{"full_name":"Mertens, Jerome","last_name":"Mertens","first_name":"Jerome"},{"full_name":"Paquola, Apuã C.M.","first_name":"Apuã C.M.","last_name":"Paquola"},{"full_name":"Ku, Manching","last_name":"Ku","first_name":"Manching"},{"full_name":"Hatch, Emily","first_name":"Emily","last_name":"Hatch"},{"last_name":"Böhnke","first_name":"Lena","full_name":"Böhnke, Lena"},{"first_name":"Shauheen","last_name":"Ladjevardi","full_name":"Ladjevardi, Shauheen"},{"last_name":"McGrath","first_name":"Sean","full_name":"McGrath, Sean"},{"full_name":"Campbell, Benjamin","first_name":"Benjamin","last_name":"Campbell"},{"full_name":"Lee, Hyungjun","last_name":"Lee","first_name":"Hyungjun"},{"full_name":"Herdy, Joseph R.","first_name":"Joseph R.","last_name":"Herdy"},{"full_name":"Gonçalves, J. Tiago","last_name":"Gonçalves","first_name":"J. Tiago"},{"full_name":"Toda, Tomohisa","first_name":"Tomohisa","last_name":"Toda"},{"first_name":"Yongsung","last_name":"Kim","full_name":"Kim, Yongsung"},{"full_name":"Winkler, Jürgen","last_name":"Winkler","first_name":"Jürgen"},{"first_name":"Jun","last_name":"Yao","full_name":"Yao, Jun"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER"},{"full_name":"Gage, Fred H.","last_name":"Gage","first_name":"Fred H."}],"date_created":"2022-04-07T07:49:51Z","article_processing_charge":"No","publication_status":"published","intvolume":"        17","title":"Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects","quality_controlled":"1","page":"705-718","publisher":"Elsevier","article_type":"original","citation":{"short":"J. Mertens, A.C.M. Paquola, M. Ku, E. Hatch, L. Böhnke, S. Ladjevardi, S. McGrath, B. Campbell, H. Lee, J.R. Herdy, J.T. Gonçalves, T. Toda, Y. Kim, J. Winkler, J. Yao, M. Hetzer, F.H. Gage, Cell Stem Cell 17 (2015) 705–718.","mla":"Mertens, Jerome, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” <i>Cell Stem Cell</i>, vol. 17, no. 6, Elsevier, 2015, pp. 705–18, doi:<a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">10.1016/j.stem.2015.09.001</a>.","ista":"Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer M, Gage FH. 2015. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 17(6), 705–718.","apa":"Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., … Gage, F. H. (2015). Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">https://doi.org/10.1016/j.stem.2015.09.001</a>","ama":"Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. <i>Cell Stem Cell</i>. 2015;17(6):705-718. doi:<a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">10.1016/j.stem.2015.09.001</a>","chicago":"Mertens, Jerome, Apuã C.M. Paquola, Manching Ku, Emily Hatch, Lena Böhnke, Shauheen Ladjevardi, Sean McGrath, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” <i>Cell Stem Cell</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">https://doi.org/10.1016/j.stem.2015.09.001</a>.","ieee":"J. Mertens <i>et al.</i>, “Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects,” <i>Cell Stem Cell</i>, vol. 17, no. 6. Elsevier, pp. 705–718, 2015."},"year":"2015","date_updated":"2022-07-18T08:44:21Z","external_id":{"pmid":["26456686"]},"day":"03","doi":"10.1016/j.stem.2015.09.001","abstract":[{"text":"Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad range of ages, either by iPSC-based reprogramming and differentiation or by direct conversion into induced neurons (iNs). While iPSCs and derived neurons did not retain aging-associated gene signatures, iNs displayed age-specific transcriptional profiles and revealed age-associated decreases in the nuclear transport receptor RanBP17. We detected an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor fibroblasts and corresponding iNs and found that reduced RanBP17 impaired NCC in young cells, while iPSC rejuvenation restored NCC in aged cells. These results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging.","lang":"eng"}],"volume":17,"extern":"1","publication":"Cell Stem Cell","oa_version":"Published Version","month":"12","keyword":["Cell Biology","Genetics","Molecular Medicine"],"language":[{"iso":"eng"}],"type":"journal_article","date_published":"2015-12-03T00:00:00Z","publication_identifier":{"issn":["1934-5909"]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.stem.2015.09.001","open_access":"1"}],"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd"}]