[{"publication":"PLoS One","has_accepted_license":"1","month":"06","article_number":"e0179377","oa_version":"Published Version","language":[{"iso":"eng"}],"date_published":"2017-06-01T00:00:00Z","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publist_id":"7034","oa":1,"publication_identifier":{"issn":["19326203"]},"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"relation":"dissertation_contains","id":"51","status":"public"}]},"file":[{"creator":"system","file_id":"4934","access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_name":"IST-2017-897-v1+1_journal.pone.0179377.pdf","date_updated":"2020-07-14T12:47:40Z","checksum":"24dd19c46fb1c761b0bcbbcd1025a3a8","file_size":5798454,"date_created":"2018-12-12T10:12:16Z"}],"author":[{"full_name":"Ukai, Hikari","last_name":"Ukai","first_name":"Hikari"},{"first_name":"Aiko","last_name":"Kawahara","full_name":"Kawahara, Aiko"},{"first_name":"Keiko","last_name":"Hirayama","full_name":"Hirayama, Keiko"},{"id":"44B7CA5A-F248-11E8-B48F-1D18A9856A87","full_name":"Case, Matthew J","first_name":"Matthew J","last_name":"Case"},{"last_name":"Aino","first_name":"Shotaro","full_name":"Aino, Shotaro"},{"last_name":"Miyabe","first_name":"Masahiro","full_name":"Miyabe, Masahiro"},{"first_name":"Ken","last_name":"Wakita","full_name":"Wakita, Ken"},{"full_name":"Oogi, Ryohei","last_name":"Oogi","first_name":"Ryohei"},{"full_name":"Kasayuki, Michiyo","last_name":"Kasayuki","first_name":"Michiyo"},{"full_name":"Kawashima, Shihomi","first_name":"Shihomi","last_name":"Kawashima"},{"full_name":"Sugimoto, Shunichi","first_name":"Shunichi","last_name":"Sugimoto"},{"first_name":"Kanako","last_name":"Chikamatsu","full_name":"Chikamatsu, Kanako"},{"full_name":"Nitta, Noritaka","last_name":"Nitta","first_name":"Noritaka"},{"full_name":"Koga, Tsuneyuki","last_name":"Koga","first_name":"Tsuneyuki"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Takai, Toshiyuki","first_name":"Toshiyuki","last_name":"Takai"},{"last_name":"Ito","first_name":"Isao","full_name":"Ito, Isao"}],"issue":"6","_id":"682","scopus_import":1,"license":"https://creativecommons.org/licenses/by/4.0/","pubrep_id":"897","title":"PirB regulates asymmetries in hippocampal circuitry","intvolume":"        12","publication_status":"published","date_created":"2018-12-11T11:47:54Z","department":[{"_id":"RySh"}],"file_date_updated":"2020-07-14T12:47:40Z","quality_controlled":"1","article_type":"original","publisher":"Public Library of Science","date_updated":"2024-03-25T23:30:07Z","citation":{"ieee":"H. Ukai <i>et al.</i>, “PirB regulates asymmetries in hippocampal circuitry,” <i>PLoS One</i>, vol. 12, no. 6. Public Library of Science, 2017.","chicago":"Ukai, Hikari, Aiko Kawahara, Keiko Hirayama, Matthew J Case, Shotaro Aino, Masahiro Miyabe, Ken Wakita, et al. “PirB Regulates Asymmetries in Hippocampal Circuitry.” <i>PLoS One</i>. Public Library of Science, 2017. <a href=\"https://doi.org/10.1371/journal.pone.0179377\">https://doi.org/10.1371/journal.pone.0179377</a>.","apa":"Ukai, H., Kawahara, A., Hirayama, K., Case, M. J., Aino, S., Miyabe, M., … Ito, I. (2017). PirB regulates asymmetries in hippocampal circuitry. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0179377\">https://doi.org/10.1371/journal.pone.0179377</a>","ama":"Ukai H, Kawahara A, Hirayama K, et al. PirB regulates asymmetries in hippocampal circuitry. <i>PLoS One</i>. 2017;12(6). doi:<a href=\"https://doi.org/10.1371/journal.pone.0179377\">10.1371/journal.pone.0179377</a>","ista":"Ukai H, Kawahara A, Hirayama K, Case MJ, Aino S, Miyabe M, Wakita K, Oogi R, Kasayuki M, Kawashima S, Sugimoto S, Chikamatsu K, Nitta N, Koga T, Shigemoto R, Takai T, Ito I. 2017. PirB regulates asymmetries in hippocampal circuitry. PLoS One. 12(6), e0179377.","mla":"Ukai, Hikari, et al. “PirB Regulates Asymmetries in Hippocampal Circuitry.” <i>PLoS One</i>, vol. 12, no. 6, e0179377, Public Library of Science, 2017, doi:<a href=\"https://doi.org/10.1371/journal.pone.0179377\">10.1371/journal.pone.0179377</a>.","short":"H. Ukai, A. Kawahara, K. Hirayama, M.J. Case, S. Aino, M. Miyabe, K. Wakita, R. Oogi, M. Kasayuki, S. Kawashima, S. Sugimoto, K. Chikamatsu, N. Nitta, T. Koga, R. Shigemoto, T. Takai, I. Ito, PLoS One 12 (2017)."},"year":"2017","abstract":[{"lang":"eng","text":"Left-right asymmetry is a fundamental feature of higher-order brain structure; however, the molecular basis of brain asymmetry remains unclear. We recently identified structural and functional asymmetries in mouse hippocampal circuitry that result from the asymmetrical distribution of two distinct populations of pyramidal cell synapses that differ in the density of the NMDA receptor subunit GluRε2 (also known as NR2B, GRIN2B or GluN2B). By examining the synaptic distribution of ε2 subunits, we previously found that β2-microglobulin-deficient mice, which lack cell surface expression of the vast majority of major histocompatibility complex class I (MHCI) proteins, do not exhibit circuit asymmetry. In the present study, we conducted electrophysiological and anatomical analyses on the hippocampal circuitry of mice with a knockout of the paired immunoglobulin-like receptor B (PirB), an MHCI receptor. As in β2-microglobulin-deficient mice, the PirB-deficient hippocampus lacked circuit asymmetries. This finding that MHCI loss-of-function mice and PirB knockout mice have identical phenotypes suggests that MHCI signals that produce hippocampal asymmetries are transduced through PirB. Our results provide evidence for a critical role of the MHCI/PirB signaling system in the generation of asymmetries in hippocampal circuitry."}],"doi":"10.1371/journal.pone.0179377","day":"01","ddc":["571"],"volume":12},{"language":[{"iso":"eng"}],"oa_version":"Published Version","month":"03","article_number":"e0174066","publication":"PLoS One","has_accepted_license":"1","file":[{"creator":"system","file_id":"4772","access_level":"open_access","relation":"main_file","file_name":"IST-2017-800-v1+1_journal.pone.0174066.pdf","content_type":"application/pdf","date_updated":"2018-12-12T10:09:47Z","file_size":3429381,"date_created":"2018-12-12T10:09:47Z"}],"status":"public","related_material":{"record":[{"status":"public","id":"5556","relation":"popular_science"},{"status":"public","relation":"dissertation_contains","id":"6392"}]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"issn":["19326203"]},"oa":1,"publist_id":"6361","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2017-03-16T00:00:00Z","type":"journal_article","publisher":"Public Library of Science","quality_controlled":"1","file_date_updated":"2018-12-12T10:09:47Z","publication_status":"published","department":[{"_id":"ToBo"}],"date_created":"2018-12-11T11:49:46Z","article_processing_charge":"Yes","title":"Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast","pubrep_id":"800","intvolume":"        12","_id":"1029","scopus_import":"1","author":[{"last_name":"Lukacisin","first_name":"Martin","full_name":"Lukacisin, Martin","orcid":"0000-0001-6549-4177","id":"298FFE8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Landon, Matthieu","first_name":"Matthieu","last_name":"Landon"},{"full_name":"Jajoo, Rishi","first_name":"Rishi","last_name":"Jajoo"}],"issue":"3","volume":12,"ddc":["570"],"doi":"10.1371/journal.pone.0174066","day":"16","abstract":[{"text":"RNA Polymerase II pauses and backtracks during transcription, with many consequences for gene expression and cellular physiology. Here, we show that the energy required to melt double-stranded nucleic acids in the transcription bubble predicts pausing in Saccharomyces cerevisiae far more accurately than nucleosome roadblocks do. In addition, the same energy difference also determines when the RNA polymerase backtracks instead of continuing to move forward. This data-driven model corroborates—in a genome wide and quantitative manner—previous evidence that sequence-dependent thermodynamic features of nucleic acids influence both transcriptional pausing and backtracking.","lang":"eng"}],"date_updated":"2024-03-25T23:30:03Z","year":"2017","citation":{"ieee":"M. Lukacisin, M. Landon, and R. Jajoo, “Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast,” <i>PLoS One</i>, vol. 12, no. 3. Public Library of Science, 2017.","chicago":"Lukacisin, Martin, Matthieu Landon, and Rishi Jajoo. “Sequence-Specific Thermodynamic Properties of Nucleic Acids Influence Both Transcriptional Pausing and Backtracking in Yeast.” <i>PLoS One</i>. Public Library of Science, 2017. <a href=\"https://doi.org/10.1371/journal.pone.0174066\">https://doi.org/10.1371/journal.pone.0174066</a>.","ama":"Lukacisin M, Landon M, Jajoo R. Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast. <i>PLoS One</i>. 2017;12(3). doi:<a href=\"https://doi.org/10.1371/journal.pone.0174066\">10.1371/journal.pone.0174066</a>","apa":"Lukacisin, M., Landon, M., &#38; Jajoo, R. (2017). Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0174066\">https://doi.org/10.1371/journal.pone.0174066</a>","ista":"Lukacisin M, Landon M, Jajoo R. 2017. Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast. PLoS One. 12(3), e0174066.","mla":"Lukacisin, Martin, et al. “Sequence-Specific Thermodynamic Properties of Nucleic Acids Influence Both Transcriptional Pausing and Backtracking in Yeast.” <i>PLoS One</i>, vol. 12, no. 3, e0174066, Public Library of Science, 2017, doi:<a href=\"https://doi.org/10.1371/journal.pone.0174066\">10.1371/journal.pone.0174066</a>.","short":"M. Lukacisin, M. Landon, R. Jajoo, PLoS One 12 (2017)."},"isi":1,"external_id":{"isi":["000396318300121"]}}]