---
_id: '5771'
abstract:
- lang: eng
  text: Retroviruses such as HIV-1 assemble and bud from infected cells in an immature,
    non-infectious form. Subsequently, a series of proteolytic cleavages catalysed
    by the viral protease leads to a spectacular structural rearrangement of the viral
    particle into a mature form that is competent to fuse with and infect a new cell.
    Maturation involves changes in the structures of protein domains, in the interactions
    between protein domains, and in the architecture of the viral components that
    are assembled by the proteins. Tight control of proteolytic cleavages at different
    sites is required for successful maturation, and the process is a major target
    of antiretroviral drugs. Here we will describe what is known about the structures
    of immature and mature retrovirus particles, and about the maturation process
    by which one transitions into the other. Despite a wealth of available data, fundamental
    questions about retroviral maturation remain unanswered.
author:
- first_name: Simone
  full_name: Mattei, Simone
  last_name: Mattei
- first_name: Florian
  full_name: Schur, Florian
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
- first_name: John AG
  full_name: Briggs, John AG
  last_name: Briggs
citation:
  ama: Mattei S, Schur FK, Briggs JA. Retrovirus maturation—an extraordinary structural
    transformation. <i>Current Opinion in Virology</i>. 2016;18(6):27-35. doi:<a href="https://doi.org/10.1016/j.coviro.2016.02.008">10.1016/j.coviro.2016.02.008</a>
  apa: Mattei, S., Schur, F. K., &#38; Briggs, J. A. (2016). Retrovirus maturation—an
    extraordinary structural transformation. <i>Current Opinion in Virology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.coviro.2016.02.008">https://doi.org/10.1016/j.coviro.2016.02.008</a>
  chicago: Mattei, Simone, Florian KM Schur, and John AG Briggs. “Retrovirus Maturation—an
    Extraordinary Structural Transformation.” <i>Current Opinion in Virology</i>.
    Elsevier, 2016. <a href="https://doi.org/10.1016/j.coviro.2016.02.008">https://doi.org/10.1016/j.coviro.2016.02.008</a>.
  ieee: S. Mattei, F. K. Schur, and J. A. Briggs, “Retrovirus maturation—an extraordinary
    structural transformation,” <i>Current Opinion in Virology</i>, vol. 18, no. 6.
    Elsevier, pp. 27–35, 2016.
  ista: Mattei S, Schur FK, Briggs JA. 2016. Retrovirus maturation—an extraordinary
    structural transformation. Current Opinion in Virology. 18(6), 27–35.
  mla: Mattei, Simone, et al. “Retrovirus Maturation—an Extraordinary Structural Transformation.”
    <i>Current Opinion in Virology</i>, vol. 18, no. 6, Elsevier, 2016, pp. 27–35,
    doi:<a href="https://doi.org/10.1016/j.coviro.2016.02.008">10.1016/j.coviro.2016.02.008</a>.
  short: S. Mattei, F.K. Schur, J.A. Briggs, Current Opinion in Virology 18 (2016)
    27–35.
date_created: 2018-12-20T21:13:59Z
date_published: 2016-03-22T00:00:00Z
date_updated: 2021-01-12T08:03:22Z
day: '22'
ddc:
- '570'
doi: 10.1016/j.coviro.2016.02.008
extern: '1'
file:
- access_level: open_access
  checksum: 320939d28ebd1adfb122338019892508
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-09T13:05:44Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5812'
  file_name: 2016_CurrentOpinion_Mattei.pdf
  file_size: 1773842
  relation: main_file
file_date_updated: 2020-07-14T12:47:11Z
has_accepted_license: '1'
intvolume: '        18'
issue: '6'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 27-35
publication: Current Opinion in Virology
publication_identifier:
  issn:
  - 1879-6257
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Retrovirus maturation—an extraordinary structural transformation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2016'
...