[{"publication":"Wiley Interdisciplinary Reviews: Developmental Biology","date_updated":"2024-03-07T15:03:00Z","ec_funded":1,"department":[{"_id":"AnKi"}],"related_material":{"record":[{"id":"14323","status":"public","relation":"dissertation_contains"}]},"oa":1,"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","author":[{"id":"4CED352A-F248-11E8-B48F-1D18A9856A87","full_name":"Kuzmicz-Kowalska, Katarzyna","first_name":"Katarzyna","last_name":"Kuzmicz-Kowalska"},{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","first_name":"Anna","last_name":"Kicheva"}],"_id":"7883","file":[{"date_updated":"2020-11-24T13:11:39Z","relation":"main_file","file_size":2527276,"date_created":"2020-11-24T13:11:39Z","file_name":"2020_WIREs_DevBio_KuzmiczKowalska.pdf","access_level":"open_access","success":1,"checksum":"f0a7745d48afa09ea7025e876a0145a8","file_id":"8800","creator":"dernst","content_type":"application/pdf"}],"date_created":"2020-05-24T22:01:00Z","abstract":[{"lang":"eng","text":"All vertebrates have a spinal cord with dimensions and shape specific to their species. Yet how species‐specific organ size and shape are achieved is a fundamental unresolved question in biology. The formation and sculpting of organs begins during embryonic development. As it develops, the spinal cord extends in anterior–posterior direction in synchrony with the overall growth of the body. The dorsoventral (DV) and apicobasal lengths of the spinal cord neuroepithelium also change, while at the same time a characteristic pattern of neural progenitor subtypes along the DV axis is established and elaborated. At the basis of these changes in tissue size and shape are biophysical determinants, such as the change in cell number, cell size and shape, and anisotropic tissue growth. These processes are controlled by global tissue‐scale regulators, such as morphogen signaling gradients as well as mechanical forces. Current challenges in the field are to uncover how these tissue‐scale regulatory mechanisms are translated to the cellular and molecular level, and how regulation of distinct cellular processes gives rise to an overall defined size. Addressing these questions will help not only to achieve a better understanding of how size is controlled, but also of how tissue size is coordinated with the specification of pattern."}],"article_number":"e383","year":"2021","citation":{"ama":"Kuzmicz-Kowalska K, Kicheva A. Regulation of size and scale in vertebrate spinal cord development. <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. 2021. doi:<a href=\"https://doi.org/10.1002/wdev.383\">10.1002/wdev.383</a>","ista":"Kuzmicz-Kowalska K, Kicheva A. 2021. Regulation of size and scale in vertebrate spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology., e383.","ieee":"K. Kuzmicz-Kowalska and A. Kicheva, “Regulation of size and scale in vertebrate spinal cord development,” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. Wiley, 2021.","mla":"Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale in Vertebrate Spinal Cord Development.” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>, e383, Wiley, 2021, doi:<a href=\"https://doi.org/10.1002/wdev.383\">10.1002/wdev.383</a>.","chicago":"Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale in Vertebrate Spinal Cord Development.” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/wdev.383\">https://doi.org/10.1002/wdev.383</a>.","short":"K. Kuzmicz-Kowalska, A. Kicheva, Wiley Interdisciplinary Reviews: Developmental Biology (2021).","apa":"Kuzmicz-Kowalska, K., &#38; Kicheva, A. (2021). Regulation of size and scale in vertebrate spinal cord development. <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. Wiley. <a href=\"https://doi.org/10.1002/wdev.383\">https://doi.org/10.1002/wdev.383</a>"},"file_date_updated":"2020-11-24T13:11:39Z","oa_version":"Published Version","article_processing_charge":"Yes (via OA deal)","title":"Regulation of size and scale in vertebrate spinal cord development","publication_status":"published","article_type":"original","publication_identifier":{"issn":["17597684"],"eissn":["17597692"]},"acknowledgement":"Austrian Academy of Sciences, Grant/Award Number: DOC fellowship for Katarzyna Kuzmicz-Kowalska; Austrian Science Fund, Grant/Award Number: F78 (Stem Cell Modulation); H2020 European Research Council, Grant/Award Number: 680037","doi":"10.1002/wdev.383","scopus_import":"1","status":"public","month":"04","isi":1,"language":[{"iso":"eng"}],"ddc":["570"],"external_id":{"pmid":["32391980"],"isi":["000531419400001"]},"date_published":"2021-04-15T00:00:00Z","type":"journal_article","publisher":"Wiley","pmid":1,"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"project":[{"_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord","grant_number":"680037","call_identifier":"H2020"},{"_id":"267AF0E4-B435-11E9-9278-68D0E5697425","name":"The role of morphogens in the regulation of neural tube growth"},{"grant_number":"F07802","_id":"059DF620-7A3F-11EA-A408-12923DDC885E","name":"Morphogen control of growth and pattern in the spinal cord"}],"quality_controlled":"1","day":"15"},{"day":"11","quality_controlled":"1","issue":"6","license":"https://creativecommons.org/licenses/by-nc/4.0/","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png"},"publisher":"Wiley-Blackwell","pmid":1,"date_published":"2017-08-11T00:00:00Z","external_id":{"isi":["000412827400005"],"pmid":["28800674"]},"type":"journal_article","language":[{"iso":"eng"}],"ddc":["570"],"month":"08","isi":1,"status":"public","publist_id":"6927","doi":"10.1002/wdev.288","scopus_import":"1","article_type":"original","publication_identifier":{"issn":["17597684"]},"publication_status":"published","title":"The genetic encoded toolbox for electron microscopy and connectomics","file_date_updated":"2020-07-14T12:47:57Z","article_processing_charge":"No","oa_version":"Submitted Version","article_number":"e288","year":"2017","citation":{"ista":"Shigemoto R, Jösch MA. 2017. The genetic encoded toolbox for electron microscopy and connectomics. WIREs Developmental Biology. 6(6), e288.","ieee":"R. Shigemoto and M. A. Jösch, “The genetic encoded toolbox for electron microscopy and connectomics,” <i>WIREs Developmental Biology</i>, vol. 6, no. 6. Wiley-Blackwell, 2017.","ama":"Shigemoto R, Jösch MA. The genetic encoded toolbox for electron microscopy and connectomics. <i>WIREs Developmental Biology</i>. 2017;6(6). doi:<a href=\"https://doi.org/10.1002/wdev.288\">10.1002/wdev.288</a>","mla":"Shigemoto, Ryuichi, and Maximilian A. Jösch. “The Genetic Encoded Toolbox for Electron Microscopy and Connectomics.” <i>WIREs Developmental Biology</i>, vol. 6, no. 6, e288, Wiley-Blackwell, 2017, doi:<a href=\"https://doi.org/10.1002/wdev.288\">10.1002/wdev.288</a>.","apa":"Shigemoto, R., &#38; Jösch, M. A. (2017). The genetic encoded toolbox for electron microscopy and connectomics. <i>WIREs Developmental Biology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/wdev.288\">https://doi.org/10.1002/wdev.288</a>","short":"R. Shigemoto, M.A. Jösch, WIREs Developmental Biology 6 (2017).","chicago":"Shigemoto, Ryuichi, and Maximilian A Jösch. “The Genetic Encoded Toolbox for Electron Microscopy and Connectomics.” <i>WIREs Developmental Biology</i>. Wiley-Blackwell, 2017. <a href=\"https://doi.org/10.1002/wdev.288\">https://doi.org/10.1002/wdev.288</a>."},"abstract":[{"lang":"eng","text":"Developments in bioengineering and molecular biology have introduced a palette of genetically encoded probes for identification of specific cell populations in electron microscopy. These probes can be targeted to distinct cellular compartments, rendering them electron dense through a subsequent chemical reaction. These electron densities strongly increase the local contrast in samples prepared for electron microscopy, allowing three major advances in ultrastructural mapping of circuits: genetic identification of circuit components, targeted imaging of regions of interest and automated analysis of the tagged circuits. Together, the gains from these advances can decrease the time required for the analysis of targeted circuit motifs by over two orders of magnitude. These genetic encoded tags for electron microscopy promise to simplify the analysis of circuit motifs and become a central tool for structure‐function studies of synaptic connections in the brain. We review the current state‐of‐the‐art with an emphasis on connectomics, the quantitative analysis of neuronal structures and motifs."}],"_id":"740","date_created":"2018-12-11T11:48:15Z","file":[{"checksum":"a9370f27b1591773b7a0de299bc81c8c","content_type":"application/pdf","file_id":"7045","creator":"dernst","relation":"main_file","date_updated":"2020-07-14T12:47:57Z","file_size":1647787,"date_created":"2019-11-19T07:36:18Z","access_level":"open_access","file_name":"2017_WIREs_Shigemoto.pdf"}],"author":[{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3937-1330","full_name":"Jösch, Maximilian A","first_name":"Maximilian A","last_name":"Jösch"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"volume":6,"intvolume":"         6","department":[{"_id":"RySh"},{"_id":"MaJö"}],"publication":"WIREs Developmental Biology","date_updated":"2023-09-27T12:51:41Z"}]