---
_id: '5989'
abstract:
- lang: eng
  text: Schistosomes are the causative agents of schistosomiasis, a neglected tropical
    disease affecting over 230 million people worldwide.Additionally to their major
    impact on human health, they are also models of choice in evolutionary biology.
    These parasitic flatwormsare unique among the common hermaphroditic trematodes
    as they have separate sexes. This so-called “evolutionary scandal”displays a female
    heterogametic genetic sex-determination system (ZZ males and ZW females), as well
    as a pronounced adult sexualdimorphism. These phenotypic differences are determined
    by a shared set of genes in both sexes, potentially leading to intralocussexual
    conflicts. To resolve these conflicts in sexually selected traits, molecular mechanisms
    such as sex-biased gene expression couldoccur, but parent-of-origin gene expression
    also provides an alternative. In this work we investigated the latter mechanism,
    that is,genes expressed preferentially from either the maternal or the paternal
    allele, inSchistosoma mansonispecies. To this end, tran-scriptomes from male and
    female hybrid adults obtained by strain crosses were sequenced. Strain-specific
    single nucleotide poly-morphism (SNP) markers allowed us to discriminate the parental
    origin, while reciprocal crosses helped to differentiate parentalexpression from
    strain-specific expression. We identified genes containing SNPs expressed in a
    parent-of-origin manner consistentwith paternal and maternal imprints. Although
    the majority of the SNPs was identified in mitochondrial and Z-specific loci,
    theremaining SNPs found in male and female transcriptomes were situated in genes
    that have the potential to explain sexual differencesin schistosome parasites.
    Furthermore, we identified and validated four new Z-specific scaffolds.
article_processing_charge: No
author:
- first_name: Julien
  full_name: Kincaid-Smith, Julien
  last_name: Kincaid-Smith
- first_name: Marion A L
  full_name: Picard, Marion A L
  id: 2C921A7A-F248-11E8-B48F-1D18A9856A87
  last_name: Picard
  orcid: 0000-0002-8101-2518
- first_name: Céline
  full_name: Cosseau, Céline
  last_name: Cosseau
- first_name: Jérôme
  full_name: Boissier, Jérôme
  last_name: Boissier
- first_name: Dany
  full_name: Severac, Dany
  last_name: Severac
- first_name: Christoph
  full_name: Grunau, Christoph
  last_name: Grunau
- first_name: Eve
  full_name: Toulza, Eve
  last_name: Toulza
citation:
  ama: Kincaid-Smith J, Picard MAL, Cosseau C, et al. Parent-of-Origin-Dependent Gene
    Expression in Male and Female Schistosome Parasites. <i>Genome Biology and Evolution</i>.
    2018;10(3):840-856. doi:<a href="https://doi.org/10.1093/gbe/evy037">10.1093/gbe/evy037</a>
  apa: Kincaid-Smith, J., Picard, M. A. L., Cosseau, C., Boissier, J., Severac, D.,
    Grunau, C., &#38; Toulza, E. (2018). Parent-of-Origin-Dependent Gene Expression
    in Male and Female Schistosome Parasites. <i>Genome Biology and Evolution</i>.
    Oxford University Press. <a href="https://doi.org/10.1093/gbe/evy037">https://doi.org/10.1093/gbe/evy037</a>
  chicago: Kincaid-Smith, Julien, Marion A L Picard, Céline Cosseau, Jérôme Boissier,
    Dany Severac, Christoph Grunau, and Eve Toulza. “Parent-of-Origin-Dependent Gene
    Expression in Male and Female Schistosome Parasites.” <i>Genome Biology and Evolution</i>.
    Oxford University Press, 2018. <a href="https://doi.org/10.1093/gbe/evy037">https://doi.org/10.1093/gbe/evy037</a>.
  ieee: J. Kincaid-Smith <i>et al.</i>, “Parent-of-Origin-Dependent Gene Expression
    in Male and Female Schistosome Parasites,” <i>Genome Biology and Evolution</i>,
    vol. 10, no. 3. Oxford University Press, pp. 840–856, 2018.
  ista: Kincaid-Smith J, Picard MAL, Cosseau C, Boissier J, Severac D, Grunau C, Toulza
    E. 2018. Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome
    Parasites. Genome Biology and Evolution. 10(3), 840–856.
  mla: Kincaid-Smith, Julien, et al. “Parent-of-Origin-Dependent Gene Expression in
    Male and Female Schistosome Parasites.” <i>Genome Biology and Evolution</i>, vol.
    10, no. 3, Oxford University Press, 2018, pp. 840–56, doi:<a href="https://doi.org/10.1093/gbe/evy037">10.1093/gbe/evy037</a>.
  short: J. Kincaid-Smith, M.A.L. Picard, C. Cosseau, J. Boissier, D. Severac, C.
    Grunau, E. Toulza, Genome Biology and Evolution 10 (2018) 840–856.
date_created: 2019-02-14T12:13:52Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-19T14:39:08Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evy037
external_id:
  isi:
  - '000429483700013'
file:
- access_level: open_access
  checksum: 736a459cb77de5824354466bb0331caf
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-14T12:20:01Z
  date_updated: 2020-07-14T12:47:15Z
  file_id: '5991'
  file_name: 2018_GBE_Kincaid_Smith.pdf
  file_size: 529755
  relation: main_file
file_date_updated: 2020-07-14T12:47:15Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 840-856
publication: Genome Biology and Evolution
publication_identifier:
  issn:
  - 1759-6653
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10
year: '2018'
...