---
_id: '558'
abstract:
- lang: eng
text: Immune specificity is the degree to which a host’s immune system discriminates
among various pathogens or antigenic variants. Vertebrate immune memory is highly
specific due to antibody responses. On the other hand, some invertebrates show
immune priming, i.e. improved survival after secondary exposure to a previously
encountered pathogen. Until now, specificity of priming has only been demonstrated
via the septic infection route or when live pathogens were used for priming. Therefore,
we tested for specificity in the oral priming route in the red flour beetle, Tribolium
castaneum. For priming, we used pathogen-free supernatants derived from three
different strains of the entomopathogen, Bacillus thuringiensis, which express
different Cry toxin variants known for their toxicity against this beetle. Subsequent
exposure to the infective spores showed that oral priming was specific for two
naturally occurring strains, while a third engineered strain did not induce any
priming effect. Our data demonstrate that oral immune priming with a non-infectious
bacterial agent can be specific, but the priming effect is not universal across
all bacterial strains.
article_number: '0632'
article_processing_charge: No
article_type: original
author:
- first_name: Momir
full_name: Futo, Momir
last_name: Futo
- first_name: Marie
full_name: Sell, Marie
last_name: Sell
- first_name: Megan
full_name: Kutzer, Megan
id: 29D0B332-F248-11E8-B48F-1D18A9856A87
last_name: Kutzer
orcid: 0000-0002-8696-6978
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
citation:
ama: Futo M, Sell M, Kutzer M, Kurtz J. Specificity of oral immune priming in the
red flour beetle Tribolium castaneum. Biology Letters. 2017;13(12). doi:10.1098/rsbl.2017.0632
apa: Futo, M., Sell, M., Kutzer, M., & Kurtz, J. (2017). Specificity of oral
immune priming in the red flour beetle Tribolium castaneum. Biology Letters.
The Royal Society. https://doi.org/10.1098/rsbl.2017.0632
chicago: Futo, Momir, Marie Sell, Megan Kutzer, and Joachim Kurtz. “Specificity
of Oral Immune Priming in the Red Flour Beetle Tribolium Castaneum.” Biology
Letters. The Royal Society, 2017. https://doi.org/10.1098/rsbl.2017.0632.
ieee: M. Futo, M. Sell, M. Kutzer, and J. Kurtz, “Specificity of oral immune priming
in the red flour beetle Tribolium castaneum,” Biology Letters, vol. 13,
no. 12. The Royal Society, 2017.
ista: Futo M, Sell M, Kutzer M, Kurtz J. 2017. Specificity of oral immune priming
in the red flour beetle Tribolium castaneum. Biology Letters. 13(12), 0632.
mla: Futo, Momir, et al. “Specificity of Oral Immune Priming in the Red Flour Beetle
Tribolium Castaneum.” Biology Letters, vol. 13, no. 12, 0632, The Royal
Society, 2017, doi:10.1098/rsbl.2017.0632.
short: M. Futo, M. Sell, M. Kutzer, J. Kurtz, Biology Letters 13 (2017).
date_created: 2018-12-11T11:47:10Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-10-18T06:42:25Z
day: '01'
department:
- _id: SyCr
doi: 10.1098/rsbl.2017.0632
external_id:
pmid:
- '29237813'
intvolume: ' 13'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
pmid: 1
publication: Biology Letters
publication_identifier:
issn:
- 1744-9561
publication_status: published
publisher: The Royal Society
publist_id: '7255'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Specificity of oral immune priming in the red flour beetle Tribolium castaneum
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2017'
...
---
_id: '561'
abstract:
- lang: eng
text: Restriction–modification systems are widespread genetic elements that protect
bacteria from bacteriophage infections by recognizing and cleaving heterologous
DNA at short, well-defined sequences called restriction sites. Bioinformatic evidence
shows that restriction sites are significantly underrepresented in bacteriophage
genomes, presumably because bacteriophages with fewer restriction sites are more
likely to escape cleavage by restriction–modification systems. However, how mutations
in restriction sites affect the likelihood of bacteriophage escape is unknown.
Using the bacteriophage l and the restriction–modification system EcoRI, we show
that while mutation effects at different restriction sites are unequal, they are
independent. As a result, the probability of bacteriophage escape increases with
each mutated restriction site. Our results experimentally support the role of
restriction site avoidance as a response to selection imposed by restriction–modification
systems and offer an insight into the events underlying the process of bacteriophage
escape.
acknowledgement: This work was funded by an HFSP Young Investigators' grant RGY0079/2011
(C.C.G.). M.P. is a recipient of a DOC Fellowship of the Austrian Academy of Science
at the Institute of Science and Technology Austria.
article_number: '20170646'
article_processing_charge: No
article_type: original
author:
- first_name: Maros
full_name: Pleska, Maros
id: 4569785E-F248-11E8-B48F-1D18A9856A87
last_name: Pleska
orcid: 0000-0001-7460-7479
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
citation:
ama: Pleska M, Guet CC. Effects of mutations in phage restriction sites during escape
from restriction–modification. Biology Letters. 2017;13(12). doi:10.1098/rsbl.2017.0646
apa: Pleska, M., & Guet, C. C. (2017). Effects of mutations in phage restriction
sites during escape from restriction–modification. Biology Letters. The
Royal Society. https://doi.org/10.1098/rsbl.2017.0646
chicago: Pleska, Maros, and Calin C Guet. “Effects of Mutations in Phage Restriction
Sites during Escape from Restriction–Modification.” Biology Letters. The
Royal Society, 2017. https://doi.org/10.1098/rsbl.2017.0646.
ieee: M. Pleska and C. C. Guet, “Effects of mutations in phage restriction sites
during escape from restriction–modification,” Biology Letters, vol. 13,
no. 12. The Royal Society, 2017.
ista: Pleska M, Guet CC. 2017. Effects of mutations in phage restriction sites during
escape from restriction–modification. Biology Letters. 13(12), 20170646.
mla: Pleska, Maros, and Calin C. Guet. “Effects of Mutations in Phage Restriction
Sites during Escape from Restriction–Modification.” Biology Letters, vol.
13, no. 12, 20170646, The Royal Society, 2017, doi:10.1098/rsbl.2017.0646.
short: M. Pleska, C.C. Guet, Biology Letters 13 (2017).
date_created: 2018-12-11T11:47:11Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-09-07T11:59:32Z
day: '01'
department:
- _id: CaGu
doi: 10.1098/rsbl.2017.0646
external_id:
pmid:
- '29237814'
intvolume: ' 13'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1098/rsbl.2017.0646
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 251BCBEC-B435-11E9-9278-68D0E5697425
grant_number: RGY0079/2011
name: Multi-Level Conflicts in Evolutionary Dynamics of Restriction-Modification
Systems (HFSP Young investigators' grant)
- _id: 251D65D8-B435-11E9-9278-68D0E5697425
grant_number: '24210'
name: Effects of Stochasticity on the Function of Restriction-Modi cation Systems
at the Single-Cell Level (DOC Fellowship)
publication: Biology Letters
publication_identifier:
issn:
- 1744-9561
publication_status: published
publisher: The Royal Society
publist_id: '7253'
quality_controlled: '1'
related_material:
record:
- id: '9847'
relation: research_data
status: public
- id: '202'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Effects of mutations in phage restriction sites during escape from restriction–modification
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2017'
...
---
_id: '7753'
abstract:
- lang: eng
text: 'In many species, females show reduced expression of a trait that is under
sexual selection in males, and this expression is thought to be maintained through
genetic associations with the male phenotype. However, there is also the potential
for the female trait to convey an advantage in intrasexual conflicts over resources.
We tested this hypothesis in a feral population of Soay sheep, in which males
and females have a polymorphism for horn development, producing either full (normal
horned), reduced (scurred) or no (polled, females only) horns. During the lambing
period, females who possessed horns were more likely to initiate and win aggressive
interactions, independent of age, weight and birthing status. The occurrence of
aggression was also context dependent, decreasing over the lambing period and
associated with local density. Our results demonstrate that a trait that confers
benefits to males during intrasexual competition for mates may also be used by
females in intrasexual competition over resources: males use weaponry to gain
mates, whereas females use weaponry to gain food.'
article_processing_charge: No
article_type: original
author:
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Loeske E.B
full_name: Kruuk, Loeske E.B
last_name: Kruuk
citation:
ama: 'Robinson MR, Kruuk LE. Function of weaponry in females: The use of horns in
intrasexual competition for resources in female Soay sheep. Biology Letters.
2007;3(6):651-654. doi:10.1098/rsbl.2007.0278'
apa: 'Robinson, M. R., & Kruuk, L. E. . (2007). Function of weaponry in females:
The use of horns in intrasexual competition for resources in female Soay sheep.
Biology Letters. The Royal Society. https://doi.org/10.1098/rsbl.2007.0278'
chicago: 'Robinson, Matthew Richard, and Loeske E.B Kruuk. “Function of Weaponry
in Females: The Use of Horns in Intrasexual Competition for Resources in Female
Soay Sheep.” Biology Letters. The Royal Society, 2007. https://doi.org/10.1098/rsbl.2007.0278.'
ieee: 'M. R. Robinson and L. E. . Kruuk, “Function of weaponry in females: The use
of horns in intrasexual competition for resources in female Soay sheep,” Biology
Letters, vol. 3, no. 6. The Royal Society, pp. 651–654, 2007.'
ista: 'Robinson MR, Kruuk LE. 2007. Function of weaponry in females: The use of
horns in intrasexual competition for resources in female Soay sheep. Biology Letters.
3(6), 651–654.'
mla: 'Robinson, Matthew Richard, and Loeske E. .. Kruuk. “Function of Weaponry in
Females: The Use of Horns in Intrasexual Competition for Resources in Female Soay
Sheep.” Biology Letters, vol. 3, no. 6, The Royal Society, 2007, pp. 651–54,
doi:10.1098/rsbl.2007.0278.'
short: M.R. Robinson, L.E.. Kruuk, Biology Letters 3 (2007) 651–654.
date_created: 2020-04-30T11:02:28Z
date_published: 2007-08-21T00:00:00Z
date_updated: 2021-01-12T08:15:18Z
day: '21'
doi: 10.1098/rsbl.2007.0278
extern: '1'
external_id:
pmid:
- '17711817'
intvolume: ' 3'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1098/rsbl.2007.0278
month: '08'
oa: 1
oa_version: Published Version
page: 651-654
pmid: 1
publication: Biology Letters
publication_identifier:
issn:
- 1744-9561
- 1744-957X
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
status: public
title: 'Function of weaponry in females: The use of horns in intrasexual competition
for resources in female Soay sheep'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2007'
...