---
_id: '12140'
abstract:
- lang: eng
text: Microglia are dynamic cells, constantly surveying their surroundings and interacting
with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical
role of microglia in modulating synaptic transmission and plasticity in the developing
brain. In the past decade, novel pharmacological and genetic strategies have allowed
the acute removal of microglia, opening the possibility to explore and understand
the role of microglia also in the adult brain. In this review, we summarized and
discussed the contribution of microglia depletion strategies to the current understanding
of the role of microglia on synaptic function, learning and memory, and behavior
both in physiological and pathological conditions. We first described the available
microglia depletion methods highlighting their main strengths and weaknesses.
We then reviewed the impact of microglia depletion on structural and functional
synaptic plasticity. Next, we focused our analysis on the effects of microglia
depletion on behavior, including general locomotor activity, sensory perception,
motor function, sociability, learning and memory both in healthy animals and animal
models of disease. Finally, we integrated the findings from the reviewed studies
and discussed the emerging roles of microglia on the maintenance of synaptic function,
learning, memory strength and forgetfulness, and the implications of microglia
depletion in models of brain disease.
acknowledgement: "The write-up of the review was supported by Sapienza University
of Rome (Fondi di Ateneo, grant numbers #MA32117A7B698029 and #PH12017270934C3C
to SD), Regione Lazio (POR FSE 2014/20, grant number #19036AP000000019 to SD), Fulbright
2019 (grant number\r\n#FSP-P005556 to SD), Institute Pasteur Italia (Fondi Cenci
Bolognetti #363 to DR), and Network of European Funding for Neuroscience Research
(ERA-NET NEURON Transnational\r\nResearch Projects on Neurodevelopmental Disorders
2021, grant acronym #JTC2021-SHANKAstro to DR)."
article_number: '1022431'
article_processing_charge: No
article_type: original
author:
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Laura
full_name: Ferrucci, Laura
last_name: Ferrucci
- first_name: Azka
full_name: Khan, Azka
last_name: Khan
- first_name: Silvia
full_name: Di Angelantonio, Silvia
last_name: Di Angelantonio
- first_name: Davide
full_name: Ragozzino, Davide
last_name: Ragozzino
- first_name: Ingrid
full_name: Reverte, Ingrid
last_name: Reverte
citation:
ama: Basilico B, Ferrucci L, Khan A, Di Angelantonio S, Ragozzino D, Reverte I.
What microglia depletion approaches tell us about the role of microglia on synaptic
function and behavior. Frontiers in Cellular Neuroscience. 2022;16. doi:10.3389/fncel.2022.1022431
apa: Basilico, B., Ferrucci, L., Khan, A., Di Angelantonio, S., Ragozzino, D., &
Reverte, I. (2022). What microglia depletion approaches tell us about the role
of microglia on synaptic function and behavior. Frontiers in Cellular Neuroscience.
Frontiers Media. https://doi.org/10.3389/fncel.2022.1022431
chicago: Basilico, Bernadette, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio,
Davide Ragozzino, and Ingrid Reverte. “What Microglia Depletion Approaches Tell
Us about the Role of Microglia on Synaptic Function and Behavior.” Frontiers
in Cellular Neuroscience. Frontiers Media, 2022. https://doi.org/10.3389/fncel.2022.1022431.
ieee: B. Basilico, L. Ferrucci, A. Khan, S. Di Angelantonio, D. Ragozzino, and I.
Reverte, “What microglia depletion approaches tell us about the role of microglia
on synaptic function and behavior,” Frontiers in Cellular Neuroscience,
vol. 16. Frontiers Media, 2022.
ista: Basilico B, Ferrucci L, Khan A, Di Angelantonio S, Ragozzino D, Reverte I.
2022. What microglia depletion approaches tell us about the role of microglia
on synaptic function and behavior. Frontiers in Cellular Neuroscience. 16, 1022431.
mla: Basilico, Bernadette, et al. “What Microglia Depletion Approaches Tell Us about
the Role of Microglia on Synaptic Function and Behavior.” Frontiers in Cellular
Neuroscience, vol. 16, 1022431, Frontiers Media, 2022, doi:10.3389/fncel.2022.1022431.
short: B. Basilico, L. Ferrucci, A. Khan, S. Di Angelantonio, D. Ragozzino, I. Reverte,
Frontiers in Cellular Neuroscience 16 (2022).
date_created: 2023-01-12T12:04:50Z
date_published: 2022-11-04T00:00:00Z
date_updated: 2023-08-04T08:56:10Z
day: '04'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.3389/fncel.2022.1022431
external_id:
isi:
- '000886526600001'
pmid:
- '36406752'
file:
- access_level: open_access
checksum: 84696213ecf99182c58a9f34b9ff2e23
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T09:16:29Z
date_updated: 2023-01-24T09:16:29Z
file_id: '12352'
file_name: 2022_FrontiersNeuroscience_Basilico.pdf
file_size: 6399987
relation: main_file
success: 1
file_date_updated: 2023-01-24T09:16:29Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
keyword:
- Cellular and Molecular Neuroscience
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Cellular Neuroscience
publication_identifier:
issn:
- 1662-5102
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: What microglia depletion approaches tell us about the role of microglia on
synaptic function and behavior
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2022'
...