---
_id: '9019'
abstract:
- lang: eng
  text: Targeting protein–protein interactions has long been considered as a very
    difficult if impossible task, but over the past decade, front lines have moved.
    The number of successful examples is exponentially growing. This review presents
    a rapid overview of recent advances in this field considering the strengths and
    weaknesses of the small molecule approaches and alternative strategies such as
    the selection or design of artificial antibodies, peptides or peptidomimetics.
- lang: fre
  text: Cibler les interactions protéine–protéine a longtemps été considéré comme
    une tâche très difficile, voire impossible, mais, depuis les dix dernières années,
    les lignes ont bougé. Le nombre d’exemples de réussites s’accroît exponentiellement.
    Cette revue présente un rapide panorama des avancées récentes dans ce domaine,
    considérant les forces et les faiblesses de l’approche « petite molécule » ainsi
    que des stratégies alternatives comme la sélection ou le design d’anticorps artificiels,
    de peptides ou de peptidomimétiques.
article_processing_charge: No
article_type: original
author:
- first_name: May M
  full_name: Bakail, May M
  id: FB3C3F8E-522F-11EA-B186-22963DDC885E
  last_name: Bakail
  orcid: 0000-0002-9592-1587
- first_name: Francoise
  full_name: Ochsenbein, Francoise
  last_name: Ochsenbein
citation:
  ama: Bakail MM, Ochsenbein F. Targeting protein–protein interactions, a wide open
    field for drug design. <i>Comptes Rendus Chimie</i>. 2016;19(1-2):19-27. doi:<a
    href="https://doi.org/10.1016/j.crci.2015.12.004">10.1016/j.crci.2015.12.004</a>
  apa: Bakail, M. M., &#38; Ochsenbein, F. (2016). Targeting protein–protein interactions,
    a wide open field for drug design. <i>Comptes Rendus Chimie</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.crci.2015.12.004">https://doi.org/10.1016/j.crci.2015.12.004</a>
  chicago: Bakail, May M, and Francoise Ochsenbein. “Targeting Protein–Protein Interactions,
    a Wide Open Field for Drug Design.” <i>Comptes Rendus Chimie</i>. Elsevier, 2016.
    <a href="https://doi.org/10.1016/j.crci.2015.12.004">https://doi.org/10.1016/j.crci.2015.12.004</a>.
  ieee: M. M. Bakail and F. Ochsenbein, “Targeting protein–protein interactions, a
    wide open field for drug design,” <i>Comptes Rendus Chimie</i>, vol. 19, no. 1–2.
    Elsevier, pp. 19–27, 2016.
  ista: Bakail MM, Ochsenbein F. 2016. Targeting protein–protein interactions, a wide
    open field for drug design. Comptes Rendus Chimie. 19(1–2), 19–27.
  mla: Bakail, May M., and Francoise Ochsenbein. “Targeting Protein–Protein Interactions,
    a Wide Open Field for Drug Design.” <i>Comptes Rendus Chimie</i>, vol. 19, no.
    1–2, Elsevier, 2016, pp. 19–27, doi:<a href="https://doi.org/10.1016/j.crci.2015.12.004">10.1016/j.crci.2015.12.004</a>.
  short: M.M. Bakail, F. Ochsenbein, Comptes Rendus Chimie 19 (2016) 19–27.
date_created: 2021-01-19T11:11:54Z
date_published: 2016-02-06T00:00:00Z
date_updated: 2023-02-23T13:46:55Z
day: '06'
ddc:
- '570'
doi: 10.1016/j.crci.2015.12.004
extern: '1'
file:
- access_level: open_access
  checksum: c262814ffdbfe95900256ab9ff42cdf5
  content_type: application/pdf
  creator: dernst
  date_created: 2021-01-22T12:36:52Z
  date_updated: 2021-01-22T12:36:52Z
  file_id: '9035'
  file_name: 2016_ComptesRendueChimie_Bakail.pdf
  file_size: 2045260
  relation: main_file
  success: 1
file_date_updated: 2021-01-22T12:36:52Z
has_accepted_license: '1'
intvolume: '        19'
issue: 1-2
keyword:
- General Chemistry
- General Chemical Engineering
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 19-27
publication: Comptes Rendus Chimie
publication_identifier:
  issn:
  - 1631-0748
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Targeting protein–protein interactions, a wide open field for drug design
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2016'
...