@article{11062,
  abstract     = {Most neurons are not replaced during an animal’s lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins. To study the lifespans of cells and proteins in adult tissues, we combined isotope labeling of mice with a hybrid imaging method (MIMS-EM). Using 15N mapping, we show that liver and pancreas are composed of cells with vastly different ages, many as old as the animal. Strikingly, we also found that a subset of fibroblasts and endothelial cells, both known for their replicative potential, are characterized by the absence of cell division during adulthood. In addition, we show that the primary cilia of beta cells and neurons contains different structural regions with vastly different lifespans. Based on these results, we propose that age mosaicism across multiple scales is a fundamental principle of adult tissue, cell, and protein complex organization.},
  author       = {Arrojo e Drigo, Rafael and Lev-Ram, Varda and Tyagi, Swati and Ramachandra, Ranjan and Deerinck, Thomas and Bushong, Eric and Phan, Sebastien and Orphan, Victoria and Lechene, Claude and Ellisman, Mark H. and HETZER, Martin W},
  issn         = {1550-4131},
  journal      = {Cell Metabolism},
  keywords     = {Cell Biology, Molecular Biology, Physiology},
  number       = {2},
  pages        = {343--351.e3},
  publisher    = {Elsevier},
  title        = {{Age mosaicism across multiple scales in adult tissues}},
  doi          = {10.1016/j.cmet.2019.05.010},
  volume       = {30},
  year         = {2019},
}

@article{6145,
  author       = {Cohen, Merav and Reale, Vincenzina and Olofsson, Birgitta and Knights, Andrew and Evans, Peter and de Bono, Mario},
  issn         = {1550-4131},
  journal      = {Cell Metabolism},
  number       = {4},
  pages        = {375--385},
  publisher    = {Elsevier},
  title        = {{Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling}},
  doi          = {10.1016/j.cmet.2009.02.003},
  volume       = {9},
  year         = {2009},
}