[{"external_id":{"pmid":["30482949"]},"related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41593-018-0307-x"}]},"title":"Motor primitives in space and time via targeted gain modulation in cortical networks","publication":"Nature Neuroscience","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276991/"}],"issue":"12","citation":{"ama":"Stroud JP, Porter MA, Hennequin G, Vogels TP. Motor primitives in space and time via targeted gain modulation in cortical networks. <i>Nature Neuroscience</i>. 2018;21(12):1774-1783. doi:<a href=\"https://doi.org/10.1038/s41593-018-0276-0\">10.1038/s41593-018-0276-0</a>","ista":"Stroud JP, Porter MA, Hennequin G, Vogels TP. 2018. Motor primitives in space and time via targeted gain modulation in cortical networks. Nature Neuroscience. 21(12), 1774–1783.","apa":"Stroud, J. P., Porter, M. A., Hennequin, G., &#38; Vogels, T. P. (2018). Motor primitives in space and time via targeted gain modulation in cortical networks. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41593-018-0276-0\">https://doi.org/10.1038/s41593-018-0276-0</a>","short":"J.P. Stroud, M.A. Porter, G. Hennequin, T.P. Vogels, Nature Neuroscience 21 (2018) 1774–1783.","mla":"Stroud, Jake P., et al. “Motor Primitives in Space and Time via Targeted Gain Modulation in Cortical Networks.” <i>Nature Neuroscience</i>, vol. 21, no. 12, Springer Nature, 2018, pp. 1774–83, doi:<a href=\"https://doi.org/10.1038/s41593-018-0276-0\">10.1038/s41593-018-0276-0</a>.","ieee":"J. P. Stroud, M. A. Porter, G. Hennequin, and T. P. Vogels, “Motor primitives in space and time via targeted gain modulation in cortical networks,” <i>Nature Neuroscience</i>, vol. 21, no. 12. Springer Nature, pp. 1774–1783, 2018.","chicago":"Stroud, Jake P., Mason A. Porter, Guillaume Hennequin, and Tim P Vogels. “Motor Primitives in Space and Time via Targeted Gain Modulation in Cortical Networks.” <i>Nature Neuroscience</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41593-018-0276-0\">https://doi.org/10.1038/s41593-018-0276-0</a>."},"abstract":[{"lang":"eng","text":"Motor cortex (M1) exhibits a rich repertoire of neuronal activities to support the generation of complex movements. Although recent neuronal-network models capture many qualitative aspects of M1 dynamics, they can generate only a few distinct movements. Additionally, it is unclear how M1 efficiently controls movements over a wide range of shapes and speeds. We demonstrate that modulation of neuronal input–output gains in recurrent neuronal-network models with a fixed architecture can dramatically reorganize neuronal activity and thus downstream muscle outputs. Consistent with the observation of diffuse neuromodulatory projections to M1, a relatively small number of modulatory control units provide sufficient flexibility to adjust high-dimensional network activity using a simple reward-based learning rule. Furthermore, it is possible to assemble novel movements from previously learned primitives, and one can separately change movement speed while preserving movement shape. Our results provide a new perspective on the role of modulatory systems in controlling recurrent cortical activity."}],"publication_status":"published","page":"1774-1783","oa_version":"Submitted Version","day":"01","status":"public","date_updated":"2021-01-12T08:16:46Z","article_type":"original","volume":21,"quality_controlled":"1","publication_identifier":{"issn":["1097-6256","1546-1726"]},"month":"12","intvolume":"        21","extern":"1","article_processing_charge":"No","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","pmid":1,"date_created":"2020-06-30T13:18:02Z","date_published":"2018-12-01T00:00:00Z","oa":1,"_id":"8073","author":[{"last_name":"Stroud","full_name":"Stroud, Jake P.","first_name":"Jake P."},{"first_name":"Mason A.","full_name":"Porter, Mason A.","last_name":"Porter"},{"first_name":"Guillaume","full_name":"Hennequin, Guillaume","last_name":"Hennequin"},{"first_name":"Tim P","full_name":"Vogels, Tim P","last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181"}],"type":"journal_article","publisher":"Springer Nature","year":"2018","language":[{"iso":"eng"}],"doi":"10.1038/s41593-018-0276-0"},{"type":"journal_article","publisher":"Nature Publishing Group","year":"2012","language":[{"iso":"eng"}],"doi":"10.1038/nn.3060","date_published":"2012-04-01T00:00:00Z","oa":1,"_id":"3258","author":[{"full_name":"Kim, Sooyun","first_name":"Sooyun","last_name":"Kim","id":"394AB1C8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"José","full_name":"Guzmán, José","orcid":"0000-0003-2209-5242","last_name":"Guzmán","id":"30CC5506-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hua","full_name":"Hu, Hua","id":"4AC0145C-F248-11E8-B48F-1D18A9856A87","last_name":"Hu"},{"last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M"}],"intvolume":"        15","article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","pmid":1,"acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft (TR 3/B10) and the European Union (European Research Council Advanced grant to P.J.).","department":[{"_id":"PeJo"}],"date_created":"2018-12-11T12:02:18Z","volume":15,"article_type":"original","quality_controlled":"1","publication_identifier":{"issn":["1546-1726"]},"publist_id":"3390","month":"04","status":"public","date_updated":"2023-09-07T11:43:52Z","abstract":[{"text":"CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. It is generally thought that proximal synapses from the mossy fibers activate these neurons most efficiently, whereas distal inputs from the perforant path have a weaker modulatory influence. We used confocally targeted patch-clamp recording from dendrites and axons to map the activation of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two distinct dendritic domains. In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na+ channel–mediated dendritic spikes are efficiently initiated by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed a high Na+-to-K+ conductance density ratio, providing ideal conditions for active backpropagation and dendritic spike initiation. Dendritic spikes may enhance the computational power of CA3 pyramidal neurons in the hippocampal network.","lang":"eng"}],"oa_version":"Published Version","publication_status":"published","page":"600 - 606","day":"01","issue":"4","scopus_import":"1","project":[{"grant_number":"SFB-TR3-TP10B","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425"}],"citation":{"ama":"Kim S, Guzmán J, Hu H, Jonas PM. Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>. 2012;15(4):600-606. doi:<a href=\"https://doi.org/10.1038/nn.3060\">10.1038/nn.3060</a>","apa":"Kim, S., Guzmán, J., Hu, H., &#38; Jonas, P. M. (2012). Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn.3060\">https://doi.org/10.1038/nn.3060</a>","ista":"Kim S, Guzmán J, Hu H, Jonas PM. 2012. Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience. 15(4), 600–606.","mla":"Kim, Sooyun, et al. “Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>, vol. 15, no. 4, Nature Publishing Group, 2012, pp. 600–06, doi:<a href=\"https://doi.org/10.1038/nn.3060\">10.1038/nn.3060</a>.","short":"S. Kim, J. Guzmán, H. Hu, P.M. Jonas, Nature Neuroscience 15 (2012) 600–606.","ieee":"S. Kim, J. Guzmán, H. Hu, and P. M. Jonas, “Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons,” <i>Nature Neuroscience</i>, vol. 15, no. 4. Nature Publishing Group, pp. 600–606, 2012.","chicago":"Kim, Sooyun, José Guzmán, Hua Hu, and Peter M Jonas. “Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nn.3060\">https://doi.org/10.1038/nn.3060</a>."},"external_id":{"pmid":["22388958"]},"related_material":{"record":[{"relation":"dissertation_contains","id":"2964","status":"public"}]},"title":"Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons","publication":"Nature Neuroscience","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617474/"}]},{"date_published":"2012-03-04T00:00:00Z","oa":1,"_id":"6136","author":[{"full_name":"Busch, Karl Emanuel","first_name":"Karl Emanuel","last_name":"Busch"},{"last_name":"Laurent","full_name":"Laurent, Patrick","first_name":"Patrick"},{"first_name":"Zoltan","full_name":"Soltesz, Zoltan","last_name":"Soltesz"},{"last_name":"Murphy","full_name":"Murphy, Robin Joseph","first_name":"Robin Joseph"},{"last_name":"Faivre","full_name":"Faivre, Olivier","first_name":"Olivier"},{"first_name":"Berthold","full_name":"Hedwig, Berthold","last_name":"Hedwig"},{"full_name":"Thomas, Martin","first_name":"Martin","last_name":"Thomas"},{"first_name":"Heather L","full_name":"Smith, Heather L","last_name":"Smith"},{"full_name":"de Bono, Mario","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","last_name":"de Bono","orcid":"0000-0001-8347-0443"}],"type":"journal_article","publisher":"Springer Nature","year":"2012","language":[{"iso":"eng"}],"doi":"10.1038/nn.3061","volume":15,"quality_controlled":"1","publication_identifier":{"issn":["1097-6256","1546-1726"]},"month":"03","intvolume":"        15","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","extern":"1","pmid":1,"date_created":"2019-03-20T14:23:30Z","abstract":[{"lang":"eng","text":"Tonic receptors convey stimulus duration and intensity and are implicated in homeostatic control. However, how tonic homeostatic signals are generated and how they reconfigure neural circuits and modify animal behavior is poorly understood. Here we show that Caenorhabditis elegans O2-sensing neurons are tonic receptors that continuously signal ambient [O2] to set the animal's behavioral state. Sustained signaling relied on a Ca2+ relay involving L-type voltage-gated Ca2+ channels, the ryanodine and the inositol-1,4,5-trisphosphate receptors. Tonic activity evoked continuous neuropeptide release, which helps elicit the enduring behavioral state associated with high [O2]. Sustained O2 receptor signaling was propagated to downstream neural circuits, including the hub interneuron RMG. O2 receptors evoked similar locomotory states at particular O2 concentrations, regardless of previous d[O2]/dt. However, a phasic component of the URX receptors' response to high d[O2]/dt, as well as tonic-to-phasic transformations in downstream interneurons, enabled transient reorientation movements shaped by d[O2]/dt. Our results highlight how tonic homeostatic signals can generate both transient and enduring behavioral change."}],"page":"581-591","oa_version":"Submitted Version","publication_status":"published","day":"04","status":"public","date_updated":"2021-01-12T08:06:17Z","external_id":{"pmid":["22388961"]},"title":"Tonic signaling from O2 sensors sets neural circuit activity and behavioral state","publication":"Nature Neuroscience","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564487/","open_access":"1"}],"issue":"4","citation":{"ieee":"K. E. Busch <i>et al.</i>, “Tonic signaling from O2 sensors sets neural circuit activity and behavioral state,” <i>Nature Neuroscience</i>, vol. 15, no. 4. Springer Nature, pp. 581–591, 2012.","chicago":"Busch, Karl Emanuel, Patrick Laurent, Zoltan Soltesz, Robin Joseph Murphy, Olivier Faivre, Berthold Hedwig, Martin Thomas, Heather L Smith, and Mario de Bono. “Tonic Signaling from O2 Sensors Sets Neural Circuit Activity and Behavioral State.” <i>Nature Neuroscience</i>. Springer Nature, 2012. <a href=\"https://doi.org/10.1038/nn.3061\">https://doi.org/10.1038/nn.3061</a>.","ama":"Busch KE, Laurent P, Soltesz Z, et al. Tonic signaling from O2 sensors sets neural circuit activity and behavioral state. <i>Nature Neuroscience</i>. 2012;15(4):581-591. doi:<a href=\"https://doi.org/10.1038/nn.3061\">10.1038/nn.3061</a>","short":"K.E. Busch, P. Laurent, Z. Soltesz, R.J. Murphy, O. Faivre, B. Hedwig, M. Thomas, H.L. Smith, M. de Bono, Nature Neuroscience 15 (2012) 581–591.","apa":"Busch, K. E., Laurent, P., Soltesz, Z., Murphy, R. J., Faivre, O., Hedwig, B., … de Bono, M. (2012). Tonic signaling from O2 sensors sets neural circuit activity and behavioral state. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nn.3061\">https://doi.org/10.1038/nn.3061</a>","mla":"Busch, Karl Emanuel, et al. “Tonic Signaling from O2 Sensors Sets Neural Circuit Activity and Behavioral State.” <i>Nature Neuroscience</i>, vol. 15, no. 4, Springer Nature, 2012, pp. 581–91, doi:<a href=\"https://doi.org/10.1038/nn.3061\">10.1038/nn.3061</a>.","ista":"Busch KE, Laurent P, Soltesz Z, Murphy RJ, Faivre O, Hedwig B, Thomas M, Smith HL, de Bono M. 2012. Tonic signaling from O2 sensors sets neural circuit activity and behavioral state. Nature Neuroscience. 15(4), 581–591."}},{"pmid":1,"date_created":"2020-06-25T13:10:55Z","intvolume":"        12","article_processing_charge":"No","extern":"1","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","quality_controlled":"1","publication_identifier":{"issn":["1097-6256","1546-1726"]},"month":"04","article_type":"original","volume":12,"publisher":"Springer Nature","year":"2009","language":[{"iso":"eng"}],"doi":"10.1038/nn.2276","type":"journal_article","oa":1,"_id":"8026","author":[{"last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181","first_name":"Tim P","full_name":"Vogels, Tim P"},{"full_name":"Abbott, L F","first_name":"L F","last_name":"Abbott"}],"date_published":"2009-04-01T00:00:00Z","citation":{"ama":"Vogels TP, Abbott LF. Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. <i>Nature Neuroscience</i>. 2009;12(4):483-491. doi:<a href=\"https://doi.org/10.1038/nn.2276\">10.1038/nn.2276</a>","apa":"Vogels, T. P., &#38; Abbott, L. F. (2009). Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nn.2276\">https://doi.org/10.1038/nn.2276</a>","short":"T.P. Vogels, L.F. Abbott, Nature Neuroscience 12 (2009) 483–491.","mla":"Vogels, Tim P., and L. F. Abbott. “Gating Multiple Signals through Detailed Balance of Excitation and Inhibition in Spiking Networks.” <i>Nature Neuroscience</i>, vol. 12, no. 4, Springer Nature, 2009, pp. 483–91, doi:<a href=\"https://doi.org/10.1038/nn.2276\">10.1038/nn.2276</a>.","ista":"Vogels TP, Abbott LF. 2009. Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. Nature Neuroscience. 12(4), 483–491.","ieee":"T. P. Vogels and L. F. Abbott, “Gating multiple signals through detailed balance of excitation and inhibition in spiking networks,” <i>Nature Neuroscience</i>, vol. 12, no. 4. Springer Nature, pp. 483–491, 2009.","chicago":"Vogels, Tim P, and L F Abbott. “Gating Multiple Signals through Detailed Balance of Excitation and Inhibition in Spiking Networks.” <i>Nature Neuroscience</i>. Springer Nature, 2009. <a href=\"https://doi.org/10.1038/nn.2276\">https://doi.org/10.1038/nn.2276</a>."},"issue":"4","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693069/"}],"external_id":{"pmid":["19305402"]},"title":"Gating multiple signals through detailed balance of excitation and inhibition in spiking networks","publication":"Nature Neuroscience","date_updated":"2021-01-12T08:16:36Z","status":"public","abstract":[{"text":"Recent theoretical work has provided a basic understanding of signal propagation in networks of spiking neurons, but mechanisms for gating and controlling these signals have not been investigated previously. Here we introduce an idea for the gating of multiple signals in cortical networks that combines principles of signal propagation with aspects of balanced networks. Specifically, we studied networks in which incoming excitatory signals are normally cancelled by locally evoked inhibition, leaving the targeted layer unresponsive. Transmission can be gated 'on' by modulating excitatory and inhibitory gains to upset this detailed balance. We illustrate gating through detailed balance in large networks of integrate-and-fire neurons. We show successful gating of multiple signals and study failure modes that produce effects reminiscent of clinically observed pathologies. Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals.","lang":"eng"}],"page":"483-491","publication_status":"published","oa_version":"Submitted Version","day":"01"},{"abstract":[{"lang":"eng","text":"Social and solitary feeding in natural Caenorhabditis elegans isolates are associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1: social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V. Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18 and flp-21 genes as NPR-1 ligands and show that these peptides can differentially activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21 deletion partially phenocopied the npr-1(null) phenotype, which is consistent with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands."}],"oa_version":"None","date_published":"2003-10-12T00:00:00Z","page":"1178-1185","publication_status":"published","day":"12","_id":"6156","author":[{"last_name":"Rogers","full_name":"Rogers, Candida","first_name":"Candida"},{"first_name":"Vincenzina","full_name":"Reale, Vincenzina","last_name":"Reale"},{"full_name":"Kim, Kyuhyung","first_name":"Kyuhyung","last_name":"Kim"},{"first_name":"Heather","full_name":"Chatwin, Heather","last_name":"Chatwin"},{"last_name":"Li","full_name":"Li, Chris","first_name":"Chris"},{"last_name":"Evans","first_name":"Peter","full_name":"Evans, Peter"},{"id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","last_name":"de Bono","orcid":"0000-0001-8347-0443","first_name":"Mario","full_name":"de Bono, Mario"}],"type":"journal_article","status":"public","date_updated":"2021-01-12T08:06:25Z","publisher":"Springer Nature","year":"2003","language":[{"iso":"eng"}],"doi":"10.1038/nn1140","external_id":{"pmid":["14555955"]},"volume":6,"title":"Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1","publication":"Nature Neuroscience","quality_controlled":"1","publication_identifier":{"issn":["1097-6256","1546-1726"]},"month":"10","intvolume":"         6","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","issue":"11","extern":"1","pmid":1,"citation":{"ieee":"C. Rogers <i>et al.</i>, “Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1,” <i>Nature Neuroscience</i>, vol. 6, no. 11. Springer Nature, pp. 1178–1185, 2003.","chicago":"Rogers, Candida, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris Li, Peter Evans, and Mario de Bono. “Inhibition of Caenorhabditis Elegans Social Feeding by FMRFamide-Related Peptide Activation of NPR-1.” <i>Nature Neuroscience</i>. Springer Nature, 2003. <a href=\"https://doi.org/10.1038/nn1140\">https://doi.org/10.1038/nn1140</a>.","ama":"Rogers C, Reale V, Kim K, et al. Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. <i>Nature Neuroscience</i>. 2003;6(11):1178-1185. doi:<a href=\"https://doi.org/10.1038/nn1140\">10.1038/nn1140</a>","short":"C. Rogers, V. Reale, K. Kim, H. Chatwin, C. Li, P. Evans, M. de Bono, Nature Neuroscience 6 (2003) 1178–1185.","mla":"Rogers, Candida, et al. “Inhibition of Caenorhabditis Elegans Social Feeding by FMRFamide-Related Peptide Activation of NPR-1.” <i>Nature Neuroscience</i>, vol. 6, no. 11, Springer Nature, 2003, pp. 1178–85, doi:<a href=\"https://doi.org/10.1038/nn1140\">10.1038/nn1140</a>.","apa":"Rogers, C., Reale, V., Kim, K., Chatwin, H., Li, C., Evans, P., &#38; de Bono, M. (2003). Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nn1140\">https://doi.org/10.1038/nn1140</a>","ista":"Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M. 2003. Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nature Neuroscience. 6(11), 1178–1185."},"date_created":"2019-03-21T09:47:53Z"}]