---
_id: '11069'
abstract:
- lang: eng
  text: Repeated rounds of nuclear envelope (NE) rupture and repair have been observed
    in laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization.
    Currently, the causes of NE rupture are unclear. Here, we show that NE rupture
    in cancer cells relies on the assembly of contractile actin bundles that interact
    with the nucleus via the linker of nucleoskeleton and cytoskeleton (LINC) complex.
    We found that the loss of actin bundles or the LINC complex did not rescue nuclear
    lamina defects, a previously identified determinant of nuclear membrane stability,
    but did decrease the number and size of chromatin hernias. Finally, NE rupture
    inhibition could be rescued in cells treated with actin-depolymerizing drugs by
    mechanically constraining nucleus height. These data suggest a model of NE rupture
    where weak membrane areas, caused by defects in lamina organization, rupture because
    of an increase in intranuclear pressure from actin-based nucleus confinement.
article_processing_charge: No
article_type: original
author:
- first_name: Emily M.
  full_name: Hatch, Emily M.
  last_name: Hatch
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Hatch EM, Hetzer M. Nuclear envelope rupture is induced by actin-based nucleus
    confinement. <i>Journal of Cell Biology</i>. 2016;215(1):27-36. doi:<a href="https://doi.org/10.1083/jcb.201603053">10.1083/jcb.201603053</a>
  apa: Hatch, E. M., &#38; Hetzer, M. (2016). Nuclear envelope rupture is induced
    by actin-based nucleus confinement. <i>Journal of Cell Biology</i>. Rockefeller
    University Press. <a href="https://doi.org/10.1083/jcb.201603053">https://doi.org/10.1083/jcb.201603053</a>
  chicago: Hatch, Emily M., and Martin Hetzer. “Nuclear Envelope Rupture Is Induced
    by Actin-Based Nucleus Confinement.” <i>Journal of Cell Biology</i>. Rockefeller
    University Press, 2016. <a href="https://doi.org/10.1083/jcb.201603053">https://doi.org/10.1083/jcb.201603053</a>.
  ieee: E. M. Hatch and M. Hetzer, “Nuclear envelope rupture is induced by actin-based
    nucleus confinement,” <i>Journal of Cell Biology</i>, vol. 215, no. 1. Rockefeller
    University Press, pp. 27–36, 2016.
  ista: Hatch EM, Hetzer M. 2016. Nuclear envelope rupture is induced by actin-based
    nucleus confinement. Journal of Cell Biology. 215(1), 27–36.
  mla: Hatch, Emily M., and Martin Hetzer. “Nuclear Envelope Rupture Is Induced by
    Actin-Based Nucleus Confinement.” <i>Journal of Cell Biology</i>, vol. 215, no.
    1, Rockefeller University Press, 2016, pp. 27–36, doi:<a href="https://doi.org/10.1083/jcb.201603053">10.1083/jcb.201603053</a>.
  short: E.M. Hatch, M. Hetzer, Journal of Cell Biology 215 (2016) 27–36.
date_created: 2022-04-07T07:47:42Z
date_published: 2016-10-03T00:00:00Z
date_updated: 2022-07-18T08:33:47Z
day: '03'
doi: 10.1083/jcb.201603053
extern: '1'
external_id:
  pmid:
  - '27697922'
intvolume: '       215'
issue: '1'
keyword:
- Cell Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1083/jcb.201603053
month: '10'
oa: 1
oa_version: Published Version
page: 27-36
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  issn:
  - 0021-9525
  - 1540-8140
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nuclear envelope rupture is induced by actin-based nucleus confinement
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 215
year: '2016'
...
---
_id: '11081'
abstract:
- lang: eng
  text: In eukaryotic cells the nuclear genome is enclosed by the nuclear envelope
    (NE). In metazoans, the NE breaks down in mitosis and it has been assumed that
    the physical barrier separating nucleoplasm and cytoplasm remains intact during
    the rest of the cell cycle and cell differentiation. However, recent studies suggest
    that nonmitotic NE remodeling plays a critical role in development, virus infection,
    laminopathies, and cancer. Although the mechanisms underlying these NE restructuring
    events are currently being defined, one common theme is activation of protein
    kinase C family members in the interphase nucleus to disrupt the nuclear lamina,
    demonstrating the importance of the lamina in maintaining nuclear integrity.
article_processing_charge: No
article_type: review
author:
- first_name: Emily
  full_name: Hatch, Emily
  last_name: Hatch
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease.
    <i>Journal of Cell Biology</i>. 2014;205(2):133-141. doi:<a href="https://doi.org/10.1083/jcb.201402003">10.1083/jcb.201402003</a>
  apa: Hatch, E., &#38; Hetzer, M. (2014). Breaching the nuclear envelope in development
    and disease. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a
    href="https://doi.org/10.1083/jcb.201402003">https://doi.org/10.1083/jcb.201402003</a>
  chicago: Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development
    and Disease.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2014.
    <a href="https://doi.org/10.1083/jcb.201402003">https://doi.org/10.1083/jcb.201402003</a>.
  ieee: E. Hatch and M. Hetzer, “Breaching the nuclear envelope in development and
    disease,” <i>Journal of Cell Biology</i>, vol. 205, no. 2. Rockefeller University
    Press, pp. 133–141, 2014.
  ista: Hatch E, Hetzer M. 2014. Breaching the nuclear envelope in development and
    disease. Journal of Cell Biology. 205(2), 133–141.
  mla: Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development
    and Disease.” <i>Journal of Cell Biology</i>, vol. 205, no. 2, Rockefeller University
    Press, 2014, pp. 133–41, doi:<a href="https://doi.org/10.1083/jcb.201402003">10.1083/jcb.201402003</a>.
  short: E. Hatch, M. Hetzer, Journal of Cell Biology 205 (2014) 133–141.
date_created: 2022-04-07T07:50:13Z
date_published: 2014-04-21T00:00:00Z
date_updated: 2022-07-18T08:45:09Z
day: '21'
doi: 10.1083/jcb.201402003
extern: '1'
external_id:
  pmid:
  - '24751535'
intvolume: '       205'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1083/jcb.201402003
month: '04'
oa: 1
oa_version: Published Version
page: 133-141
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  issn:
  - 1540-8140
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Breaching the nuclear envelope in development and disease
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 205
year: '2014'
...