---
_id: '7596'
abstract:
- lang: eng
  text: Casein kinase1 (CK1) plays crucial roles in regulating growth and development
    via phosphorylating various substrates throughout the eukaryote kingdom. Blue
    light is crucial for normal growth of both plants and animals, and blue light
    receptor cryptochrome2 (CRY2) undergoes blue light–dependent phosphorylation and
    degradation in planta. To study the function of plant CK1s, systematic genetic
    analysis showed that deficiency of two paralogous Arabidopsis thaliana CK1s, CK1.3
    and CK1.4, caused shortened hypocotyls, especially under blue light, while overexpression
    of either CK1.3 or CK1.4 resulted in the insensitive response to blue light and
    delayed flowering under long-day conditions. CK1.3 or CK1.4 act dependently on
    CRY2, and overexpression of CK1.3 or CK1.4 significantly suppresses the hypersensitive
    response to blue light by CRY2 overexpression. Biochemical studies showed that
    CK1.3 and CK1.4 directly phosphorylate CRY2 at Ser-587 and Thr-603 in vitro and
    negatively regulate CRY2 stability in planta, which are stimulated by blue light,
    further confirming the crucial roles of CK1.3 and CK1.4 in blue light responses
    through phosphorylating CRY2. Interestingly, expression of CK1.3 and CK1.4 is
    stimulated by blue light and feedback regulated by CRY2-mediated signaling. These
    results provide direct evidence for CRY2 phosphorylation and informative clues
    on the mechanisms of CRY2-mediated light responses.
article_processing_charge: No
article_type: original
author:
- first_name: Shutang
  full_name: Tan, Shutang
  id: 2DE75584-F248-11E8-B48F-1D18A9856A87
  last_name: Tan
  orcid: 0000-0002-0471-8285
- first_name: C.
  full_name: Dai, C.
  last_name: Dai
- first_name: H.-T.
  full_name: Liu, H.-T.
  last_name: Liu
- first_name: H.-W.
  full_name: Xue, H.-W.
  last_name: Xue
citation:
  ama: Tan S, Dai C, Liu H-T, Xue H-W. Arabidopsis casein kinase1 proteins CK1.3 and
    CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling. <i>The Plant
    Cell</i>. 2013;25(7):2618-2632. doi:<a href="https://doi.org/10.1105/tpc.113.114322">10.1105/tpc.113.114322</a>
  apa: Tan, S., Dai, C., Liu, H.-T., &#38; Xue, H.-W. (2013). Arabidopsis casein kinase1
    proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling.
    <i>The Plant Cell</i>. American Society of Plant Biologists. <a href="https://doi.org/10.1105/tpc.113.114322">https://doi.org/10.1105/tpc.113.114322</a>
  chicago: Tan, Shutang, C. Dai, H.-T. Liu, and H.-W. Xue. “Arabidopsis Casein Kinase1
    Proteins CK1.3 and CK1.4 Phosphorylate Cryptochrome2 to Regulate Blue Light Signaling.”
    <i>The Plant Cell</i>. American Society of Plant Biologists, 2013. <a href="https://doi.org/10.1105/tpc.113.114322">https://doi.org/10.1105/tpc.113.114322</a>.
  ieee: S. Tan, C. Dai, H.-T. Liu, and H.-W. Xue, “Arabidopsis casein kinase1 proteins
    CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling,”
    <i>The Plant Cell</i>, vol. 25, no. 7. American Society of Plant Biologists, pp.
    2618–2632, 2013.
  ista: Tan S, Dai C, Liu H-T, Xue H-W. 2013. Arabidopsis casein kinase1 proteins
    CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling.
    The Plant Cell. 25(7), 2618–2632.
  mla: Tan, Shutang, et al. “Arabidopsis Casein Kinase1 Proteins CK1.3 and CK1.4 Phosphorylate
    Cryptochrome2 to Regulate Blue Light Signaling.” <i>The Plant Cell</i>, vol. 25,
    no. 7, American Society of Plant Biologists, 2013, pp. 2618–32, doi:<a href="https://doi.org/10.1105/tpc.113.114322">10.1105/tpc.113.114322</a>.
  short: S. Tan, C. Dai, H.-T. Liu, H.-W. Xue, The Plant Cell 25 (2013) 2618–2632.
date_created: 2020-03-21T16:06:55Z
date_published: 2013-08-26T00:00:00Z
date_updated: 2021-01-12T08:14:24Z
day: '26'
doi: 10.1105/tpc.113.114322
extern: '1'
external_id:
  pmid:
  - '23897926'
intvolume: '        25'
issue: '7'
language:
- iso: eng
month: '08'
oa_version: None
page: 2618-2632
pmid: 1
publication: The Plant Cell
publication_identifier:
  issn:
  - 1040-4651
  - 1532-298X
publication_status: published
publisher: American Society of Plant Biologists
quality_controlled: '1'
status: public
title: Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2
  to regulate blue light signaling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2013'
...