---
_id: '6855'
abstract:
- lang: eng
  text: Many traits of interest are highly heritable and genetically complex, meaning
    that much of the variation they exhibit arises from differences at numerous loci
    in the genome. Complex traits and their evolution have been studied for more than
    a century, but only in the last decade have genome-wide association studies (GWASs)
    in humans begun to reveal their genetic basis. Here, we bring these threads of
    research together to ask how findings from GWASs can further our understanding
    of the processes that give rise to heritable variation in complex traits and of
    the genetic basis of complex trait evolution in response to changing selection
    pressures (i.e., of polygenic adaptation). Conversely, we ask how evolutionary
    thinking helps us to interpret findings from GWASs and informs related efforts
    of practical importance.
article_processing_charge: No
author:
- first_name: Guy
  full_name: Sella, Guy
  last_name: Sella
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Sella G, Barton NH. Thinking about the evolution of complex traits in the era
    of genome-wide association studies. <i>Annual Review of Genomics and Human Genetics</i>.
    2019;20:461-493. doi:<a href="https://doi.org/10.1146/annurev-genom-083115-022316">10.1146/annurev-genom-083115-022316</a>
  apa: Sella, G., &#38; Barton, N. H. (2019). Thinking about the evolution of complex
    traits in the era of genome-wide association studies. <i>Annual Review of Genomics
    and Human Genetics</i>. Annual Reviews. <a href="https://doi.org/10.1146/annurev-genom-083115-022316">https://doi.org/10.1146/annurev-genom-083115-022316</a>
  chicago: Sella, Guy, and Nicholas H Barton. “Thinking about the Evolution of Complex
    Traits in the Era of Genome-Wide Association Studies.” <i>Annual Review of Genomics
    and Human Genetics</i>. Annual Reviews, 2019. <a href="https://doi.org/10.1146/annurev-genom-083115-022316">https://doi.org/10.1146/annurev-genom-083115-022316</a>.
  ieee: G. Sella and N. H. Barton, “Thinking about the evolution of complex traits
    in the era of genome-wide association studies,” <i>Annual Review of Genomics and
    Human Genetics</i>, vol. 20. Annual Reviews, pp. 461–493, 2019.
  ista: Sella G, Barton NH. 2019. Thinking about the evolution of complex traits in
    the era of genome-wide association studies. Annual Review of Genomics and Human
    Genetics. 20, 461–493.
  mla: Sella, Guy, and Nicholas H. Barton. “Thinking about the Evolution of Complex
    Traits in the Era of Genome-Wide Association Studies.” <i>Annual Review of Genomics
    and Human Genetics</i>, vol. 20, Annual Reviews, 2019, pp. 461–93, doi:<a href="https://doi.org/10.1146/annurev-genom-083115-022316">10.1146/annurev-genom-083115-022316</a>.
  short: G. Sella, N.H. Barton, Annual Review of Genomics and Human Genetics 20 (2019)
    461–493.
date_created: 2019-09-07T14:28:29Z
date_published: 2019-07-05T00:00:00Z
date_updated: 2023-08-29T07:49:38Z
day: '05'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1146/annurev-genom-083115-022316
external_id:
  isi:
  - '000485148400020'
  pmid:
  - '31283361'
file:
- access_level: open_access
  checksum: 23d3978cf4739a89ce2c3e779f9305ca
  content_type: application/pdf
  creator: dernst
  date_created: 2019-09-09T07:22:12Z
  date_updated: 2020-07-14T12:47:42Z
  file_id: '6862'
  file_name: 2019_AnnualReview_Sella.pdf
  file_size: 411491
  relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: '        20'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 461-493
pmid: 1
publication: Annual Review of Genomics and Human Genetics
publication_identifier:
  eissn:
  - 1545-293X
  issn:
  - 1527-8204
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thinking about the evolution of complex traits in the era of genome-wide association
  studies
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2019'
...