---
_id: '8474'
abstract:
- lang: eng
  text: Hydrogen bonds are ubiquitous interactions in proteins, and are important
    for their folding and functionality. Scalar coupling constants across hydrogen
    bonds in the protein backbone, some as small as 0.5 Hz, can be directly measured
    in the solid state by NMR spectroscopy (see figure). The nuclei on both sides
    of the hydrogen bond can be identified and the size of the coupling constant can
    be measured accurately.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Matthias
  full_name: Huber, Matthias
  last_name: Huber
- first_name: René
  full_name: Verel, René
  last_name: Verel
- first_name: Matthias
  full_name: Ernst, Matthias
  last_name: Ernst
- first_name: "Beatâ\x80\NH."
  full_name: "Meier, Beatâ\x80\NH."
  last_name: Meier
citation:
  ama: Schanda P, Huber M, Verel R, Ernst M, Meier B. Direct detection of 3hJN’ hydrogen-bond
    scalar couplings in proteins by solid-state NMR spectroscopy. <i>Angewandte Chemie
    International Edition</i>. 2009;48(49):9322-9325. doi:<a href="https://doi.org/10.1002/anie.200904411">10.1002/anie.200904411</a>
  apa: Schanda, P., Huber, M., Verel, R., Ernst, M., &#38; Meier, B. (2009). Direct
    detection of 3hJN’ hydrogen-bond scalar couplings in proteins by solid-state NMR
    spectroscopy. <i>Angewandte Chemie International Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.200904411">https://doi.org/10.1002/anie.200904411</a>
  chicago: "Schanda, Paul, Matthias Huber, René Verel, Matthias Ernst, and Beatâ\x80\NH.
    Meier. “Direct Detection of 3hJN’ Hydrogen-Bond Scalar Couplings in Proteins by
    Solid-State NMR Spectroscopy.” <i>Angewandte Chemie International Edition</i>.
    Wiley, 2009. <a href=\"https://doi.org/10.1002/anie.200904411\">https://doi.org/10.1002/anie.200904411</a>."
  ieee: P. Schanda, M. Huber, R. Verel, M. Ernst, and B. Meier, “Direct detection
    of 3hJN’ hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy,”
    <i>Angewandte Chemie International Edition</i>, vol. 48, no. 49. Wiley, pp. 9322–9325,
    2009.
  ista: Schanda P, Huber M, Verel R, Ernst M, Meier B. 2009. Direct detection of 3hJN’
    hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy. Angewandte
    Chemie International Edition. 48(49), 9322–9325.
  mla: Schanda, Paul, et al. “Direct Detection of 3hJN’ Hydrogen-Bond Scalar Couplings
    in Proteins by Solid-State NMR Spectroscopy.” <i>Angewandte Chemie International
    Edition</i>, vol. 48, no. 49, Wiley, 2009, pp. 9322–25, doi:<a href="https://doi.org/10.1002/anie.200904411">10.1002/anie.200904411</a>.
  short: P. Schanda, M. Huber, R. Verel, M. Ernst, B. Meier, Angewandte Chemie International
    Edition 48 (2009) 9322–9325.
date_created: 2020-09-18T10:11:33Z
date_published: 2009-11-17T00:00:00Z
date_updated: 2021-01-12T08:19:31Z
day: '17'
doi: 10.1002/anie.200904411
extern: '1'
intvolume: '        48'
issue: '49'
keyword:
- General Chemistry
- Catalysis
language:
- iso: eng
month: '11'
oa_version: None
page: 9322-9325
publication: Angewandte Chemie International Edition
publication_identifier:
  issn:
  - 1433-7851
  - 1521-3773
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Direct detection of 3hJN' hydrogen-bond scalar couplings in proteins by solid-state
  NMR spectroscopy
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2009'
...