---
_id: '12940'
abstract:
- lang: eng
  text: Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization
    (EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization
    techniques for mass spectrometry. However, every single method has its limitation
    in terms of polarity and molecular weight of analyte molecules. After the miniaturization
    of every possible component of the different ion sources, we finally were able
    to embed two emitters and an ion transfer tubing into a small, hand-held device.
    The pen-like interface is connected to the mass spectrometer and a separate control
    unit via a bundle of flexible tubing and cables. The novel device allows the user
    to ionize an extended range of chemicals by simple switching between DESI, voltage-free
    EASI, or LTP ionization as well as to freely move the interface over a surface
    of interest. A mini camera, which is mounted on the tip of the pen, magnifies
    the desorption area and enables a simple positioning of the pen. The interface
    was successfully tested using different types of chemicals, pharmaceuticals, and
    real life samples. Moreover, the combination of optical data from the camera module
    and chemical data obtained by mass analysis facilitates a novel type of imaging
    mass spectrometry, which we name “interactive mass spectrometry imaging (IMSI)”.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Christina
  full_name: Meisenbichler, Christina
  last_name: Meisenbichler
- first_name: Florian
  full_name: Kluibenschedl, Florian
  id: 7499e70e-eb2c-11ec-b98b-f925648bc9d9
  last_name: Kluibenschedl
- first_name: Thomas
  full_name: Müller, Thomas
  last_name: Müller
citation:
  ama: Meisenbichler C, Kluibenschedl F, Müller T. A 3-in-1 hand-held ambient mass
    spectrometry interface for identification and 2D localization of chemicals on
    surfaces. <i>Analytical Chemistry</i>. 2020;92(21):14314-14318. doi:<a href="https://doi.org/10.1021/acs.analchem.0c02615">10.1021/acs.analchem.0c02615</a>
  apa: Meisenbichler, C., Kluibenschedl, F., &#38; Müller, T. (2020). A 3-in-1 hand-held
    ambient mass spectrometry interface for identification and 2D localization of
    chemicals on surfaces. <i>Analytical Chemistry</i>. American Chemical Society.
    <a href="https://doi.org/10.1021/acs.analchem.0c02615">https://doi.org/10.1021/acs.analchem.0c02615</a>
  chicago: Meisenbichler, Christina, Florian Kluibenschedl, and Thomas Müller. “A
    3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D
    Localization of Chemicals on Surfaces.” <i>Analytical Chemistry</i>. American
    Chemical Society, 2020. <a href="https://doi.org/10.1021/acs.analchem.0c02615">https://doi.org/10.1021/acs.analchem.0c02615</a>.
  ieee: C. Meisenbichler, F. Kluibenschedl, and T. Müller, “A 3-in-1 hand-held ambient
    mass spectrometry interface for identification and 2D localization of chemicals
    on surfaces,” <i>Analytical Chemistry</i>, vol. 92, no. 21. American Chemical
    Society, pp. 14314–14318, 2020.
  ista: Meisenbichler C, Kluibenschedl F, Müller T. 2020. A 3-in-1 hand-held ambient
    mass spectrometry interface for identification and 2D localization of chemicals
    on surfaces. Analytical Chemistry. 92(21), 14314–14318.
  mla: Meisenbichler, Christina, et al. “A 3-in-1 Hand-Held Ambient Mass Spectrometry
    Interface for Identification and 2D Localization of Chemicals on Surfaces.” <i>Analytical
    Chemistry</i>, vol. 92, no. 21, American Chemical Society, 2020, pp. 14314–18,
    doi:<a href="https://doi.org/10.1021/acs.analchem.0c02615">10.1021/acs.analchem.0c02615</a>.
  short: C. Meisenbichler, F. Kluibenschedl, T. Müller, Analytical Chemistry 92 (2020)
    14314–14318.
date_created: 2023-05-10T14:50:19Z
date_published: 2020-10-16T00:00:00Z
date_updated: 2023-05-15T08:01:20Z
day: '16'
doi: 10.1021/acs.analchem.0c02615
extern: '1'
external_id:
  pmid:
  - '33063994'
intvolume: '        92'
issue: '21'
keyword:
- Analytical Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1021/acs.analchem.0c02615
month: '10'
oa: 1
oa_version: Published Version
page: 14314-14318
pmid: 1
publication: Analytical Chemistry
publication_identifier:
  issn:
  - 0003-2700
  - 1520-6882
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: A 3-in-1 hand-held ambient mass spectrometry interface for identification and
  2D localization of chemicals on surfaces
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 92
year: '2020'
...
---
_id: '7300'
abstract:
- lang: eng
  text: Photoinduced electron transfer (PET), which causes pH-dependent quenching
    of fluorescent dyes, is more effectively introduced by phenolic groups than by
    amino groups which have been much more commonly used so far. That is demonstrated
    by fluorescence measurements involving several classes of fluorophores. Electrochemical
    measurements show that PET in several amino-modified dyes is thermodynamically
    favorable, even though it was not experimentally found, underlining the importance
    of kinetic aspects to the process. Consequently, the attachment of phenolic groups
    allows for fast and simple preparation of a wide selection of fluorescent pH-probes
    with tailor-made spectral properties, sensitive ranges, and individual advantages,
    so that a large number of applications can be realized. Fluorophores carrying
    phenolic groups may also be used for sensing analytes other than pH or molecular
    switching and signaling.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
  full_name: Aigner, Daniel
  last_name: Aigner
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Martin
  full_name: Wilkening, Martin
  last_name: Wilkening
- first_name: Robert
  full_name: Saf, Robert
  last_name: Saf
- first_name: Sergey M.
  full_name: Borisov, Sergey M.
  last_name: Borisov
- first_name: Ingo
  full_name: Klimant, Ingo
  last_name: Klimant
citation:
  ama: Aigner D, Freunberger SA, Wilkening M, Saf R, Borisov SM, Klimant I. Enhancing
    photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated
    phenols. <i>Analytical Chemistry</i>. 2014;86(18):9293-9300. doi:<a href="https://doi.org/10.1021/ac502513g">10.1021/ac502513g</a>
  apa: Aigner, D., Freunberger, S. A., Wilkening, M., Saf, R., Borisov, S. M., &#38;
    Klimant, I. (2014). Enhancing photoinduced electron transfer efficiency of fluorescent
    pH-probes with halogenated phenols. <i>Analytical Chemistry</i>. ACS. <a href="https://doi.org/10.1021/ac502513g">https://doi.org/10.1021/ac502513g</a>
  chicago: Aigner, Daniel, Stefan Alexander Freunberger, Martin Wilkening, Robert
    Saf, Sergey M. Borisov, and Ingo Klimant. “Enhancing Photoinduced Electron Transfer
    Efficiency of Fluorescent PH-Probes with Halogenated Phenols.” <i>Analytical Chemistry</i>.
    ACS, 2014. <a href="https://doi.org/10.1021/ac502513g">https://doi.org/10.1021/ac502513g</a>.
  ieee: D. Aigner, S. A. Freunberger, M. Wilkening, R. Saf, S. M. Borisov, and I.
    Klimant, “Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes
    with halogenated phenols,” <i>Analytical Chemistry</i>, vol. 86, no. 18. ACS,
    pp. 9293–9300, 2014.
  ista: Aigner D, Freunberger SA, Wilkening M, Saf R, Borisov SM, Klimant I. 2014.
    Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with
    halogenated phenols. Analytical Chemistry. 86(18), 9293–9300.
  mla: Aigner, Daniel, et al. “Enhancing Photoinduced Electron Transfer Efficiency
    of Fluorescent PH-Probes with Halogenated Phenols.” <i>Analytical Chemistry</i>,
    vol. 86, no. 18, ACS, 2014, pp. 9293–300, doi:<a href="https://doi.org/10.1021/ac502513g">10.1021/ac502513g</a>.
  short: D. Aigner, S.A. Freunberger, M. Wilkening, R. Saf, S.M. Borisov, I. Klimant,
    Analytical Chemistry 86 (2014) 9293–9300.
date_created: 2020-01-15T12:17:17Z
date_published: 2014-08-14T00:00:00Z
date_updated: 2021-01-12T08:12:53Z
day: '14'
doi: 10.1021/ac502513g
extern: '1'
intvolume: '        86'
issue: '18'
language:
- iso: eng
month: '08'
oa_version: None
page: 9293-9300
publication: Analytical Chemistry
publication_identifier:
  issn:
  - 0003-2700
  - 1520-6882
publication_status: published
publisher: ACS
quality_controlled: '1'
status: public
title: Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes
  with halogenated phenols
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 86
year: '2014'
...