---
_id: '6117'
abstract:
- lang: eng
text: 'Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates
responses to pathogens or tissue damage, and drives autoimmune diseases. Little
is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like
properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter
their response properties and contribution to behaviour. Using unbiased genetic
screens, we delineate an IL-17 signalling pathway and show that it acts in the
RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to
input from oxygen sensors, and renders sustained escape from 21% oxygen transient
and contingent on additional stimuli. Over-activating IL-17 receptors abnormally
heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency
can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in
adults can rescue mutant defects within 6 h. These findings reveal a non-immunological
role of IL-17 modulating circuit function and behaviour.'
author:
- first_name: Changchun
full_name: Chen, Changchun
last_name: Chen
- first_name: Eisuke
full_name: Itakura, Eisuke
last_name: Itakura
- first_name: Geoffrey M.
full_name: Nelson, Geoffrey M.
last_name: Nelson
- first_name: Ming
full_name: Sheng, Ming
last_name: Sheng
- first_name: Patrick
full_name: Laurent, Patrick
last_name: Laurent
- first_name: Lorenz A.
full_name: Fenk, Lorenz A.
last_name: Fenk
- first_name: Rebecca A.
full_name: Butcher, Rebecca A.
last_name: Butcher
- first_name: Ramanujan S.
full_name: Hegde, Ramanujan S.
last_name: Hegde
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Chen C, Itakura E, Nelson GM, et al. IL-17 is a neuromodulator of Caenorhabditis
elegans sensory responses. Nature. 2017;542(7639):43-48. doi:10.1038/nature20818
apa: Chen, C., Itakura, E., Nelson, G. M., Sheng, M., Laurent, P., Fenk, L. A.,
… de Bono, M. (2017). IL-17 is a neuromodulator of Caenorhabditis elegans sensory
responses. Nature. Springer Nature. https://doi.org/10.1038/nature20818
chicago: Chen, Changchun, Eisuke Itakura, Geoffrey M. Nelson, Ming Sheng, Patrick
Laurent, Lorenz A. Fenk, Rebecca A. Butcher, Ramanujan S. Hegde, and Mario de
Bono. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.”
Nature. Springer Nature, 2017. https://doi.org/10.1038/nature20818.
ieee: C. Chen et al., “IL-17 is a neuromodulator of Caenorhabditis elegans
sensory responses,” Nature, vol. 542, no. 7639. Springer Nature, pp. 43–48,
2017.
ista: Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde
RS, de Bono M. 2017. IL-17 is a neuromodulator of Caenorhabditis elegans sensory
responses. Nature. 542(7639), 43–48.
mla: Chen, Changchun, et al. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans
Sensory Responses.” Nature, vol. 542, no. 7639, Springer Nature, 2017,
pp. 43–48, doi:10.1038/nature20818.
short: C. Chen, E. Itakura, G.M. Nelson, M. Sheng, P. Laurent, L.A. Fenk, R.A. Butcher,
R.S. Hegde, M. de Bono, Nature 542 (2017) 43–48.
date_created: 2019-03-19T14:06:41Z
date_published: 2017-02-02T00:00:00Z
date_updated: 2021-01-12T08:06:12Z
day: '02'
doi: 10.1038/nature20818
extern: '1'
external_id:
pmid:
- ' 28099418'
intvolume: ' 542'
issue: '7639'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pubmed/28099418
month: '02'
oa: 1
oa_version: Submitted Version
page: 43-48
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
- 1476-4687
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 542
year: '2017'
...
---
_id: '6144'
abstract:
- lang: eng
text: Behaviours evolve by iterations of natural selection, but we have few insights
into the molecular and neural mechanisms involved. Here we show that some Caenorhabditis
elegans wild strains switch between two foraging behaviours in response to subtle
changes in ambient oxygen. This finely tuned switch is conferred by a naturally
variable hexacoordinated globin, GLB-5. GLB-5 acts with the atypical soluble guanylate
cyclases1,2,3, which are a different type of oxygen binding protein, to tune the
dynamic range of oxygen-sensing neurons close to atmospheric (21%) concentrations.
Calcium imaging indicates that one group of these neurons is activated when oxygen
rises towards 21%, and is inhibited as oxygen drops below 21%. The soluble guanylate
cyclase GCY-35 is required for high oxygen to activate the neurons; GLB-5 provides
inhibitory input when oxygen decreases below 21%. Together, these oxygen binding
proteins tune neuronal and behavioural responses to a narrow oxygen concentration
range close to atmospheric levels. The effect of the glb-5 gene on oxygen sensing
and foraging is modified by the naturally variable neuropeptide receptor npr-1
(refs 4, 5), providing insights into how polygenic variation reshapes neural circuit
function.
author:
- first_name: Annelie
full_name: Persson, Annelie
last_name: Persson
- first_name: Einav
full_name: Gross, Einav
last_name: Gross
- first_name: Patrick
full_name: Laurent, Patrick
last_name: Laurent
- first_name: Karl Emanuel
full_name: Busch, Karl Emanuel
last_name: Busch
- first_name: Hugo
full_name: Bretes, Hugo
last_name: Bretes
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Persson A, Gross E, Laurent P, Busch KE, Bretes H, de Bono M. Natural variation
in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans. Nature.
2009;458(7241):1030-1033. doi:10.1038/nature07820
apa: Persson, A., Gross, E., Laurent, P., Busch, K. E., Bretes, H., & de Bono,
M. (2009). Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis
elegans. Nature. Springer Nature. https://doi.org/10.1038/nature07820
chicago: Persson, Annelie, Einav Gross, Patrick Laurent, Karl Emanuel Busch, Hugo
Bretes, and Mario de Bono. “Natural Variation in a Neural Globin Tunes Oxygen
Sensing in Wild Caenorhabditis Elegans.” Nature. Springer Nature, 2009.
https://doi.org/10.1038/nature07820.
ieee: A. Persson, E. Gross, P. Laurent, K. E. Busch, H. Bretes, and M. de Bono,
“Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis
elegans,” Nature, vol. 458, no. 7241. Springer Nature, pp. 1030–1033, 2009.
ista: Persson A, Gross E, Laurent P, Busch KE, Bretes H, de Bono M. 2009. Natural
variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.
Nature. 458(7241), 1030–1033.
mla: Persson, Annelie, et al. “Natural Variation in a Neural Globin Tunes Oxygen
Sensing in Wild Caenorhabditis Elegans.” Nature, vol. 458, no. 7241, Springer
Nature, 2009, pp. 1030–33, doi:10.1038/nature07820.
short: A. Persson, E. Gross, P. Laurent, K.E. Busch, H. Bretes, M. de Bono, Nature
458 (2009) 1030–1033.
date_created: 2019-03-21T07:48:44Z
date_published: 2009-04-23T00:00:00Z
date_updated: 2021-01-12T08:06:20Z
day: '23'
doi: 10.1038/nature07820
extern: '1'
external_id:
pmid:
- '19262507'
intvolume: ' 458'
issue: '7241'
language:
- iso: eng
month: '04'
oa_version: None
page: 1030-1033
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
- 1476-4687
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis
elegans
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 458
year: '2009'
...