---
_id: '6988'
abstract:
- lang: eng
  text: 'Platelets are central players in thrombosis and hemostasis but are increasingly
    recognized as key components of the immune system. They shape ensuing immune responses
    by recruiting leukocytes, and support the development of adaptive immunity. Recent
    data shed new light on the complex role of platelets in immunity. Here, we summarize
    experimental and clinical data on the role of platelets in host defense against
    bacteria. Platelets bind, contain, and kill bacteria directly; however, platelet
    proinflammatory effector functions and cross-talk with the coagulation system,
    can also result in damage to the host (e.g., acute lung injury and sepsis). Novel
    clinical insights support this dichotomy: platelet inhibition/thrombocytopenia
    can be either harmful or protective, depending on pathophysiological context.
    Clinical studies are currently addressing this aspect in greater depth.'
article_processing_charge: No
article_type: review
author:
- first_name: Leo
  full_name: Nicolai, Leo
  last_name: Nicolai
- first_name: Florian R
  full_name: Gärtner, Florian R
  id: 397A88EE-F248-11E8-B48F-1D18A9856A87
  last_name: Gärtner
  orcid: 0000-0001-6120-3723
- first_name: Steffen
  full_name: Massberg, Steffen
  last_name: Massberg
citation:
  ama: 'Nicolai L, Gärtner FR, Massberg S. Platelets in host defense: Experimental
    and clinical insights. <i>Trends in Immunology</i>. 2019;40(10):922-938. doi:<a
    href="https://doi.org/10.1016/j.it.2019.08.004">10.1016/j.it.2019.08.004</a>'
  apa: 'Nicolai, L., Gärtner, F. R., &#38; Massberg, S. (2019). Platelets in host
    defense: Experimental and clinical insights. <i>Trends in Immunology</i>. Cell
    Press. <a href="https://doi.org/10.1016/j.it.2019.08.004">https://doi.org/10.1016/j.it.2019.08.004</a>'
  chicago: 'Nicolai, Leo, Florian R Gärtner, and Steffen Massberg. “Platelets in Host
    Defense: Experimental and Clinical Insights.” <i>Trends in Immunology</i>. Cell
    Press, 2019. <a href="https://doi.org/10.1016/j.it.2019.08.004">https://doi.org/10.1016/j.it.2019.08.004</a>.'
  ieee: 'L. Nicolai, F. R. Gärtner, and S. Massberg, “Platelets in host defense: Experimental
    and clinical insights,” <i>Trends in Immunology</i>, vol. 40, no. 10. Cell Press,
    pp. 922–938, 2019.'
  ista: 'Nicolai L, Gärtner FR, Massberg S. 2019. Platelets in host defense: Experimental
    and clinical insights. Trends in Immunology. 40(10), 922–938.'
  mla: 'Nicolai, Leo, et al. “Platelets in Host Defense: Experimental and Clinical
    Insights.” <i>Trends in Immunology</i>, vol. 40, no. 10, Cell Press, 2019, pp.
    922–38, doi:<a href="https://doi.org/10.1016/j.it.2019.08.004">10.1016/j.it.2019.08.004</a>.'
  short: L. Nicolai, F.R. Gärtner, S. Massberg, Trends in Immunology 40 (2019) 922–938.
date_created: 2019-11-04T16:27:36Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2023-08-30T07:19:23Z
day: '01'
department:
- _id: MiSi
doi: 10.1016/j.it.2019.08.004
ec_funded: 1
external_id:
  isi:
  - '000493292100005'
  pmid:
  - '31601520'
intvolume: '        40'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 922-938
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '747687'
  name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Trends in Immunology
publication_identifier:
  issn:
  - 1471-4906
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Platelets in host defense: Experimental and clinical insights'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 40
year: '2019'
...