---
_id: '11084'
abstract:
- lang: eng
  text: Protein turnover is an effective way of maintaining a functional proteome,
    as old and potentially damaged polypeptides are destroyed and replaced by newly
    synthesized copies. An increasing number of intracellular proteins, however, have
    been identified that evade this turnover process and instead are maintained over
    a cell's lifetime. This diverse group of long-lived proteins might be particularly
    prone to accumulation of damage and thus have a crucial role in the functional
    deterioration of key regulatory processes during ageing.
article_processing_charge: No
article_type: original
author:
- first_name: Brandon H.
  full_name: Toyama, Brandon H.
  last_name: Toyama
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: 'Toyama BH, Hetzer M. Protein homeostasis: Live long, won’t prosper. <i>Nature
    Reviews Molecular Cell Biology</i>. 2013;14:55-61. doi:<a href="https://doi.org/10.1038/nrm3496">10.1038/nrm3496</a>'
  apa: 'Toyama, B. H., &#38; Hetzer, M. (2013). Protein homeostasis: Live long, won’t
    prosper. <i>Nature Reviews Molecular Cell Biology</i>. Springer Nature. <a href="https://doi.org/10.1038/nrm3496">https://doi.org/10.1038/nrm3496</a>'
  chicago: 'Toyama, Brandon H., and Martin Hetzer. “Protein Homeostasis: Live Long,
    Won’t Prosper.” <i>Nature Reviews Molecular Cell Biology</i>. Springer Nature,
    2013. <a href="https://doi.org/10.1038/nrm3496">https://doi.org/10.1038/nrm3496</a>.'
  ieee: 'B. H. Toyama and M. Hetzer, “Protein homeostasis: Live long, won’t prosper,”
    <i>Nature Reviews Molecular Cell Biology</i>, vol. 14. Springer Nature, pp. 55–61,
    2013.'
  ista: 'Toyama BH, Hetzer M. 2013. Protein homeostasis: Live long, won’t prosper.
    Nature Reviews Molecular Cell Biology. 14, 55–61.'
  mla: 'Toyama, Brandon H., and Martin Hetzer. “Protein Homeostasis: Live Long, Won’t
    Prosper.” <i>Nature Reviews Molecular Cell Biology</i>, vol. 14, Springer Nature,
    2013, pp. 55–61, doi:<a href="https://doi.org/10.1038/nrm3496">10.1038/nrm3496</a>.'
  short: B.H. Toyama, M. Hetzer, Nature Reviews Molecular Cell Biology 14 (2013) 55–61.
date_created: 2022-04-07T07:50:43Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2022-07-18T08:37:53Z
day: '01'
doi: 10.1038/nrm3496
extern: '1'
external_id:
  pmid:
  - '23258296'
intvolume: '        14'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 55-61
pmid: 1
publication: Nature Reviews Molecular Cell Biology
publication_identifier:
  issn:
  - 1471-0072
  - 1471-0080
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Protein homeostasis: Live long, won''t prosper'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 14
year: '2013'
...