[{"publication_identifier":{"issn":["1471-0056"],"eissn":["1471-0064"]},"type":"journal_article","date_published":"2019-01-01T00:00:00Z","status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","oa_version":"None","month":"01","publication":"Nature Reviews Genetics","keyword":["Genetics (clinical)","Genetics","Molecular Biology"],"language":[{"iso":"eng"}],"day":"01","doi":"10.1038/s41576-018-0063-5","abstract":[{"lang":"eng","text":"The genome is packaged and organized nonrandomly within the 3D space of the nucleus to promote efficient gene expression and to faithfully maintain silencing of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of proteins that actively participate in chromatin organization and gene regulation. Technological advances are providing views of genome organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear organization and gene regulation. These genome regulatory roles of proteins of the nuclear periphery have important influences on development, disease and ageing."}],"citation":{"ieee":"A. Buchwalter, J. M. Kaneshiro, and M. Hetzer, “Coaching from the sidelines: The nuclear periphery in genome regulation,” <i>Nature Reviews Genetics</i>, vol. 20, no. 1. Springer Nature, pp. 39–50, 2019.","chicago":"Buchwalter, Abigail, Jeanae M. Kaneshiro, and Martin Hetzer. “Coaching from the Sidelines: The Nuclear Periphery in Genome Regulation.” <i>Nature Reviews Genetics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41576-018-0063-5\">https://doi.org/10.1038/s41576-018-0063-5</a>.","apa":"Buchwalter, A., Kaneshiro, J. M., &#38; Hetzer, M. (2019). Coaching from the sidelines: The nuclear periphery in genome regulation. <i>Nature Reviews Genetics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41576-018-0063-5\">https://doi.org/10.1038/s41576-018-0063-5</a>","ama":"Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear periphery in genome regulation. <i>Nature Reviews Genetics</i>. 2019;20(1):39-50. doi:<a href=\"https://doi.org/10.1038/s41576-018-0063-5\">10.1038/s41576-018-0063-5</a>","ista":"Buchwalter A, Kaneshiro JM, Hetzer M. 2019. Coaching from the sidelines: The nuclear periphery in genome regulation. Nature Reviews Genetics. 20(1), 39–50.","short":"A. Buchwalter, J.M. Kaneshiro, M. Hetzer, Nature Reviews Genetics 20 (2019) 39–50.","mla":"Buchwalter, Abigail, et al. “Coaching from the Sidelines: The Nuclear Periphery in Genome Regulation.” <i>Nature Reviews Genetics</i>, vol. 20, no. 1, Springer Nature, 2019, pp. 39–50, doi:<a href=\"https://doi.org/10.1038/s41576-018-0063-5\">10.1038/s41576-018-0063-5</a>."},"year":"2019","date_updated":"2022-07-18T08:31:42Z","external_id":{"pmid":["30356165"]},"volume":20,"extern":"1","date_created":"2022-04-07T07:44:45Z","article_processing_charge":"No","publication_status":"published","intvolume":"        20","title":"Coaching from the sidelines: The nuclear periphery in genome regulation","scopus_import":"1","_id":"11059","pmid":1,"issue":"1","author":[{"first_name":"Abigail","last_name":"Buchwalter","full_name":"Buchwalter, Abigail"},{"full_name":"Kaneshiro, Jeanae M.","first_name":"Jeanae M.","last_name":"Kaneshiro"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W"}],"publisher":"Springer Nature","article_type":"review","quality_controlled":"1","page":"39-50"},{"publication":"Nature Reviews Genetics","oa_version":"None","month":"01","language":[{"iso":"eng"}],"date_published":"2002-01-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["1471-0056"]},"publist_id":"1831","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","pmid":1,"_id":"4261","scopus_import":"1","author":[{"first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Peter","last_name":"Keightley","full_name":"Keightley, Peter"}],"publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:07:55Z","title":"Understanding quantitative genetic variation","intvolume":"         3","page":"11 - 21","quality_controlled":"1","publisher":"Nature Publishing Group","article_type":"original","date_updated":"2023-06-06T10:07:00Z","citation":{"ieee":"N. H. Barton and P. Keightley, “Understanding quantitative genetic variation,” <i>Nature Reviews Genetics</i>, vol. 3. Nature Publishing Group, pp. 11–21, 2002.","chicago":"Barton, Nicholas H, and Peter Keightley. “Understanding Quantitative Genetic Variation.” <i>Nature Reviews Genetics</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/nrg700\">https://doi.org/10.1038/nrg700</a>.","apa":"Barton, N. H., &#38; Keightley, P. (2002). Understanding quantitative genetic variation. <i>Nature Reviews Genetics</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nrg700\">https://doi.org/10.1038/nrg700</a>","ama":"Barton NH, Keightley P. Understanding quantitative genetic variation. <i>Nature Reviews Genetics</i>. 2002;3:11-21. doi:<a href=\"https://doi.org/10.1038/nrg700\">10.1038/nrg700</a>","ista":"Barton NH, Keightley P. 2002. Understanding quantitative genetic variation. Nature Reviews Genetics. 3, 11–21.","mla":"Barton, Nicholas H., and Peter Keightley. “Understanding Quantitative Genetic Variation.” <i>Nature Reviews Genetics</i>, vol. 3, Nature Publishing Group, 2002, pp. 11–21, doi:<a href=\"https://doi.org/10.1038/nrg700\">10.1038/nrg700</a>.","short":"N.H. Barton, P. Keightley, Nature Reviews Genetics 3 (2002) 11–21."},"year":"2002","external_id":{"pmid":["11823787"]},"doi":"10.1038/nrg700","day":"01","abstract":[{"lang":"eng","text":"Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL) — the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability."}],"volume":3,"extern":"1"}]