---
_id: '5789'
abstract:
- lang: eng
  text: Tissue morphogenesis is driven by mechanical forces that elicit changes in
    cell size, shape and motion. The extent by which forces deform tissues critically
    depends on the rheological properties of the recipient tissue. Yet, whether and
    how dynamic changes in tissue rheology affect tissue morphogenesis and how they
    are regulated within the developing organism remain unclear. Here, we show that
    blastoderm spreading at the onset of zebrafish morphogenesis relies on a rapid,
    pronounced and spatially patterned tissue fluidization. Blastoderm fluidization
    is temporally controlled by mitotic cell rounding-dependent cell–cell contact
    disassembly during the last rounds of cell cleavages. Moreover, fluidization is
    spatially restricted to the central blastoderm by local activation of non-canonical
    Wnt signalling within the blastoderm margin, increasing cell cohesion and thereby
    counteracting the effect of mitotic rounding on contact disassembly. Overall,
    our results identify a fluidity transition mediated by loss of cell cohesion as
    a critical regulator of embryo morphogenesis.
acknowledged_ssus:
- _id: Bio
article_processing_charge: No
article_type: original
author:
- first_name: Nicoletta
  full_name: Petridou, Nicoletta
  id: 2A003F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Petridou
  orcid: 0000-0002-8451-1195
- first_name: Silvia
  full_name: Grigolon, Silvia
  last_name: Grigolon
- first_name: Guillaume
  full_name: Salbreux, Guillaume
  last_name: Salbreux
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Petridou N, Grigolon S, Salbreux G, Hannezo EB, Heisenberg C-PJ. Fluidization-mediated
    tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. <i>Nature
    Cell Biology</i>. 2019;21:169–178. doi:<a href="https://doi.org/10.1038/s41556-018-0247-4">10.1038/s41556-018-0247-4</a>
  apa: Petridou, N., Grigolon, S., Salbreux, G., Hannezo, E. B., &#38; Heisenberg,
    C.-P. J. (2019). Fluidization-mediated tissue spreading by mitotic cell rounding
    and non-canonical Wnt signalling. <i>Nature Cell Biology</i>. Nature Publishing
    Group. <a href="https://doi.org/10.1038/s41556-018-0247-4">https://doi.org/10.1038/s41556-018-0247-4</a>
  chicago: Petridou, Nicoletta, Silvia Grigolon, Guillaume Salbreux, Edouard B Hannezo,
    and Carl-Philipp J Heisenberg. “Fluidization-Mediated Tissue Spreading by Mitotic
    Cell Rounding and Non-Canonical Wnt Signalling.” <i>Nature Cell Biology</i>. Nature
    Publishing Group, 2019. <a href="https://doi.org/10.1038/s41556-018-0247-4">https://doi.org/10.1038/s41556-018-0247-4</a>.
  ieee: N. Petridou, S. Grigolon, G. Salbreux, E. B. Hannezo, and C.-P. J. Heisenberg,
    “Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical
    Wnt signalling,” <i>Nature Cell Biology</i>, vol. 21. Nature Publishing Group,
    pp. 169–178, 2019.
  ista: Petridou N, Grigolon S, Salbreux G, Hannezo EB, Heisenberg C-PJ. 2019. Fluidization-mediated
    tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. Nature
    Cell Biology. 21, 169–178.
  mla: Petridou, Nicoletta, et al. “Fluidization-Mediated Tissue Spreading by Mitotic
    Cell Rounding and Non-Canonical Wnt Signalling.” <i>Nature Cell Biology</i>, vol.
    21, Nature Publishing Group, 2019, pp. 169–178, doi:<a href="https://doi.org/10.1038/s41556-018-0247-4">10.1038/s41556-018-0247-4</a>.
  short: N. Petridou, S. Grigolon, G. Salbreux, E.B. Hannezo, C.-P.J. Heisenberg,
    Nature Cell Biology 21 (2019) 169–178.
date_created: 2018-12-30T22:59:15Z
date_published: 2019-02-01T00:00:00Z
date_updated: 2023-09-11T14:03:28Z
day: '01'
ddc:
- '570'
department:
- _id: CaHe
- _id: EdHa
doi: 10.1038/s41556-018-0247-4
ec_funded: 1
external_id:
  isi:
  - '000457468300011'
  pmid:
  - '30559456'
file:
- access_level: open_access
  checksum: e38523787b3bc84006f2793de99ad70f
  content_type: application/pdf
  creator: dernst
  date_created: 2020-10-21T07:18:35Z
  date_updated: 2020-10-21T07:18:35Z
  file_id: '8685'
  file_name: 2018_NatureCellBio_Petridou_accepted.pdf
  file_size: 71590590
  relation: main_file
  success: 1
file_date_updated: 2020-10-21T07:18:35Z
has_accepted_license: '1'
intvolume: '        21'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Submitted Version
page: 169–178
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
- _id: 253E54C8-B435-11E9-9278-68D0E5697425
  grant_number: ALTF710-2016
  name: Molecular mechanism of auxindriven formative divisions delineating lateral
    root organogenesis in plants (EMBO fellowship)
publication: Nature Cell Biology
publication_identifier:
  issn:
  - '14657392'
publication_status: published
publisher: Nature Publishing Group
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/when-a-fish-becomes-fluid/
scopus_import: '1'
status: public
title: Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical
  Wnt signalling
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 21
year: '2019'
...
---
_id: '678'
abstract:
- lang: eng
  text: The seminal observation that mechanical signals can elicit changes in biochemical
    signalling within cells, a process commonly termed mechanosensation and mechanotransduction,
    has revolutionized our understanding of the role of cell mechanics in various
    fundamental biological processes, such as cell motility, adhesion, proliferation
    and differentiation. In this Review, we will discuss how the interplay and feedback
    between mechanical and biochemical signals control tissue morphogenesis and cell
    fate specification in embryonic development.
author:
- first_name: Nicoletta
  full_name: Petridou, Nicoletta
  id: 2A003F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Petridou
  orcid: 0000-0002-8451-1195
- first_name: Zoltan P
  full_name: Spiro, Zoltan P
  id: 426AD026-F248-11E8-B48F-1D18A9856A87
  last_name: Spiro
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Petridou N, Spiro ZP, Heisenberg C-PJ. Multiscale force sensing in development.
    <i>Nature Cell Biology</i>. 2017;19(6):581-588. doi:<a href="https://doi.org/10.1038/ncb3524">10.1038/ncb3524</a>
  apa: Petridou, N., Spiro, Z. P., &#38; Heisenberg, C.-P. J. (2017). Multiscale force
    sensing in development. <i>Nature Cell Biology</i>. Nature Publishing Group. <a
    href="https://doi.org/10.1038/ncb3524">https://doi.org/10.1038/ncb3524</a>
  chicago: Petridou, Nicoletta, Zoltan P Spiro, and Carl-Philipp J Heisenberg. “Multiscale
    Force Sensing in Development.” <i>Nature Cell Biology</i>. Nature Publishing Group,
    2017. <a href="https://doi.org/10.1038/ncb3524">https://doi.org/10.1038/ncb3524</a>.
  ieee: N. Petridou, Z. P. Spiro, and C.-P. J. Heisenberg, “Multiscale force sensing
    in development,” <i>Nature Cell Biology</i>, vol. 19, no. 6. Nature Publishing
    Group, pp. 581–588, 2017.
  ista: Petridou N, Spiro ZP, Heisenberg C-PJ. 2017. Multiscale force sensing in development.
    Nature Cell Biology. 19(6), 581–588.
  mla: Petridou, Nicoletta, et al. “Multiscale Force Sensing in Development.” <i>Nature
    Cell Biology</i>, vol. 19, no. 6, Nature Publishing Group, 2017, pp. 581–88, doi:<a
    href="https://doi.org/10.1038/ncb3524">10.1038/ncb3524</a>.
  short: N. Petridou, Z.P. Spiro, C.-P.J. Heisenberg, Nature Cell Biology 19 (2017)
    581–588.
date_created: 2018-12-11T11:47:53Z
date_published: 2017-05-31T00:00:00Z
date_updated: 2021-01-12T08:08:59Z
day: '31'
department:
- _id: CaHe
doi: 10.1038/ncb3524
intvolume: '        19'
issue: '6'
language:
- iso: eng
month: '05'
oa_version: None
page: 581 - 588
project:
- _id: 25236028-B435-11E9-9278-68D0E5697425
  grant_number: ALTF534-2016
  name: The generation and function of anisotropic tissue tension in zebrafish epiboly
    (EMBO Fellowship)
publication: Nature Cell Biology
publication_identifier:
  issn:
  - '14657392'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7040'
quality_controlled: '1'
scopus_import: 1
status: public
title: Multiscale force sensing in development
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...
---
_id: '661'
abstract:
- lang: eng
  text: During embryonic development, mechanical forces are essential for cellular
    rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish
    embryo, friction forces are generated at the interface between anterior axial
    mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole
    and neurectoderm progenitors moving in the opposite direction towards the vegetal
    pole of the embryo. These friction forces lead to global rearrangement of cells
    within the neurectoderm and determine the position of the neural anlage. Using
    a combination of experiments and simulations, we show that this process depends
    on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated
    adhesion between those tissues. Our data thus establish the emergence of friction
    forces at the interface between moving tissues as a critical force-generating
    process shaping the embryo.
acknowledged_ssus:
- _id: SSU
author:
- first_name: Michael
  full_name: Smutny, Michael
  id: 3FE6E4E8-F248-11E8-B48F-1D18A9856A87
  last_name: Smutny
  orcid: 0000-0002-5920-9090
- first_name: Zsuzsa
  full_name: Ákos, Zsuzsa
  last_name: Ákos
- first_name: Silvia
  full_name: Grigolon, Silvia
  last_name: Grigolon
- first_name: Shayan
  full_name: Shamipour, Shayan
  id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
  last_name: Shamipour
- first_name: Verena
  full_name: Ruprecht, Verena
  last_name: Ruprecht
- first_name: Daniel
  full_name: Capek, Daniel
  id: 31C42484-F248-11E8-B48F-1D18A9856A87
  last_name: Capek
  orcid: 0000-0001-5199-9940
- first_name: Martin
  full_name: Behrndt, Martin
  id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
  last_name: Behrndt
- first_name: Ekaterina
  full_name: Papusheva, Ekaterina
  id: 41DB591E-F248-11E8-B48F-1D18A9856A87
  last_name: Papusheva
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
- first_name: Tamás
  full_name: Vicsek, Tamás
  last_name: Vicsek
- first_name: Guillaume
  full_name: Salbreux, Guillaume
  last_name: Salbreux
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Smutny M, Ákos Z, Grigolon S, et al. Friction forces position the neural anlage.
    <i>Nature Cell Biology</i>. 2017;19:306-317. doi:<a href="https://doi.org/10.1038/ncb3492">10.1038/ncb3492</a>
  apa: Smutny, M., Ákos, Z., Grigolon, S., Shamipour, S., Ruprecht, V., Capek, D.,
    … Heisenberg, C.-P. J. (2017). Friction forces position the neural anlage. <i>Nature
    Cell Biology</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/ncb3492">https://doi.org/10.1038/ncb3492</a>
  chicago: Smutny, Michael, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena
    Ruprecht, Daniel Capek, Martin Behrndt, et al. “Friction Forces Position the Neural
    Anlage.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/ncb3492">https://doi.org/10.1038/ncb3492</a>.
  ieee: M. Smutny <i>et al.</i>, “Friction forces position the neural anlage,” <i>Nature
    Cell Biology</i>, vol. 19. Nature Publishing Group, pp. 306–317, 2017.
  ista: Smutny M, Ákos Z, Grigolon S, Shamipour S, Ruprecht V, Capek D, Behrndt M,
    Papusheva E, Tada M, Hof B, Vicsek T, Salbreux G, Heisenberg C-PJ. 2017. Friction
    forces position the neural anlage. Nature Cell Biology. 19, 306–317.
  mla: Smutny, Michael, et al. “Friction Forces Position the Neural Anlage.” <i>Nature
    Cell Biology</i>, vol. 19, Nature Publishing Group, 2017, pp. 306–17, doi:<a href="https://doi.org/10.1038/ncb3492">10.1038/ncb3492</a>.
  short: M. Smutny, Z. Ákos, S. Grigolon, S. Shamipour, V. Ruprecht, D. Capek, M.
    Behrndt, E. Papusheva, M. Tada, B. Hof, T. Vicsek, G. Salbreux, C.-P.J. Heisenberg,
    Nature Cell Biology 19 (2017) 306–317.
date_created: 2018-12-11T11:47:46Z
date_published: 2017-03-27T00:00:00Z
date_updated: 2024-03-25T23:30:21Z
day: '27'
department:
- _id: CaHe
- _id: BjHo
- _id: Bio
doi: 10.1038/ncb3492
ec_funded: 1
external_id:
  pmid:
  - '28346437'
intvolume: '        19'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://europepmc.org/articles/pmc5635970
month: '03'
oa: 1
oa_version: Submitted Version
page: 306 - 317
pmid: 1
project:
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '306589'
  name: Decoding the complexity of turbulence at its origin
- _id: 252ABD0A-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 930-B20
  name: Control of Epithelial Cell Layer Spreading in Zebrafish
publication: Nature Cell Biology
publication_identifier:
  issn:
  - '14657392'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7074'
quality_controlled: '1'
related_material:
  record:
  - id: '50'
    relation: dissertation_contains
    status: public
  - id: '8350'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Friction forces position the neural anlage
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...