---
_id: '9016'
abstract:
- lang: eng
  text: Inhibiting the histone H3–ASF1 (anti‐silencing function 1) protein–protein
    interaction (PPI) represents a potential approach for treating numerous cancers.
    As an α‐helix‐mediated PPI, constraining the key histone H3 helix (residues 118–135)
    is a strategy through which chemical probes might be elaborated to test this hypothesis.
    In this work, variant H3118–135 peptides bearing pentenylglycine residues at the
    i and i+4 positions were constrained by olefin metathesis. Biophysical analyses
    revealed that promotion of a bioactive helical conformation depends on the position
    at which the constraint is introduced, but that the potency of binding towards
    ASF1 is unaffected by the constraint and instead that enthalpy–entropy compensation
    occurs.
article_processing_charge: No
article_type: original
author:
- first_name: May M
  full_name: Bakail, May M
  id: FB3C3F8E-522F-11EA-B186-22963DDC885E
  last_name: Bakail
  orcid: 0000-0002-9592-1587
- first_name: Silvia
  full_name: Rodriguez‐Marin, Silvia
  last_name: Rodriguez‐Marin
- first_name: Zsófia
  full_name: Hegedüs, Zsófia
  last_name: Hegedüs
- first_name: Marie E.
  full_name: Perrin, Marie E.
  last_name: Perrin
- first_name: Françoise
  full_name: Ochsenbein, Françoise
  last_name: Ochsenbein
- first_name: Andrew J.
  full_name: Wilson, Andrew J.
  last_name: Wilson
citation:
  ama: Bakail MM, Rodriguez‐Marin S, Hegedüs Z, Perrin ME, Ochsenbein F, Wilson AJ.
    Recognition of ASF1 by using hydrocarbon‐constrained peptides. <i>ChemBioChem</i>.
    2019;20(7):891-895. doi:<a href="https://doi.org/10.1002/cbic.201800633">10.1002/cbic.201800633</a>
  apa: Bakail, M. M., Rodriguez‐Marin, S., Hegedüs, Z., Perrin, M. E., Ochsenbein,
    F., &#38; Wilson, A. J. (2019). Recognition of ASF1 by using hydrocarbon‐constrained
    peptides. <i>ChemBioChem</i>. Wiley. <a href="https://doi.org/10.1002/cbic.201800633">https://doi.org/10.1002/cbic.201800633</a>
  chicago: Bakail, May M, Silvia Rodriguez‐Marin, Zsófia Hegedüs, Marie E. Perrin,
    Françoise Ochsenbein, and Andrew J. Wilson. “Recognition of ASF1 by Using Hydrocarbon‐constrained
    Peptides.” <i>ChemBioChem</i>. Wiley, 2019. <a href="https://doi.org/10.1002/cbic.201800633">https://doi.org/10.1002/cbic.201800633</a>.
  ieee: M. M. Bakail, S. Rodriguez‐Marin, Z. Hegedüs, M. E. Perrin, F. Ochsenbein,
    and A. J. Wilson, “Recognition of ASF1 by using hydrocarbon‐constrained peptides,”
    <i>ChemBioChem</i>, vol. 20, no. 7. Wiley, pp. 891–895, 2019.
  ista: Bakail MM, Rodriguez‐Marin S, Hegedüs Z, Perrin ME, Ochsenbein F, Wilson AJ.
    2019. Recognition of ASF1 by using hydrocarbon‐constrained peptides. ChemBioChem.
    20(7), 891–895.
  mla: Bakail, May M., et al. “Recognition of ASF1 by Using Hydrocarbon‐constrained
    Peptides.” <i>ChemBioChem</i>, vol. 20, no. 7, Wiley, 2019, pp. 891–95, doi:<a
    href="https://doi.org/10.1002/cbic.201800633">10.1002/cbic.201800633</a>.
  short: M.M. Bakail, S. Rodriguez‐Marin, Z. Hegedüs, M.E. Perrin, F. Ochsenbein,
    A.J. Wilson, ChemBioChem 20 (2019) 891–895.
date_created: 2021-01-19T10:59:14Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2023-02-23T13:46:48Z
day: '01'
doi: 10.1002/cbic.201800633
extern: '1'
intvolume: '        20'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.1002/cbic.201800633'
month: '04'
oa: 1
oa_version: Published Version
page: 891-895
publication: ChemBioChem
publication_identifier:
  issn:
  - 1439-4227
  - 1439-7633
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Recognition of ASF1 by using hydrocarbon‐constrained peptides
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2019'
...