---
_id: '1913'
abstract:
- lang: eng
  text: 'Deposits of phosphorylated tau protein and convergence of pathology in the
    hippocampus are the hallmarks of neurodegenerative tauopathies. Thus we aimed
    to evaluate whether regional and cellular vulnerability patterns in the hippocampus
    distinguish tauopathies or are influenced by their concomitant presence. Methods:
    We created a heat map of phospho-tau (AT8) immunoreactivity patterns in 24 hippocampal
    subregions/layers in individuals with Alzheimer''s disease (AD)-related neurofibrillary
    degeneration (n = 40), Pick''s disease (n = 8), progressive supranuclear palsy
    (n = 7), corticobasal degeneration (n = 6), argyrophilic grain disease (AGD, n
    = 18), globular glial tauopathy (n = 5), and tau-astrogliopathy of the elderly
    (n = 10). AT8 immunoreactivity patterns were compared by mathematical analysis.
    Results: Our study reveals disease-specific hot spots and regional selective vulnerability
    for these disorders. The pattern of hippocampal AD-related tau pathology is strongly
    influenced by concomitant AGD. Mathematical analysis reveals that hippocampal
    involvement in primary tauopathies is distinguishable from early-stage AD-related
    neurofibrillary degeneration. Conclusion: Our data demonstrate disease-specific
    AT8 immunoreactivity patterns and hot spots in the hippocampus even in tauopathies,
    which primarily do not affect the hippocampus. These hot spots can be shifted
    to other regions by the co-occurrence of tauopathies like AGD. Our observations
    support the notion that globular glial tauopathies and tau-astrogliopathy of the
    elderly are distinct entities.'
acknowledgement: This study was supported by the European Commission’s 7th Framework
  Programme under GA No. 278486, ‘DEVELAGE’.
article_processing_charge: No
article_type: original
author:
- first_name: Ivan
  full_name: Milenković, Ivan
  last_name: Milenković
- first_name: Tatjana
  full_name: Petrov, Tatjana
  id: 3D5811FC-F248-11E8-B48F-1D18A9856A87
  last_name: Petrov
  orcid: 0000-0002-9041-0905
- first_name: Gábor
  full_name: Kovács, Gábor
  last_name: Kovács
citation:
  ama: Milenković I, Petrov T, Kovács G. Patterns of hippocampal tau pathology differentiate
    neurodegenerative dementias. <i>Dementia and Geriatric Cognitive Disorders</i>.
    2014;38(5-6):375-388. doi:<a href="https://doi.org/10.1159/000365548">10.1159/000365548</a>
  apa: Milenković, I., Petrov, T., &#38; Kovács, G. (2014). Patterns of hippocampal
    tau pathology differentiate neurodegenerative dementias. <i>Dementia and Geriatric
    Cognitive Disorders</i>. Karger Publishers. <a href="https://doi.org/10.1159/000365548">https://doi.org/10.1159/000365548</a>
  chicago: Milenković, Ivan, Tatjana Petrov, and Gábor Kovács. “Patterns of Hippocampal
    Tau Pathology Differentiate Neurodegenerative Dementias.” <i>Dementia and Geriatric
    Cognitive Disorders</i>. Karger Publishers, 2014. <a href="https://doi.org/10.1159/000365548">https://doi.org/10.1159/000365548</a>.
  ieee: I. Milenković, T. Petrov, and G. Kovács, “Patterns of hippocampal tau pathology
    differentiate neurodegenerative dementias,” <i>Dementia and Geriatric Cognitive
    Disorders</i>, vol. 38, no. 5–6. Karger Publishers, pp. 375–388, 2014.
  ista: Milenković I, Petrov T, Kovács G. 2014. Patterns of hippocampal tau pathology
    differentiate neurodegenerative dementias. Dementia and Geriatric Cognitive Disorders.
    38(5–6), 375–388.
  mla: Milenković, Ivan, et al. “Patterns of Hippocampal Tau Pathology Differentiate
    Neurodegenerative Dementias.” <i>Dementia and Geriatric Cognitive Disorders</i>,
    vol. 38, no. 5–6, Karger Publishers, 2014, pp. 375–88, doi:<a href="https://doi.org/10.1159/000365548">10.1159/000365548</a>.
  short: I. Milenković, T. Petrov, G. Kovács, Dementia and Geriatric Cognitive Disorders
    38 (2014) 375–388.
date_created: 2018-12-11T11:54:41Z
date_published: 2014-11-07T00:00:00Z
date_updated: 2023-10-17T10:21:17Z
day: '07'
department:
- _id: CaGu
doi: 10.1159/000365548
external_id:
  pmid:
  - '25195847'
intvolume: '        38'
issue: 5-6
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://kops.uni-konstanz.de/bitstream/123456789/42127/1/Milenkovic_2-17ivylo2up0798.pdf
month: '11'
oa: 1
oa_version: Published Version
page: 375 - 388
pmid: 1
publication: Dementia and Geriatric Cognitive Disorders
publication_identifier:
  issn:
  - 1420-8008
publication_status: published
publisher: Karger Publishers
publist_id: '5181'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Patterns of hippocampal tau pathology differentiate neurodegenerative dementias
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2014'
...