[{"abstract":[{"lang":"eng","text":"To respond to auxin, the chief orchestrator of their multicellularity, plants evolved multiple receptor systems and signal transduction cascades. Despite decades of research, however, we are still lacking a satisfactory synthesis of various auxin signaling mechanisms. The chief discrepancy and historical controversy of the field is that of rapid and slow auxin effects on plant physiology and development. How is it possible that ions begin to trickle across the plasma membrane as soon as auxin enters the cell, even though the best-characterized transcriptional auxin pathway can take effect only after tens of minutes? Recently, unexpected progress has been made in understanding this and other unknowns of auxin signaling. We provide a perspective on these exciting developments and concepts whose general applicability might have ramifications beyond auxin signaling."}],"citation":{"ieee":"L. Fiedler and J. Friml, “Rapid auxin signaling: Unknowns old and new,” <i>Current Opinion in Plant Biology</i>, vol. 75, no. 10. Elsevier, 2023.","ista":"Fiedler L, Friml J. 2023. Rapid auxin signaling: Unknowns old and new. Current Opinion in Plant Biology. 75(10), 102443.","ama":"Fiedler L, Friml J. Rapid auxin signaling: Unknowns old and new. <i>Current Opinion in Plant Biology</i>. 2023;75(10). doi:<a href=\"https://doi.org/10.1016/j.pbi.2023.102443\">10.1016/j.pbi.2023.102443</a>","mla":"Fiedler, Lukas, and Jiří Friml. “Rapid Auxin Signaling: Unknowns Old and New.” <i>Current Opinion in Plant Biology</i>, vol. 75, no. 10, 102443, Elsevier, 2023, doi:<a href=\"https://doi.org/10.1016/j.pbi.2023.102443\">10.1016/j.pbi.2023.102443</a>.","chicago":"Fiedler, Lukas, and Jiří Friml. “Rapid Auxin Signaling: Unknowns Old and New.” <i>Current Opinion in Plant Biology</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.pbi.2023.102443\">https://doi.org/10.1016/j.pbi.2023.102443</a>.","short":"L. Fiedler, J. Friml, Current Opinion in Plant Biology 75 (2023).","apa":"Fiedler, L., &#38; Friml, J. (2023). Rapid auxin signaling: Unknowns old and new. <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2023.102443\">https://doi.org/10.1016/j.pbi.2023.102443</a>"},"year":"2023","article_number":"102443","date_created":"2023-09-10T22:01:11Z","file":[{"content_type":"application/pdf","file_id":"14482","creator":"amally","checksum":"1c476c3414d2dfb0c85db0cb6cfd8a28","file_name":"Fiedler CurrOpinOlantBiol 2023_revised.pdf","access_level":"open_access","success":1,"file_size":737872,"date_created":"2023-11-02T17:03:20Z","date_updated":"2023-11-02T17:03:20Z","relation":"main_file"}],"_id":"14313","publication_identifier":{"issn":["1369-5266"]},"acknowledgement":"The opening quote is not intended to reflect any political views of the authors. The authors by no means endorse the rhetoric of Donald Rumsfeld or the 2003 invasion of Iraq by the United States. Nevertheless, Rumsfeld's quote led to both public and academic debates on the concept of known and unknown unknowns, which can be applied to the recent unexpected developments in the auxin signaling field. We thank Linlin Qi and Huihuang Chen for their suggestions on figure presentation and inspiring discussions of TIR1/AFB signaling. Finally, we thank Aroosa Hussain for discussion of Greek mythology.","article_type":"review","scopus_import":"1","doi":"10.1016/j.pbi.2023.102443","oa_version":"Submitted Version","article_processing_charge":"No","file_date_updated":"2023-11-02T17:03:20Z","publication_status":"published","title":"Rapid auxin signaling: Unknowns old and new","intvolume":"        75","date_updated":"2023-11-07T08:17:13Z","publication":"Current Opinion in Plant Biology","department":[{"_id":"JiFr"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Lukas","last_name":"Fiedler","id":"7c417475-8972-11ed-ae7b-8b674ca26986","full_name":"Fiedler, Lukas"},{"last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"volume":75,"oa":1,"has_accepted_license":"1","issue":"10","day":"01","quality_controlled":"1","ddc":["580"],"language":[{"iso":"eng"}],"status":"public","month":"10","pmid":1,"publisher":"Elsevier","type":"journal_article","external_id":{"pmid":["37666097"]},"date_published":"2023-10-01T00:00:00Z"},{"doi":"10.1016/j.pbi.2022.102174","scopus_import":"1","article_type":"original","publication_identifier":{"issn":["1369-5266"]},"acknowledgement":"The authors apologize to those researchers whose work was not cited. In addition, exciting topics such as PIN polarization in context of phyllotaxis, shoot branching and termination of gravitropic bending, or role of additional auxin transporters could not have been included owing to lack of space. This work was supported by the Czech Science Foundation GAČR (GA18-26981S). The authors also acknowledge the EMBO for supporting J.H. with a long-term fellowship (ALTF217-2021).","title":"Auxin canalization: From speculative models toward molecular players","publication_status":"published","file_date_updated":"2022-03-10T13:34:09Z","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","article_number":"102174","year":"2022","citation":{"apa":"Hajny, J., Tan, S., &#38; Friml, J. (2022). Auxin canalization: From speculative models toward molecular players. <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">https://doi.org/10.1016/j.pbi.2022.102174</a>","short":"J. Hajny, S. Tan, J. Friml, Current Opinion in Plant Biology 65 (2022).","chicago":"Hajny, Jakub, Shutang Tan, and Jiří Friml. “Auxin Canalization: From Speculative Models toward Molecular Players.” <i>Current Opinion in Plant Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">https://doi.org/10.1016/j.pbi.2022.102174</a>.","mla":"Hajny, Jakub, et al. “Auxin Canalization: From Speculative Models toward Molecular Players.” <i>Current Opinion in Plant Biology</i>, vol. 65, no. 2, 102174, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">10.1016/j.pbi.2022.102174</a>.","ista":"Hajny J, Tan S, Friml J. 2022. Auxin canalization: From speculative models toward molecular players. Current Opinion in Plant Biology. 65(2), 102174.","ieee":"J. Hajny, S. Tan, and J. Friml, “Auxin canalization: From speculative models toward molecular players,” <i>Current Opinion in Plant Biology</i>, vol. 65, no. 2. Elsevier, 2022.","ama":"Hajny J, Tan S, Friml J. Auxin canalization: From speculative models toward molecular players. <i>Current Opinion in Plant Biology</i>. 2022;65(2). doi:<a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">10.1016/j.pbi.2022.102174</a>"},"abstract":[{"text":"Among the most fascinated properties of the plant hormone auxin is its ability to promote formation of its own directional transport routes. These gradually narrowing auxin channels form from the auxin source toward the sink and involve coordinated, collective polarization of individual cells. Once established, the channels provide positional information, along which new vascular strands form, for example, during organogenesis, regeneration, or leave venation. The main prerequisite of this still mysterious auxin canalization mechanism is a feedback between auxin signaling and its directional transport. This is manifested by auxin-induced re-arrangements of polar, subcellular localization of PIN-FORMED (PIN) auxin exporters. Immanent open questions relate to how position of auxin source and sink as well as tissue context are sensed and translated into tissue polarization and how cells communicate to polarize coordinately. Recently, identification of the first molecular players opens new avenues into molecular studies of this intriguing example of self-organizing plant development.","lang":"eng"}],"_id":"10768","file":[{"checksum":"f1ee02b6fb4200934eeb31fa69120885","creator":"dernst","file_id":"10844","content_type":"application/pdf","file_size":820322,"relation":"main_file","date_updated":"2022-03-10T13:34:09Z","date_created":"2022-03-10T13:34:09Z","file_name":"2022_CurrentOpPlantBiology_Hajny.pdf","success":1,"access_level":"open_access"}],"date_created":"2022-02-20T23:01:32Z","author":[{"last_name":"Hajny","first_name":"Jakub","full_name":"Hajny, Jakub","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2140-7195"},{"full_name":"Tan, Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0471-8285","last_name":"Tan","first_name":"Shutang"},{"last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"volume":65,"intvolume":"        65","department":[{"_id":"JiFr"}],"publication":"Current Opinion in Plant Biology","date_updated":"2023-08-02T14:29:12Z","day":"01","quality_controlled":"1","issue":"2","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publisher":"Elsevier","pmid":1,"external_id":{"pmid":["35123880"],"isi":["000758724700004"]},"date_published":"2022-02-01T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"ddc":["580"],"month":"02","isi":1,"status":"public"},{"publication_identifier":{"issn":["1369-5266"],"eissn":["1879-0356"]},"acknowledgement":"Research in J.F. laboratory is funded by the European Union's Horizon 2020 program (ERC grant agreement n° 742985); C.L. is supported by the Austrian Science Fund (FWF grant P 31493).","article_type":"original","scopus_import":"1","doi":"10.1016/j.pbi.2019.10.003","article_processing_charge":"No","oa_version":"None","publication_status":"published","title":"Auxin signalling in growth: Schrödinger's cat out of the bag","abstract":[{"lang":"eng","text":"The phytohormone auxin acts as an amazingly versatile coordinator of plant growth and development. With its morphogen-like properties, auxin controls sites and timing of differentiation and/or growth responses both, in quantitative and qualitative terms. Specificity in the auxin response depends largely on distinct modes of signal transmission, by which individual cells perceive and convert auxin signals into a remarkable diversity of responses. The best understood, or so-called canonical mechanism of auxin perception ultimately results in variable adjustments of the cellular transcriptome, via a short, nuclear signal transduction pathway. Additional findings that accumulated over decades implied that an additional, presumably, cell surface-based auxin perception mechanism mediates very rapid cellular responses and decisively contributes to the cell's overall hormonal response. Recent investigations into both, nuclear and cell surface auxin signalling challenged this assumed partition of roles for different auxin signalling pathways and revealed an unexpected complexity in transcriptional and non-transcriptional cellular responses mediated by auxin."}],"citation":{"ama":"Gallei MC, Luschnig C, Friml J. Auxin signalling in growth: Schrödinger’s cat out of the bag. <i>Current Opinion in Plant Biology</i>. 2020;53(2):43-49. doi:<a href=\"https://doi.org/10.1016/j.pbi.2019.10.003\">10.1016/j.pbi.2019.10.003</a>","ista":"Gallei MC, Luschnig C, Friml J. 2020. Auxin signalling in growth: Schrödinger’s cat out of the bag. Current Opinion in Plant Biology. 53(2), 43–49.","ieee":"M. C. Gallei, C. Luschnig, and J. Friml, “Auxin signalling in growth: Schrödinger’s cat out of the bag,” <i>Current Opinion in Plant Biology</i>, vol. 53, no. 2. Elsevier, pp. 43–49, 2020.","apa":"Gallei, M. C., Luschnig, C., &#38; Friml, J. (2020). Auxin signalling in growth: Schrödinger’s cat out of the bag. <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2019.10.003\">https://doi.org/10.1016/j.pbi.2019.10.003</a>","chicago":"Gallei, Michelle C, Christian Luschnig, and Jiří Friml. “Auxin Signalling in Growth: Schrödinger’s Cat out of the Bag.” <i>Current Opinion in Plant Biology</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.pbi.2019.10.003\">https://doi.org/10.1016/j.pbi.2019.10.003</a>.","short":"M.C. Gallei, C. Luschnig, J. Friml, Current Opinion in Plant Biology 53 (2020) 43–49.","mla":"Gallei, Michelle C., et al. “Auxin Signalling in Growth: Schrödinger’s Cat out of the Bag.” <i>Current Opinion in Plant Biology</i>, vol. 53, no. 2, Elsevier, 2020, pp. 43–49, doi:<a href=\"https://doi.org/10.1016/j.pbi.2019.10.003\">10.1016/j.pbi.2019.10.003</a>."},"year":"2020","date_created":"2019-12-02T12:05:26Z","_id":"7142","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"orcid":"0000-0003-1286-7368","id":"35A03822-F248-11E8-B48F-1D18A9856A87","full_name":"Gallei, Michelle C","first_name":"Michelle C","last_name":"Gallei"},{"full_name":"Luschnig, Christian","last_name":"Luschnig","first_name":"Christian"},{"first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"}],"volume":53,"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"11626"}]},"intvolume":"        53","date_updated":"2023-08-17T14:07:22Z","ec_funded":1,"publication":"Current Opinion in Plant Biology","department":[{"_id":"JiFr"}],"day":"01","page":"43-49","quality_controlled":"1","project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985","call_identifier":"H2020"}],"issue":"2","pmid":1,"publisher":"Elsevier","type":"journal_article","external_id":{"pmid":["31760231"],"isi":["000521120600007"]},"date_published":"2020-02-01T00:00:00Z","language":[{"iso":"eng"}],"status":"public","isi":1,"month":"02"},{"page":"124-130","day":"01","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"has_accepted_license":"1","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"}],"pmid":1,"publisher":"Elsevier","type":"journal_article","date_published":"2019-12-01T00:00:00Z","external_id":{"isi":["000502890600017"],"pmid":["31585333"]},"ddc":["580"],"language":[{"iso":"eng"}],"isi":1,"month":"12","status":"public","scopus_import":"1","doi":"10.1016/j.pbi.2019.08.006","publication_identifier":{"issn":["1369-5266"]},"article_type":"original","title":"Targeted cell ablation-based insights into wound healing and restorative patterning","publication_status":"published","article_processing_charge":"No","oa_version":"Published Version","file_date_updated":"2020-07-14T12:47:45Z","citation":{"ama":"Hörmayer L, Friml J. Targeted cell ablation-based insights into wound healing and restorative patterning. <i>Current Opinion in Plant Biology</i>. 2019;52:124-130. doi:<a href=\"https://doi.org/10.1016/j.pbi.2019.08.006\">10.1016/j.pbi.2019.08.006</a>","ieee":"L. Hörmayer and J. Friml, “Targeted cell ablation-based insights into wound healing and restorative patterning,” <i>Current Opinion in Plant Biology</i>, vol. 52. Elsevier, pp. 124–130, 2019.","ista":"Hörmayer L, Friml J. 2019. Targeted cell ablation-based insights into wound healing and restorative patterning. Current Opinion in Plant Biology. 52, 124–130.","mla":"Hörmayer, Lukas, and Jiří Friml. “Targeted Cell Ablation-Based Insights into Wound Healing and Restorative Patterning.” <i>Current Opinion in Plant Biology</i>, vol. 52, Elsevier, 2019, pp. 124–30, doi:<a href=\"https://doi.org/10.1016/j.pbi.2019.08.006\">10.1016/j.pbi.2019.08.006</a>.","short":"L. Hörmayer, J. Friml, Current Opinion in Plant Biology 52 (2019) 124–130.","chicago":"Hörmayer, Lukas, and Jiří Friml. “Targeted Cell Ablation-Based Insights into Wound Healing and Restorative Patterning.” <i>Current Opinion in Plant Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.pbi.2019.08.006\">https://doi.org/10.1016/j.pbi.2019.08.006</a>.","apa":"Hörmayer, L., &#38; Friml, J. (2019). Targeted cell ablation-based insights into wound healing and restorative patterning. <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2019.08.006\">https://doi.org/10.1016/j.pbi.2019.08.006</a>"},"year":"2019","abstract":[{"text":"Plants as sessile organisms are constantly under attack by herbivores, rough environmental situations, or mechanical pressure. These challenges often lead to the induction of wounds or destruction of already specified and developed tissues. Additionally, wounding makes plants vulnerable to invasion by pathogens, which is why wound signalling often triggers specific defence responses. To stay competitive or, eventually, survive under these circumstances, plants need to regenerate efficiently, which in rigid, tissue migration-incompatible plant tissues requires post-embryonic patterning and organogenesis. Now, several studies used laser-assisted single cell ablation in the Arabidopsis root tip as a minimal wounding proxy. Here, we discuss their findings and put them into context of a broader spectrum of wound signalling, pathogen responses and tissue as well as organ regeneration.","lang":"eng"}],"file":[{"access_level":"open_access","file_name":"2019_CurrentOpinionPlant_Hoermayer.pdf","file_size":1659288,"relation":"main_file","date_updated":"2020-07-14T12:47:45Z","date_created":"2019-10-14T14:48:21Z","content_type":"application/pdf","file_id":"6946","creator":"dernst","checksum":"d6fd68a6e965f1efe3f0bf2d2070a616"}],"date_created":"2019-10-14T07:00:24Z","_id":"6943","author":[{"first_name":"Lukas","last_name":"Hörmayer","id":"2EEE7A2A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8295-2926","full_name":"Hörmayer, Lukas"},{"last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","volume":52,"related_material":{"record":[{"id":"9992","relation":"dissertation_contains","status":"public"}]},"oa":1,"intvolume":"        52","department":[{"_id":"JiFr"}],"ec_funded":1,"date_updated":"2024-03-25T23:30:06Z","publication":"Current Opinion in Plant Biology"},{"date_updated":"2023-09-07T14:56:55Z","publication":"Current Opinion in Plant Biology","department":[{"_id":"EvBe"}],"intvolume":"        52","volume":52,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva","first_name":"Eva","last_name":"Benková"},{"first_name":"Yasin","last_name":"Dagdas","full_name":"Dagdas, Yasin"}],"date_created":"2020-01-29T16:00:07Z","_id":"7394","citation":{"mla":"Benková, Eva, and Yasin Dagdas. “Editorial Overview: Cell Biology in the Era of Omics?” <i>Current Opinion in Plant Biology</i>, vol. 52, no. 12, Elsevier, 2019, pp. A1–2, doi:<a href=\"https://doi.org/10.1016/j.pbi.2019.11.002\">10.1016/j.pbi.2019.11.002</a>.","chicago":"Benková, Eva, and Yasin Dagdas. “Editorial Overview: Cell Biology in the Era of Omics?” <i>Current Opinion in Plant Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.pbi.2019.11.002\">https://doi.org/10.1016/j.pbi.2019.11.002</a>.","apa":"Benková, E., &#38; Dagdas, Y. (2019). Editorial overview: Cell biology in the era of omics? <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2019.11.002\">https://doi.org/10.1016/j.pbi.2019.11.002</a>","short":"E. Benková, Y. Dagdas, Current Opinion in Plant Biology 52 (2019) A1–A2.","ieee":"E. Benková and Y. Dagdas, “Editorial overview: Cell biology in the era of omics?,” <i>Current Opinion in Plant Biology</i>, vol. 52, no. 12. Elsevier, pp. A1–A2, 2019.","ista":"Benková E, Dagdas Y. 2019. Editorial overview: Cell biology in the era of omics? Current Opinion in Plant Biology. 52(12), A1–A2.","ama":"Benková E, Dagdas Y. Editorial overview: Cell biology in the era of omics? <i>Current Opinion in Plant Biology</i>. 2019;52(12):A1-A2. doi:<a href=\"https://doi.org/10.1016/j.pbi.2019.11.002\">10.1016/j.pbi.2019.11.002</a>"},"year":"2019","article_processing_charge":"No","oa_version":"None","publication_status":"published","title":"Editorial overview: Cell biology in the era of omics?","publication_identifier":{"issn":["1369-5266"]},"article_type":"letter_note","scopus_import":"1","doi":"10.1016/j.pbi.2019.11.002","status":"public","isi":1,"month":"12","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2019-12-01T00:00:00Z","external_id":{"pmid":["31787165"],"isi":["000502890600001"]},"pmid":1,"publisher":"Elsevier","issue":"12","quality_controlled":"1","day":"01","page":"A1-A2"},{"issue":"5","quality_controlled":"1","page":"554-559","month":"10","status":"public","language":[{"iso":"eng"}],"extern":"1","type":"journal_article","external_id":{"pmid":["18774331"]},"date_published":"2008-10-01T00:00:00Z","pmid":1,"publisher":"Elsevier ","date_created":"2021-06-08T13:13:37Z","_id":"9537","citation":{"ama":"Zilberman D. The evolving functions of DNA methylation. <i>Current Opinion in Plant Biology</i>. 2008;11(5):554-559. doi:<a href=\"https://doi.org/10.1016/j.pbi.2008.07.004\">10.1016/j.pbi.2008.07.004</a>","ieee":"D. Zilberman, “The evolving functions of DNA methylation,” <i>Current Opinion in Plant Biology</i>, vol. 11, no. 5. Elsevier , pp. 554–559, 2008.","ista":"Zilberman D. 2008. The evolving functions of DNA methylation. Current Opinion in Plant Biology. 11(5), 554–559.","apa":"Zilberman, D. (2008). The evolving functions of DNA methylation. <i>Current Opinion in Plant Biology</i>. Elsevier . <a href=\"https://doi.org/10.1016/j.pbi.2008.07.004\">https://doi.org/10.1016/j.pbi.2008.07.004</a>","chicago":"Zilberman, Daniel. “The Evolving Functions of DNA Methylation.” <i>Current Opinion in Plant Biology</i>. Elsevier , 2008. <a href=\"https://doi.org/10.1016/j.pbi.2008.07.004\">https://doi.org/10.1016/j.pbi.2008.07.004</a>.","short":"D. Zilberman, Current Opinion in Plant Biology 11 (2008) 554–559.","mla":"Zilberman, Daniel. “The Evolving Functions of DNA Methylation.” <i>Current Opinion in Plant Biology</i>, vol. 11, no. 5, Elsevier , 2008, pp. 554–59, doi:<a href=\"https://doi.org/10.1016/j.pbi.2008.07.004\">10.1016/j.pbi.2008.07.004</a>."},"year":"2008","abstract":[{"text":"DNA methylation is an ancient process found in all domains of life. Although the enzymes that mediate methylation have remained highly conserved, DNA methylation has been adapted for a variety of uses throughout evolution, including defense against transposable elements and control of gene expression. Defects in DNA methylation are linked to human diseases, including cancer. Methylation has been lost several times in the course of animal and fungal evolution, thus limiting the opportunity for study in common model organisms. In the past decade, plants have emerged as a premier model system for genetic dissection of DNA methylation. A recent combination of plant genetics with powerful genomic approaches has led to a number of exciting discoveries and promises many more.","lang":"eng"}],"title":"The evolving functions of DNA methylation","publication_status":"published","article_processing_charge":"No","oa_version":"None","scopus_import":"1","doi":"10.1016/j.pbi.2008.07.004","publication_identifier":{"issn":["1369-5266"]},"article_type":"review","department":[{"_id":"DaZi"}],"date_updated":"2021-12-14T08:54:07Z","publication":"Current Opinion in Plant Biology","intvolume":"        11","volume":11,"author":[{"full_name":"Zilberman, Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","orcid":"0000-0002-0123-8649","last_name":"Zilberman","first_name":"Daniel"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9"}]