---
_id: '2228'
abstract:
- lang: eng
  text: Fast-spiking, parvalbumin-expressing GABAergic interneurons, a large proportion
    of which are basket cells (BCs), have a key role in feedforward and feedback inhibition,
    gamma oscillations and complex information processing. For these functions, fast
    propagation of action potentials (APs) from the soma to the presynaptic terminals
    is important. However, the functional properties of interneuron axons remain elusive.
    We examined interneuron axons by confocally targeted subcellular patch-clamp recording
    in rat hippocampal slices. APs were initiated in the proximal axon ∼20 μm from
    the soma and propagated to the distal axon with high reliability and speed. Subcellular
    mapping revealed a stepwise increase of Na^+ conductance density from the soma
    to the proximal axon, followed by a further gradual increase in the distal axon.
    Active cable modeling and experiments with partial channel block revealed that
    low axonal Na^+ conductance density was sufficient for reliability, but high Na^+
    density was necessary for both speed of propagation and fast-spiking AP phenotype.
    Our results suggest that a supercritical density of Na^+ channels compensates
    for the morphological properties of interneuron axons (small segmental diameter,
    extensive branching and high bouton density), ensuring fast AP propagation and
    high-frequency repetitive firing.
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Hu H, Jonas PM. A supercritical density of Na^+ channels ensures fast signaling
    in GABAergic interneuron axons. <i>Nature Neuroscience</i>. 2014;17(5):686-693.
    doi:<a href="https://doi.org/10.1038/nn.3678">10.1038/nn.3678</a>
  apa: Hu, H., &#38; Jonas, P. M. (2014). A supercritical density of Na^+ channels
    ensures fast signaling in GABAergic interneuron axons. <i>Nature Neuroscience</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/nn.3678">https://doi.org/10.1038/nn.3678</a>
  chicago: Hu, Hua, and Peter M Jonas. “A Supercritical Density of Na^+ Channels Ensures
    Fast Signaling in GABAergic Interneuron Axons.” <i>Nature Neuroscience</i>. Nature
    Publishing Group, 2014. <a href="https://doi.org/10.1038/nn.3678">https://doi.org/10.1038/nn.3678</a>.
  ieee: H. Hu and P. M. Jonas, “A supercritical density of Na^+ channels ensures fast
    signaling in GABAergic interneuron axons,” <i>Nature Neuroscience</i>, vol. 17,
    no. 5. Nature Publishing Group, pp. 686–693, 2014.
  ista: Hu H, Jonas PM. 2014. A supercritical density of Na^+ channels ensures fast
    signaling in GABAergic interneuron axons. Nature Neuroscience. 17(5), 686–693.
  mla: Hu, Hua, and Peter M. Jonas. “A Supercritical Density of Na^+ Channels Ensures
    Fast Signaling in GABAergic Interneuron Axons.” <i>Nature Neuroscience</i>, vol.
    17, no. 5, Nature Publishing Group, 2014, pp. 686–93, doi:<a href="https://doi.org/10.1038/nn.3678">10.1038/nn.3678</a>.
  short: H. Hu, P.M. Jonas, Nature Neuroscience 17 (2014) 686–693.
date_created: 2018-12-11T11:56:26Z
date_published: 2014-03-23T00:00:00Z
date_updated: 2021-01-12T06:56:08Z
day: '23'
department:
- _id: PeJo
doi: 10.1038/nn.3678
ec_funded: 1
intvolume: '        17'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286295/
month: '03'
oa: 1
oa_version: Submitted Version
page: 686-693
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Nature Neuroscience
publication_identifier:
  issn:
  - '10976256'
publication_status: published
publisher: Nature Publishing Group
publist_id: '4733'
quality_controlled: '1'
scopus_import: 1
status: public
title: A supercritical density of Na^+ channels ensures fast signaling in GABAergic
  interneuron axons
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2014'
...