[{"language":[{"iso":"eng"}],"keyword":["Multidisciplinary"],"publication":"Science","oa_version":"None","month":"07","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2021-07-02T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0036-8075","1095-9203"]},"quality_controlled":"1","publisher":"American Association for the Advancement of Science (AAAS)","article_type":"original","_id":"12187","pmid":1,"scopus_import":"1","author":[{"first_name":"Jincheng","last_name":"Long","full_name":"Long, Jincheng"},{"first_name":"James","last_name":"Walker","full_name":"Walker, James"},{"last_name":"She","first_name":"Wenjing","full_name":"She, Wenjing"},{"full_name":"Aldridge, Billy","first_name":"Billy","last_name":"Aldridge"},{"first_name":"Hongbo","last_name":"Gao","full_name":"Gao, Hongbo"},{"full_name":"Deans, Samuel","first_name":"Samuel","last_name":"Deans"},{"first_name":"Martin","last_name":"Vickers","full_name":"Vickers, Martin"},{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234","full_name":"Feng, Xiaoqi","first_name":"Xiaoqi","last_name":"Feng"}],"issue":"6550","publication_status":"published","department":[{"_id":"XiFe"}],"date_created":"2023-01-16T09:15:14Z","article_processing_charge":"No","title":"Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis","intvolume":"       373","acknowledgement":"We thank the John Innes Centre Bioimaging Facility (S. Lopez, E. Wegel, and K. Findlay) for their assistance with microscopy and the Norwich BioScience Institute Partnership Computing Infrastructure for Science Group for high-performance computing resources. Funding: This work was funded by a European Research Council Starting Grant (“SexMeth” 804981; J.L., J.W., and X.F.), a Sainsbury Charitable Foundation studentship (J.W.), two Biotechnology and Biological Sciences Research Council (BBSRC) grants (BBS0096201 and BBP0135111; W.S., M.V., and X.F.), two John Innes Foundation studentships (B.A. and S.D.), and a BBSRC David Phillips Fellowship (BBL0250431; H.G. and X.F.). Author contributions: J.L., J.W., and X.F. designed the study and wrote the manuscript; J.L., W.S., B.A., H.G., and S.D. performed the experiments; and J.L., J.W., B.A., H.G., S.D., M.V., and X.F. analyzed the data. Competing interests: The authors declare no competing interests. Data and material availability: All sequencing data have been deposited in the Gene Expression Omnibus (GEO) under accession no. GSE161625. Accession nos. of published datasets used in this study are listed in table S6. Published software used in this study include Bowtie v1.2.2 (https://doi.org/10.1002/0471250953.bi1107s32), Bismark v0.22.2 (https://doi.org/10.1093/bioinformatics/btr167), Kallisto v0.43.0 (https://doi.org/10.1038/nbt0816-888d), Shortstack v3.8.5 (https://doi.org/10.1534/g3.116.030452), and Cutadapt v1.15 (https://doi.org/10.1089/cmb.2017.0096). TrimGalore v0.4.1 and MarkDuplicates v1.141 are available from https://github.com/FelixKrueger/TrimGalore and https://github.com/broadinstitute/picard, respectively. All remaining data are in the main paper or the supplementary materials.","volume":373,"extern":"1","date_updated":"2023-05-08T10:56:39Z","year":"2021","citation":{"mla":"Long, Jincheng, et al. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>, vol. 373, no. 6550, American Association for the Advancement of Science (AAAS), 2021, doi:<a href=\"https://doi.org/10.1126/science.abh0556\">10.1126/science.abh0556</a>.","short":"J. Long, J. Walker, W. She, B. Aldridge, H. Gao, S. Deans, M. Vickers, X. Feng, Science 373 (2021).","ista":"Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Vickers M, Feng X. 2021. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science. 373(6550).","apa":"Long, J., Walker, J., She, W., Aldridge, B., Gao, H., Deans, S., … Feng, X. (2021). Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.abh0556\">https://doi.org/10.1126/science.abh0556</a>","ama":"Long J, Walker J, She W, et al. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. <i>Science</i>. 2021;373(6550). doi:<a href=\"https://doi.org/10.1126/science.abh0556\">10.1126/science.abh0556</a>","chicago":"Long, Jincheng, James Walker, Wenjing She, Billy Aldridge, Hongbo Gao, Samuel Deans, Martin Vickers, and Xiaoqi Feng. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2021. <a href=\"https://doi.org/10.1126/science.abh0556\">https://doi.org/10.1126/science.abh0556</a>.","ieee":"J. Long <i>et al.</i>, “Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis,” <i>Science</i>, vol. 373, no. 6550. American Association for the Advancement of Science (AAAS), 2021."},"external_id":{"pmid":["34210850"]},"doi":"10.1126/science.abh0556","day":"02","abstract":[{"lang":"eng","text":"Genomes of germ cells present an existential vulnerability to organisms because germ cell mutations will propagate to future generations. Transposable elements are one source of such mutations. In the small flowering plant Arabidopsis, Long et al. found that genome methylation in the male germline is directed by small interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective by Mosher). These germline siRNAs silence germline transposons and establish inherited methylation patterns in sperm, thus maintaining the integrity of the plant genome across generations."}]},{"publication":"Science","project":[{"call_identifier":"FP7","_id":"25DC711C-B435-11E9-9278-68D0E5697425","name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects","grant_number":"243071"}],"oa_version":"Published Version","month":"11","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2018-11-23T00:00:00Z","publication_identifier":{"issn":["1095-9203"]},"oa":1,"publist_id":"8049","main_file_link":[{"url":"https://serval.unil.ch/resource/serval:BIB_E9228C205467.P001/REF.pdf","open_access":"1"}],"status":"public","related_material":{"record":[{"status":"public","id":"13055","relation":"research_data"}],"link":[{"url":"https://ist.ac.at/en/news/for-ants-unity-is-strength-and-health/","relation":"press_release","description":"News on IST Homepage"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","_id":"7","issue":"6417","author":[{"first_name":"Nathalie","last_name":"Stroeymeyt","full_name":"Stroeymeyt, Nathalie"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V","first_name":"Anna V","last_name":"Grasse"},{"last_name":"Crespi","first_name":"Alessandro","full_name":"Crespi, Alessandro"},{"full_name":"Mersch, Danielle","last_name":"Mersch","first_name":"Danielle"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Laurent","last_name":"Keller","full_name":"Keller, Laurent"}],"article_processing_charge":"No","date_created":"2018-12-11T11:44:07Z","department":[{"_id":"SyCr"}],"publication_status":"published","intvolume":"       362","title":"Social network plasticity decreases disease transmission in a eusocial insect","quality_controlled":"1","ec_funded":1,"page":"941 - 945","publisher":"AAAS","article_type":"original","citation":{"ieee":"N. Stroeymeyt, A. V. Grasse, A. Crespi, D. Mersch, S. Cremer, and L. Keller, “Social network plasticity decreases disease transmission in a eusocial insect,” <i>Science</i>, vol. 362, no. 6417. AAAS, pp. 941–945, 2018.","chicago":"Stroeymeyt, Nathalie, Anna V Grasse, Alessandro Crespi, Danielle Mersch, Sylvia Cremer, and Laurent Keller. “Social Network Plasticity Decreases Disease Transmission in a Eusocial Insect.” <i>Science</i>. AAAS, 2018. <a href=\"https://doi.org/10.1126/science.aat4793\">https://doi.org/10.1126/science.aat4793</a>.","apa":"Stroeymeyt, N., Grasse, A. V., Crespi, A., Mersch, D., Cremer, S., &#38; Keller, L. (2018). Social network plasticity decreases disease transmission in a eusocial insect. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aat4793\">https://doi.org/10.1126/science.aat4793</a>","ama":"Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. Social network plasticity decreases disease transmission in a eusocial insect. <i>Science</i>. 2018;362(6417):941-945. doi:<a href=\"https://doi.org/10.1126/science.aat4793\">10.1126/science.aat4793</a>","ista":"Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. 2018. Social network plasticity decreases disease transmission in a eusocial insect. Science. 362(6417), 941–945.","mla":"Stroeymeyt, Nathalie, et al. “Social Network Plasticity Decreases Disease Transmission in a Eusocial Insect.” <i>Science</i>, vol. 362, no. 6417, AAAS, 2018, pp. 941–45, doi:<a href=\"https://doi.org/10.1126/science.aat4793\">10.1126/science.aat4793</a>.","short":"N. Stroeymeyt, A.V. Grasse, A. Crespi, D. Mersch, S. Cremer, L. Keller, Science 362 (2018) 941–945."},"year":"2018","date_updated":"2023-10-17T11:50:05Z","external_id":{"isi":["000451124500041"]},"isi":1,"day":"23","doi":"10.1126/science.aat4793","abstract":[{"text":"Animal social networks are shaped by multiple selection pressures, including the need to ensure efficient communication and functioning while simultaneously limiting disease transmission. Social animals could potentially further reduce epidemic risk by altering their social networks in the presence of pathogens, yet there is currently no evidence for such pathogen-triggered responses. We tested this hypothesis experimentally in the ant Lasius niger using a combination of automated tracking, controlled pathogen exposure, transmission quantification, and temporally explicit simulations. Pathogen exposure induced behavioral changes in both exposed ants and their nestmates, which helped contain the disease by reinforcing key transmission-inhibitory properties of the colony's contact network. This suggests that social network plasticity in response to pathogens is an effective strategy for mitigating the effects of disease in social groups.","lang":"eng"}],"volume":362,"acknowledgement":"This project was funded by two European Research Council Advanced Grants (Social Life, 249375, and resiliANT, 741491) and two Swiss National Science Foundation grants (CR32I3_141063 and 310030_156732) to L.K. and a European Research Council Starting Grant (SocialVaccines, 243071) to S.C."},{"doi":"10.1126/science.aar8486","day":"03","abstract":[{"lang":"eng","text":"Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores."}],"date_updated":"2021-01-12T08:15:04Z","year":"2018","citation":{"ista":"Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. 2018. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 361(6401), 511–516.","mla":"Tucci, Serena, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>, vol. 361, no. 6401, American Association for the Advancement of Science, 2018, pp. 511–16, doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>.","short":"S. Tucci, S.H. Vohr, R.C. McCoy, B. Vernot, M.R. Robinson, C. Barbieri, B.J. Nelson, W. Fu, G.A. Purnomo, H. Sudoyo, E.E. Eichler, G. Barbujani, P.M. Visscher, J.M. Akey, R.E. Green, Science 361 (2018) 511–516.","chicago":"Tucci, Serena, Samuel H. Vohr, Rajiv C. McCoy, Benjamin Vernot, Matthew Richard Robinson, Chiara Barbieri, Brad J. Nelson, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>. American Association for the Advancement of Science, 2018. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>.","ieee":"S. Tucci <i>et al.</i>, “Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia,” <i>Science</i>, vol. 361, no. 6401. American Association for the Advancement of Science, pp. 511–516, 2018.","apa":"Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., … Green, R. E. (2018). Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>","ama":"Tucci S, Vohr SH, McCoy RC, et al. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. 2018;361(6401):511-516. doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>"},"external_id":{"pmid":["30072539"]},"volume":361,"extern":"1","publication_status":"published","article_processing_charge":"No","date_created":"2020-04-30T10:43:24Z","title":"Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia","intvolume":"       361","_id":"7718","pmid":1,"author":[{"full_name":"Tucci, Serena","last_name":"Tucci","first_name":"Serena"},{"last_name":"Vohr","first_name":"Samuel H.","full_name":"Vohr, Samuel H."},{"last_name":"McCoy","first_name":"Rajiv C.","full_name":"McCoy, Rajiv C."},{"first_name":"Benjamin","last_name":"Vernot","full_name":"Vernot, Benjamin"},{"id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard"},{"first_name":"Chiara","last_name":"Barbieri","full_name":"Barbieri, Chiara"},{"full_name":"Nelson, Brad J.","first_name":"Brad J.","last_name":"Nelson"},{"first_name":"Wenqing","last_name":"Fu","full_name":"Fu, Wenqing"},{"first_name":"Gludhug A.","last_name":"Purnomo","full_name":"Purnomo, Gludhug A."},{"full_name":"Sudoyo, Herawati","first_name":"Herawati","last_name":"Sudoyo"},{"first_name":"Evan E.","last_name":"Eichler","full_name":"Eichler, Evan E."},{"last_name":"Barbujani","first_name":"Guido","full_name":"Barbujani, Guido"},{"last_name":"Visscher","first_name":"Peter M.","full_name":"Visscher, Peter M."},{"full_name":"Akey, Joshua M.","last_name":"Akey","first_name":"Joshua M."},{"last_name":"Green","first_name":"Richard E.","full_name":"Green, Richard E."}],"issue":"6401","publisher":"American Association for the Advancement of Science","article_type":"original","page":"511-516","quality_controlled":"1","publication_identifier":{"issn":["0036-8075","1095-9203"]},"date_published":"2018-08-03T00:00:00Z","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","oa_version":"None","month":"08","publication":"Science","language":[{"iso":"eng"}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","extern":"1","volume":337,"abstract":[{"lang":"eng","text":"The rechargeable nonaqueous lithium-air (Li-O2) battery is receiving a great deal of interest because, theoretically, its specific energy far exceeds the best that can be achieved with lithium-ion cells. Operation of the rechargeable Li-O2 battery depends critically on repeated and highly reversible formation/decomposition of lithium peroxide (Li2O2) at the cathode upon cycling. Here, we show that this process is possible with the use of a dimethyl sulfoxide electrolyte and a porous gold electrode (95% capacity retention from cycles 1 to 100), whereas previously only partial Li2O2 formation/decomposition and limited cycling could occur. Furthermore, we present data indicating that the kinetics of Li2O2 oxidation on charge is approximately 10 times faster than on carbon electrodes."}],"day":"03","publication_identifier":{"issn":["0036-8075","1095-9203"]},"doi":"10.1126/science.1223985","type":"journal_article","date_published":"2012-08-03T00:00:00Z","year":"2012","citation":{"ama":"Peng Z, Freunberger SA, Chen Y, Bruce PG. A reversible and higher-rate Li-O2 battery. <i>Science</i>. 2012;337(6094):563-566. doi:<a href=\"https://doi.org/10.1126/science.1223985\">10.1126/science.1223985</a>","apa":"Peng, Z., Freunberger, S. A., Chen, Y., &#38; Bruce, P. G. (2012). A reversible and higher-rate Li-O2 battery. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.1223985\">https://doi.org/10.1126/science.1223985</a>","ieee":"Z. Peng, S. A. Freunberger, Y. Chen, and P. G. Bruce, “A reversible and higher-rate Li-O2 battery,” <i>Science</i>, vol. 337, no. 6094. AAAS, pp. 563–566, 2012.","chicago":"Peng, Z., Stefan Alexander Freunberger, Y. Chen, and P. G. Bruce. “A Reversible and Higher-Rate Li-O2 Battery.” <i>Science</i>. AAAS, 2012. <a href=\"https://doi.org/10.1126/science.1223985\">https://doi.org/10.1126/science.1223985</a>.","mla":"Peng, Z., et al. “A Reversible and Higher-Rate Li-O2 Battery.” <i>Science</i>, vol. 337, no. 6094, AAAS, 2012, pp. 563–66, doi:<a href=\"https://doi.org/10.1126/science.1223985\">10.1126/science.1223985</a>.","short":"Z. Peng, S.A. Freunberger, Y. Chen, P.G. Bruce, Science 337 (2012) 563–566.","ista":"Peng Z, Freunberger SA, Chen Y, Bruce PG. 2012. A reversible and higher-rate Li-O2 battery. Science. 337(6094), 563–566."},"date_updated":"2021-01-12T08:12:57Z","article_type":"original","publisher":"AAAS","language":[{"iso":"eng"}],"quality_controlled":"1","page":"563-566","intvolume":"       337","title":"A reversible and higher-rate Li-O2 battery","month":"08","article_processing_charge":"No","date_created":"2020-01-15T12:19:23Z","publication_status":"published","oa_version":"None","issue":"6094","author":[{"first_name":"Z.","last_name":"Peng","full_name":"Peng, Z."},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger","first_name":"Stefan Alexander"},{"full_name":"Chen, Y.","first_name":"Y.","last_name":"Chen"},{"full_name":"Bruce, P. G.","first_name":"P. G.","last_name":"Bruce"}],"_id":"7310","publication":"Science"},{"author":[{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","first_name":"Tim P","last_name":"Vogels","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P"},{"first_name":"H.","last_name":"Sprekeler","full_name":"Sprekeler, H."},{"first_name":"F.","last_name":"Zenke","full_name":"Zenke, F."},{"first_name":"C.","last_name":"Clopath","full_name":"Clopath, C."},{"last_name":"Gerstner","first_name":"W.","full_name":"Gerstner, W."}],"issue":"6062","_id":"8074","pmid":1,"scopus_import":"1","title":"Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks","intvolume":"       334","publication_status":"published","article_processing_charge":"No","date_created":"2020-06-30T13:26:17Z","page":"1569-1573","quality_controlled":"1","article_type":"original","publisher":"American Association for the Advancement of Science","external_id":{"pmid":["22075724"]},"date_updated":"2021-06-02T14:57:22Z","year":"2011","citation":{"ama":"Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. <i>Science</i>. 2011;334(6062):1569-1573. doi:<a href=\"https://doi.org/10.1126/science.1211095\">10.1126/science.1211095</a>","apa":"Vogels, T. P., Sprekeler, H., Zenke, F., Clopath, C., &#38; Gerstner, W. (2011). Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1211095\">https://doi.org/10.1126/science.1211095</a>","chicago":"Vogels, Tim P, H. Sprekeler, F. Zenke, C. Clopath, and W. Gerstner. “Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks.” <i>Science</i>. American Association for the Advancement of Science, 2011. <a href=\"https://doi.org/10.1126/science.1211095\">https://doi.org/10.1126/science.1211095</a>.","ieee":"T. P. Vogels, H. Sprekeler, F. Zenke, C. Clopath, and W. Gerstner, “Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks,” <i>Science</i>, vol. 334, no. 6062. American Association for the Advancement of Science, pp. 1569–1573, 2011.","mla":"Vogels, Tim P., et al. “Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks.” <i>Science</i>, vol. 334, no. 6062, American Association for the Advancement of Science, 2011, pp. 1569–73, doi:<a href=\"https://doi.org/10.1126/science.1211095\">10.1126/science.1211095</a>.","short":"T.P. Vogels, H. Sprekeler, F. Zenke, C. Clopath, W. Gerstner, Science 334 (2011) 1569–1573.","ista":"Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. 2011. Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. Science. 334(6062), 1569–1573."},"abstract":[{"text":"Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interaction of excitatory and inhibitory receptive field plasticity. The introduction of inhibitory plasticity in suitable recurrent networks provides a homeostatic mechanism that leads to asynchronous irregular network states. Further, it can accommodate synaptic memories with activity patterns that become indiscernible from the background state but can be reactivated by external stimuli. Our results suggest an essential role of inhibitory plasticity in the formation and maintenance of functional cortical circuitry.","lang":"eng"}],"doi":"10.1126/science.1211095","day":"16","extern":"1","volume":334,"publication":"Science","month":"12","oa_version":"None","language":[{"iso":"eng"}],"date_published":"2011-12-16T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0036-8075","1095-9203"]},"status":"public","related_material":{"link":[{"url":"https://doi.org/10.1126/science.336.6083.802-c","relation":"erratum"}]},"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425"},{"language":[{"iso":"eng"}],"keyword":["Multidisciplinary"],"publication":"Science","month":"04","oa_version":"None","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","date_published":"2006-04-21T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0036-8075","1095-9203"]},"page":"440-443","quality_controlled":"1","article_type":"original","publisher":"American Association for the Advancement of Science","author":[{"first_name":"Maximiliano A.","last_name":"D'Angelo","full_name":"D'Angelo, Maximiliano A."},{"full_name":"Anderson, Daniel J.","last_name":"Anderson","first_name":"Daniel J."},{"first_name":"Erin","last_name":"Richard","full_name":"Richard, Erin"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"}],"issue":"5772","_id":"11118","pmid":1,"scopus_import":"1","title":"Nuclear pores form de novo from both sides of the nuclear envelope","intvolume":"       312","publication_status":"published","article_processing_charge":"No","date_created":"2022-04-07T07:56:32Z","extern":"1","volume":312,"external_id":{"pmid":["16627745"]},"date_updated":"2022-07-18T08:57:04Z","year":"2006","citation":{"mla":"D’Angelo, Maximiliano A., et al. “Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope.” <i>Science</i>, vol. 312, no. 5772, American Association for the Advancement of Science, 2006, pp. 440–43, doi:<a href=\"https://doi.org/10.1126/science.1124196\">10.1126/science.1124196</a>.","short":"M.A. D’Angelo, D.J. Anderson, E. Richard, M. Hetzer, Science 312 (2006) 440–443.","ista":"D’Angelo MA, Anderson DJ, Richard E, Hetzer M. 2006. Nuclear pores form de novo from both sides of the nuclear envelope. Science. 312(5772), 440–443.","apa":"D’Angelo, M. A., Anderson, D. J., Richard, E., &#38; Hetzer, M. (2006). Nuclear pores form de novo from both sides of the nuclear envelope. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1124196\">https://doi.org/10.1126/science.1124196</a>","ama":"D’Angelo MA, Anderson DJ, Richard E, Hetzer M. Nuclear pores form de novo from both sides of the nuclear envelope. <i>Science</i>. 2006;312(5772):440-443. doi:<a href=\"https://doi.org/10.1126/science.1124196\">10.1126/science.1124196</a>","chicago":"D’Angelo, Maximiliano A., Daniel J. Anderson, Erin Richard, and Martin Hetzer. “Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope.” <i>Science</i>. American Association for the Advancement of Science, 2006. <a href=\"https://doi.org/10.1126/science.1124196\">https://doi.org/10.1126/science.1124196</a>.","ieee":"M. A. D’Angelo, D. J. Anderson, E. Richard, and M. Hetzer, “Nuclear pores form de novo from both sides of the nuclear envelope,” <i>Science</i>, vol. 312, no. 5772. American Association for the Advancement of Science, pp. 440–443, 2006."},"abstract":[{"text":"Nuclear pore complexes are multiprotein channels that span the double lipid bilayer of the nuclear envelope. How new pores are inserted into the intact nuclear envelope of proliferating and differentiating eukaryotic cells is unknown. We found that the Nup107-160 complex was incorporated into assembly sites in the nuclear envelope from both the nucleoplasmic and the cytoplasmic sides. Nuclear pore insertion required the generation of Ran guanosine triphosphate in the nuclear and cytoplasmic compartments. Newly formed nuclear pore complexes did not contain structural components of preexisting pores, suggesting that they can form de novo.","lang":"eng"}],"doi":"10.1126/science.1124196","day":"21"},{"language":[{"iso":"eng"}],"quality_controlled":"1","page":"2011-2015","article_type":"original","publisher":"American Association for the Advancement of Science","issue":"5666","author":[{"full_name":"Brunet, Anne","last_name":"Brunet","first_name":"Anne"},{"full_name":"Sweeney, Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601","last_name":"Sweeney","first_name":"Lora Beatrice Jaeger","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425"},{"full_name":"Sturgill, J Fitzhugh ","first_name":"J Fitzhugh ","last_name":"Sturgill"},{"first_name":"Katrin","last_name":"Chua","full_name":"Chua, Katrin"},{"full_name":"Greer, Paul","last_name":"Greer","first_name":"Paul"},{"last_name":"Lin","first_name":"Yingxi","full_name":"Lin, Yingxi"},{"full_name":"Tran, Hien","first_name":"Hien","last_name":"Tran"},{"first_name":"Sarah","last_name":"Ross","full_name":"Ross, Sarah"},{"last_name":"Mostoslavsky","first_name":"Raul","full_name":"Mostoslavsky, Raul"},{"last_name":"Cohen","first_name":"Haim","full_name":"Cohen, Haim"},{"first_name":"Linda","last_name":"Hu","full_name":"Hu, Linda"},{"first_name":"Hwei-Ling","last_name":"Chen","full_name":"Chen, Hwei-Ling"},{"full_name":"Jedrychowski, Mark","last_name":"Jedrychowski","first_name":"Mark"},{"first_name":"Steven","last_name":"Gygi","full_name":"Gygi, Steven"},{"full_name":"Sinclair, David","last_name":"Sinclair","first_name":"David"},{"full_name":"Alt, Frederick","last_name":"Alt","first_name":"Frederick"},{"first_name":"Michael","last_name":"Greenberg","full_name":"Greenberg, Michael"}],"_id":"7706","publication":"Science","intvolume":"       303","title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","month":"03","date_created":"2020-04-30T10:37:41Z","article_processing_charge":"No","oa_version":"None","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","extern":"1","volume":303,"type":"journal_article","date_published":"2004-03-26T00:00:00Z","citation":{"ista":"Brunet A, Sweeney LB, Sturgill JF, Chua K, Greer P, Lin Y, Tran H, Ross S, Mostoslavsky R, Cohen H, Hu L, Chen H-L, Jedrychowski M, Gygi S, Sinclair D, Alt F, Greenberg M. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 303(5666), 2011–2015.","short":"A. Brunet, L.B. Sweeney, J.F. Sturgill, K. Chua, P. Greer, Y. Lin, H. Tran, S. Ross, R. Mostoslavsky, H. Cohen, L. Hu, H.-L. Chen, M. Jedrychowski, S. Gygi, D. Sinclair, F. Alt, M. Greenberg, Science 303 (2004) 2011–2015.","mla":"Brunet, Anne, et al. “Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase.” <i>Science</i>, vol. 303, no. 5666, American Association for the Advancement of Science, 2004, pp. 2011–15, doi:<a href=\"https://doi.org/10.1126/science.1094637\">10.1126/science.1094637</a>.","chicago":"Brunet, Anne, Lora B. Sweeney, J Fitzhugh  Sturgill, Katrin Chua, Paul Greer, Yingxi Lin, Hien Tran, et al. “Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase.” <i>Science</i>. American Association for the Advancement of Science, 2004. <a href=\"https://doi.org/10.1126/science.1094637\">https://doi.org/10.1126/science.1094637</a>.","ieee":"A. Brunet <i>et al.</i>, “Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase,” <i>Science</i>, vol. 303, no. 5666. American Association for the Advancement of Science, pp. 2011–2015, 2004.","apa":"Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K., Greer, P., Lin, Y., … Greenberg, M. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1094637\">https://doi.org/10.1126/science.1094637</a>","ama":"Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. <i>Science</i>. 2004;303(5666):2011-2015. doi:<a href=\"https://doi.org/10.1126/science.1094637\">10.1126/science.1094637</a>"},"year":"2004","date_updated":"2024-01-31T10:14:17Z","abstract":[{"lang":"eng","text":"The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity. SIRT1 and the FOXO transcription factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1 deacetylated FOXO3 in vitro and within cells. SIRT1 had a dual effect on FOXO3 function: SIRT1 increased FOXO3's ability to induce cell cycle arrest and resistance to oxidative stress but inhibited FOXO3's ability to induce cell death. Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance."}],"day":"26","publication_identifier":{"issn":["0036-8075","1095-9203"]},"doi":"10.1126/science.1094637"}]