---
_id: '14257'
abstract:
- lang: eng
  text: Mapping the complex and dense arrangement of cells and their connectivity
    in brain tissue demands nanoscale spatial resolution imaging. Super-resolution
    optical microscopy excels at visualizing specific molecules and individual cells
    but fails to provide tissue context. Here we developed Comprehensive Analysis
    of Tissues across Scales (CATS), a technology to densely map brain tissue architecture
    from millimeter regional to nanometer synaptic scales in diverse chemically fixed
    brain preparations, including rodent and human. CATS uses fixation-compatible
    extracellular labeling and optical imaging, including stimulated emission depletion
    or expansion microscopy, to comprehensively delineate cellular structures. It
    enables three-dimensional reconstruction of single synapses and mapping of synaptic
    connectivity by identification and analysis of putative synaptic cleft regions.
    Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed
    and quantified the synaptic input and output structure of identified neurons.
    We furthermore demonstrate applicability to clinically derived human tissue samples,
    including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing
    the cellular architecture of brain tissue in health and disease.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: M-Shop
- _id: E-Lib
acknowledgement: 'We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak
  for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I.
  Erber for technical assistance; and M. Tomschik for support with obtaining human
  samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata
  for computational support and hardware control. We are grateful to R. Shigemoto
  and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University)
  for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly
  provided by S. Grant (University of Edinburgh). We acknowledge expert support by
  Institute of Science and Technology Austria’s scientific computing, imaging and
  optics, preclinical and lab support facilities and by the Miba machine shop and
  library. We gratefully acknowledge funding by the following sources: Austrian Science
  Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232
  (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award
  (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27
  (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.);
  European Union’s Horizon 2020 research and innovation programme, European Research
  Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020
  research and innovation programme, European Research Council (ERC) grant 692692
  – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under
  the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions
  Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Julia M
  full_name: Michalska, Julia M
  id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
  last_name: Michalska
  orcid: 0000-0003-3862-1235
- first_name: Julia
  full_name: Lyudchik, Julia
  id: 46E28B80-F248-11E8-B48F-1D18A9856A87
  last_name: Lyudchik
- first_name: Philipp
  full_name: Velicky, Philipp
  id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
  last_name: Velicky
  orcid: 0000-0002-2340-7431
- first_name: Hana
  full_name: Korinkova, Hana
  id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed
  last_name: Korinkova
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Alban
  full_name: Cenameri, Alban
  id: 9ac8f577-2357-11eb-997a-e566c5550886
  last_name: Cenameri
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Nicole
  full_name: Amberg, Nicole
  id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
  last_name: Amberg
  orcid: 0000-0002-3183-8207
- first_name: Alessandro
  full_name: Venturino, Alessandro
  id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
  last_name: Venturino
  orcid: 0000-0003-2356-9403
- first_name: Karl
  full_name: Roessler, Karl
  last_name: Roessler
- first_name: Thomas
  full_name: Czech, Thomas
  last_name: Czech
- first_name: Romana
  full_name: Höftberger, Romana
  last_name: Höftberger
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
citation:
  ama: Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture
    across millimeter to nanometer scales. <i>Nature Biotechnology</i>. 2023. doi:<a
    href="https://doi.org/10.1038/s41587-023-01911-8">10.1038/s41587-023-01911-8</a>
  apa: Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri,
    A., … Danzl, J. G. (2023). Imaging brain tissue architecture across millimeter
    to nanometer scales. <i>Nature Biotechnology</i>. Springer Nature. <a href="https://doi.org/10.1038/s41587-023-01911-8">https://doi.org/10.1038/s41587-023-01911-8</a>
  chicago: Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake
    Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture
    across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>. Springer
    Nature, 2023. <a href="https://doi.org/10.1038/s41587-023-01911-8">https://doi.org/10.1038/s41587-023-01911-8</a>.
  ieee: J. M. Michalska <i>et al.</i>, “Imaging brain tissue architecture across millimeter
    to nanometer scales,” <i>Nature Biotechnology</i>. Springer Nature, 2023.
  ista: Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer
    CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino
    G, Jonas PM, Danzl JG. 2023. Imaging brain tissue architecture across millimeter
    to nanometer scales. Nature Biotechnology.
  mla: Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter
    to Nanometer Scales.” <i>Nature Biotechnology</i>, Springer Nature, 2023, doi:<a
    href="https://doi.org/10.1038/s41587-023-01911-8">10.1038/s41587-023-01911-8</a>.
  short: J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri,
    C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S.
    Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology (2023).
date_created: 2023-09-03T22:01:15Z
date_published: 2023-08-31T00:00:00Z
date_updated: 2024-02-21T12:18:18Z
day: '31'
department:
- _id: SaSi
- _id: GaNo
- _id: PeJo
- _id: JoDa
- _id: Bio
- _id: RySh
doi: 10.1038/s41587-023-01911-8
ec_funded: 1
external_id:
  isi:
  - '001065254200001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41587-023-01911-8
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03600
  name: Optical control of synaptic function via adhesion molecules
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1232-B24
  name: Molecular Drug Targets
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: The Wittgenstein Prize
- _id: 23889792-32DE-11EA-91FC-C7463DDC885E
  name: High content imaging to decode human immune cell interactions in health and
    allergic disease
- _id: 25444568-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715508'
  name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
    and in vitro Models
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9
  call_identifier: H2020
  grant_number: '101026635'
  name: Synaptic computations of the hippocampal CA3 circuitry
publication: Nature Biotechnology
publication_identifier:
  eissn:
  - 1546-1696
  issn:
  - 1087-0156
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/danzllab/CATS
  record:
  - id: '13126'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Imaging brain tissue architecture across millimeter to nanometer scales
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12106'
abstract:
- lang: eng
  text: Regulation of chromatin states involves the dynamic interplay between different
    histone modifications to control gene expression. Recent advances have enabled
    mapping of histone marks in single cells, but most methods are constrained to
    profile only one histone mark per cell. Here, we present an integrated experimental
    and computational framework, scChIX-seq (single-cell chromatin immunocleavage
    and unmixing sequencing), to map several histone marks in single cells. scChIX-seq
    multiplexes two histone marks together in single cells, then computationally deconvolves
    the signal using training data from respective histone mark profiles. This framework
    learns the cell-type-specific correlation structure between histone marks, and
    therefore does not require a priori assumptions of their genomic distributions.
    Using scChIX-seq, we demonstrate multimodal analysis of histone marks in single
    cells across a range of mark combinations. Modeling dynamics of in vitro macrophage
    differentiation enables integrated analysis of chromatin velocity. Overall, scChIX-seq
    unlocks systematic interrogation of the interplay between histone modifications
    in single cells.
acknowledgement: We thank M. van Loenhout for experimental advice on purifying cell
  types from the bone marrow, R. van der Linden for expertise with FACS and M. Blotenburg
  for help with cell typing the mouse organogenesis dataset. We thank M. Saraswat
  and O. Stegle for discussions on multinomial distributions. This work was supported
  by a European Research Council Advanced grant (ERC-AdG 742225-IntScOmics); Nederlandse
  Organisatie voor Wetenschappelijk Onderzoek (NWO) TOP grant (NWO CW 714.016.001)
  and NWO grant (OCENW.GROOT.2019.017); the Swiss National Science Foundation Early
  Postdoc Mobility (P2ELP3-184488 to P.Z. and P2BSP3-174991 to J.Y.); Marie Sklodowska-Curie
  Actions Postdoc (798573 to P.Z.) and the Human Frontier for Science Program Long-Term
  Fellowships (LT000209-2018-L to P.Z. and LT000097-2019-L to J.Y.). This work is
  part of the Oncode Institute which is financed partly by the Dutch Cancer Society.
article_processing_charge: No
article_type: original
author:
- first_name: Jake
  full_name: Yeung, Jake
  id: 123012b2-db30-11eb-b4d8-a35840c0551b
  last_name: Yeung
  orcid: 0000-0003-1732-1559
- first_name: Maria
  full_name: Florescu, Maria
  last_name: Florescu
- first_name: Peter
  full_name: Zeller, Peter
  last_name: Zeller
- first_name: Buys Anton
  full_name: De Barbanson, Buys Anton
  last_name: De Barbanson
- first_name: Max D.
  full_name: Wellenstein, Max D.
  last_name: Wellenstein
- first_name: Alexander
  full_name: Van Oudenaarden, Alexander
  last_name: Van Oudenaarden
citation:
  ama: Yeung J, Florescu M, Zeller P, De Barbanson BA, Wellenstein MD, Van Oudenaarden
    A. scChIX-seq infers dynamic relationships between histone modifications in single
    cells. <i>Nature Biotechnology</i>. 2023;41:813–823. doi:<a href="https://doi.org/10.1038/s41587-022-01560-3">10.1038/s41587-022-01560-3</a>
  apa: Yeung, J., Florescu, M., Zeller, P., De Barbanson, B. A., Wellenstein, M. D.,
    &#38; Van Oudenaarden, A. (2023). scChIX-seq infers dynamic relationships between
    histone modifications in single cells. <i>Nature Biotechnology</i>. Springer Nature.
    <a href="https://doi.org/10.1038/s41587-022-01560-3">https://doi.org/10.1038/s41587-022-01560-3</a>
  chicago: Yeung, Jake, Maria Florescu, Peter Zeller, Buys Anton De Barbanson, Max
    D. Wellenstein, and Alexander Van Oudenaarden. “ScChIX-Seq Infers Dynamic Relationships
    between Histone Modifications in Single Cells.” <i>Nature Biotechnology</i>. Springer
    Nature, 2023. <a href="https://doi.org/10.1038/s41587-022-01560-3">https://doi.org/10.1038/s41587-022-01560-3</a>.
  ieee: J. Yeung, M. Florescu, P. Zeller, B. A. De Barbanson, M. D. Wellenstein, and
    A. Van Oudenaarden, “scChIX-seq infers dynamic relationships between histone modifications
    in single cells,” <i>Nature Biotechnology</i>, vol. 41. Springer Nature, pp. 813–823,
    2023.
  ista: Yeung J, Florescu M, Zeller P, De Barbanson BA, Wellenstein MD, Van Oudenaarden
    A. 2023. scChIX-seq infers dynamic relationships between histone modifications
    in single cells. Nature Biotechnology. 41, 813–823.
  mla: Yeung, Jake, et al. “ScChIX-Seq Infers Dynamic Relationships between Histone
    Modifications in Single Cells.” <i>Nature Biotechnology</i>, vol. 41, Springer
    Nature, 2023, pp. 813–823, doi:<a href="https://doi.org/10.1038/s41587-022-01560-3">10.1038/s41587-022-01560-3</a>.
  short: J. Yeung, M. Florescu, P. Zeller, B.A. De Barbanson, M.D. Wellenstein, A.
    Van Oudenaarden, Nature Biotechnology 41 (2023) 813–823.
date_created: 2023-01-08T23:00:53Z
date_published: 2023-06-01T00:00:00Z
date_updated: 2023-08-16T11:32:33Z
day: '01'
ddc:
- '570'
department:
- _id: ScienComp
doi: 10.1038/s41587-022-01560-3
external_id:
  isi:
  - '000909067600003'
file:
- access_level: open_access
  checksum: 668447a1c8d360b68f8aaf9e08ed644f
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-16T11:30:45Z
  date_updated: 2023-08-16T11:30:45Z
  file_id: '14066'
  file_name: 2023_NatureBioTech_Yeung.pdf
  file_size: 12040976
  relation: main_file
  success: 1
file_date_updated: 2023-08-16T11:30:45Z
has_accepted_license: '1'
intvolume: '        41'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 813–823
publication: Nature Biotechnology
publication_identifier:
  eissn:
  - 1546-1696
  issn:
  - 1087-0156
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: scChIX-seq infers dynamic relationships between histone modifications in single
  cells
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2023'
...
---
_id: '7889'
abstract:
- lang: eng
  text: Autoluminescent plants engineered to express a bacterial bioluminescence gene
    cluster in plastids have not been widely adopted because of low light output.
    We engineered tobacco plants with a fungal bioluminescence system that converts
    caffeic acid (present in all plants) into luciferin and report self-sustained
    luminescence that is visible to the naked eye. Our findings could underpin development
    of a suite of imaging tools for plants.
acknowledgement: "This study was designed, performed and funded by Planta LLC. We
  thank K. Wood for assisting in manuscript development. Planta acknowledges support
  from the Skolkovo Innovation Centre. We thank D. Bolotin and the Milaboratory (milaboratory.com)
  for access to computing and storage infrastructure. We thank S. Shakhov for providing\r\nphotography
  equipment. The Synthetic Biology Group is funded by the MRC London Institute of
  Medical Sciences (UKRI MC-A658-5QEA0, K.S.S.). K.S.S. is supported by an Imperial
  College Research Fellowship. Experiments were partially carried out using equipment
  provided by the Institute of Bioorganic Chemistry of the Russian Academy\r\nof Sciences
  Сore Facility (CKP IBCH; supported by the Russian Ministry of Education and Science
  Grant RFMEFI62117X0018). The F.A.K. lab is supported by ERC grant agreement 771209—CharFL.
  This project received funding from the European Union’s Horizon 2020 Research and
  Innovation Programme under Marie Skłodowska-Curie\r\nGrant Agreement 665385. K.S.S.
  acknowledges support by President’s Grant 075-15-2019-411. Design and assembly of
  some of the plasmids was supported by Russian Science Foundation grant 19-74-10102.
  Imaging experiments were partially supported by Russian Science Foundation grant
  17-14-01169p. LC-MS/MS analyses of extracts were\r\nsupported by Russian Science
  Foundation grant 16-14-00052p. Design and assembly of plasmids was partially supported
  by grant 075-15-2019-1789 from the Ministry of Science and Higher Education of the
  Russian Federation allocated to the Center for Precision Genome Editing and Genetic
  Technologies for Biomedicine. The authors\r\nwould like to acknowledge the work
  of Genomics Core Facility of the Skolkovo Institute of Science and Technology, which
  performed the sequencing and bioinformatic analysis."
article_processing_charge: No
article_type: original
author:
- first_name: Tatiana
  full_name: Mitiouchkina, Tatiana
  last_name: Mitiouchkina
- first_name: Alexander S.
  full_name: Mishin, Alexander S.
  last_name: Mishin
- first_name: Louisa
  full_name: Gonzalez Somermeyer, Louisa
  id: 4720D23C-F248-11E8-B48F-1D18A9856A87
  last_name: Gonzalez Somermeyer
  orcid: 0000-0001-9139-5383
- first_name: Nadezhda M.
  full_name: Markina, Nadezhda M.
  last_name: Markina
- first_name: Tatiana V.
  full_name: Chepurnyh, Tatiana V.
  last_name: Chepurnyh
- first_name: Elena B.
  full_name: Guglya, Elena B.
  last_name: Guglya
- first_name: Tatiana A.
  full_name: Karataeva, Tatiana A.
  last_name: Karataeva
- first_name: Kseniia A.
  full_name: Palkina, Kseniia A.
  last_name: Palkina
- first_name: Ekaterina S.
  full_name: Shakhova, Ekaterina S.
  last_name: Shakhova
- first_name: Liliia I.
  full_name: Fakhranurova, Liliia I.
  last_name: Fakhranurova
- first_name: Sofia V.
  full_name: Chekova, Sofia V.
  last_name: Chekova
- first_name: Aleksandra S.
  full_name: Tsarkova, Aleksandra S.
  last_name: Tsarkova
- first_name: Yaroslav V.
  full_name: Golubev, Yaroslav V.
  last_name: Golubev
- first_name: Vadim V.
  full_name: Negrebetsky, Vadim V.
  last_name: Negrebetsky
- first_name: Sergey A.
  full_name: Dolgushin, Sergey A.
  last_name: Dolgushin
- first_name: Pavel V.
  full_name: Shalaev, Pavel V.
  last_name: Shalaev
- first_name: Dmitry
  full_name: Shlykov, Dmitry
  last_name: Shlykov
- first_name: Olesya A.
  full_name: Melnik, Olesya A.
  last_name: Melnik
- first_name: Victoria O.
  full_name: Shipunova, Victoria O.
  last_name: Shipunova
- first_name: Sergey M.
  full_name: Deyev, Sergey M.
  last_name: Deyev
- first_name: Andrey I.
  full_name: Bubyrev, Andrey I.
  last_name: Bubyrev
- first_name: Alexander S.
  full_name: Pushin, Alexander S.
  last_name: Pushin
- first_name: Vladimir V.
  full_name: Choob, Vladimir V.
  last_name: Choob
- first_name: Sergey V.
  full_name: Dolgov, Sergey V.
  last_name: Dolgov
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Ilia V.
  full_name: Yampolsky, Ilia V.
  last_name: Yampolsky
- first_name: Karen S.
  full_name: Sarkisyan, Karen S.
  last_name: Sarkisyan
citation:
  ama: Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, et al. Plants with genetically
    encoded autoluminescence. <i>Nature Biotechnology</i>. 2020;38:944-946. doi:<a
    href="https://doi.org/10.1038/s41587-020-0500-9">10.1038/s41587-020-0500-9</a>
  apa: Mitiouchkina, T., Mishin, A. S., Gonzalez Somermeyer, L., Markina, N. M., Chepurnyh,
    T. V., Guglya, E. B., … Sarkisyan, K. S. (2020). Plants with genetically encoded
    autoluminescence. <i>Nature Biotechnology</i>. Springer Nature. <a href="https://doi.org/10.1038/s41587-020-0500-9">https://doi.org/10.1038/s41587-020-0500-9</a>
  chicago: Mitiouchkina, Tatiana, Alexander S. Mishin, Louisa Gonzalez Somermeyer,
    Nadezhda M. Markina, Tatiana V. Chepurnyh, Elena B. Guglya, Tatiana A. Karataeva,
    et al. “Plants with Genetically Encoded Autoluminescence.” <i>Nature Biotechnology</i>.
    Springer Nature, 2020. <a href="https://doi.org/10.1038/s41587-020-0500-9">https://doi.org/10.1038/s41587-020-0500-9</a>.
  ieee: T. Mitiouchkina <i>et al.</i>, “Plants with genetically encoded autoluminescence,”
    <i>Nature Biotechnology</i>, vol. 38. Springer Nature, pp. 944–946, 2020.
  ista: Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, Markina NM, Chepurnyh TV,
    Guglya EB, Karataeva TA, Palkina KA, Shakhova ES, Fakhranurova LI, Chekova SV,
    Tsarkova AS, Golubev YV, Negrebetsky VV, Dolgushin SA, Shalaev PV, Shlykov D,
    Melnik OA, Shipunova VO, Deyev SM, Bubyrev AI, Pushin AS, Choob VV, Dolgov SV,
    Kondrashov F, Yampolsky IV, Sarkisyan KS. 2020. Plants with genetically encoded
    autoluminescence. Nature Biotechnology. 38, 944–946.
  mla: Mitiouchkina, Tatiana, et al. “Plants with Genetically Encoded Autoluminescence.”
    <i>Nature Biotechnology</i>, vol. 38, Springer Nature, 2020, pp. 944–46, doi:<a
    href="https://doi.org/10.1038/s41587-020-0500-9">10.1038/s41587-020-0500-9</a>.
  short: T. Mitiouchkina, A.S. Mishin, L. Gonzalez Somermeyer, N.M. Markina, T.V.
    Chepurnyh, E.B. Guglya, T.A. Karataeva, K.A. Palkina, E.S. Shakhova, L.I. Fakhranurova,
    S.V. Chekova, A.S. Tsarkova, Y.V. Golubev, V.V. Negrebetsky, S.A. Dolgushin, P.V.
    Shalaev, D. Shlykov, O.A. Melnik, V.O. Shipunova, S.M. Deyev, A.I. Bubyrev, A.S.
    Pushin, V.V. Choob, S.V. Dolgov, F. Kondrashov, I.V. Yampolsky, K.S. Sarkisyan,
    Nature Biotechnology 38 (2020) 944–946.
date_created: 2020-05-25T15:02:00Z
date_published: 2020-04-27T00:00:00Z
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title: Plants with genetically encoded autoluminescence
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volume: 38
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...