---
_id: '12162'
abstract:
- lang: eng
  text: Homeostatic balance in the intestinal epithelium relies on a fast cellular
    turnover, which is coordinated by an intricate interplay between biochemical signalling,
    mechanical forces and organ geometry. We review recent modelling approaches that
    have been developed to understand different facets of this remarkable homeostatic
    equilibrium. Existing models offer different, albeit complementary, perspectives
    on the problem. First, biomechanical models aim to explain the local and global
    mechanical stresses driving cell renewal as well as tissue shape maintenance.
    Second, compartmental models provide insights into the conditions necessary to
    keep a constant flow of cells with well-defined ratios of cell types, and how
    perturbations can lead to an unbalance of relative compartment sizes. A third
    family of models address, at the cellular level, the nature and regulation of
    stem fate choices that are necessary to fuel cellular turnover. We also review
    how these different approaches are starting to be integrated together across scales,
    to provide quantitative predictions and new conceptual frameworks to think about
    the dynamics of cell renewal in complex tissues.
acknowledgement: "This work received funding from the ERC under the European Union’s
  Horizon 2020 research and innovation programme (grant agreement No. 851288 to E.H.).\r\nB.
  C-M wants to acknowledge the support of the field of excellence Complexity of Life,
  in Basic Research and Innovation of the University of Graz."
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Bernat
  full_name: Corominas-Murtra, Bernat
  id: 43BE2298-F248-11E8-B48F-1D18A9856A87
  last_name: Corominas-Murtra
  orcid: 0000-0001-9806-5643
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
citation:
  ama: Corominas-Murtra B, Hannezo EB. Modelling the dynamics of mammalian gut homeostasis.
    <i>Seminars in Cell &#38; Developmental Biology</i>. 2023;150-151:58-65. doi:<a
    href="https://doi.org/10.1016/j.semcdb.2022.11.005">10.1016/j.semcdb.2022.11.005</a>
  apa: Corominas-Murtra, B., &#38; Hannezo, E. B. (2023). Modelling the dynamics of
    mammalian gut homeostasis. <i>Seminars in Cell &#38; Developmental Biology</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.semcdb.2022.11.005">https://doi.org/10.1016/j.semcdb.2022.11.005</a>
  chicago: Corominas-Murtra, Bernat, and Edouard B Hannezo. “Modelling the Dynamics
    of Mammalian Gut Homeostasis.” <i>Seminars in Cell &#38; Developmental Biology</i>.
    Elsevier, 2023. <a href="https://doi.org/10.1016/j.semcdb.2022.11.005">https://doi.org/10.1016/j.semcdb.2022.11.005</a>.
  ieee: B. Corominas-Murtra and E. B. Hannezo, “Modelling the dynamics of mammalian
    gut homeostasis,” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 150–151.
    Elsevier, pp. 58–65, 2023.
  ista: Corominas-Murtra B, Hannezo EB. 2023. Modelling the dynamics of mammalian
    gut homeostasis. Seminars in Cell &#38; Developmental Biology. 150–151, 58–65.
  mla: Corominas-Murtra, Bernat, and Edouard B. Hannezo. “Modelling the Dynamics of
    Mammalian Gut Homeostasis.” <i>Seminars in Cell &#38; Developmental Biology</i>,
    vol. 150–151, Elsevier, 2023, pp. 58–65, doi:<a href="https://doi.org/10.1016/j.semcdb.2022.11.005">10.1016/j.semcdb.2022.11.005</a>.
  short: B. Corominas-Murtra, E.B. Hannezo, Seminars in Cell &#38; Developmental Biology
    150–151 (2023) 58–65.
date_created: 2023-01-12T12:09:47Z
date_published: 2023-12-02T00:00:00Z
date_updated: 2024-01-16T13:22:32Z
day: '02'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.semcdb.2022.11.005
ec_funded: 1
external_id:
  isi:
  - '001053522200001'
  pmid:
  - '36470715'
file:
- access_level: open_access
  checksum: c619887cf130f4649bf3035417186004
  content_type: application/pdf
  creator: dernst
  date_created: 2024-01-08T10:16:04Z
  date_updated: 2024-01-08T10:16:04Z
  file_id: '14741'
  file_name: 2023_SeminarsCellDevBiology_CorominasMurtra.pdf
  file_size: 1343750
  relation: main_file
  success: 1
file_date_updated: 2024-01-08T10:16:04Z
has_accepted_license: '1'
isi: 1
keyword:
- Cell Biology
- Developmental Biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 58-65
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '851288'
  name: Design Principles of Branching Morphogenesis
publication: Seminars in Cell & Developmental Biology
publication_identifier:
  issn:
  - 1084-9521
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modelling the dynamics of mammalian gut homeostasis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 150-151
year: '2023'
...
---
_id: '4148'
abstract:
- lang: eng
  text: Members of the Wnt family have been implicated in a variety of developmental
    processes including axis formation, Patterning of the central nervous system and
    tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway
    similar to that involved in the establishment of planar cell polarity in Drosophila
    regulates convergent extension movements during zebrafish and Xenopus gastrulation.
    This finding provides a good starting point to dissect the complex cell biology
    and genetic regulation of vertebrate gastrulation movements.
acknowledgement: We would like to thank Steve Wilson for encouraging us to write this
  article and for critical comments on this manuscript, and Lila Solnica-Krezel for
  communicating results prior to publication. MT is supported by an MRC Career Development
  Award, MLC by a Wellcome Trust Fellowship and CPH by an Emmy–Noether–Fellowship
  from the DFG.
article_processing_charge: No
article_type: original
author:
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
- first_name: Miguel
  full_name: Concha, Miguel
  last_name: Concha
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Tada M, Concha M, Heisenberg C-PJ. Non-canonical Wnt signalling and regulation
    of gastrulation movements. <i>Seminars in Cell &#38; Developmental Biology</i>.
    2002;13(3):251-260. doi:<a href="https://doi.org/10.1016/S1084-9521(02)00052-6">10.1016/S1084-9521(02)00052-6</a>
  apa: Tada, M., Concha, M., &#38; Heisenberg, C.-P. J. (2002). Non-canonical Wnt
    signalling and regulation of gastrulation movements. <i>Seminars in Cell &#38;
    Developmental Biology</i>. Academic Press. <a href="https://doi.org/10.1016/S1084-9521(02)00052-6">https://doi.org/10.1016/S1084-9521(02)00052-6</a>
  chicago: Tada, Masazumi, Miguel Concha, and Carl-Philipp J Heisenberg. “Non-Canonical
    Wnt Signalling and Regulation of Gastrulation Movements.” <i>Seminars in Cell
    &#38; Developmental Biology</i>. Academic Press, 2002. <a href="https://doi.org/10.1016/S1084-9521(02)00052-6">https://doi.org/10.1016/S1084-9521(02)00052-6</a>.
  ieee: M. Tada, M. Concha, and C.-P. J. Heisenberg, “Non-canonical Wnt signalling
    and regulation of gastrulation movements,” <i>Seminars in Cell &#38; Developmental
    Biology</i>, vol. 13, no. 3. Academic Press, pp. 251–260, 2002.
  ista: Tada M, Concha M, Heisenberg C-PJ. 2002. Non-canonical Wnt signalling and
    regulation of gastrulation movements. Seminars in Cell &#38; Developmental Biology.
    13(3), 251–260.
  mla: Tada, Masazumi, et al. “Non-Canonical Wnt Signalling and Regulation of Gastrulation
    Movements.” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 13, no.
    3, Academic Press, 2002, pp. 251–60, doi:<a href="https://doi.org/10.1016/S1084-9521(02)00052-6">10.1016/S1084-9521(02)00052-6</a>.
  short: M. Tada, M. Concha, C.-P.J. Heisenberg, Seminars in Cell &#38; Developmental
    Biology 13 (2002) 251–260.
date_created: 2018-12-11T12:07:13Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-06-07T09:50:14Z
day: '01'
doi: 10.1016/S1084-9521(02)00052-6
extern: '1'
external_id:
  pmid:
  - '12137734'
intvolume: '        13'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 251 - 260
pmid: 1
publication: Seminars in Cell & Developmental Biology
publication_identifier:
  issn:
  - 1084-9521
publication_status: published
publisher: Academic Press
publist_id: '1973'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-canonical Wnt signalling and regulation of gastrulation movements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2002'
...
---
_id: '4196'
abstract:
- lang: eng
  text: During vertebrate gastrulation, large cellular rearrangements lead to the
    formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish
    offer many genetic and experimental advantages for studying vertebrate gastrulation
    movements. For instance, several mutants, including silberblick, knypek and trilobite,
    exhibit defects in morphogenesis during gastrulation. The identification of the
    genes mutated in these lines together with the analysis of the mutant phenotypes
    has provided new insights into the molecular and cellular mechanisms that underlie
    vertebrate gastrulation movements.
acknowledgement: We would like to thank Miguel Concha, Will Norton, Tim Geach, Suzanne
  Eaton, Kimbo Kotovic, Jenny Geiger and Steve Wilson for critical comments on this
  manuscript, and Lila Solnica-Krezel for providing results prior to publication.
  C.-P.H. is supported by an Emmy-Noether-Fellowship from the DFG and M.T. by an MRC
  Career Development Award.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
citation:
  ama: 'Heisenberg C-PJ, Tada M. Zebrafish gastrulation movements: bridging cell and
    developmental biology. <i>Seminars in Cell &#38; Developmental Biology</i>. 2002;13(6):471-479.
    doi:<a href="https://doi.org/10.1016/S1084952102001003">10.1016/S1084952102001003</a>'
  apa: 'Heisenberg, C.-P. J., &#38; Tada, M. (2002). Zebrafish gastrulation movements:
    bridging cell and developmental biology. <i>Seminars in Cell &#38; Developmental
    Biology</i>. Academic Press. <a href="https://doi.org/10.1016/S1084952102001003">https://doi.org/10.1016/S1084952102001003</a>'
  chicago: 'Heisenberg, Carl-Philipp J, and Masazumi Tada. “Zebrafish Gastrulation
    Movements: Bridging Cell and Developmental Biology.” <i>Seminars in Cell &#38;
    Developmental Biology</i>. Academic Press, 2002. <a href="https://doi.org/10.1016/S1084952102001003">https://doi.org/10.1016/S1084952102001003</a>.'
  ieee: 'C.-P. J. Heisenberg and M. Tada, “Zebrafish gastrulation movements: bridging
    cell and developmental biology,” <i>Seminars in Cell &#38; Developmental Biology</i>,
    vol. 13, no. 6. Academic Press, pp. 471–479, 2002.'
  ista: 'Heisenberg C-PJ, Tada M. 2002. Zebrafish gastrulation movements: bridging
    cell and developmental biology. Seminars in Cell &#38; Developmental Biology.
    13(6), 471–479.'
  mla: 'Heisenberg, Carl-Philipp J., and Masazumi Tada. “Zebrafish Gastrulation Movements:
    Bridging Cell and Developmental Biology.” <i>Seminars in Cell &#38; Developmental
    Biology</i>, vol. 13, no. 6, Academic Press, 2002, pp. 471–79, doi:<a href="https://doi.org/10.1016/S1084952102001003">10.1016/S1084952102001003</a>.'
  short: C.-P.J. Heisenberg, M. Tada, Seminars in Cell &#38; Developmental Biology
    13 (2002) 471–479.
date_created: 2018-12-11T12:07:31Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-07T09:28:48Z
day: '01'
doi: 10.1016/S1084952102001003
extern: '1'
external_id:
  pmid:
  - '12468250'
intvolume: '        13'
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 471 - 479
pmid: 1
publication: Seminars in Cell & Developmental Biology
publication_identifier:
  issn:
  - 1084-9521
publication_status: published
publisher: Academic Press
publist_id: '1920'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Zebrafish gastrulation movements: bridging cell and developmental biology'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2002'
...