---
_id: '14484'
abstract:
- lang: eng
  text: Intercellular signaling molecules, known as morphogens, act at a long range
    in developing tissues to provide spatial information and control properties such
    as cell fate and tissue growth. The production, transport, and removal of morphogens
    shape their concentration profiles in time and space. Downstream signaling cascades
    and gene regulatory networks within cells then convert the spatiotemporal morphogen
    profiles into distinct cellular responses. Current challenges are to understand
    the diverse molecular and cellular mechanisms underlying morphogen gradient formation,
    as well as the logic of downstream regulatory circuits involved in morphogen interpretation.
    This knowledge, combining experimental and theoretical results, is essential to
    understand emerging properties of morphogen-controlled systems, such as robustness
    and scaling.
acknowledgement: We are grateful to Zena Hadjivasiliou for comments on this article.
  A.K. is supported by grants from the European Research Council under the European
  Union (EU) Horizon 2020 research and innovation program (680037) and Horizon Europe
  (101044579), and the Austrian Science Fund (F78) (Stem Cell Modulation). J.B. is
  supported by the Francis Crick Institute, which receives its core funding from Cancer
  Research UK (CC001051), the UK Medical Research Council (CC001051), and the Wellcome
  Trust (CC001051), and by a grant from the European Research Council under the EU
  Horizon 2020 research and innovation program (742138).
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: James
  full_name: Briscoe, James
  last_name: Briscoe
citation:
  ama: Kicheva A, Briscoe J. Control of tissue development by morphogens. <i>Annual
    Review of Cell and Developmental Biology</i>. 2023;39:91-121. doi:<a href="https://doi.org/10.1146/annurev-cellbio-020823-011522">10.1146/annurev-cellbio-020823-011522</a>
  apa: Kicheva, A., &#38; Briscoe, J. (2023). Control of tissue development by morphogens.
    <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href="https://doi.org/10.1146/annurev-cellbio-020823-011522">https://doi.org/10.1146/annurev-cellbio-020823-011522</a>
  chicago: Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.”
    <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2023.
    <a href="https://doi.org/10.1146/annurev-cellbio-020823-011522">https://doi.org/10.1146/annurev-cellbio-020823-011522</a>.
  ieee: A. Kicheva and J. Briscoe, “Control of tissue development by morphogens,”
    <i>Annual Review of Cell and Developmental Biology</i>, vol. 39. Annual Reviews,
    pp. 91–121, 2023.
  ista: Kicheva A, Briscoe J. 2023. Control of tissue development by morphogens. Annual
    Review of Cell and Developmental Biology. 39, 91–121.
  mla: Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.”
    <i>Annual Review of Cell and Developmental Biology</i>, vol. 39, Annual Reviews,
    2023, pp. 91–121, doi:<a href="https://doi.org/10.1146/annurev-cellbio-020823-011522">10.1146/annurev-cellbio-020823-011522</a>.
  short: A. Kicheva, J. Briscoe, Annual Review of Cell and Developmental Biology 39
    (2023) 91–121.
date_created: 2023-11-05T23:00:53Z
date_published: 2023-10-16T00:00:00Z
date_updated: 2023-11-06T09:56:24Z
day: '16'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1146/annurev-cellbio-020823-011522
ec_funded: 1
external_id:
  pmid:
  - '37418774'
file:
- access_level: open_access
  checksum: 461726014cf5907010afbd418d3c13ec
  content_type: application/pdf
  creator: dernst
  date_created: 2023-11-06T09:47:50Z
  date_updated: 2023-11-06T09:47:50Z
  file_id: '14491'
  file_name: 2023_AnnualReviews_Kicheva.pdf
  file_size: 434819
  relation: main_file
  success: 1
file_date_updated: 2023-11-06T09:47:50Z
has_accepted_license: '1'
intvolume: '        39'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 91-121
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
- _id: bd7e737f-d553-11ed-ba76-d69ffb5ee3aa
  grant_number: '101044579'
  name: Mechanisms of tissue size regulation in spinal cord development
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
  grant_number: F07802
  name: Morphogen control of growth and pattern in the spinal cord
publication: Annual Review of Cell and Developmental Biology
publication_identifier:
  eissn:
  - 1530-8995
  issn:
  - 1081-0706
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Control of tissue development by morphogens
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2023'
...
---
_id: '11120'
abstract:
- lang: eng
  text: The nuclear envelope (NE) is a highly specialized membrane that delineates
    the eukaryotic cell nucleus. It is composed of the inner and outer nuclear membranes,
    nuclear pore complexes (NPCs) and, in metazoa, the lamina. The NE not only regulates
    the trafficking of macromolecules between nucleoplasm and cytosol but also provides
    anchoring sites for chromatin and the cytoskeleton. Through these interactions,
    the NE helps position the nucleus within the cell and chromosomes within the nucleus,
    thereby regulating the expression of certain genes. The NE is not static, rather
    it is continuously remodeled during cell division. The most dramatic example of
    NE reorganization occurs during mitosis in metazoa when the NE undergoes a complete
    cycle of disassembly and reformation. Despite the importance of the NE for eukaryotic
    cell life, relatively little is known about its biogenesis or many of its functions.
    We thus are far from understanding the molecular etiology of a diverse group of
    NE-associated diseases.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
- first_name: Tobias C.
  full_name: Walther, Tobias C.
  last_name: Walther
- first_name: Iain W.
  full_name: Mattaj, Iain W.
  last_name: Mattaj
citation:
  ama: 'Hetzer M, Walther TC, Mattaj IW. Pushing the envelope: Structure, function,
    and dynamics of the nuclear periphery. <i>Annual Review of Cell and Developmental
    Biology</i>. 2005;21:347-380. doi:<a href="https://doi.org/10.1146/annurev.cellbio.21.090704.151152">10.1146/annurev.cellbio.21.090704.151152</a>'
  apa: 'Hetzer, M., Walther, T. C., &#38; Mattaj, I. W. (2005). Pushing the envelope:
    Structure, function, and dynamics of the nuclear periphery. <i>Annual Review of
    Cell and Developmental Biology</i>. Annual Reviews. <a href="https://doi.org/10.1146/annurev.cellbio.21.090704.151152">https://doi.org/10.1146/annurev.cellbio.21.090704.151152</a>'
  chicago: 'Hetzer, Martin, Tobias C. Walther, and Iain W. Mattaj. “Pushing the Envelope:
    Structure, Function, and Dynamics of the Nuclear Periphery.” <i>Annual Review
    of Cell and Developmental Biology</i>. Annual Reviews, 2005. <a href="https://doi.org/10.1146/annurev.cellbio.21.090704.151152">https://doi.org/10.1146/annurev.cellbio.21.090704.151152</a>.'
  ieee: 'M. Hetzer, T. C. Walther, and I. W. Mattaj, “Pushing the envelope: Structure,
    function, and dynamics of the nuclear periphery,” <i>Annual Review of Cell and
    Developmental Biology</i>, vol. 21. Annual Reviews, pp. 347–380, 2005.'
  ista: 'Hetzer M, Walther TC, Mattaj IW. 2005. Pushing the envelope: Structure, function,
    and dynamics of the nuclear periphery. Annual Review of Cell and Developmental
    Biology. 21, 347–380.'
  mla: 'Hetzer, Martin, et al. “Pushing the Envelope: Structure, Function, and Dynamics
    of the Nuclear Periphery.” <i>Annual Review of Cell and Developmental Biology</i>,
    vol. 21, Annual Reviews, 2005, pp. 347–80, doi:<a href="https://doi.org/10.1146/annurev.cellbio.21.090704.151152">10.1146/annurev.cellbio.21.090704.151152</a>.'
  short: M. Hetzer, T.C. Walther, I.W. Mattaj, Annual Review of Cell and Developmental
    Biology 21 (2005) 347–380.
date_created: 2022-04-07T07:56:52Z
date_published: 2005-11-10T00:00:00Z
date_updated: 2022-07-18T08:57:34Z
day: '10'
doi: 10.1146/annurev.cellbio.21.090704.151152
extern: '1'
external_id:
  pmid:
  - '16212499'
intvolume: '        21'
keyword:
- Cell Biology
- Developmental Biology
language:
- iso: eng
month: '11'
oa_version: None
page: 347-380
pmid: 1
publication: Annual Review of Cell and Developmental Biology
publication_identifier:
  eissn:
  - 1530-8995
  issn:
  - 1081-0706
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Pushing the envelope: Structure, function, and dynamics of the nuclear periphery'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 21
year: '2005'
...