[{"date_updated":"2023-11-06T09:56:24Z","status":"public","ec_funded":1,"abstract":[{"lang":"eng","text":"Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling."}],"oa_version":"Published Version","page":"91-121","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"day":"16","project":[{"grant_number":"680037","call_identifier":"H2020","name":"Coordination of Patterning And Growth In the Spinal Cord","_id":"B6FC0238-B512-11E9-945C-1524E6697425"},{"grant_number":"101044579","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa","name":"Mechanisms of tissue size regulation in spinal cord development"},{"grant_number":"F07802","_id":"059DF620-7A3F-11EA-A408-12923DDC885E","name":"Morphogen control of growth and pattern in the spinal cord"}],"citation":{"chicago":"Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.” <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2023. <a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">https://doi.org/10.1146/annurev-cellbio-020823-011522</a>.","ieee":"A. Kicheva and J. Briscoe, “Control of tissue development by morphogens,” <i>Annual Review of Cell and Developmental Biology</i>, vol. 39. Annual Reviews, pp. 91–121, 2023.","short":"A. Kicheva, J. Briscoe, Annual Review of Cell and Developmental Biology 39 (2023) 91–121.","apa":"Kicheva, A., &#38; Briscoe, J. (2023). Control of tissue development by morphogens. <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">https://doi.org/10.1146/annurev-cellbio-020823-011522</a>","mla":"Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.” <i>Annual Review of Cell and Developmental Biology</i>, vol. 39, Annual Reviews, 2023, pp. 91–121, doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">10.1146/annurev-cellbio-020823-011522</a>.","ista":"Kicheva A, Briscoe J. 2023. Control of tissue development by morphogens. Annual Review of Cell and Developmental Biology. 39, 91–121.","ama":"Kicheva A, Briscoe J. Control of tissue development by morphogens. <i>Annual Review of Cell and Developmental Biology</i>. 2023;39:91-121. doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">10.1146/annurev-cellbio-020823-011522</a>"},"has_accepted_license":"1","scopus_import":"1","external_id":{"pmid":["37418774"]},"file":[{"creator":"dernst","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_name":"2023_AnnualReviews_Kicheva.pdf","file_size":434819,"checksum":"461726014cf5907010afbd418d3c13ec","file_id":"14491","date_created":"2023-11-06T09:47:50Z","success":1,"date_updated":"2023-11-06T09:47:50Z"}],"title":"Control of tissue development by morphogens","publication":"Annual Review of Cell and Developmental Biology","publisher":"Annual Reviews","year":"2023","language":[{"iso":"eng"}],"doi":"10.1146/annurev-cellbio-020823-011522","type":"journal_article","oa":1,"_id":"14484","author":[{"full_name":"Kicheva, Anna","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva","orcid":"0000-0003-4509-4998"},{"first_name":"James","full_name":"Briscoe, James","last_name":"Briscoe"}],"date_published":"2023-10-16T00:00:00Z","pmid":1,"acknowledgement":"We are grateful to Zena Hadjivasiliou for comments on this article. A.K. is supported by grants from the European Research Council under the European Union (EU) Horizon 2020 research and innovation program (680037) and Horizon Europe (101044579), and the Austrian Science Fund (F78) (Stem Cell Modulation). J.B. is supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (CC001051), the UK Medical Research Council (CC001051), and the Wellcome Trust (CC001051), and by a grant from the European Research Council under the EU Horizon 2020 research and innovation program (742138).","department":[{"_id":"AnKi"}],"date_created":"2023-11-05T23:00:53Z","intvolume":"        39","ddc":["570"],"article_processing_charge":"Yes (in subscription journal)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2023-11-06T09:47:50Z","quality_controlled":"1","publication_identifier":{"eissn":["1530-8995"],"issn":["1081-0706"]},"month":"10","article_type":"review","volume":39},{"title":"Pushing the envelope: Structure, function, and dynamics of the nuclear periphery","external_id":{"pmid":["16212499"]},"publication":"Annual Review of Cell and Developmental Biology","scopus_import":"1","citation":{"ama":"Hetzer M, Walther TC, Mattaj IW. Pushing the envelope: Structure, function, and dynamics of the nuclear periphery. <i>Annual Review of Cell and Developmental Biology</i>. 2005;21:347-380. doi:<a href=\"https://doi.org/10.1146/annurev.cellbio.21.090704.151152\">10.1146/annurev.cellbio.21.090704.151152</a>","apa":"Hetzer, M., Walther, T. C., &#38; Mattaj, I. W. (2005). Pushing the envelope: Structure, function, and dynamics of the nuclear periphery. <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.cellbio.21.090704.151152\">https://doi.org/10.1146/annurev.cellbio.21.090704.151152</a>","short":"M. Hetzer, T.C. Walther, I.W. Mattaj, Annual Review of Cell and Developmental Biology 21 (2005) 347–380.","mla":"Hetzer, Martin, et al. “Pushing the Envelope: Structure, Function, and Dynamics of the Nuclear Periphery.” <i>Annual Review of Cell and Developmental Biology</i>, vol. 21, Annual Reviews, 2005, pp. 347–80, doi:<a href=\"https://doi.org/10.1146/annurev.cellbio.21.090704.151152\">10.1146/annurev.cellbio.21.090704.151152</a>.","ista":"Hetzer M, Walther TC, Mattaj IW. 2005. Pushing the envelope: Structure, function, and dynamics of the nuclear periphery. Annual Review of Cell and Developmental Biology. 21, 347–380.","ieee":"M. Hetzer, T. C. Walther, and I. W. Mattaj, “Pushing the envelope: Structure, function, and dynamics of the nuclear periphery,” <i>Annual Review of Cell and Developmental Biology</i>, vol. 21. Annual Reviews, pp. 347–380, 2005.","chicago":"Hetzer, Martin, Tobias C. Walther, and Iain W. Mattaj. “Pushing the Envelope: Structure, Function, and Dynamics of the Nuclear Periphery.” <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2005. <a href=\"https://doi.org/10.1146/annurev.cellbio.21.090704.151152\">https://doi.org/10.1146/annurev.cellbio.21.090704.151152</a>."},"abstract":[{"lang":"eng","text":"The nuclear envelope (NE) is a highly specialized membrane that delineates the eukaryotic cell nucleus. It is composed of the inner and outer nuclear membranes, nuclear pore complexes (NPCs) and, in metazoa, the lamina. The NE not only regulates the trafficking of macromolecules between nucleoplasm and cytosol but also provides anchoring sites for chromatin and the cytoskeleton. Through these interactions, the NE helps position the nucleus within the cell and chromosomes within the nucleus, thereby regulating the expression of certain genes. The NE is not static, rather it is continuously remodeled during cell division. The most dramatic example of NE reorganization occurs during mitosis in metazoa when the NE undergoes a complete cycle of disassembly and reformation. Despite the importance of the NE for eukaryotic cell life, relatively little is known about its biogenesis or many of its functions. We thus are far from understanding the molecular etiology of a diverse group of NE-associated diseases."}],"day":"10","page":"347-380","publication_status":"published","oa_version":"None","status":"public","date_updated":"2022-07-18T08:57:34Z","volume":21,"article_type":"original","publication_identifier":{"issn":["1081-0706"],"eissn":["1530-8995"]},"quality_controlled":"1","month":"11","intvolume":"        21","keyword":["Cell Biology","Developmental Biology"],"article_processing_charge":"No","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","extern":"1","pmid":1,"date_created":"2022-04-07T07:56:52Z","date_published":"2005-11-10T00:00:00Z","_id":"11120","author":[{"full_name":"HETZER, Martin W","first_name":"Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"last_name":"Walther","full_name":"Walther, Tobias C.","first_name":"Tobias C."},{"last_name":"Mattaj","first_name":"Iain W.","full_name":"Mattaj, Iain W."}],"type":"journal_article","year":"2005","publisher":"Annual Reviews","doi":"10.1146/annurev.cellbio.21.090704.151152","language":[{"iso":"eng"}]}]