---
_id: '9641'
abstract:
- lang: eng
  text: At the encounter with a novel environment, contextual memory formation is
    greatly enhanced, accompanied with increased arousal and active exploration. Although
    this phenomenon has been widely observed in animal and human daily life, how the
    novelty in the environment is detected and contributes to contextual memory formation
    has lately started to be unveiled. The hippocampus has been studied for many decades
    for its largely known roles in encoding spatial memory, and a growing body of
    evidence indicates a differential involvement of dorsal and ventral hippocampal
    divisions in novelty detection. In this brief review article, we discuss the recent
    findings of the role of mossy cells in the ventral hippocampal moiety in novelty
    detection and put them in perspective with other novelty-related pathways in the
    hippocampus. We propose a mechanism for novelty-driven memory acquisition in the
    dentate gyrus by the direct projection of ventral mossy cells to dorsal dentate
    granule cells. By this projection, the ventral hippocampus sends novelty signals
    to the dorsal hippocampus, opening a gate for memory encoding in dentate granule
    cells based on information coming from the entorhinal cortex. We conclude that,
    contrary to the presently accepted functional independence, the dorsal and ventral
    hippocampi cooperate to link the novelty and contextual information, and this
    dorso-ventral interaction is crucial for the novelty-dependent memory formation.
acknowledgement: This work was supported by a European Research Council Advanced Grant
  694539 to Ryuichi Shigemoto.
article_number: '107486'
article_processing_charge: No
article_type: original
author:
- first_name: Felipe
  full_name: Fredes, Felipe
  last_name: Fredes
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Fredes F, Shigemoto R. The role of hippocampal mossy cells in novelty detection.
    <i>Neurobiology of Learning and Memory</i>. 2021;183. doi:<a href="https://doi.org/10.1016/j.nlm.2021.107486">10.1016/j.nlm.2021.107486</a>
  apa: Fredes, F., &#38; Shigemoto, R. (2021). The role of hippocampal mossy cells
    in novelty detection. <i>Neurobiology of Learning and Memory</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.nlm.2021.107486">https://doi.org/10.1016/j.nlm.2021.107486</a>
  chicago: Fredes, Felipe, and Ryuichi Shigemoto. “The Role of Hippocampal Mossy Cells
    in Novelty Detection.” <i>Neurobiology of Learning and Memory</i>. Elsevier, 2021.
    <a href="https://doi.org/10.1016/j.nlm.2021.107486">https://doi.org/10.1016/j.nlm.2021.107486</a>.
  ieee: F. Fredes and R. Shigemoto, “The role of hippocampal mossy cells in novelty
    detection,” <i>Neurobiology of Learning and Memory</i>, vol. 183. Elsevier, 2021.
  ista: Fredes F, Shigemoto R. 2021. The role of hippocampal mossy cells in novelty
    detection. Neurobiology of Learning and Memory. 183, 107486.
  mla: Fredes, Felipe, and Ryuichi Shigemoto. “The Role of Hippocampal Mossy Cells
    in Novelty Detection.” <i>Neurobiology of Learning and Memory</i>, vol. 183, 107486,
    Elsevier, 2021, doi:<a href="https://doi.org/10.1016/j.nlm.2021.107486">10.1016/j.nlm.2021.107486</a>.
  short: F. Fredes, R. Shigemoto, Neurobiology of Learning and Memory 183 (2021).
date_created: 2021-07-11T22:01:16Z
date_published: 2021-06-30T00:00:00Z
date_updated: 2023-08-10T14:10:37Z
day: '30'
ddc:
- '610'
department:
- _id: RySh
doi: 10.1016/j.nlm.2021.107486
ec_funded: 1
external_id:
  isi:
  - '000677694900004'
  pmid:
  - '34214666'
file:
- access_level: open_access
  checksum: 8e8298a9e8c7df146ad23f32c2a63929
  content_type: application/pdf
  creator: cziletti
  date_created: 2021-07-19T13:46:06Z
  date_updated: 2021-07-19T13:46:06Z
  file_id: '9694'
  file_name: 2021_NeurobLearnMemory_Fredes.pdf
  file_size: 1994793
  relation: main_file
  success: 1
file_date_updated: 2021-07-19T13:46:06Z
has_accepted_license: '1'
intvolume: '       183'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694539'
  name: 'In situ analysis of single channel subunit composition in neurons: physiological
    implication in synaptic plasticity and behaviour'
publication: Neurobiology of Learning and Memory
publication_identifier:
  eissn:
  - '10959564'
  issn:
  - '10747427'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The role of hippocampal mossy cells in novelty detection
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 183
year: '2021'
...