---
_id: '1017'
abstract:
- lang: eng
  text: The development of the vertebrate central nervous system is reliant on a complex
    cascade of biological processes that include mitotic division, relocation of migrating
    neurons, and the extension of dendritic and axonal processes. Each of these cellular
    events requires the diverse functional repertoire of the microtubule cytoskeleton
    for the generation of forces, assembly of macromolecular complexes and transport
    of molecules and organelles. The tubulins are a multi-gene family that encode
    for the constituents of microtubules, and have been implicated in a spectrum of
    neurological disorders. Evidence is building that different tubulins tune the
    functional properties of the microtubule cytoskeleton dependent on the cell type,
    developmental profile and subcellular localisation. Here we review of the origins
    of the functional specification of the tubulin gene family in the developing brain
    at a transcriptional, translational, and post-transcriptional level. We remind
    the reader that tubulins are not just loading controls for your average Western
    blot.
article_processing_charge: No
author:
- first_name: Martin
  full_name: Breuss, Martin
  last_name: Breuss
- first_name: Ines
  full_name: Leca, Ines
  last_name: Leca
- first_name: Thomas
  full_name: Gstrein, Thomas
  last_name: Gstrein
- first_name: Andi H
  full_name: Hansen, Andi H
  id: 38853E16-F248-11E8-B48F-1D18A9856A87
  last_name: Hansen
- first_name: David
  full_name: Keays, David
  last_name: Keays
citation:
  ama: 'Breuss M, Leca I, Gstrein T, Hansen AH, Keays D. Tubulins and brain development:
    The origins of functional specification. <i>Molecular and Cellular Neuroscience</i>.
    2017;84:58-67. doi:<a href="https://doi.org/10.1016/j.mcn.2017.03.002">10.1016/j.mcn.2017.03.002</a>'
  apa: 'Breuss, M., Leca, I., Gstrein, T., Hansen, A. H., &#38; Keays, D. (2017).
    Tubulins and brain development: The origins of functional specification. <i>Molecular
    and Cellular Neuroscience</i>. Academic Press. <a href="https://doi.org/10.1016/j.mcn.2017.03.002">https://doi.org/10.1016/j.mcn.2017.03.002</a>'
  chicago: 'Breuss, Martin, Ines Leca, Thomas Gstrein, Andi H Hansen, and David Keays.
    “Tubulins and Brain Development: The Origins of Functional Specification.” <i>Molecular
    and Cellular Neuroscience</i>. Academic Press, 2017. <a href="https://doi.org/10.1016/j.mcn.2017.03.002">https://doi.org/10.1016/j.mcn.2017.03.002</a>.'
  ieee: 'M. Breuss, I. Leca, T. Gstrein, A. H. Hansen, and D. Keays, “Tubulins and
    brain development: The origins of functional specification,” <i>Molecular and
    Cellular Neuroscience</i>, vol. 84. Academic Press, pp. 58–67, 2017.'
  ista: 'Breuss M, Leca I, Gstrein T, Hansen AH, Keays D. 2017. Tubulins and brain
    development: The origins of functional specification. Molecular and Cellular Neuroscience.
    84, 58–67.'
  mla: 'Breuss, Martin, et al. “Tubulins and Brain Development: The Origins of Functional
    Specification.” <i>Molecular and Cellular Neuroscience</i>, vol. 84, Academic
    Press, 2017, pp. 58–67, doi:<a href="https://doi.org/10.1016/j.mcn.2017.03.002">10.1016/j.mcn.2017.03.002</a>.'
  short: M. Breuss, I. Leca, T. Gstrein, A.H. Hansen, D. Keays, Molecular and Cellular
    Neuroscience 84 (2017) 58–67.
date_created: 2018-12-11T11:49:42Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2023-09-22T09:42:15Z
day: '01'
ddc:
- '571'
department:
- _id: SiHi
doi: 10.1016/j.mcn.2017.03.002
external_id:
  isi:
  - '000415140700007'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:19Z
  date_updated: 2018-12-12T10:09:19Z
  file_id: '4742'
  file_name: IST-2017-806-v1+2_1-s2.0-S1044743116302500-main_1_.pdf
  file_size: 1436377
  relation: main_file
file_date_updated: 2018-12-12T10:09:19Z
has_accepted_license: '1'
intvolume: '        84'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 58 - 67
publication: Molecular and Cellular Neuroscience
publication_identifier:
  issn:
  - '10447431'
publication_status: published
publisher: Academic Press
publist_id: '6377'
pubrep_id: '806'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Tubulins and brain development: The origins of functional specification'
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 84
year: '2017'
...