---
_id: '867'
abstract:
- lang: eng
  text: Genes with new functions often evolve by gene duplication. Alternative splicing
    is another means of evolutionary innovation in eukaryotes, which allows a single
    gene to encode functionally diverse proteins. We investigate a connection between
    these two evolutionary phenomena. For ∼10% of the described cases of substitution
    alternative splicing, such that either one or another amino acid sequence is included
    into the protein, evidence of origin by tandem exon duplication was found. This
    is a conservative estimate because alternative exons are typically short and,
    on many occasions, duplicates may have diverged beyond recognition. Dating exon
    duplications through a combination of the available experimental data on alternative
    splicing in orthologous genes from different species and computational analysis
    indicates that most of the duplications antedate at least the radiation of mammalian
    orders or even the radiation of vertebrate classes. At present, tandem exon duplication
    is the only mechanism of evolution of substitution alternative splicing that can
    be specifically demonstrated. Along with gene duplication, this could be a major
    route for generating functional diversity during evolution of multicellular eukaryotes.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Eugene
  full_name: Koonin, Eugene
  last_name: Koonin
citation:
  ama: Kondrashov F, Koonin E. Origin of alternative splicing by tandem exon duplication.
    <i>Human Molecular Genetics</i>. 2001;10(23):2661-2669. doi:<a href="https://doi.org/10.1093/hmg/10.23.2661">10.1093/hmg/10.23.2661</a>
  apa: Kondrashov, F., &#38; Koonin, E. (2001). Origin of alternative splicing by
    tandem exon duplication. <i>Human Molecular Genetics</i>. Oxford University Press.
    <a href="https://doi.org/10.1093/hmg/10.23.2661">https://doi.org/10.1093/hmg/10.23.2661</a>
  chicago: Kondrashov, Fyodor, and Eugene Koonin. “Origin of Alternative Splicing
    by Tandem Exon Duplication.” <i>Human Molecular Genetics</i>. Oxford University
    Press, 2001. <a href="https://doi.org/10.1093/hmg/10.23.2661">https://doi.org/10.1093/hmg/10.23.2661</a>.
  ieee: F. Kondrashov and E. Koonin, “Origin of alternative splicing by tandem exon
    duplication,” <i>Human Molecular Genetics</i>, vol. 10, no. 23. Oxford University
    Press, pp. 2661–2669, 2001.
  ista: Kondrashov F, Koonin E. 2001. Origin of alternative splicing by tandem exon
    duplication. Human Molecular Genetics. 10(23), 2661–2669.
  mla: Kondrashov, Fyodor, and Eugene Koonin. “Origin of Alternative Splicing by Tandem
    Exon Duplication.” <i>Human Molecular Genetics</i>, vol. 10, no. 23, Oxford University
    Press, 2001, pp. 2661–69, doi:<a href="https://doi.org/10.1093/hmg/10.23.2661">10.1093/hmg/10.23.2661</a>.
  short: F. Kondrashov, E. Koonin, Human Molecular Genetics 10 (2001) 2661–2669.
date_created: 2018-12-11T11:48:55Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-06-02T08:39:47Z
day: '01'
doi: 10.1093/hmg/10.23.2661
extern: '1'
external_id:
  pmid:
  - '11726553'
intvolume: '        10'
issue: '23'
language:
- iso: eng
month: '11'
oa_version: Published Version
page: 2661 - 2669
pmid: 1
publication: Human Molecular Genetics
publication_identifier:
  issn:
  - 0964-6906
publication_status: published
publisher: Oxford University Press
publist_id: '6777'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Origin of alternative splicing by tandem exon duplication
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2001'
...