---
_id: '2249'
abstract:
- lang: eng
  text: The unfolded protein response (UPR) is a signaling network triggered by overload
    of protein-folding demand in the endoplasmic reticulum (ER), a condition termed
    ER stress. The UPR is critical for growth and development; nonetheless, connections
    between the UPR and other cellular regulatory processes remain largely unknown.
    Here, we identify a link between the UPR and the phytohormone auxin, a master
    regulator of plant physiology. We show that ER stress triggers down-regulation
    of auxin receptors and transporters in Arabidopsis thaliana. We also demonstrate
    that an Arabidopsis mutant of a conserved ER stress sensor IRE1 exhibits defects
    in the auxin response and levels. These data not only support that the plant IRE1
    is required for auxin homeostasis, they also reveal a species-specific feature
    of IRE1 in multicellular eukaryotes. Furthermore, by establishing that UPR activation
    is reduced in mutants of ER-localized auxin transporters, including PIN5, we define
    a long-neglected biological significance of ER-based auxin regulation. We further
    examine the functional relationship of IRE1 and PIN5 by showing that an ire1 pin5
    triple mutant enhances defects of UPR activation and auxin homeostasis in ire1
    or pin5. Our results imply that the plant UPR has evolved a hormone-dependent
    strategy for coordinating ER function with physiological processes.
author:
- first_name: Yani
  full_name: Chen, Yani
  last_name: Chen
- first_name: Kyaw
  full_name: Aung, Kyaw
  last_name: Aung
- first_name: Jakub
  full_name: Rolčík, Jakub
  last_name: Rolčík
- first_name: Kathryn
  full_name: Walicki, Kathryn
  last_name: Walicki
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Federica
  full_name: Brandizzí, Federica
  last_name: Brandizzí
citation:
  ama: Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzí F. Inter-regulation
    of the unfolded protein response and auxin signaling. <i>Plant Journal</i>. 2014;77(1):97-107.
    doi:<a href="https://doi.org/10.1111/tpj.12373">10.1111/tpj.12373</a>
  apa: Chen, Y., Aung, K., Rolčík, J., Walicki, K., Friml, J., &#38; Brandizzí, F.
    (2014). Inter-regulation of the unfolded protein response and auxin signaling.
    <i>Plant Journal</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/tpj.12373">https://doi.org/10.1111/tpj.12373</a>
  chicago: Chen, Yani, Kyaw Aung, Jakub Rolčík, Kathryn Walicki, Jiří Friml, and Federica
    Brandizzí. “Inter-Regulation of the Unfolded Protein Response and Auxin Signaling.”
    <i>Plant Journal</i>. Wiley-Blackwell, 2014. <a href="https://doi.org/10.1111/tpj.12373">https://doi.org/10.1111/tpj.12373</a>.
  ieee: Y. Chen, K. Aung, J. Rolčík, K. Walicki, J. Friml, and F. Brandizzí, “Inter-regulation
    of the unfolded protein response and auxin signaling,” <i>Plant Journal</i>, vol.
    77, no. 1. Wiley-Blackwell, pp. 97–107, 2014.
  ista: Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzí F. 2014. Inter-regulation
    of the unfolded protein response and auxin signaling. Plant Journal. 77(1), 97–107.
  mla: Chen, Yani, et al. “Inter-Regulation of the Unfolded Protein Response and Auxin
    Signaling.” <i>Plant Journal</i>, vol. 77, no. 1, Wiley-Blackwell, 2014, pp. 97–107,
    doi:<a href="https://doi.org/10.1111/tpj.12373">10.1111/tpj.12373</a>.
  short: Y. Chen, K. Aung, J. Rolčík, K. Walicki, J. Friml, F. Brandizzí, Plant Journal
    77 (2014) 97–107.
date_created: 2018-12-11T11:56:34Z
date_published: 2014-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:17Z
day: '01'
department:
- _id: JiFr
doi: 10.1111/tpj.12373
intvolume: '        77'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981873/
month: '01'
oa: 1
oa_version: Submitted Version
page: 97 - 107
publication: Plant Journal
publication_identifier:
  issn:
  - '09607412'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4699'
quality_controlled: '1'
scopus_import: 1
status: public
title: Inter-regulation of the unfolded protein response and auxin signaling
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 77
year: '2014'
...
---
_id: '2253'
abstract:
- lang: eng
  text: Plant growth is achieved predominantly by cellular elongation, which is thought
    to be controlled on several levels by apoplastic auxin. Auxin export into the
    apoplast is achieved by plasma membrane efflux catalysts of the PIN-FORMED (PIN)
    and ATP-binding cassette protein subfamily B/phosphor- glycoprotein (ABCB/PGP)
    classes; the latter were shown to depend on interaction with the FKBP42, TWISTED
    DWARF1 (TWD1). Here by using a transgenic approach in combination with phenotypical,
    biochemical and cell biological analyses we demonstrate the importance of a putative
    C-terminal in-plane membrane anchor of TWD1 in the regulation of ABCB-mediated
    auxin transport. In contrast with dwarfed twd1 loss-of-function alleles, TWD1
    gain-of-function lines that lack a putative in-plane membrane anchor (HA-TWD1-Ct)
    show hypermorphic plant architecture, characterized by enhanced stem length and
    leaf surface but reduced shoot branching. Greater hypocotyl length is the result
    of enhanced cell elongation that correlates with reduced polar auxin transport
    capacity for HA-TWD1-Ct. As a consequence, HA-TWD1-Ct displays higher hypocotyl
    auxin accumulation, which is shown to result in elevated auxin-induced cell elongation
    rates. Our data highlight the importance of C-terminal membrane anchoring for
    TWD1 action, which is required for specific regulation of ABCB-mediated auxin
    transport. These data support a model in which TWD1 controls lateral ABCB1-mediated
    export into the apoplast, which is required for auxin-mediated cell elongation.
article_processing_charge: No
article_type: original
author:
- first_name: Aurélien
  full_name: Bailly, Aurélien
  last_name: Bailly
- first_name: Bangjun
  full_name: Wang, Bangjun
  last_name: Wang
- first_name: Marta
  full_name: Zwiewka, Marta
  last_name: Zwiewka
- first_name: Stephan
  full_name: Pollmann, Stephan
  last_name: Pollmann
- first_name: Daniel
  full_name: Schenck, Daniel
  last_name: Schenck
- first_name: Hartwig
  full_name: Lüthen, Hartwig
  last_name: Lüthen
- first_name: Alexander
  full_name: Schulz, Alexander
  last_name: Schulz
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Markus
  full_name: Geisler, Markus
  last_name: Geisler
citation:
  ama: Bailly A, Wang B, Zwiewka M, et al. Expression of TWISTED DWARF1 lacking its
    in-plane membrane anchor leads to increased cell elongation and hypermorphic growth.
    <i>Plant Journal</i>. 2014;77(1):108-118. doi:<a href="https://doi.org/10.1111/tpj.12369">10.1111/tpj.12369</a>
  apa: Bailly, A., Wang, B., Zwiewka, M., Pollmann, S., Schenck, D., Lüthen, H., …
    Geisler, M. (2014). Expression of TWISTED DWARF1 lacking its in-plane membrane
    anchor leads to increased cell elongation and hypermorphic growth. <i>Plant Journal</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1111/tpj.12369">https://doi.org/10.1111/tpj.12369</a>
  chicago: Bailly, Aurélien, Bangjun Wang, Marta Zwiewka, Stephan Pollmann, Daniel
    Schenck, Hartwig Lüthen, Alexander Schulz, Jiří Friml, and Markus Geisler. “Expression
    of TWISTED DWARF1 Lacking Its In-Plane Membrane Anchor Leads to Increased Cell
    Elongation and Hypermorphic Growth.” <i>Plant Journal</i>. Wiley-Blackwell, 2014.
    <a href="https://doi.org/10.1111/tpj.12369">https://doi.org/10.1111/tpj.12369</a>.
  ieee: A. Bailly <i>et al.</i>, “Expression of TWISTED DWARF1 lacking its in-plane
    membrane anchor leads to increased cell elongation and hypermorphic growth,” <i>Plant
    Journal</i>, vol. 77, no. 1. Wiley-Blackwell, pp. 108–118, 2014.
  ista: Bailly A, Wang B, Zwiewka M, Pollmann S, Schenck D, Lüthen H, Schulz A, Friml
    J, Geisler M. 2014. Expression of TWISTED DWARF1 lacking its in-plane membrane
    anchor leads to increased cell elongation and hypermorphic growth. Plant Journal.
    77(1), 108–118.
  mla: Bailly, Aurélien, et al. “Expression of TWISTED DWARF1 Lacking Its In-Plane
    Membrane Anchor Leads to Increased Cell Elongation and Hypermorphic Growth.” <i>Plant
    Journal</i>, vol. 77, no. 1, Wiley-Blackwell, 2014, pp. 108–18, doi:<a href="https://doi.org/10.1111/tpj.12369">10.1111/tpj.12369</a>.
  short: A. Bailly, B. Wang, M. Zwiewka, S. Pollmann, D. Schenck, H. Lüthen, A. Schulz,
    J. Friml, M. Geisler, Plant Journal 77 (2014) 108–118.
date_created: 2018-12-11T11:56:35Z
date_published: 2014-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:18Z
day: '01'
department:
- _id: JiFr
doi: 10.1111/tpj.12369
intvolume: '        77'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/tpj.12369
month: '01'
oa: 1
oa_version: Published Version
page: 108 - 118
project:
- _id: 256BDAB0-B435-11E9-9278-68D0E5697425
  name: Innovationsförderung in der Grenzregion Österreich – Tschechische Republik
    durch die Schaffung von Synergien im Bereich der Forschungsinfrastruktur
publication: Plant Journal
publication_identifier:
  issn:
  - '09607412'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4694'
quality_controlled: '1'
scopus_import: 1
status: public
title: Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to
  increased cell elongation and hypermorphic growth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 77
year: '2014'
...