---
_id: '8131'
abstract:
- lang: eng
  text: The possibility to generate construct valid animal models enabled the development
    and testing of therapeutic strategies targeting the core features of autism spectrum
    disorders (ASDs). At the same time, these studies highlighted the necessity of
    identifying sensitive developmental time windows for successful therapeutic interventions.
    Animal and human studies also uncovered the possibility to stratify the variety
    of ASDs in molecularly distinct subgroups, potentially facilitating effective
    treatment design. Here, we focus on the molecular pathways emerging as commonly
    affected by mutations in diverse ASD-risk genes, on their role during critical
    windows of brain development and the potential treatments targeting these biological
    processes.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Bernadette
  full_name: Basilico, Bernadette
  id: 36035796-5ACA-11E9-A75E-7AF2E5697425
  last_name: Basilico
  orcid: 0000-0003-1843-3173
- first_name: Jasmin
  full_name: Morandell, Jasmin
  id: 4739D480-F248-11E8-B48F-1D18A9856A87
  last_name: Morandell
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Basilico B, Morandell J, Novarino G. Molecular mechanisms for targeted ASD
    treatments. <i>Current Opinion in Genetics and Development</i>. 2020;65(12):126-137.
    doi:<a href="https://doi.org/10.1016/j.gde.2020.06.004">10.1016/j.gde.2020.06.004</a>
  apa: Basilico, B., Morandell, J., &#38; Novarino, G. (2020). Molecular mechanisms
    for targeted ASD treatments. <i>Current Opinion in Genetics and Development</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.gde.2020.06.004">https://doi.org/10.1016/j.gde.2020.06.004</a>
  chicago: Basilico, Bernadette, Jasmin Morandell, and Gaia Novarino. “Molecular Mechanisms
    for Targeted ASD Treatments.” <i>Current Opinion in Genetics and Development</i>.
    Elsevier, 2020. <a href="https://doi.org/10.1016/j.gde.2020.06.004">https://doi.org/10.1016/j.gde.2020.06.004</a>.
  ieee: B. Basilico, J. Morandell, and G. Novarino, “Molecular mechanisms for targeted
    ASD treatments,” <i>Current Opinion in Genetics and Development</i>, vol. 65,
    no. 12. Elsevier, pp. 126–137, 2020.
  ista: Basilico B, Morandell J, Novarino G. 2020. Molecular mechanisms for targeted
    ASD treatments. Current Opinion in Genetics and Development. 65(12), 126–137.
  mla: Basilico, Bernadette, et al. “Molecular Mechanisms for Targeted ASD Treatments.”
    <i>Current Opinion in Genetics and Development</i>, vol. 65, no. 12, Elsevier,
    2020, pp. 126–37, doi:<a href="https://doi.org/10.1016/j.gde.2020.06.004">10.1016/j.gde.2020.06.004</a>.
  short: B. Basilico, J. Morandell, G. Novarino, Current Opinion in Genetics and Development
    65 (2020) 126–137.
date_created: 2020-07-19T22:00:58Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-09-10T12:04:25Z
day: '01'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1016/j.gde.2020.06.004
ec_funded: 1
external_id:
  isi:
  - '000598918900019'
  pmid:
  - '32659636'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2020-07-22T06:47:45Z
  date_updated: 2020-07-22T06:47:45Z
  file_id: '8146'
  file_name: 2020_CurrentOpGenetics_Basilico.pdf
  file_size: 1381545
  relation: main_file
  success: 1
file_date_updated: 2020-07-22T06:47:45Z
has_accepted_license: '1'
intvolume: '        65'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 126-137
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1232-B24
  name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
  grant_number: F07807
  name: Neural stem cells in autism and epilepsy
publication: Current Opinion in Genetics and Development
publication_identifier:
  eissn:
  - '18790380'
  issn:
  - 0959437X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '8620'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Molecular mechanisms for targeted ASD treatments
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 65
year: '2020'
...
---
_id: '1004'
abstract:
- lang: eng
  text: The fundamental tasks of the root system are, besides anchoring, mediating
    interactions between plant and soil and providing the plant with water and nutrients.
    The architecture of the root system is controlled by endogenous mechanisms that
    constantly integrate environmental signals, such as availability of nutrients
    and water. Extremely important for efficient soil exploitation and survival under
    less favorable conditions is the developmental flexibility of the root system
    that is largely determined by its postembryonic branching capacity. Modulation
    of initiation and outgrowth of lateral roots provides roots with an exceptional
    plasticity, allows optimal adjustment to underground heterogeneity, and enables
    effective soil exploitation and use of resources. Here we discuss recent advances
    in understanding the molecular mechanisms that shape the plant root system and
    integrate external cues to adapt to the changing environment.
article_processing_charge: No
author:
- first_name: Krisztina
  full_name: Ötvös, Krisztina
  id: 29B901B0-F248-11E8-B48F-1D18A9856A87
  last_name: Ötvös
  orcid: 0000-0002-5503-4983
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Ötvös K, Benková E. Spatiotemporal mechanisms of root branching. <i>Current
    Opinion in Genetics &#38; Development</i>. 2017;45:82-89. doi:<a href="https://doi.org/10.1016/j.gde.2017.03.010">10.1016/j.gde.2017.03.010</a>
  apa: Ötvös, K., &#38; Benková, E. (2017). Spatiotemporal mechanisms of root branching.
    <i>Current Opinion in Genetics &#38; Development</i>. Elsevier. <a href="https://doi.org/10.1016/j.gde.2017.03.010">https://doi.org/10.1016/j.gde.2017.03.010</a>
  chicago: Ötvös, Krisztina, and Eva Benková. “Spatiotemporal Mechanisms of Root Branching.”
    <i>Current Opinion in Genetics &#38; Development</i>. Elsevier, 2017. <a href="https://doi.org/10.1016/j.gde.2017.03.010">https://doi.org/10.1016/j.gde.2017.03.010</a>.
  ieee: K. Ötvös and E. Benková, “Spatiotemporal mechanisms of root branching,” <i>Current
    Opinion in Genetics &#38; Development</i>, vol. 45. Elsevier, pp. 82–89, 2017.
  ista: Ötvös K, Benková E. 2017. Spatiotemporal mechanisms of root branching. Current
    Opinion in Genetics &#38; Development. 45, 82–89.
  mla: Ötvös, Krisztina, and Eva Benková. “Spatiotemporal Mechanisms of Root Branching.”
    <i>Current Opinion in Genetics &#38; Development</i>, vol. 45, Elsevier, 2017,
    pp. 82–89, doi:<a href="https://doi.org/10.1016/j.gde.2017.03.010">10.1016/j.gde.2017.03.010</a>.
  short: K. Ötvös, E. Benková, Current Opinion in Genetics &#38; Development 45 (2017)
    82–89.
date_created: 2018-12-11T11:49:38Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2023-09-22T09:48:15Z
day: '01'
ddc:
- '575'
department:
- _id: EvBe
doi: 10.1016/j.gde.2017.03.010
external_id:
  isi:
  - '000404880400013'
  pmid:
  - '28391060'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-17T08:00:36Z
  date_updated: 2019-04-17T08:00:36Z
  file_id: '6336'
  file_name: Otvos_Benkova_CurOpDevBiol_2017.pdf
  file_size: 364133
  relation: main_file
  success: 1
file_date_updated: 2019-04-17T08:00:36Z
has_accepted_license: '1'
intvolume: '        45'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 82 - 89
pmid: 1
project:
- _id: 2542D156-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 1774-B16
  name: Hormone cross-talk drives nutrient dependent plant development
publication: Current Opinion in Genetics & Development
publication_identifier:
  issn:
  - 0959437X
publication_status: published
publisher: Elsevier
publist_id: '6394'
pubrep_id: '1017'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spatiotemporal mechanisms of root branching
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 45
year: '2017'
...