---
_id: '4202'
abstract:
- lang: eng
  text: NERVE growth factor (NGF) injected into the otherwise unlesioned adult rat
    septum induced sprouting of presumptive cholinergic fibres positive for p75(NGFR)
    and acetylcholinesterase (AChE). These fibres did not stain for tyrosine hydroxylase
    and therefore did not represent sympathetic ingrowth. Neurofilament staining on
    adjacent sections revealed fibres with similar morphology, suggesting new outgrowth
    in the form of sprouting rather than the upregulation of p75(NGFR) and AChE in
    pre-existing fibres. Simultaneous injections of subneurotoxic doses of N-methyl-D-aspartate
    (NMDA) significantly potentiated the effect of NGF on cholinergic fibre sprouting
    and caused pronounced glial fibrillary acidic protein (GFAP)positive astrocytosis.
    Application of NMDA alone did not elicit sprouting of this type. These findings
    indicate that NGF can induce the sprouting of uninjured adult rat septal cholinergic
    fibres in vivo and suggest that reactive astrocytes are not inhibitory to cholinergic
    axonal outgrowth, and might serve as a substrate for growing axons in the presence
    of NGF.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: John
  full_name: Cooper, John
  last_name: Cooper
- first_name: J
  full_name: Berke, J
  last_name: Berke
- first_name: Michael
  full_name: Sofroniew, Michael
  last_name: Sofroniew
citation:
  ama: Heisenberg C-PJ, Cooper J, Berke J, Sofroniew M. NMDA potentiates NGF-induced
    sprouting of septal cholinergic fibres. <i>Neuroreport</i>. 1994;5(4):413-416.
    doi:<a href="https://doi.org/10.1097/00001756-199401120-00010 ">10.1097/00001756-199401120-00010
    </a>
  apa: Heisenberg, C.-P. J., Cooper, J., Berke, J., &#38; Sofroniew, M. (1994). NMDA
    potentiates NGF-induced sprouting of septal cholinergic fibres. <i>Neuroreport</i>.
    Lippincott, Williams &#38; Wilkins. <a href="https://doi.org/10.1097/00001756-199401120-00010
    ">https://doi.org/10.1097/00001756-199401120-00010 </a>
  chicago: Heisenberg, Carl-Philipp J, John Cooper, J Berke, and Michael Sofroniew.
    “NMDA Potentiates NGF-Induced Sprouting of Septal Cholinergic Fibres.” <i>Neuroreport</i>.
    Lippincott, Williams &#38; Wilkins, 1994. <a href="https://doi.org/10.1097/00001756-199401120-00010
    ">https://doi.org/10.1097/00001756-199401120-00010 </a>.
  ieee: C.-P. J. Heisenberg, J. Cooper, J. Berke, and M. Sofroniew, “NMDA potentiates
    NGF-induced sprouting of septal cholinergic fibres,” <i>Neuroreport</i>, vol.
    5, no. 4. Lippincott, Williams &#38; Wilkins, pp. 413–416, 1994.
  ista: Heisenberg C-PJ, Cooper J, Berke J, Sofroniew M. 1994. NMDA potentiates NGF-induced
    sprouting of septal cholinergic fibres. Neuroreport. 5(4), 413–416.
  mla: Heisenberg, Carl-Philipp J., et al. “NMDA Potentiates NGF-Induced Sprouting
    of Septal Cholinergic Fibres.” <i>Neuroreport</i>, vol. 5, no. 4, Lippincott,
    Williams &#38; Wilkins, 1994, pp. 413–16, doi:<a href="https://doi.org/10.1097/00001756-199401120-00010
    ">10.1097/00001756-199401120-00010 </a>.
  short: C.-P.J. Heisenberg, J. Cooper, J. Berke, M. Sofroniew, Neuroreport 5 (1994)
    413–416.
date_created: 2018-12-11T12:07:33Z
date_published: 1994-01-12T00:00:00Z
date_updated: 2022-06-02T10:07:25Z
day: '12'
doi: '10.1097/00001756-199401120-00010 '
extern: '1'
intvolume: '         5'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://journals.lww.com/neuroreport/Abstract/1994/01120/NMDA_potentiates_NGF_induced_sprouting_of_septal.10.aspx
month: '01'
oa_version: None
page: 413 - 416
publication: Neuroreport
publication_identifier:
  issn:
  - 0959-4965
publication_status: published
publisher: Lippincott, Williams & Wilkins
publist_id: '1915'
quality_controlled: '1'
scopus_import: '1'
status: public
title: NMDA potentiates NGF-induced sprouting of septal cholinergic fibres
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1994'
...
---
_id: '4195'
abstract:
- lang: eng
  text: The effects of tri-iodothyronine (T3), which are known to affect cerebellar
    development, were tested on neuronal survival and differentiation of cultured
    cerebellar granule neurons. T3 in physiological concentrations increased both
    granule neuron survival after three days in culture and synaptic vesicle protein
    formation, as shown by immunostaining with antibodies against synaptophysin. Likewise,
    T3 increased the mRNA level for synapsin(I), but not that for GAP43 in granule
    neurons. Antibodies against microtubule associated protein Tau, which is expressed
    in developing neurites, showed that T3 also enhanced neurite formation.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Hans
  full_name: Thoenen, Hans
  last_name: Thoenen
- first_name: Dan
  full_name: Lindholm, Dan
  last_name: Lindholm
citation:
  ama: Heisenberg C-PJ, Thoenen H, Lindholm D. Triiodothyronine Regulates Survival
    and Differentiation of Rat Cerebellar Granule Neurons. <i>Neuroreport</i>. 1992;3(8):685-688.
    doi:<a href="https://doi.org/10.1097/00001756-199208000-00008 ">10.1097/00001756-199208000-00008
    </a>
  apa: Heisenberg, C.-P. J., Thoenen, H., &#38; Lindholm, D. (1992). Triiodothyronine
    Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons. <i>Neuroreport</i>.
    Lippincott, Williams &#38; Wilkins. <a href="https://doi.org/10.1097/00001756-199208000-00008
    ">https://doi.org/10.1097/00001756-199208000-00008 </a>
  chicago: Heisenberg, Carl-Philipp J, Hans Thoenen, and Dan Lindholm. “Triiodothyronine
    Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons.” <i>Neuroreport</i>.
    Lippincott, Williams &#38; Wilkins, 1992. <a href="https://doi.org/10.1097/00001756-199208000-00008
    ">https://doi.org/10.1097/00001756-199208000-00008 </a>.
  ieee: C.-P. J. Heisenberg, H. Thoenen, and D. Lindholm, “Triiodothyronine Regulates
    Survival and Differentiation of Rat Cerebellar Granule Neurons,” <i>Neuroreport</i>,
    vol. 3, no. 8. Lippincott, Williams &#38; Wilkins, pp. 685–688, 1992.
  ista: Heisenberg C-PJ, Thoenen H, Lindholm D. 1992. Triiodothyronine Regulates Survival
    and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 3(8), 685–688.
  mla: Heisenberg, Carl-Philipp J., et al. “Triiodothyronine Regulates Survival and
    Differentiation of Rat Cerebellar Granule Neurons.” <i>Neuroreport</i>, vol. 3,
    no. 8, Lippincott, Williams &#38; Wilkins, 1992, pp. 685–88, doi:<a href="https://doi.org/10.1097/00001756-199208000-00008
    ">10.1097/00001756-199208000-00008 </a>.
  short: C.-P.J. Heisenberg, H. Thoenen, D. Lindholm, Neuroreport 3 (1992) 685–688.
date_created: 2018-12-11T12:07:31Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-15T15:25:24Z
day: '01'
doi: '10.1097/00001756-199208000-00008 '
extern: '1'
external_id:
  pmid:
  - '1387811 '
intvolume: '         3'
issue: '8'
language:
- iso: eng
main_file_link:
- url: https://journals.lww.com/neuroreport/abstract/1992/08000/tri_iodothyronine_regulates_survival_and.8.aspx
month: '01'
oa_version: None
page: 685 - 688
pmid: 1
publication: Neuroreport
publication_identifier:
  eissn:
  - 1473-558X
  issn:
  - 0959-4965
publication_status: published
publisher: Lippincott, Williams & Wilkins
publist_id: '1922'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule
  Neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '1992'
...