---
_id: '13965'
abstract:
- lang: eng
  text: Many modes and mechanisms of epigenetic inheritance have been elucidated in
    eukaryotes. Most of them are relatively short-term, generally not exceeding one
    or a few organismal generations. However, emerging evidence indicates that one
    mechanism, cytosine DNA methylation, can mediate epigenetic inheritance over much
    longer timescales, which are mostly or completely inaccessible in the laboratory.
    Here we discuss the evidence for, and mechanisms and implications of, such long-term
    epigenetic inheritance. We argue that compelling evidence supports the long-term
    epigenetic inheritance of gene body methylation, at least in the model angiosperm
    Arabidopsis thaliana, and that variation in such methylation can therefore serve
    as an epigenetic basis for phenotypic variation in natural populations.
article_number: '102087'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Elizabeth
  full_name: Hollwey, Elizabeth
  id: b8c4f54b-e484-11eb-8fdc-a54df64ef6dd
  last_name: Hollwey
- first_name: Amy
  full_name: Briffa, Amy
  last_name: Briffa
- first_name: Martin
  full_name: Howard, Martin
  last_name: Howard
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Hollwey E, Briffa A, Howard M, Zilberman D. Concepts, mechanisms and implications
    of long-term epigenetic inheritance. <i>Current Opinion in Genetics and Development</i>.
    2023;81(8). doi:<a href="https://doi.org/10.1016/j.gde.2023.102087">10.1016/j.gde.2023.102087</a>
  apa: Hollwey, E., Briffa, A., Howard, M., &#38; Zilberman, D. (2023). Concepts,
    mechanisms and implications of long-term epigenetic inheritance. <i>Current Opinion
    in Genetics and Development</i>. Elsevier. <a href="https://doi.org/10.1016/j.gde.2023.102087">https://doi.org/10.1016/j.gde.2023.102087</a>
  chicago: Hollwey, Elizabeth, Amy Briffa, Martin Howard, and Daniel Zilberman. “Concepts,
    Mechanisms and Implications of Long-Term Epigenetic Inheritance.” <i>Current Opinion
    in Genetics and Development</i>. Elsevier, 2023. <a href="https://doi.org/10.1016/j.gde.2023.102087">https://doi.org/10.1016/j.gde.2023.102087</a>.
  ieee: E. Hollwey, A. Briffa, M. Howard, and D. Zilberman, “Concepts, mechanisms
    and implications of long-term epigenetic inheritance,” <i>Current Opinion in Genetics
    and Development</i>, vol. 81, no. 8. Elsevier, 2023.
  ista: Hollwey E, Briffa A, Howard M, Zilberman D. 2023. Concepts, mechanisms and
    implications of long-term epigenetic inheritance. Current Opinion in Genetics
    and Development. 81(8), 102087.
  mla: Hollwey, Elizabeth, et al. “Concepts, Mechanisms and Implications of Long-Term
    Epigenetic Inheritance.” <i>Current Opinion in Genetics and Development</i>, vol.
    81, no. 8, 102087, Elsevier, 2023, doi:<a href="https://doi.org/10.1016/j.gde.2023.102087">10.1016/j.gde.2023.102087</a>.
  short: E. Hollwey, A. Briffa, M. Howard, D. Zilberman, Current Opinion in Genetics
    and Development 81 (2023).
date_created: 2023-08-06T22:01:10Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2023-12-13T12:05:31Z
day: '01'
ddc:
- '570'
department:
- _id: DaZi
doi: 10.1016/j.gde.2023.102087
external_id:
  isi:
  - '001047020200001'
  pmid:
  - '37441873'
file:
- access_level: open_access
  checksum: a294cd9506b80ed6ef218ef44ed32765
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-07T08:32:26Z
  date_updated: 2023-08-07T08:32:26Z
  file_id: '13980'
  file_name: 2023_CurrentOpinionGenetics_Hollwey.pdf
  file_size: 2568632
  relation: main_file
  success: 1
file_date_updated: 2023-08-07T08:32:26Z
has_accepted_license: '1'
intvolume: '        81'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Current Opinion in Genetics and Development
publication_identifier:
  eissn:
  - 1879-0380
  issn:
  - 0959-437X
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Concepts, mechanisms and implications of long-term epigenetic inheritance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2023'
...
---
_id: '9528'
abstract:
- lang: eng
  text: Accumulating evidence points toward diverse functions for plant chromatin.
    Remarkable progress has been made over the last few years in elucidating the mechanisms
    for a number of these functions. Activity of the histone demethylase IBM1 accurately
    targets DNA methylation to silent repeats and transposable elements, not to genes.
    A genetic screen uncovered the surprising role of H2A.Z-containing nucleosomes
    in sensing precise differences in ambient temperature and consequent gene regulation.
    Precise maintenance of chromosome number is assured by a histone modification
    that suppresses inappropriate DNA replication and by centromeric histone H3 regulation
    of chromosome segregation. Histones and noncoding RNAs regulate FLOWERING LOCUS
    C, the expression of which quantitatively measures the duration of cold exposure,
    functioning as memory of winter. These findings are a testament to the power of
    using plants to research chromatin organization, and demonstrate examples of how
    chromatin functions to achieve biological accuracy, precision, and memory.
article_processing_charge: No
article_type: review
author:
- first_name: Jason T.
  full_name: Huff, Jason T.
  last_name: Huff
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Huff JT, Zilberman D. Regulation of biological accuracy, precision, and memory
    by plant chromatin organization. <i>Current Opinion in Genetics and Development</i>.
    2012;22(2):132-138. doi:<a href="https://doi.org/10.1016/j.gde.2012.01.007">10.1016/j.gde.2012.01.007</a>
  apa: Huff, J. T., &#38; Zilberman, D. (2012). Regulation of biological accuracy,
    precision, and memory by plant chromatin organization. <i>Current Opinion in Genetics
    and Development</i>. Elsevier. <a href="https://doi.org/10.1016/j.gde.2012.01.007">https://doi.org/10.1016/j.gde.2012.01.007</a>
  chicago: Huff, Jason T., and Daniel Zilberman. “Regulation of Biological Accuracy,
    Precision, and Memory by Plant Chromatin Organization.” <i>Current Opinion in
    Genetics and Development</i>. Elsevier, 2012. <a href="https://doi.org/10.1016/j.gde.2012.01.007">https://doi.org/10.1016/j.gde.2012.01.007</a>.
  ieee: J. T. Huff and D. Zilberman, “Regulation of biological accuracy, precision,
    and memory by plant chromatin organization,” <i>Current Opinion in Genetics and
    Development</i>, vol. 22, no. 2. Elsevier, pp. 132–138, 2012.
  ista: Huff JT, Zilberman D. 2012. Regulation of biological accuracy, precision,
    and memory by plant chromatin organization. Current Opinion in Genetics and Development.
    22(2), 132–138.
  mla: Huff, Jason T., and Daniel Zilberman. “Regulation of Biological Accuracy, Precision,
    and Memory by Plant Chromatin Organization.” <i>Current Opinion in Genetics and
    Development</i>, vol. 22, no. 2, Elsevier, 2012, pp. 132–38, doi:<a href="https://doi.org/10.1016/j.gde.2012.01.007">10.1016/j.gde.2012.01.007</a>.
  short: J.T. Huff, D. Zilberman, Current Opinion in Genetics and Development 22 (2012)
    132–138.
date_created: 2021-06-08T08:58:52Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2021-12-14T08:32:38Z
department:
- _id: DaZi
doi: 10.1016/j.gde.2012.01.007
extern: '1'
external_id:
  pmid:
  - '22336527'
intvolume: '        22'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 132-138
pmid: 1
publication: Current Opinion in Genetics and Development
publication_identifier:
  issn:
  - 0959-437X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regulation of biological accuracy, precision, and memory by plant chromatin
  organization
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 22
year: '2012'
...
---
_id: '9529'
abstract:
- lang: eng
  text: Eukaryotic organisms have the remarkable ability to inherit states of gene
    activity without altering the underlying DNA sequence. This epigenetic inheritance
    can persist over thousands of years, providing an alternative to genetic mutations
    as a substrate for natural selection. Epigenetic inheritance might be propagated
    by differences in DNA methylation, post-translational histone modifications, and
    deposition of histone variants. Mounting evidence also indicates that small interfering
    RNA (siRNA)-mediated mechanisms play central roles in setting up and maintaining
    states of gene activity. Much of the epigenetic machinery of many organisms, including
    Arabidopsis, appears to be directed at silencing viruses and transposable elements,
    with epigenetic regulation of endogenous genes being mostly derived from such
    processes.
article_processing_charge: No
article_type: review
author:
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: Steven
  full_name: Henikoff, Steven
  last_name: Henikoff
citation:
  ama: 'Zilberman D, Henikoff S. Epigenetic inheritance in Arabidopsis: Selective
    silence. <i>Current Opinion in Genetics and Development</i>. 2005;15(5):557-562.
    doi:<a href="https://doi.org/10.1016/j.gde.2005.07.002">10.1016/j.gde.2005.07.002</a>'
  apa: 'Zilberman, D., &#38; Henikoff, S. (2005). Epigenetic inheritance in Arabidopsis:
    Selective silence. <i>Current Opinion in Genetics and Development</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.gde.2005.07.002">https://doi.org/10.1016/j.gde.2005.07.002</a>'
  chicago: 'Zilberman, Daniel, and Steven Henikoff. “Epigenetic Inheritance in Arabidopsis:
    Selective Silence.” <i>Current Opinion in Genetics and Development</i>. Elsevier,
    2005. <a href="https://doi.org/10.1016/j.gde.2005.07.002">https://doi.org/10.1016/j.gde.2005.07.002</a>.'
  ieee: 'D. Zilberman and S. Henikoff, “Epigenetic inheritance in Arabidopsis: Selective
    silence,” <i>Current Opinion in Genetics and Development</i>, vol. 15, no. 5.
    Elsevier, pp. 557–562, 2005.'
  ista: 'Zilberman D, Henikoff S. 2005. Epigenetic inheritance in Arabidopsis: Selective
    silence. Current Opinion in Genetics and Development. 15(5), 557–562.'
  mla: 'Zilberman, Daniel, and Steven Henikoff. “Epigenetic Inheritance in Arabidopsis:
    Selective Silence.” <i>Current Opinion in Genetics and Development</i>, vol. 15,
    no. 5, Elsevier, 2005, pp. 557–62, doi:<a href="https://doi.org/10.1016/j.gde.2005.07.002">10.1016/j.gde.2005.07.002</a>.'
  short: D. Zilberman, S. Henikoff, Current Opinion in Genetics and Development 15
    (2005) 557–562.
date_created: 2021-06-08T09:05:56Z
date_published: 2005-10-01T00:00:00Z
date_updated: 2021-12-14T09:13:13Z
department:
- _id: DaZi
doi: 10.1016/j.gde.2005.07.002
extern: '1'
external_id:
  pmid:
  - '16085410'
intvolume: '        15'
issue: '5'
language:
- iso: eng
month: '10'
oa_version: None
page: 557-562
pmid: 1
publication: Current Opinion in Genetics and Development
publication_identifier:
  issn:
  - 0959-437X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Epigenetic inheritance in Arabidopsis: Selective silence'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 15
year: '2005'
...