---
_id: '1026'
abstract:
- lang: eng
  text: The optogenetic revolution enabled spatially-precise and temporally-precise
    control over protein function, signaling pathway activation, and animal behavior
    with tremendous success in the dissection of signaling networks and neural circuits.
    Very recently, optogenetic methods have been paired with optical reporters in
    novel drug screening platforms. In these all-optical platforms, light remotely
    activated ion channels and kinases thereby obviating the use of electrophysiology
    or reagents. Consequences were remarkable operational simplicity, throughput,
    and cost-effectiveness that culminated in the identification of new drug candidates.
    These blueprints for all-optical assays also revealed potential pitfalls and inspire
    all-optical variants of other screens, such as those that aim at better understanding
    dynamic drug action or orphan protein function.
acknowledgement: This work was supported by grants of the European Union Seventh Framework
  Programme (CIG-303564), the Human Frontier Science Program (RGY0084_2012), and the
  Austrian Science Fund FWF (W1232 MolecularDrugTargets).
article_processing_charge: No
article_type: original
author:
- first_name: Viviana
  full_name: Agus, Viviana
  last_name: Agus
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
citation:
  ama: 'Agus V, Janovjak HL. Optogenetic methods in drug screening: Technologies and
    applications. <i>Current Opinion in Biotechnology</i>. 2017;48:8-14. doi:<a href="https://doi.org/10.1016/j.copbio.2017.02.006">10.1016/j.copbio.2017.02.006</a>'
  apa: 'Agus, V., &#38; Janovjak, H. L. (2017). Optogenetic methods in drug screening:
    Technologies and applications. <i>Current Opinion in Biotechnology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.copbio.2017.02.006">https://doi.org/10.1016/j.copbio.2017.02.006</a>'
  chicago: 'Agus, Viviana, and Harald L Janovjak. “Optogenetic Methods in Drug Screening:
    Technologies and Applications.” <i>Current Opinion in Biotechnology</i>. Elsevier,
    2017. <a href="https://doi.org/10.1016/j.copbio.2017.02.006">https://doi.org/10.1016/j.copbio.2017.02.006</a>.'
  ieee: 'V. Agus and H. L. Janovjak, “Optogenetic methods in drug screening: Technologies
    and applications,” <i>Current Opinion in Biotechnology</i>, vol. 48. Elsevier,
    pp. 8–14, 2017.'
  ista: 'Agus V, Janovjak HL. 2017. Optogenetic methods in drug screening: Technologies
    and applications. Current Opinion in Biotechnology. 48, 8–14.'
  mla: 'Agus, Viviana, and Harald L. Janovjak. “Optogenetic Methods in Drug Screening:
    Technologies and Applications.” <i>Current Opinion in Biotechnology</i>, vol.
    48, Elsevier, 2017, pp. 8–14, doi:<a href="https://doi.org/10.1016/j.copbio.2017.02.006">10.1016/j.copbio.2017.02.006</a>.'
  short: V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.
date_created: 2018-12-11T11:49:45Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-09-22T09:26:06Z
day: '01'
department:
- _id: HaJa
doi: 10.1016/j.copbio.2017.02.006
ec_funded: 1
external_id:
  isi:
  - '000418313200003'
intvolume: '        48'
isi: 1
language:
- iso: eng
month: '12'
oa_version: None
page: 8 - 14
project:
- _id: 255BFFFA-B435-11E9-9278-68D0E5697425
  grant_number: RGY0084/2012
  name: In situ real-time imaging of neurotransmitter signaling using designer optical
    sensors (HFSP Young Investigator)
- _id: 25548C20-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '303564'
  name: Microbial Ion Channels for Synthetic Neurobiology
- _id: 255A6082-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1232-B24
  name: Molecular Drug Targets
publication: Current Opinion in Biotechnology
publication_identifier:
  issn:
  - '09581669'
publication_status: published
publisher: Elsevier
publist_id: '6365'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Optogenetic methods in drug screening: Technologies and applications'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 48
year: '2017'
...