---
_id: '11333'
abstract:
- lang: eng
  text: Adenosine triphosphate (ATP) is the energy source for various biochemical
    processes and biomolecular motors in living things. Development of ATP antagonists
    and their stimuli-controlled actions offer a novel approach to regulate biological
    processes. Herein, we developed azobenzene-based photoswitchable ATP antagonists
    for controlling the activity of motor proteins; cytoplasmic and axonemal dyneins.
    The new ATP antagonists showed reversible photoswitching of cytoplasmic dynein
    activity in an in vitro dynein-microtubule system due to the trans and cis photoisomerization
    of their azobenzene segment. Importantly, our ATP antagonists reversibly regulated
    the axonemal dynein motor activity for the force generation in a demembranated
    model of Chlamydomonas reinhardtii. We found that the trans and cis isomers of
    ATP antagonists significantly differ in their affinity to the ATP binding site.
article_number: e202200807
article_processing_charge: No
article_type: original
author:
- first_name: Sampreeth
  full_name: Thayyil, Sampreeth
  last_name: Thayyil
- first_name: Yukinori
  full_name: Nishigami, Yukinori
  last_name: Nishigami
- first_name: Muhammad J
  full_name: Islam, Muhammad J
  id: C94881D2-008F-11EA-8E08-2637E6697425
  last_name: Islam
- first_name: P. K.
  full_name: Hashim, P. K.
  last_name: Hashim
- first_name: Ken'Ya
  full_name: Furuta, Ken'Ya
  last_name: Furuta
- first_name: Kazuhiro
  full_name: Oiwa, Kazuhiro
  last_name: Oiwa
- first_name: Jian
  full_name: Yu, Jian
  last_name: Yu
- first_name: Min
  full_name: Yao, Min
  last_name: Yao
- first_name: Toshiyuki
  full_name: Nakagaki, Toshiyuki
  last_name: Nakagaki
- first_name: Nobuyuki
  full_name: Tamaoki, Nobuyuki
  last_name: Tamaoki
citation:
  ama: Thayyil S, Nishigami Y, Islam MJ, et al. Dynamic control of microbial movement
    by photoswitchable ATP antagonists. <i>Chemistry - A European Journal</i>. 2022;28(30).
    doi:<a href="https://doi.org/10.1002/chem.202200807">10.1002/chem.202200807</a>
  apa: Thayyil, S., Nishigami, Y., Islam, M. J., Hashim, P. K., Furuta, K., Oiwa,
    K., … Tamaoki, N. (2022). Dynamic control of microbial movement by photoswitchable
    ATP antagonists. <i>Chemistry - A European Journal</i>. Wiley. <a href="https://doi.org/10.1002/chem.202200807">https://doi.org/10.1002/chem.202200807</a>
  chicago: Thayyil, Sampreeth, Yukinori Nishigami, Muhammad J Islam, P. K. Hashim,
    Ken’Ya Furuta, Kazuhiro Oiwa, Jian Yu, Min Yao, Toshiyuki Nakagaki, and Nobuyuki
    Tamaoki. “Dynamic Control of Microbial Movement by Photoswitchable ATP Antagonists.”
    <i>Chemistry - A European Journal</i>. Wiley, 2022. <a href="https://doi.org/10.1002/chem.202200807">https://doi.org/10.1002/chem.202200807</a>.
  ieee: S. Thayyil <i>et al.</i>, “Dynamic control of microbial movement by photoswitchable
    ATP antagonists,” <i>Chemistry - A European Journal</i>, vol. 28, no. 30. Wiley,
    2022.
  ista: Thayyil S, Nishigami Y, Islam MJ, Hashim PK, Furuta K, Oiwa K, Yu J, Yao M,
    Nakagaki T, Tamaoki N. 2022. Dynamic control of microbial movement by photoswitchable
    ATP antagonists. Chemistry - A European Journal. 28(30), e202200807.
  mla: Thayyil, Sampreeth, et al. “Dynamic Control of Microbial Movement by Photoswitchable
    ATP Antagonists.” <i>Chemistry - A European Journal</i>, vol. 28, no. 30, e202200807,
    Wiley, 2022, doi:<a href="https://doi.org/10.1002/chem.202200807">10.1002/chem.202200807</a>.
  short: S. Thayyil, Y. Nishigami, M.J. Islam, P.K. Hashim, K. Furuta, K. Oiwa, J.
    Yu, M. Yao, T. Nakagaki, N. Tamaoki, Chemistry - A European Journal 28 (2022).
date_created: 2022-04-24T22:01:44Z
date_published: 2022-05-25T00:00:00Z
date_updated: 2023-10-03T10:58:31Z
day: '25'
department:
- _id: RySh
doi: 10.1002/chem.202200807
external_id:
  isi:
  - '000781658800001'
  pmid:
  - '35332959'
intvolume: '        28'
isi: 1
issue: '30'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/chem.202200807
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Chemistry - A European Journal
publication_identifier:
  eissn:
  - '15213765'
  issn:
  - '09476539'
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic control of microbial movement by photoswitchable ATP antagonists
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2022'
...