---
_id: '4185'
abstract:
- lang: eng
  text: Wnt genes play important roles in regulating patterning and morphogenesis
    during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence
    and extension movements, but not cell fate specification during gastrulation.
    To determine if other Wnt genes functionally interact with slb/wnt11, we analysed
    the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided
    and zygotically expressed at all stages during gastrulation. The analysis of ppt
    mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent
    extension movements in posterior regions of the gastrula, while its function in
    more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions
    downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5
    in this process. The characterisation of the role of Ppt/Wnt5 provides insight
    into the functional diversity of Wnt genes in regulating vertebrate gastrulation
    movements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
acknowledgement: We thank Michael Brand, Florian Raible, Gerlinde Reim, Tobias Langenberg,
  Jennifer Geiger and Kate Poole for helpful comments on earlier versions of this
  manuscript. We are grateful to Henry Roehl and Christiane Nüsslein Volhard for sending
  us the ppt mutant stock. M.T. was supported by a Career Development Fellowship from
  the MRC. B.K., H.M. and C.P.H. are supported by an Emmy Noether-Fellowship from
  the DFG.
article_processing_charge: No
article_type: original
author:
- first_name: Beate
  full_name: Kilian, Beate
  last_name: Kilian
- first_name: Hannu
  full_name: Mansukoski, Hannu
  last_name: Mansukoski
- first_name: Filipa
  full_name: Barbosa, Filipa
  last_name: Barbosa
- first_name: Florian
  full_name: Ulrich, Florian
  last_name: Ulrich
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C-PJ. The role
    of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation.
    <i>Mechanisms of Development</i>. 2003;120(4):467-476. doi:<a href="https://doi.org/10.1016/S0925-4773(03)00004-2">10.1016/S0925-4773(03)00004-2</a>
  apa: Kilian, B., Mansukoski, H., Barbosa, F., Ulrich, F., Tada, M., &#38; Heisenberg,
    C.-P. J. (2003). The role of Ppt/Wnt5 in regulating cell shape and movement during
    zebrafish gastrulation. <i>Mechanisms of Development</i>. Elsevier. <a href="https://doi.org/10.1016/S0925-4773(03)00004-2">https://doi.org/10.1016/S0925-4773(03)00004-2</a>
  chicago: Kilian, Beate, Hannu Mansukoski, Filipa Barbosa, Florian Ulrich, Masazumi
    Tada, and Carl-Philipp J Heisenberg. “The Role of Ppt/Wnt5 in Regulating Cell
    Shape and Movement during Zebrafish Gastrulation.” <i>Mechanisms of Development</i>.
    Elsevier, 2003. <a href="https://doi.org/10.1016/S0925-4773(03)00004-2">https://doi.org/10.1016/S0925-4773(03)00004-2</a>.
  ieee: B. Kilian, H. Mansukoski, F. Barbosa, F. Ulrich, M. Tada, and C.-P. J. Heisenberg,
    “The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation,”
    <i>Mechanisms of Development</i>, vol. 120, no. 4. Elsevier, pp. 467–476, 2003.
  ista: Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C-PJ. 2003.
    The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation.
    Mechanisms of Development. 120(4), 467–476.
  mla: Kilian, Beate, et al. “The Role of Ppt/Wnt5 in Regulating Cell Shape and Movement
    during Zebrafish Gastrulation.” <i>Mechanisms of Development</i>, vol. 120, no.
    4, Elsevier, 2003, pp. 467–76, doi:<a href="https://doi.org/10.1016/S0925-4773(03)00004-2">10.1016/S0925-4773(03)00004-2</a>.
  short: B. Kilian, H. Mansukoski, F. Barbosa, F. Ulrich, M. Tada, C.-P.J. Heisenberg,
    Mechanisms of Development 120 (2003) 467–476.
date_created: 2018-12-11T12:07:27Z
date_published: 2003-04-01T00:00:00Z
date_updated: 2024-02-27T09:46:39Z
day: '01'
doi: 10.1016/S0925-4773(03)00004-2
extern: '1'
external_id:
  pmid:
  - '12676324 '
intvolume: '       120'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 467 - 476
pmid: 1
publication: Mechanisms of Development
publication_identifier:
  issn:
  - 0925-4773
publication_status: published
publisher: Elsevier
publist_id: '1934'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish
  gastrulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 120
year: '2003'
...