---
_id: '12235'
abstract:
- lang: eng
  text: "Background: About 800 women die every day worldwide from pregnancy-related
    complications, including excessive blood loss, infections and high-blood pressure
    (World Health Organization, 2019). To improve screening for high-risk pregnancies,
    we set out to identify patterns of maternal hematological changes associated with
    future pregnancy complications.\r\n\r\nMethods: Using mixed effects models, we
    established changes in 14 complete blood count (CBC) parameters for 1710 healthy
    pregnancies and compared them to measurements from 98 pregnancy-induced hypertension,
    106 gestational diabetes and 339 postpartum hemorrhage cases.\r\n\r\nResults:
    Results show interindividual variations, but good individual repeatability in
    CBC values during physiological pregnancies, allowing the identification of specific
    alterations in women with obstetric complications. For example, in women with
    uncomplicated pregnancies, haemoglobin count decreases of 0.12 g/L (95% CI −0.16,
    −0.09) significantly per gestation week (p value <.001). Interestingly, this decrease
    is three times more pronounced in women who will develop pregnancy-induced hypertension,
    with an additional decrease of 0.39 g/L (95% CI −0.51, −0.26). We also confirm
    that obstetric complications and white CBC predict the likelihood of giving birth
    earlier during pregnancy.\r\n\r\nConclusion: We provide a comprehensive description
    of the associations between haematological changes through pregnancy and three
    major obstetric complications to support strategies for prevention, early-diagnosis
    and maternal care."
acknowledgement: This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181),
  and by core funding from the Institute of Science and Technology Austria. We would
  like to thank the participants of the study and all the midwives and doctors involved
  for the computerized obstetrical data from the CHUV Maternity Hospital. Open access
  funding provided by Universite de Lausanne.
article_processing_charge: No
article_type: original
author:
- first_name: Marion
  full_name: Patxot, Marion
  last_name: Patxot
- first_name: Miloš
  full_name: Stojanov, Miloš
  last_name: Stojanov
- first_name: Sven Erik
  full_name: Ojavee, Sven Erik
  last_name: Ojavee
- first_name: Rosanna Pescini
  full_name: Gobert, Rosanna Pescini
  last_name: Gobert
- first_name: Zoltán
  full_name: Kutalik, Zoltán
  last_name: Kutalik
- first_name: Mathilde
  full_name: Gavillet, Mathilde
  last_name: Gavillet
- first_name: David
  full_name: Baud, David
  last_name: Baud
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
citation:
  ama: 'Patxot M, Stojanov M, Ojavee SE, et al. Haematological changes from conception
    to childbirth: An indicator of major pregnancy complications. <i>European Journal
    of Haematology</i>. 2022;109(5):566-575. doi:<a href="https://doi.org/10.1111/ejh.13844">10.1111/ejh.13844</a>'
  apa: 'Patxot, M., Stojanov, M., Ojavee, S. E., Gobert, R. P., Kutalik, Z., Gavillet,
    M., … Robinson, M. R. (2022). Haematological changes from conception to childbirth:
    An indicator of major pregnancy complications. <i>European Journal of Haematology</i>.
    Wiley. <a href="https://doi.org/10.1111/ejh.13844">https://doi.org/10.1111/ejh.13844</a>'
  chicago: 'Patxot, Marion, Miloš Stojanov, Sven Erik Ojavee, Rosanna Pescini Gobert,
    Zoltán Kutalik, Mathilde Gavillet, David Baud, and Matthew Richard Robinson. “Haematological
    Changes from Conception to Childbirth: An Indicator of Major Pregnancy Complications.”
    <i>European Journal of Haematology</i>. Wiley, 2022. <a href="https://doi.org/10.1111/ejh.13844">https://doi.org/10.1111/ejh.13844</a>.'
  ieee: 'M. Patxot <i>et al.</i>, “Haematological changes from conception to childbirth:
    An indicator of major pregnancy complications,” <i>European Journal of Haematology</i>,
    vol. 109, no. 5. Wiley, pp. 566–575, 2022.'
  ista: 'Patxot M, Stojanov M, Ojavee SE, Gobert RP, Kutalik Z, Gavillet M, Baud D,
    Robinson MR. 2022. Haematological changes from conception to childbirth: An indicator
    of major pregnancy complications. European Journal of Haematology. 109(5), 566–575.'
  mla: 'Patxot, Marion, et al. “Haematological Changes from Conception to Childbirth:
    An Indicator of Major Pregnancy Complications.” <i>European Journal of Haematology</i>,
    vol. 109, no. 5, Wiley, 2022, pp. 566–75, doi:<a href="https://doi.org/10.1111/ejh.13844">10.1111/ejh.13844</a>.'
  short: M. Patxot, M. Stojanov, S.E. Ojavee, R.P. Gobert, Z. Kutalik, M. Gavillet,
    D. Baud, M.R. Robinson, European Journal of Haematology 109 (2022) 566–575.
date_created: 2023-01-16T09:50:58Z
date_published: 2022-11-01T00:00:00Z
date_updated: 2023-08-04T09:36:21Z
day: '01'
ddc:
- '570'
- '610'
department:
- _id: MaRo
doi: 10.1111/ejh.13844
external_id:
  isi:
  - '000849690500001'
  pmid:
  - '36059200'
file:
- access_level: open_access
  checksum: a676d732f67c2990197e34f96b219370
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-27T11:42:43Z
  date_updated: 2023-01-27T11:42:43Z
  file_id: '12426'
  file_name: 2022_EuropJourHaematology_Patxot.pdf
  file_size: 1225073
  relation: main_file
  success: 1
file_date_updated: 2023-01-27T11:42:43Z
has_accepted_license: '1'
intvolume: '       109'
isi: 1
issue: '5'
keyword:
- Hematology
- General Medicine
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: 566-575
pmid: 1
publication: European Journal of Haematology
publication_identifier:
  eissn:
  - 1600-0609
  issn:
  - 0902-4441
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Haematological changes from conception to childbirth: An indicator of major
  pregnancy complications'
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 109
year: '2022'
...