---
_id: '8674'
abstract:
- lang: eng
  text: 'Extrasynaptic actions of glutamate are limited by high-affinity transporters
    expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point
    transmission in excitatory circuits. Memory formation in the brain is associated
    with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic
    glutamate actions is poorly understood. Here, we used advanced imaging methods,
    in situ and in vivo, to find that a classical synaptic memory mechanism, long-term
    potentiation (LTP), triggers withdrawal of PAPs from potentiated synapses. Optical
    glutamate sensors combined with patch-clamp and 3D molecular localization reveal
    that LTP induction thus prompts spatial retreat of astroglial glutamate transporters,
    boosting glutamate spillover and NMDA-receptor-mediated inter-synaptic cross-talk.
    The LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling
    protein cofilin but does not depend on major Ca2+-dependent cascades in astrocytes.
    We have therefore uncovered a mechanism by which a memory trace at one synapse
    could alter signal handling by multiple neighboring connections.'
acknowledgement: We thank J. Angibaud for organotypic cultures and R. Chereau and
  J. Tonnesen for help with the STED microscope; also D. Gonzales and the Neurocentre
  Magendie INSERM U1215 Genotyping Platform, for breeding management and genotyping.
  This work was supported by the Wellcome Trust Principal Fellowships 101896 and 212251,
  ERC Advanced Grant 323113, ERC Proof-of-Concept Grant 767372, EC FP7 ITN 606950,
  and EU CSA 811011 (D.A.R.); NRW-Rückkehrerpogramm, UCL Excellence Fellowship, German
  Research Foundation (DFG) SPP1757 and SFB1089 (C.H.); Human Frontiers Science Program
  (C.H., C.J.J., and H.J.); EMBO Long-Term Fellowship (L.B.); Marie Curie FP7 PIRG08-GA-2010-276995
  (A.P.), ASTROMODULATION (S.R.); Equipe FRM DEQ 201 303 26519, Conseil Régional d’Aquitaine
  R12056GG, INSERM (S.H.R.O.); ANR SUPERTri, ANR Castro (ANR-17-CE16-0002), R-13-BSV4-0007-01,
  Université de Bordeaux, labex BRAIN (S.H.R.O. and U.V.N.); CNRS (A.P., S.H.R.O.,
  and U.V.N.); HFSP, ANR CEXC, and France-BioImaging ANR-10-INSB-04 (U.V.N.); and
  FP7 MemStick Project No. 201600 (M.G.S.).
article_processing_charge: No
article_type: original
author:
- first_name: Christian
  full_name: Henneberger, Christian
  last_name: Henneberger
- first_name: Lucie
  full_name: Bard, Lucie
  last_name: Bard
- first_name: Aude
  full_name: Panatier, Aude
  last_name: Panatier
- first_name: James P.
  full_name: Reynolds, James P.
  last_name: Reynolds
- first_name: Olga
  full_name: Kopach, Olga
  last_name: Kopach
- first_name: Nikolay I.
  full_name: Medvedev, Nikolay I.
  last_name: Medvedev
- first_name: Daniel
  full_name: Minge, Daniel
  last_name: Minge
- first_name: Michel K.
  full_name: Herde, Michel K.
  last_name: Herde
- first_name: Stefanie
  full_name: Anders, Stefanie
  last_name: Anders
- first_name: Igor
  full_name: Kraev, Igor
  last_name: Kraev
- first_name: Janosch P.
  full_name: Heller, Janosch P.
  last_name: Heller
- first_name: Sylvain
  full_name: Rama, Sylvain
  last_name: Rama
- first_name: Kaiyu
  full_name: Zheng, Kaiyu
  last_name: Zheng
- first_name: Thomas P.
  full_name: Jensen, Thomas P.
  last_name: Jensen
- first_name: Inmaculada
  full_name: Sanchez-Romero, Inmaculada
  id: 3D9C5D30-F248-11E8-B48F-1D18A9856A87
  last_name: Sanchez-Romero
- first_name: Colin J.
  full_name: Jackson, Colin J.
  last_name: Jackson
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Ole Petter
  full_name: Ottersen, Ole Petter
  last_name: Ottersen
- first_name: Erlend Arnulf
  full_name: Nagelhus, Erlend Arnulf
  last_name: Nagelhus
- first_name: Stephane H.R.
  full_name: Oliet, Stephane H.R.
  last_name: Oliet
- first_name: Michael G.
  full_name: Stewart, Michael G.
  last_name: Stewart
- first_name: U. VAlentin
  full_name: Nägerl, U. VAlentin
  last_name: Nägerl
- first_name: 'Dmitri A. '
  full_name: 'Rusakov, Dmitri A. '
  last_name: Rusakov
citation:
  ama: Henneberger C, Bard L, Panatier A, et al. LTP induction boosts glutamate spillover
    by driving withdrawal of perisynaptic astroglia. <i>Neuron</i>. 2020;108(5):P919-936.E11.
    doi:<a href="https://doi.org/10.1016/j.neuron.2020.08.030">10.1016/j.neuron.2020.08.030</a>
  apa: Henneberger, C., Bard, L., Panatier, A., Reynolds, J. P., Kopach, O., Medvedev,
    N. I., … Rusakov, D. A. (2020). LTP induction boosts glutamate spillover by driving
    withdrawal of perisynaptic astroglia. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2020.08.030">https://doi.org/10.1016/j.neuron.2020.08.030</a>
  chicago: Henneberger, Christian, Lucie Bard, Aude Panatier, James P. Reynolds, Olga
    Kopach, Nikolay I. Medvedev, Daniel Minge, et al. “LTP Induction Boosts Glutamate
    Spillover by Driving Withdrawal of Perisynaptic Astroglia.” <i>Neuron</i>. Elsevier,
    2020. <a href="https://doi.org/10.1016/j.neuron.2020.08.030">https://doi.org/10.1016/j.neuron.2020.08.030</a>.
  ieee: C. Henneberger <i>et al.</i>, “LTP induction boosts glutamate spillover by
    driving withdrawal of perisynaptic astroglia,” <i>Neuron</i>, vol. 108, no. 5.
    Elsevier, p. P919–936.E11, 2020.
  ista: Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge
    D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero
    I, Jackson CJ, Janovjak HL, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl
    UVa, Rusakov DA. 2020. LTP induction boosts glutamate spillover by driving withdrawal
    of perisynaptic astroglia. Neuron. 108(5), P919–936.E11.
  mla: Henneberger, Christian, et al. “LTP Induction Boosts Glutamate Spillover by
    Driving Withdrawal of Perisynaptic Astroglia.” <i>Neuron</i>, vol. 108, no. 5,
    Elsevier, 2020, p. P919–936.E11, doi:<a href="https://doi.org/10.1016/j.neuron.2020.08.030">10.1016/j.neuron.2020.08.030</a>.
  short: C. Henneberger, L. Bard, A. Panatier, J.P. Reynolds, O. Kopach, N.I. Medvedev,
    D. Minge, M.K. Herde, S. Anders, I. Kraev, J.P. Heller, S. Rama, K. Zheng, T.P.
    Jensen, I. Sanchez-Romero, C.J. Jackson, H.L. Janovjak, O.P. Ottersen, E.A. Nagelhus,
    S.H.R. Oliet, M.G. Stewart, U.Va. Nägerl, D.A. Rusakov, Neuron 108 (2020) P919–936.E11.
date_created: 2020-10-18T22:01:38Z
date_published: 2020-12-09T00:00:00Z
date_updated: 2023-08-22T09:59:29Z
day: '09'
ddc:
- '570'
department:
- _id: HaJa
doi: 10.1016/j.neuron.2020.08.030
external_id:
  isi:
  - '000603428000010'
  pmid:
  - '32976770'
file:
- access_level: open_access
  checksum: 054562bb50165ef9a1f46631c1c5e36b
  content_type: application/pdf
  creator: dernst
  date_created: 2020-12-10T14:42:09Z
  date_updated: 2020-12-10T14:42:09Z
  file_id: '8939'
  file_name: 2020_Neuron_Henneberger.pdf
  file_size: 7518960
  relation: main_file
  success: 1
file_date_updated: 2020-12-10T14:42:09Z
has_accepted_license: '1'
intvolume: '       108'
isi: 1
issue: '5'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: P919-936.E11
pmid: 1
publication: Neuron
publication_identifier:
  eissn:
  - '10974199'
  issn:
  - '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic
  astroglia
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 108
year: '2020'
...
---
_id: '7684'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
  full_name: Gridchyn, Igor
  id: 4B60654C-F248-11E8-B48F-1D18A9856A87
  last_name: Gridchyn
  orcid: 0000-0002-1807-1929
- first_name: Philipp
  full_name: Schönenberger, Philipp
  id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
  last_name: Schönenberger
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption
    of hippocampal replay leads to selective memory deficit. <i>Neuron</i>. 2020;106(2):291-300.e6.
    doi:<a href="https://doi.org/10.1016/j.neuron.2020.01.021">10.1016/j.neuron.2020.01.021</a>
  apa: Gridchyn, I., Schönenberger, P., O’Neill, J., &#38; Csicsvari, J. L. (2020).
    Assembly-specific disruption of hippocampal replay leads to selective memory deficit.
    <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2020.01.021">https://doi.org/10.1016/j.neuron.2020.01.021</a>
  chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
    “Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory
    Deficit.” <i>Neuron</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.neuron.2020.01.021">https://doi.org/10.1016/j.neuron.2020.01.021</a>.
  ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific
    disruption of hippocampal replay leads to selective memory deficit,” <i>Neuron</i>,
    vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020.
  ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific
    disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2),
    291–300.e6.
  mla: Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay
    Leads to Selective Memory Deficit.” <i>Neuron</i>, vol. 106, no. 2, Elsevier,
    2020, p. 291–300.e6, doi:<a href="https://doi.org/10.1016/j.neuron.2020.01.021">10.1016/j.neuron.2020.01.021</a>.
  short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020)
    291–300.e6.
date_created: 2020-04-26T22:00:45Z
date_published: 2020-04-22T00:00:00Z
date_updated: 2023-08-21T06:15:31Z
day: '22'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.021
ec_funded: 1
external_id:
  isi:
  - '000528268200013'
  pmid:
  - '32070475'
intvolume: '       106'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2020.01.021
month: '04'
oa: 1
oa_version: Published Version
page: 291-300.e6
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281511'
  name: Memory-related information processing in neuronal circuits of the hippocampus
    and entorhinal cortex
publication: Neuron
publication_identifier:
  eissn:
  - '10974199'
  issn:
  - '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/librarian-of-memory/
scopus_import: '1'
status: public
title: Assembly-specific disruption of hippocampal replay leads to selective memory
  deficit
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '6830'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ximena
  full_name: Contreras, Ximena
  id: 475990FE-F248-11E8-B48F-1D18A9856A87
  last_name: Contreras
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Contreras X, Hippenmeyer S. Memo1 tiles the radial glial cell grid. <i>Neuron</i>.
    2019;103(5):750-752. doi:<a href="https://doi.org/10.1016/j.neuron.2019.08.021">10.1016/j.neuron.2019.08.021</a>
  apa: Contreras, X., &#38; Hippenmeyer, S. (2019). Memo1 tiles the radial glial cell
    grid. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2019.08.021">https://doi.org/10.1016/j.neuron.2019.08.021</a>
  chicago: Contreras, Ximena, and Simon Hippenmeyer. “Memo1 Tiles the Radial Glial
    Cell Grid.” <i>Neuron</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.neuron.2019.08.021">https://doi.org/10.1016/j.neuron.2019.08.021</a>.
  ieee: X. Contreras and S. Hippenmeyer, “Memo1 tiles the radial glial cell grid,”
    <i>Neuron</i>, vol. 103, no. 5. Elsevier, pp. 750–752, 2019.
  ista: Contreras X, Hippenmeyer S. 2019. Memo1 tiles the radial glial cell grid.
    Neuron. 103(5), 750–752.
  mla: Contreras, Ximena, and Simon Hippenmeyer. “Memo1 Tiles the Radial Glial Cell
    Grid.” <i>Neuron</i>, vol. 103, no. 5, Elsevier, 2019, pp. 750–52, doi:<a href="https://doi.org/10.1016/j.neuron.2019.08.021">10.1016/j.neuron.2019.08.021</a>.
  short: X. Contreras, S. Hippenmeyer, Neuron 103 (2019) 750–752.
date_created: 2019-08-25T22:00:50Z
date_published: 2019-09-04T00:00:00Z
date_updated: 2024-03-25T23:30:23Z
day: '04'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2019.08.021
external_id:
  isi:
  - '000484400200002'
  pmid:
  - '31487522'
intvolume: '       103'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2019.08.021
month: '09'
oa: 1
oa_version: Published Version
page: 750-752
pmid: 1
publication: Neuron
publication_identifier:
  eissn:
  - '10974199'
  issn:
  - '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '7902'
    relation: part_of_dissertation
    status: public
scopus_import: '1'
status: public
title: Memo1 tiles the radial glial cell grid
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 103
year: '2019'
...
---
_id: '944'
abstract:
- lang: eng
  text: The concerted production of neurons and glia by neural stem cells (NSCs) is
    essential for neural circuit assembly. In the developing cerebral cortex, radial
    glia progenitors (RGPs) generate nearly all neocortical neurons and certain glia
    lineages. RGP proliferation behavior shows a high degree of non-stochasticity,
    thus a deterministic characteristic of neuron and glia production. However, the
    cellular and molecular mechanisms controlling RGP behavior and proliferation dynamics
    in neurogenesis and glia generation remain unknown. By using mosaic analysis with
    double markers (MADM)-based genetic paradigms enabling the sparse and global knockout
    with unprecedented single-cell resolution, we identified Lgl1 as a critical regulatory
    component. We uncover Lgl1-dependent tissue-wide community effects required for
    embryonic cortical neurogenesis and novel cell-autonomous Lgl1 functions controlling
    RGP-mediated glia genesis and postnatal NSC behavior. These results suggest that
    NSC-mediated neuron and glia production is tightly regulated through the concerted
    interplay of sequential Lgl1-dependent global and cell intrinsic mechanisms.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
article_processing_charge: No
author:
- first_name: Robert J
  full_name: Beattie, Robert J
  id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
  last_name: Beattie
  orcid: 0000-0002-8483-8753
- first_name: Maria P
  full_name: Postiglione, Maria P
  id: 2C67902A-F248-11E8-B48F-1D18A9856A87
  last_name: Postiglione
- first_name: Laura
  full_name: Burnett, Laura
  id: 3B717F68-F248-11E8-B48F-1D18A9856A87
  last_name: Burnett
  orcid: 0000-0002-8937-410X
- first_name: Susanne
  full_name: Laukoter, Susanne
  id: 2D6B7A9A-F248-11E8-B48F-1D18A9856A87
  last_name: Laukoter
  orcid: 0000-0002-7903-3010
- first_name: Carmen
  full_name: Streicher, Carmen
  id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
  last_name: Streicher
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Guanxi
  full_name: Xiao, Guanxi
  last_name: Xiao
- first_name: Olga
  full_name: Klezovitch, Olga
  last_name: Klezovitch
- first_name: Valeri
  full_name: Vasioukhin, Valeri
  last_name: Vasioukhin
- first_name: Troy
  full_name: Ghashghaei, Troy
  last_name: Ghashghaei
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Beattie RJ, Postiglione MP, Burnett L, et al. Mosaic analysis with double markers
    reveals distinct sequential functions of Lgl1 in neural stem cells. <i>Neuron</i>.
    2017;94(3):517-533.e3. doi:<a href="https://doi.org/10.1016/j.neuron.2017.04.012">10.1016/j.neuron.2017.04.012</a>
  apa: Beattie, R. J., Postiglione, M. P., Burnett, L., Laukoter, S., Streicher, C.,
    Pauler, F., … Hippenmeyer, S. (2017). Mosaic analysis with double markers reveals
    distinct sequential functions of Lgl1 in neural stem cells. <i>Neuron</i>. Cell
    Press. <a href="https://doi.org/10.1016/j.neuron.2017.04.012">https://doi.org/10.1016/j.neuron.2017.04.012</a>
  chicago: Beattie, Robert J, Maria P Postiglione, Laura Burnett, Susanne Laukoter,
    Carmen Streicher, Florian Pauler, Guanxi Xiao, et al. “Mosaic Analysis with Double
    Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells.” <i>Neuron</i>.
    Cell Press, 2017. <a href="https://doi.org/10.1016/j.neuron.2017.04.012">https://doi.org/10.1016/j.neuron.2017.04.012</a>.
  ieee: R. J. Beattie <i>et al.</i>, “Mosaic analysis with double markers reveals
    distinct sequential functions of Lgl1 in neural stem cells,” <i>Neuron</i>, vol.
    94, no. 3. Cell Press, p. 517–533.e3, 2017.
  ista: Beattie RJ, Postiglione MP, Burnett L, Laukoter S, Streicher C, Pauler F,
    Xiao G, Klezovitch O, Vasioukhin V, Ghashghaei T, Hippenmeyer S. 2017. Mosaic
    analysis with double markers reveals distinct sequential functions of Lgl1 in
    neural stem cells. Neuron. 94(3), 517–533.e3.
  mla: Beattie, Robert J., et al. “Mosaic Analysis with Double Markers Reveals Distinct
    Sequential Functions of Lgl1 in Neural Stem Cells.” <i>Neuron</i>, vol. 94, no.
    3, Cell Press, 2017, p. 517–533.e3, doi:<a href="https://doi.org/10.1016/j.neuron.2017.04.012">10.1016/j.neuron.2017.04.012</a>.
  short: R.J. Beattie, M.P. Postiglione, L. Burnett, S. Laukoter, C. Streicher, F.
    Pauler, G. Xiao, O. Klezovitch, V. Vasioukhin, T. Ghashghaei, S. Hippenmeyer,
    Neuron 94 (2017) 517–533.e3.
date_created: 2018-12-11T11:49:20Z
date_published: 2017-05-03T00:00:00Z
date_updated: 2023-09-26T15:37:02Z
day: '03'
department:
- _id: SiHi
- _id: MaJö
doi: 10.1016/j.neuron.2017.04.012
ec_funded: 1
external_id:
  isi:
  - '000400466700011'
intvolume: '        94'
isi: 1
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 517 - 533.e3
project:
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618444'
  name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
publication: Neuron
publication_identifier:
  issn:
  - '08966273'
publication_status: published
publisher: Cell Press
publist_id: '6473'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mosaic analysis with double markers reveals distinct sequential functions of
  Lgl1 in neural stem cells
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 94
year: '2017'
...
---
_id: '991'
abstract:
- lang: eng
  text: Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for
    lysosome fusion, but its function at fast synapses is controversial. The paper
    by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held
    in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains,
    resulting in reliable and temporally precise high-frequency transmission. Thus,
    a slow Ca2+ sensor contributes to the fast signaling properties of the calyx synapse.
article_processing_charge: No
author:
- first_name: Chong
  full_name: Chen, Chong
  id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Chen C, Jonas PM. Synaptotagmins: That’s why so many. <i>Neuron</i>. 2017;94(4):694-696.
    doi:<a href="https://doi.org/10.1016/j.neuron.2017.05.011">10.1016/j.neuron.2017.05.011</a>'
  apa: 'Chen, C., &#38; Jonas, P. M. (2017). Synaptotagmins: That’s why so many. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2017.05.011">https://doi.org/10.1016/j.neuron.2017.05.011</a>'
  chicago: 'Chen, Chong, and Peter M Jonas. “Synaptotagmins: That’s Why so Many.”
    <i>Neuron</i>. Elsevier, 2017. <a href="https://doi.org/10.1016/j.neuron.2017.05.011">https://doi.org/10.1016/j.neuron.2017.05.011</a>.'
  ieee: 'C. Chen and P. M. Jonas, “Synaptotagmins: That’s why so many,” <i>Neuron</i>,
    vol. 94, no. 4. Elsevier, pp. 694–696, 2017.'
  ista: 'Chen C, Jonas PM. 2017. Synaptotagmins: That’s why so many. Neuron. 94(4),
    694–696.'
  mla: 'Chen, Chong, and Peter M. Jonas. “Synaptotagmins: That’s Why so Many.” <i>Neuron</i>,
    vol. 94, no. 4, Elsevier, 2017, pp. 694–96, doi:<a href="https://doi.org/10.1016/j.neuron.2017.05.011">10.1016/j.neuron.2017.05.011</a>.'
  short: C. Chen, P.M. Jonas, Neuron 94 (2017) 694–696.
date_created: 2018-12-11T11:49:34Z
date_published: 2017-05-17T00:00:00Z
date_updated: 2023-09-22T09:54:37Z
day: '17'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2017.05.011
external_id:
  isi:
  - '000401415100002'
intvolume: '        94'
isi: 1
issue: '4'
language:
- iso: eng
month: '05'
oa_version: None
page: 694 - 696
publication: Neuron
publication_identifier:
  issn:
  - '08966273'
publication_status: published
publisher: Elsevier
publist_id: '6408'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Synaptotagmins: That’s why so many'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 94
year: '2017'
...
---
_id: '2241'
abstract:
- lang: eng
  text: 'The brain demands high-energy supply and obstruction of blood flow causes
    rapid deterioration of the healthiness of brain cells. Two major events occur
    upon ischemia: acidosis and liberation of excess glutamate, which leads to excitotoxicity.
    However, cellular source of glutamate and its release mechanism upon ischemia
    remained unknown. Here we show a causal relationship between glial acidosis and
    neuronal excitotoxicity. As the major cation that flows through channelrhodopsin-2
    (ChR2) is proton, this could be regarded as an optogenetic tool for instant intracellular
    acidification. Optical activation of ChR2 expressed in glial cells led to glial
    acidification and to release of glutamate. On the other hand, glial alkalization
    via optogenetic activation of a proton pump, archaerhodopsin (ArchT), led to cessation
    of glutamate release and to the relief of ischemic brain damage in vivo. Our results
    suggest that controlling glial pH may be an effective therapeutic strategy for
    intervention of ischemic brain damage.'
author:
- first_name: Kaoru
  full_name: Beppu, Kaoru
  last_name: Beppu
- first_name: Takuya
  full_name: Sasaki, Takuya
  last_name: Sasaki
- first_name: Kenji
  full_name: Tanaka, Kenji
  last_name: Tanaka
- first_name: Akihiro
  full_name: Yamanaka, Akihiro
  last_name: Yamanaka
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Ko
  full_name: Matsui, Ko
  last_name: Matsui
citation:
  ama: Beppu K, Sasaki T, Tanaka K, et al. Optogenetic countering of glial acidosis
    suppresses glial glutamate release and ischemic brain damage. <i>Neuron</i>. 2014;81(2):314-320.
    doi:<a href="https://doi.org/10.1016/j.neuron.2013.11.011">10.1016/j.neuron.2013.11.011</a>
  apa: Beppu, K., Sasaki, T., Tanaka, K., Yamanaka, A., Fukazawa, Y., Shigemoto, R.,
    &#38; Matsui, K. (2014). Optogenetic countering of glial acidosis suppresses glial
    glutamate release and ischemic brain damage. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2013.11.011">https://doi.org/10.1016/j.neuron.2013.11.011</a>
  chicago: Beppu, Kaoru, Takuya Sasaki, Kenji Tanaka, Akihiro Yamanaka, Yugo Fukazawa,
    Ryuichi Shigemoto, and Ko Matsui. “Optogenetic Countering of Glial Acidosis Suppresses
    Glial Glutamate Release and Ischemic Brain Damage.” <i>Neuron</i>. Elsevier, 2014.
    <a href="https://doi.org/10.1016/j.neuron.2013.11.011">https://doi.org/10.1016/j.neuron.2013.11.011</a>.
  ieee: K. Beppu <i>et al.</i>, “Optogenetic countering of glial acidosis suppresses
    glial glutamate release and ischemic brain damage,” <i>Neuron</i>, vol. 81, no.
    2. Elsevier, pp. 314–320, 2014.
  ista: Beppu K, Sasaki T, Tanaka K, Yamanaka A, Fukazawa Y, Shigemoto R, Matsui K.
    2014. Optogenetic countering of glial acidosis suppresses glial glutamate release
    and ischemic brain damage. Neuron. 81(2), 314–320.
  mla: Beppu, Kaoru, et al. “Optogenetic Countering of Glial Acidosis Suppresses Glial
    Glutamate Release and Ischemic Brain Damage.” <i>Neuron</i>, vol. 81, no. 2, Elsevier,
    2014, pp. 314–20, doi:<a href="https://doi.org/10.1016/j.neuron.2013.11.011">10.1016/j.neuron.2013.11.011</a>.
  short: K. Beppu, T. Sasaki, K. Tanaka, A. Yamanaka, Y. Fukazawa, R. Shigemoto, K.
    Matsui, Neuron 81 (2014) 314–320.
date_created: 2018-12-11T11:56:31Z
date_published: 2014-01-22T00:00:00Z
date_updated: 2021-01-12T06:56:14Z
day: '22'
department:
- _id: RySh
doi: 10.1016/j.neuron.2013.11.011
intvolume: '        81'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 314 - 320
publication: Neuron
publication_identifier:
  issn:
  - '08966273'
publication_status: published
publisher: Elsevier
publist_id: '4715'
quality_controlled: '1'
scopus_import: 1
status: public
title: Optogenetic countering of glial acidosis suppresses glial glutamate release
  and ischemic brain damage
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2014'
...
---
_id: '2254'
abstract:
- lang: eng
  text: Theta-gamma network oscillations are thought to represent key reference signals
    for information processing in neuronal ensembles, but the underlying synaptic
    mechanisms remain unclear. To address this question, we performed whole-cell (WC)
    patch-clamp recordings from mature hippocampal granule cells (GCs) in vivo in
    the dentate gyrus of anesthetized and awake rats. GCs in vivo fired action potentials
    at low frequency, consistent with sparse coding in the dentate gyrus. GCs were
    exposed to barrages of fast AMPAR-mediated excitatory postsynaptic currents (EPSCs),
    primarily relayed from the entorhinal cortex, and inhibitory postsynaptic currents
    (IPSCs), presumably generated by local interneurons. EPSCs exhibited coherence
    with the field potential predominantly in the theta frequency band, whereas IPSCs
    showed coherence primarily in the gamma range. Action potentials in GCs were phase
    locked to network oscillations. Thus, theta-gamma-modulated synaptic currents
    may provide a framework for sparse temporal coding of information in the dentate
    gyrus.
author:
- first_name: Alejandro
  full_name: Pernia-Andrade, Alejandro
  id: 36963E98-F248-11E8-B48F-1D18A9856A87
  last_name: Pernia-Andrade
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Pernia-Andrade A, Jonas PM. Theta-gamma-modulated synaptic currents in hippocampal
    granule cells in vivo define a mechanism for network oscillations. <i>Neuron</i>.
    2014;81(1):140-152. doi:<a href="https://doi.org/10.1016/j.neuron.2013.09.046">10.1016/j.neuron.2013.09.046</a>
  apa: Pernia-Andrade, A., &#38; Jonas, P. M. (2014). Theta-gamma-modulated synaptic
    currents in hippocampal granule cells in vivo define a mechanism for network oscillations.
    <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2013.09.046">https://doi.org/10.1016/j.neuron.2013.09.046</a>
  chicago: Pernia-Andrade, Alejandro, and Peter M Jonas. “Theta-Gamma-Modulated Synaptic
    Currents in Hippocampal Granule Cells in Vivo Define a Mechanism for Network Oscillations.”
    <i>Neuron</i>. Elsevier, 2014. <a href="https://doi.org/10.1016/j.neuron.2013.09.046">https://doi.org/10.1016/j.neuron.2013.09.046</a>.
  ieee: A. Pernia-Andrade and P. M. Jonas, “Theta-gamma-modulated synaptic currents
    in hippocampal granule cells in vivo define a mechanism for network oscillations,”
    <i>Neuron</i>, vol. 81, no. 1. Elsevier, pp. 140–152, 2014.
  ista: Pernia-Andrade A, Jonas PM. 2014. Theta-gamma-modulated synaptic currents
    in hippocampal granule cells in vivo define a mechanism for network oscillations.
    Neuron. 81(1), 140–152.
  mla: Pernia-Andrade, Alejandro, and Peter M. Jonas. “Theta-Gamma-Modulated Synaptic
    Currents in Hippocampal Granule Cells in Vivo Define a Mechanism for Network Oscillations.”
    <i>Neuron</i>, vol. 81, no. 1, Elsevier, 2014, pp. 140–52, doi:<a href="https://doi.org/10.1016/j.neuron.2013.09.046">10.1016/j.neuron.2013.09.046</a>.
  short: A. Pernia-Andrade, P.M. Jonas, Neuron 81 (2014) 140–152.
date_created: 2018-12-11T11:56:35Z
date_published: 2014-01-08T00:00:00Z
date_updated: 2021-01-12T06:56:19Z
day: '08'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2013.09.046
ec_funded: 1
file:
- access_level: open_access
  checksum: 438547cfcd9045a22f065f2019f07849
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:48Z
  date_updated: 2020-07-14T12:45:35Z
  file_id: '4773'
  file_name: IST-2016-422-v1+1_1-s2.0-S0896627313009227-main.pdf
  file_size: 4373072
  relation: main_file
file_date_updated: 2020-07-14T12:45:35Z
has_accepted_license: '1'
intvolume: '        81'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 140 - 152
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Neuron
publication_identifier:
  issn:
  - '08966273'
publication_status: published
publisher: Elsevier
publist_id: '4692'
pubrep_id: '422'
quality_controlled: '1'
scopus_import: 1
status: public
title: Theta-gamma-modulated synaptic currents in hippocampal granule cells in vivo
  define a mechanism for network oscillations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2014'
...