@article{6138, author = {Bretscher, Andrew Jonathan and Kodama-Namba, Eiji and Busch, Karl Emanuel and Murphy, Robin Joseph and Soltesz, Zoltan and Laurent, Patrick and de Bono, Mario}, issn = {0896-6273}, journal = {Neuron}, number = {6}, pages = {1099--1113}, publisher = {Elsevier BV}, title = {{Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior}}, doi = {10.1016/j.neuron.2011.02.023}, volume = {69}, year = {2011}, } @article{7705, abstract = {Axon-axon interactions have been implicated in neural circuit assembly, but the underlying mechanisms are poorly understood. Here, we show that in the Drosophila antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from the antenna are required for the proper targeting of late-arriving ORN axons from the maxillary palp (MP). Semaphorin-1a is required for targeting of all MP but only half of the antennal ORN classes examined. Sema-1a acts nonautonomously to control ORN axon-axon interactions, in contrast to its cell-autonomous function in olfactory projection neurons. Phenotypic and genetic interaction analyses implicate PlexinA as the Sema-1a receptor in ORN targeting. Sema-1a on antennal ORN axons is required for correct targeting of MP axons within the antennal lobe, while interactions amongst MP axons facilitate their entry into the antennal lobe. We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons.}, author = {Sweeney, Lora Beatrice Jaeger and Couto, Africa and Chou, Ya-Hui and Berdnik, Daniela and Dickson, Barry J. and Luo, Liqun and Komiyama, Takaki}, issn = {0896-6273}, journal = {Neuron}, number = {2}, pages = {185--200}, publisher = {Elsevier}, title = {{Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions}}, doi = {10.1016/j.neuron.2006.12.022}, volume = {53}, year = {2007}, } @article{3140, abstract = {The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction.}, author = {Hippenmeyer, Simon and Shneider, Neil and Birchmeier, Carmen and Burden, Steven and Jessell, Thomas and Arber, Silvia}, issn = {0896-6273}, journal = {Neuron}, number = {6}, pages = {1035 -- 1049}, publisher = {Elsevier}, title = {{A role for Neuregulin1 signaling in muscle spindle differentiation}}, doi = {10.1016/S0896-6273(02)01101-7}, volume = {36}, year = {2002}, } @article{4194, abstract = {Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.}, author = {Houart, Corinne and Caneparo, Luca and Heisenberg, Carl-Philipp J and Barth, K Anukampa and Take Uchi, Masaya and Wilson, Stephen}, issn = {0896-6273}, journal = {Neuron}, number = {2}, pages = {255 -- 265}, publisher = {Elsevier}, title = {{Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling}}, doi = {10.1016/S0896-6273(02)00751-1}, volume = {35}, year = {2002}, } @article{2603, abstract = {Aggregation of neurotransmitter receptors at pre- and postsynaptic structures is crucial for efficient neuronal communication. In contrast to the wealth of information about postsynaptic specializations, little is known about the molecular organization of presynaptic membrane proteins. We show here that the metabotropic glutamate receptor mGluR7a, which localizes specifically to presynaptic active zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous systems induces coclustering dependent upon the extreme C terminus of mGluR7a and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not cluster. These results suggest that PICK1 is a component of the presynaptic machinery involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission.}, author = {Boudin, Hélène and Doan, Andrew and Xia, Jun and Shigemoto, Ryuichi and Huganir, Richard and Worley, Paul and Craig, Ann}, issn = {0896-6273}, journal = {Neuron}, number = {2}, pages = {485 -- 497}, publisher = {Elsevier}, title = {{Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site}}, doi = {10.1016/S0896-6273(00)00127-6}, volume = {28}, year = {2000}, } @article{3492, abstract = {Analysis of presynaptic determinants of synaptic strength has been difficult at cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal slices. The presynaptic action potential is very short during low-frequency stimulation but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly, suggesting that cumulative K+ channel inactivation mediates activity-dependent spike broadening. Prolongation of the presynaptic voltage waveform leads to an increase in the number of Ca2+ ions entering the terminal per action potential and to a consecutive potentiation of evoked excitatory postsynaptic currents at MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels contributes to the control of efficacy of a glutamatergic synapse in the cortex.}, author = {Geiger, Jörg and Jonas, Peter M}, issn = {0896-6273}, journal = {Neuron}, number = {3}, pages = {927 -- 939}, publisher = {Elsevier}, title = {{Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons}}, doi = {10.1016/S0896-6273(00)00164-1}, volume = {28}, year = {2000}, } @article{3542, abstract = {Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons.}, author = {Csicsvari, Jozsef L and Hirase, Hajima and Mamiya, Akira and Buzsáki, György}, issn = {0896-6273}, journal = {Neuron}, number = {2}, pages = {585 -- 594}, publisher = {Elsevier}, title = {{Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events}}, doi = {10.1016/S0896-6273(00)00135-5}, volume = {28}, year = {2000}, } @article{3521, abstract = {Spike transmission probability between pyramidal cells and interneurons in the CA1 pyramidal layer was investigated in the behaving rat by the simultaneous recording of neuronal ensembles. Population synchrony was strongest during sharp wave (SPW) bursts. However, the increase was three times larger for pyramidal cells than for interneurons. The contribution of single pyramidal cells to the discharge of interneurons was often large (up to 0.6 probability), as assessed by the presence of significant (<3 ms) peaks in the cross-correlogram. Complex-spike bursts were more effective than single spikes. Single cell contribution was higher between SPW bursts than during SPWs or theta activity. Hence, single pyramidal cells can reliably discharge interneurons, and the probability of spike transmission is behavior dependent.}, author = {Csicsvari, Jozsef L and Hirase, Hajima and Czurkó, András and Buzsáki, György}, issn = {0896-6273}, journal = {Neuron}, number = {1}, pages = {179 -- 189}, publisher = {Elsevier}, title = {{Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat}}, doi = {10.1016/S0896-6273(00)80525-5}, volume = {21}, year = {1998}, } @article{3484, abstract = {Glutamatergic transmission at a principal neuroninterneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration ≃ 4 ms; 34°C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.}, author = {Geiger, Jörg and Lubke, Joachim and Roth, Arnd and Frotscher, Michael and Jonas, Peter M}, issn = {0896-6273}, journal = {Neuron}, number = {6}, pages = {1009 -- 1023}, publisher = {Elsevier}, title = {{Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse}}, doi = {10.1016/S0896-6273(00)80339-6}, volume = {18}, year = {1997}, } @article{4174, abstract = {The epiphysial region of the dorsal diencephalon is the first site at which neurogenesis occurs in the roof of the zebrafish forebrain. We show that the homeobox containing gene floating head (flh) is required for neurogenesis to proceed in the epiphysis. In flh(-) embryos, the first few epiphysial neurons are generated, but beyond the 18 somite stage, neuronal production ceases. In contrast, in masterblind(-) (mbl(-)) embryos, epiphysial neurons are generated throughout the dorsal forebrain. We show that mbl is required to prevent the expression of flh in dorsal forebrain cells rostral to the epiphysis. Furthermore, epiphysial neurons are not ectopically induced in mbl(-)/flh(-) embryos, demonstrating that the epiphysial phenotype of mbl(-) embryos is mediated by ectopic Flh activity. We propose a role for Flh in linking the signaling pathways that regulate regional patterning to the signaling pathways that regulate neurogenesis.}, author = {Masai, Ichiro and Heisenberg, Carl-Philipp J and Barth, K Anukampa and Macdonald, Rachel and Adamek, Sylwia and Wilson, Stephen}, issn = {0896-6273}, journal = {Neuron}, number = {1}, pages = {43 -- 57}, publisher = {Elsevier}, title = {{Floating head and masterblind regulate neuronal patterning in the roof of the forebrain}}, doi = {10.1016/S0896-6273(01)80045-3}, volume = {18}, year = {1997}, } @article{3461, author = {Jonas, Peter M and Burnashev, Nail}, issn = {0896-6273}, journal = {Neuron}, number = {5}, pages = {987 -- 990}, publisher = {Elsevier}, title = {{Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels}}, doi = {10.1016/0896-6273(95)90087-X}, volume = {15}, year = {1995}, } @article{3480, abstract = {Recording of glutamate-activated currents in membrane patches was combine with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons of hippocampus and neocortex and in auditory relay neurons and Bergmann glial cells indicates that the GluR-B subunit in its flip version determines formation of receptors with relatively slow gating, whereas the GluR-D subunit promotes assembly of more rapidly gated receptors. The relation between Ca 2+ permeability of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the dominance of this subunit in determining the Ca 2+ permeability of native receptors. The results suggest that differential expression of GluR-B and GluR-D subunit genes, as well as splicing end editing of their mRNAs, account for the differences in gating and Ca 2+ permeability of native AMPAR channels.}, author = {Geiger, Jörg and Melcher, Thorsten and Koh, Duk and Sakmann, Bert and Seeburg, Peter and Jonas, Peter M and Monyer, Hannah}, issn = {0896-6273}, journal = {Neuron}, number = {1}, pages = {193 -- 204}, publisher = {Elsevier}, title = {{Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS}}, doi = {10.1016/0896-6273(95)90076-4}, volume = {15}, year = {1995}, } @article{2555, abstract = {Antibodies were raised against two distinct extracellular sequences of the rat mGluR1 metabotropic glutamate receptor expressed as bacterial fusion proteins. Both antibodies specifically reacted with mGluR1 in the rat cerebellum and inhibited the mGluR1 activity as assessed by the analysis of glutamate-stimulated inositol phosphate formation in CHO cells expressing mGluR1. Using these antibodies, we examined the role of mGluR1 in the induction of long-term depression in cultured Purkinje cells. In voltage- clamped Purkinje cells, current induced by iontophoretically applied glutamate was persistently depressed by depolarization of the Purkinje cells in conjunction with the glutamate application. The mGluR1 antibodies completely blocked the depression of glutamate-induced current. The results indicate that activation of mGluR1 is necessary for the induction of cerebellar long-term depression and that these mGluR1 antibodies can be used as selective antagonists.}, author = {Shigemoto, Ryuichi and Abe, Takaaki and Nomura, Sakashi and Nakanishi, Shigetada and Hirano, Tomoo}, issn = {0896-6273}, journal = {Neuron}, number = {6}, pages = {1245 -- 1255}, publisher = {Elsevier}, title = {{Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells}}, doi = {10.1016/0896-6273(94)90441-3}, volume = {12}, year = {1994}, } @article{2557, abstract = {The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3 was immunohistochemically examined in the rat cerebellar cortex at both light and electron microscope levels. An antibody was raised against a fusion protein containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often encountered in the vicinity of glutamatergic mossy fiber terminals. The results suggest that transmitter glutamate may exert control influences upon Golgi cells not only through dendritic mGluR2/3, but also through axonal mGluR2/3.}, author = {Ohishi, Hitoshi and Ogawa Meguro, Reiko and Shigemoto, Ryuichi and Kaneko, Takeshi and Nakanishi, Shigetada and Mizuno, Noboru}, issn = {0896-6273}, journal = {Neuron}, number = {1}, pages = {55 -- 66}, publisher = {Elsevier}, title = {{Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex}}, doi = {10.1016/0896-6273(94)90459-6}, volume = {13}, year = {1994}, } @article{3477, abstract = {Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors critically depends on the subunit composition. Using patch-clamp techniques in brain slices, we found that the Ca2+ permeability of native AMPA-type GluRs was markedly higher in nonpyramidal (P(Ca)/P(K) ≃ 0.63) than in pyramidal (P(Ca)/P(K) ≃ 0.05) neurons of rat neocortex. Analysis of mRNA in single cells indicated that the relative abundance of GluR-B-specific mRNA was significantly lower in nonpyramidal (GluR-B/GluR-non-B ≃ 0.3) than in pyramidal (GluR-B/GluR-non-B ≃ 3) cells. This suggests that differences in relative abundance of GluR-B- specific mRNA generate functional diversity of AMPA-type GluRs in neurons with respect to Ca2+ permeability.}, author = {Jonas, Peter M and Racca, Claudia and Sakmann, Bert and Seeburg, Peter and Monyer, Hannah}, issn = {0896-6273}, journal = {Neuron}, number = {6}, pages = {1281 -- 1289}, publisher = {Elsevier}, title = {{Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression}}, doi = {10.1016/0896-6273(94)90444-8}, volume = {12}, year = {1994}, } @article{2543, abstract = {Pituitary adenylate cyclase-activating polypeptide (PACAP) is a polypeptide hormone related to vasoactive intestinal polypeptide (VIP). Rat PACAP receptor cDNA was isolated from a brain cDNA library by cross-hybridization with rat VIP receptor cDNA. The recombinant PACAP receptor expressed in COS cells bound PACAP with about 1000 times higher affinity than VIP, and PACAP stimulated adenylate cyclase through the cloned PACAP receptor. The rat PACAP receptor consists of 495 amino acids, contains seven transmembrane segments, and has a significant similarity with other Gs-coupled receptors, such as VIP, glucagon, and secretin receptors. PACAP receptor mRNA was abundantly expressed in the brain, but not in the peripheral tissues except for the adrenal gland. In situ hybridization revealed a high level of expression of PACAP receptor mRNA in the hippocampal dentate gyrus, olfactory bulb, and cerebellar cortex.}, author = {Hashimoto, Hitoshi and Ishihara, Takeshi and Shigemoto, Ryuichi and Mori, Kensaku and Nagata, Shigekazu}, issn = {0896-6273}, journal = {Neuron}, number = {2}, pages = {333 -- 342}, publisher = {Elsevier}, title = {{ Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide}}, doi = {10.1016/0896-6273(93)90188-W}, volume = {11}, year = {1993}, } @article{2484, abstract = {Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.}, author = {Tanabe, Yasuto and Masu, Masayuki and Ishii, Takahiro and Shigemoto, Ryuichi and Nakanishi, Shigetada}, issn = {0896-6273}, journal = {Neuron}, number = {1}, pages = {169 -- 179}, publisher = {Elsevier}, title = {{A family of metabotropic glutamate receptors}}, doi = {10.1016/0896-6273(92)90118-W}, volume = {8}, year = {1992}, } @article{2534, abstract = {Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone, plays many physiological roles in the peripheral and central nerve systems. A functional cDNA clone of the VIP receptor was isolated from a rat lung cDNA library by cross-hybridization with the secretin receptor cDNA. VIP bound the cloned VIP receptor expressed in mouse COP cells and stimulated adenylate cyclase through the cloned receptor. The rat VIP receptor consists of 459 amino acids with a calculated Mr of 52,054 and contains seven transmembrane segments. It is structurally related to the secretin, calcitonin, and parathyroid hormone receptors, suggesting that they constitute a new subfamily of the G5 protein - coupled receptors. VIP receptor mRNA was detected in various rat tissues including liver, lung, intestines, and brain. In situ hybridization revealed that VIP receptor mRNA is widely distributed in neuronal cells of the adult rat brain, with a relatively high expression in the cerebral cortex and hippocampus.}, author = {Ishihara, Takeshi and Shigemoto, Ryuichi and Mori, Kensaku and Takahashi, Kenji and Nagata, Shigekazu}, issn = {0896-6273}, journal = {Neuron}, number = {4}, pages = {811 -- 819}, publisher = {Elsevier}, title = {{Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide}}, doi = {10.1016/0896-6273(92)90101-I}, volume = {8}, year = {1992}, }