---
_id: '194'
abstract:
- lang: eng
  text: Ants are emerging model systems to study cellular signaling because distinct
    castes possess different physiologic phenotypes within the same colony. Here we
    studied the functionality of inotocin signaling, an insect ortholog of mammalian
    oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined
    that specialization within the colony, seasonal factors, and physiologic conditions
    down-regulated the expression of the OT-like signaling system. Given this natural
    variation, we interrogated its function using RNAi knockdowns. Next-generation
    RNA sequencing of OT-like precursor knock-down ants highlighted its role in the
    regulation of genes involved in metabolism. Knock-down ants exhibited higher walking
    activity and increased self-grooming in the brood chamber. We propose that OT-like
    signaling in ants is important for regulating metabolic processes and locomotion.
article_processing_charge: No
article_type: original
author:
- first_name: Zita
  full_name: Liutkeviciute, Zita
  last_name: Liutkeviciute
- first_name: Esther
  full_name: Gil Mansilla, Esther
  last_name: Gil Mansilla
- first_name: Thomas
  full_name: Eder, Thomas
  last_name: Eder
- first_name: Barbara E
  full_name: Casillas Perez, Barbara E
  id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
  last_name: Casillas Perez
- first_name: Maria
  full_name: Giulia Di Giglio, Maria
  last_name: Giulia Di Giglio
- first_name: Edin
  full_name: Muratspahić, Edin
  last_name: Muratspahić
- first_name: Florian
  full_name: Grebien, Florian
  last_name: Grebien
- first_name: Thomas
  full_name: Rattei, Thomas
  last_name: Rattei
- first_name: Markus
  full_name: Muttenthaler, Markus
  last_name: Muttenthaler
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Christian
  full_name: Gruber, Christian
  last_name: Gruber
citation:
  ama: Liutkeviciute Z, Gil Mansilla E, Eder T, et al. Oxytocin-like signaling in
    ants influences metabolic gene expression and locomotor activity. <i>The FASEB
    Journal</i>. 2018;32(12):6808-6821. doi:<a href="https://doi.org/10.1096/fj.201800443">10.1096/fj.201800443</a>
  apa: Liutkeviciute, Z., Gil Mansilla, E., Eder, T., Casillas Perez, B. E., Giulia
    Di Giglio, M., Muratspahić, E., … Gruber, C. (2018). Oxytocin-like signaling in
    ants influences metabolic gene expression and locomotor activity. <i>The FASEB
    Journal</i>. FASEB. <a href="https://doi.org/10.1096/fj.201800443">https://doi.org/10.1096/fj.201800443</a>
  chicago: Liutkeviciute, Zita, Esther Gil Mansilla, Thomas Eder, Barbara E Casillas
    Perez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, et al. “Oxytocin-like
    Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.”
    <i>The FASEB Journal</i>. FASEB, 2018. <a href="https://doi.org/10.1096/fj.201800443">https://doi.org/10.1096/fj.201800443</a>.
  ieee: Z. Liutkeviciute <i>et al.</i>, “Oxytocin-like signaling in ants influences
    metabolic gene expression and locomotor activity,” <i>The FASEB Journal</i>, vol.
    32, no. 12. FASEB, pp. 6808–6821, 2018.
  ista: Liutkeviciute Z, Gil Mansilla E, Eder T, Casillas Perez BE, Giulia Di Giglio
    M, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber C. 2018.
    Oxytocin-like signaling in ants influences metabolic gene expression and locomotor
    activity. The FASEB Journal. 32(12), 6808–6821.
  mla: Liutkeviciute, Zita, et al. “Oxytocin-like Signaling in Ants Influences Metabolic
    Gene Expression and Locomotor Activity.” <i>The FASEB Journal</i>, vol. 32, no.
    12, FASEB, 2018, pp. 6808–21, doi:<a href="https://doi.org/10.1096/fj.201800443">10.1096/fj.201800443</a>.
  short: Z. Liutkeviciute, E. Gil Mansilla, T. Eder, B.E. Casillas Perez, M. Giulia
    Di Giglio, E. Muratspahić, F. Grebien, T. Rattei, M. Muttenthaler, S. Cremer,
    C. Gruber, The FASEB Journal 32 (2018) 6808–6821.
date_created: 2018-12-11T11:45:08Z
date_published: 2018-11-29T00:00:00Z
date_updated: 2023-09-13T09:37:32Z
day: '29'
department:
- _id: SyCr
doi: 10.1096/fj.201800443
external_id:
  isi:
  - '000449359700035'
  pmid:
  - '29939785'
intvolume: '        32'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.1096/fj.201800443'
month: '11'
oa: 1
oa_version: Published Version
page: 6808-6821
pmid: 1
project:
- _id: 25E3D34E-B435-11E9-9278-68D0E5697425
  name: Individual function and social role of oxytocin-like neuropeptides in ants
publication: The FASEB Journal
publication_identifier:
  issn:
  - '08926638'
publication_status: published
publisher: FASEB
publist_id: '7721'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oxytocin-like signaling in ants influences metabolic gene expression and locomotor
  activity
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2018'
...