---
_id: '2553'
abstract:
- lang: eng
  text: Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors
    in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1
    subtype, which is coupled to Ca2+ mobilization, was specifically localized to
    the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype,
    which is linked to stimulation of adenylate cyclase, was localized to the glomeruli.
    The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase,
    was located densely in the tubules in the outer medulla and in the distal tubules
    in the cortex. These results exhibit distinct cellular localization of three subtypes
    of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions
    via these subtypes expressed in different segments of the nephron.
acknowledgement: We thank Drs. Noboru Mizuno, Tsuyoshi Watanabe, Akihide Nakao, Chihiro
  Akazawa, and Akira Uesugi for invaluable discussions and photographic support. This
  work was supported in part by Scientific Research Grants-inAid 05404020, 04255103,
  05771975, 05671816, and 05454568 from the Ministry of Education, Science and Culture
  of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Yukihiko
  full_name: Sugimoto, Yukihiko
  last_name: Sugimoto
- first_name: Tsunehisa
  full_name: Namba, Tsunehisa
  last_name: Namba
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Manabu
  full_name: Negishi, Manabu
  last_name: Negishi
- first_name: Atsushi
  full_name: Ichikawa, Atsushi
  last_name: Ichikawa
- first_name: Shuh
  full_name: Narumiya, Shuh
  last_name: Narumiya
citation:
  ama: Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. Distinct
    cellular localization of mRNAs for three subtypes of prostaglandin E receptor
    in kidney. <i>American Journal of Physiology</i>. 1994;266(5):F823-F828. doi:<a
    href="https://doi.org/10.1152/ajprenal.1994.266.5.F823">10.1152/ajprenal.1994.266.5.F823</a>
  apa: Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., &#38; Narumiya,
    S. (1994). Distinct cellular localization of mRNAs for three subtypes of prostaglandin
    E receptor in kidney. <i>American Journal of Physiology</i>. American Physiological
    Society. <a href="https://doi.org/10.1152/ajprenal.1994.266.5.F823">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>
  chicago: Sugimoto, Yukihiko, Tsunehisa Namba, Ryuichi Shigemoto, Manabu Negishi,
    Atsushi Ichikawa, and Shuh Narumiya. “Distinct Cellular Localization of MRNAs
    for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal
    of Physiology</i>. American Physiological Society, 1994. <a href="https://doi.org/10.1152/ajprenal.1994.266.5.F823">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>.
  ieee: Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya,
    “Distinct cellular localization of mRNAs for three subtypes of prostaglandin E
    receptor in kidney,” <i>American Journal of Physiology</i>, vol. 266, no. 5. American
    Physiological Society, pp. F823–F828, 1994.
  ista: Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. 1994.
    Distinct cellular localization of mRNAs for three subtypes of prostaglandin E
    receptor in kidney. American Journal of Physiology. 266(5), F823–F828.
  mla: Sugimoto, Yukihiko, et al. “Distinct Cellular Localization of MRNAs for Three
    Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>,
    vol. 266, no. 5, American Physiological Society, 1994, pp. F823–28, doi:<a href="https://doi.org/10.1152/ajprenal.1994.266.5.F823">10.1152/ajprenal.1994.266.5.F823</a>.
  short: Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, S. Narumiya,
    American Journal of Physiology 266 (1994) F823–F828.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-05-01T00:00:00Z
date_updated: 2022-06-07T15:03:51Z
day: '01'
doi: 10.1152/ajprenal.1994.266.5.F823
extern: '1'
external_id:
  pmid:
  - '8203567'
intvolume: '       266'
issue: '5'
language:
- iso: eng
main_file_link:
- url: https://journals.physiology.org/doi/abs/10.1152/ajprenal.1994.266.5.F823
month: '05'
oa_version: None
page: F823 - F828
pmid: 1
publication: American Journal of Physiology
publication_identifier:
  issn:
  - 0363-6127
publication_status: published
publisher: American Physiological Society
publist_id: '4345'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct cellular localization of mRNAs for three subtypes of prostaglandin
  E receptor in kidney
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 266
year: '1994'
...