---
_id: '643'
abstract:
- lang: eng
  text: It has been reported that nicotinamide-overload induces oxidative stress associated
    with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This
    study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance
    tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without
    cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT)
    were also carried out in adult Sprague-Dawley rats treated with or without cumulative
    doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration
    significantly increased the plasma H2O2 levels associated with high insulin levels.
    Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration
    of nicotinic acid, another form of Vitamin B3, also significantly increased plasma
    insulin level and H2O2 generation. Moreover, cumulative administration of nicotinic
    acid or nicotinamide impaired glucose metabolism. This study suggested that excess
    Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.
article_processing_charge: No
article_type: original
author:
- first_name: Wuping
  full_name: Sun, Wuping
  last_name: Sun
- first_name: Ming-Zhu
  full_name: Zhai, Ming-Zhu
  id: 34009CFA-F248-11E8-B48F-1D18A9856A87
  last_name: Zhai
- first_name: Qian
  full_name: Zhou, Qian
  last_name: Zhou
- first_name: Chengrui
  full_name: Qian, Chengrui
  last_name: Qian
- first_name: Changyu
  full_name: Jiang, Changyu
  last_name: Jiang
citation:
  ama: Sun W, Zhai M-Z, Zhou Q, Qian C, Jiang C. Effects of B vitamins overload on
    plasma insulin level and hydrogen peroxide generation in rats. <i>Chinese Journal
    of Physiology</i>. 2017;60(4):207-214. doi:<a href="https://doi.org/10.4077/CJP.2017.BAF469">10.4077/CJP.2017.BAF469</a>
  apa: Sun, W., Zhai, M.-Z., Zhou, Q., Qian, C., &#38; Jiang, C. (2017). Effects of
    B vitamins overload on plasma insulin level and hydrogen peroxide generation in
    rats. <i>Chinese Journal of Physiology</i>. Chinese Physiological Society. <a
    href="https://doi.org/10.4077/CJP.2017.BAF469">https://doi.org/10.4077/CJP.2017.BAF469</a>
  chicago: Sun, Wuping, Ming-Zhu Zhai, Qian Zhou, Chengrui Qian, and Changyu Jiang.
    “Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide
    Generation in Rats.” <i>Chinese Journal of Physiology</i>. Chinese Physiological
    Society, 2017. <a href="https://doi.org/10.4077/CJP.2017.BAF469">https://doi.org/10.4077/CJP.2017.BAF469</a>.
  ieee: W. Sun, M.-Z. Zhai, Q. Zhou, C. Qian, and C. Jiang, “Effects of B vitamins
    overload on plasma insulin level and hydrogen peroxide generation in rats,” <i>Chinese
    Journal of Physiology</i>, vol. 60, no. 4. Chinese Physiological Society, pp.
    207–214, 2017.
  ista: Sun W, Zhai M-Z, Zhou Q, Qian C, Jiang C. 2017. Effects of B vitamins overload
    on plasma insulin level and hydrogen peroxide generation in rats. Chinese Journal
    of Physiology. 60(4), 207–214.
  mla: Sun, Wuping, et al. “Effects of B Vitamins Overload on Plasma Insulin Level
    and Hydrogen Peroxide Generation in Rats.” <i>Chinese Journal of Physiology</i>,
    vol. 60, no. 4, Chinese Physiological Society, 2017, pp. 207–14, doi:<a href="https://doi.org/10.4077/CJP.2017.BAF469">10.4077/CJP.2017.BAF469</a>.
  short: W. Sun, M.-Z. Zhai, Q. Zhou, C. Qian, C. Jiang, Chinese Journal of Physiology
    60 (2017) 207–214.
date_created: 2018-12-11T11:47:40Z
date_published: 2017-08-31T00:00:00Z
date_updated: 2021-01-12T08:07:28Z
day: '31'
ddc:
- '570'
department:
- _id: RySh
doi: 10.4077/CJP.2017.BAF469
external_id:
  pmid:
  - '28847140'
intvolume: '        60'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: Published Version
page: 207 - 214
pmid: 1
publication: Chinese Journal of Physiology
publication_identifier:
  issn:
  - '03044920'
publication_status: published
publisher: Chinese Physiological Society
publist_id: '7142'
quality_controlled: '1'
scopus_import: 1
status: public
title: Effects of B vitamins overload on plasma insulin level and hydrogen peroxide
  generation in rats
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 60
year: '2017'
...