---
_id: '6521'
abstract:
- lang: eng
text: Microglia have emerged as a critical component of neurodegenerative diseases.
Genetic manipulation of microglia can elucidate their functional impact in disease.
In neuroscience, recombinant viruses such as lentiviruses and adeno-associated
viruses (AAVs) have been successfully used to target various cell types in the
brain, although effective transduction of microglia is rare. In this review, we
provide a short background of lentiviruses and AAVs, and strategies for designing
recombinant viral vectors. Then, we will summarize recent literature on successful
microglial transductions in vitro and in vivo, and discuss the current challenges.
Finally, we provide guidelines for reporting the efficiency and specificity of
viral targeting in microglia, which will enable the microglial research community
to assess and improve methodologies for future studies.
article_number: '134310'
article_processing_charge: No
article_type: original
author:
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: Gloria
full_name: Colombo, Gloria
id: 3483CF6C-F248-11E8-B48F-1D18A9856A87
last_name: Colombo
orcid: 0000-0001-9434-8902
- first_name: Rouven
full_name: Schulz, Rouven
id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
last_name: Schulz
orcid: 0000-0001-5297-733X
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
citation:
ama: 'Maes ME, Colombo G, Schulz R, Siegert S. Targeting microglia with lentivirus
and AAV: Recent advances and remaining challenges. Neuroscience Letters.
2019;707. doi:10.1016/j.neulet.2019.134310'
apa: 'Maes, M. E., Colombo, G., Schulz, R., & Siegert, S. (2019). Targeting
microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/j.neulet.2019.134310'
chicago: 'Maes, Margaret E, Gloria Colombo, Rouven Schulz, and Sandra Siegert. “Targeting
Microglia with Lentivirus and AAV: Recent Advances and Remaining Challenges.”
Neuroscience Letters. Elsevier, 2019. https://doi.org/10.1016/j.neulet.2019.134310.'
ieee: 'M. E. Maes, G. Colombo, R. Schulz, and S. Siegert, “Targeting microglia with
lentivirus and AAV: Recent advances and remaining challenges,” Neuroscience
Letters, vol. 707. Elsevier, 2019.'
ista: 'Maes ME, Colombo G, Schulz R, Siegert S. 2019. Targeting microglia with lentivirus
and AAV: Recent advances and remaining challenges. Neuroscience Letters. 707,
134310.'
mla: 'Maes, Margaret E., et al. “Targeting Microglia with Lentivirus and AAV: Recent
Advances and Remaining Challenges.” Neuroscience Letters, vol. 707, 134310,
Elsevier, 2019, doi:10.1016/j.neulet.2019.134310.'
short: M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019).
date_created: 2019-06-05T13:16:24Z
date_published: 2019-08-10T00:00:00Z
date_updated: 2023-08-28T09:30:57Z
day: '10'
ddc:
- '570'
department:
- _id: SaSi
doi: 10.1016/j.neulet.2019.134310
ec_funded: 1
external_id:
isi:
- '000486094600037'
pmid:
- '31158432'
file:
- access_level: open_access
checksum: 553c9dbd39727fbed55ee991c51ca4d1
content_type: application/pdf
creator: dernst
date_created: 2019-06-08T11:44:20Z
date_updated: 2020-07-14T12:47:33Z
file_id: '6551'
file_name: 2019_Neuroscience_Maes.pdf
file_size: 1779287
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 707'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715571'
name: Microglia action towards neuronal circuit formation and function in health
and disease
- _id: 267F75D8-B435-11E9-9278-68D0E5697425
name: Modulating microglia through G protein-coupled receptor (GPCR) signaling
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Targeting microglia with lentivirus and AAV: Recent advances and remaining
challenges'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 707
year: '2019'
...
---
_id: '2612'
abstract:
- lang: eng
text: 'We examined immunoreactivities for γ-aminobutyric acidB-receptor (GABABR)
subtypes, GABABR1 and GABABR2, in the mesencephalic trigeminal nucleus neurons
(MTN neurons) of the rat. Immunoreactivity for GABABR1 was prominent in cell bodies
of MTN, whereas that for GABABR2 was very weak, if existed. For electron microscopy,
the immunogold-silver method for GABABR1 was combined with the immunoperoxidase
method for glutamic acid decarboxylase (GAD: the synthetic enzyme of GABA). Immunogold-silver
particles indicating GABABR1 immunoreactivity were distributed widely in the cytoplasm
of the cell bodies postsynaptic to GAD-immunoreactive axon terminals, but were
rarely associated with synaptic membrane specialization or extrasynaptic sites
of plasma membrane. It has been indicated that GABABR1 may not be transported
to plasma membrane when no GABABR2 exists. Thus, it was presumed that GABABR1
in the cell body of the rat MTN neurons might not be involved in the synaptic
transmission.'
acknowledgement: This work was supported in part by Grants-in-Aid from the National
Natural Science Foundation of China (39870262, 39970239), from the Foundation for
University Key Teacher of the Ministry of Education of China, and from the Ministry
of Education, Science, Sports, Culture and Technology of Japan (12308039, 12680743).
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Peng
full_name: Chen, Peng
last_name: Chen
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Shigemoto R, Kulik Á, et al. Immunocytochemical localization of GABAB
receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience
Letters. 2001;315(1-2):93-97. doi:10.1016/S0304-3940(01)02321-7
apa: Li, J., Shigemoto, R., Kulik, Á., Chen, P., Nomura, S., Kaneko, T., & Mizuno,
N. (2001). Immunocytochemical localization of GABAB receptors in mesencephalic
trigeminal nucleus neurons in the rat. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/S0304-3940(01)02321-7
chicago: Li, Jin, Ryuichi Shigemoto, Ákos Kulik, Peng Chen, Sakashi Nomura, Takeshi
Kaneko, and Noboru Mizuno. “Immunocytochemical Localization of GABAB Receptors
in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters.
Elsevier, 2001. https://doi.org/10.1016/S0304-3940(01)02321-7.
ieee: J. Li et al., “Immunocytochemical localization of GABAB receptors in
mesencephalic trigeminal nucleus neurons in the rat,” Neuroscience Letters,
vol. 315, no. 1–2. Elsevier, pp. 93–97, 2001.
ista: Li J, Shigemoto R, Kulik Á, Chen P, Nomura S, Kaneko T, Mizuno N. 2001. Immunocytochemical
localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in
the rat. Neuroscience Letters. 315(1–2), 93–97.
mla: Li, Jin, et al. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic
Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters, vol. 315,
no. 1–2, Elsevier, 2001, pp. 93–97, doi:10.1016/S0304-3940(01)02321-7.
short: J. Li, R. Shigemoto, Á. Kulik, P. Chen, S. Nomura, T. Kaneko, N. Mizuno,
Neuroscience Letters 315 (2001) 93–97.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-11-23T00:00:00Z
date_updated: 2023-05-22T12:30:05Z
day: '23'
doi: 10.1016/S0304-3940(01)02321-7
extern: '1'
external_id:
pmid:
- '11711223'
intvolume: ' 315'
issue: 1-2
language:
- iso: eng
month: '11'
oa_version: None
page: 93 - 97
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4287'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal
nucleus neurons in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 315
year: '2001'
...
---
_id: '2591'
abstract:
- lang: eng
text: The occurrence and distribution of the preferred receptor for the neuropeptide,
substance P (SP), the neurokinin-1 receptor (NK1R) was investigated in the vascular
supply of the rat sciatic nerve. Messenger RNA for NK1R was demonstrated by RT-PCR
in the epineurial layer where the majority of small arteries and arterioles feeding
the endoneurial vasculature are located. Immunoreactivity to NK1R-protein was
localized on the smooth muscle cells of these arterial vessels by means of immunofluorescence
using a polyclonal NK1R antiserum. This muscular localization of NK1R explains
the previously reported [Zochodne, D.W. and Ho, L.T., J. Physiol. 444 (1991) 615-
630] moderate vasoconstrictor rather than vasodilator effects of SP in this vascular
bed.
acknowledgement: The skillful technical assistance of Ms. T. Fischbach and Ms. K.
Michael and the secretarial help of Ms. P. Berger are gratefully appreciated.
article_processing_charge: No
article_type: original
author:
- first_name: Wolfgang
full_name: Kummer, Wolfgang
last_name: Kummer
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rainer
full_name: Haberberger, Rainer
last_name: Haberberger
citation:
ama: Kummer W, Shigemoto R, Haberberger R. Smooth muscle cells are the site of neurokinin-1
receptor localization in the arterial supply of the rat sciatic nerve. Neuroscience
Letters. 1999;259(2):119-122. doi:10.1016/S0304-3940(98)00926-4
apa: Kummer, W., Shigemoto, R., & Haberberger, R. (1999). Smooth muscle cells
are the site of neurokinin-1 receptor localization in the arterial supply of the
rat sciatic nerve. Neuroscience Letters. Elsevier. https://doi.org/10.1016/S0304-3940(98)00926-4
chicago: Kummer, Wolfgang, Ryuichi Shigemoto, and Rainer Haberberger. “Smooth Muscle
Cells Are the Site of Neurokinin-1 Receptor Localization in the Arterial Supply
of the Rat Sciatic Nerve.” Neuroscience Letters. Elsevier, 1999. https://doi.org/10.1016/S0304-3940(98)00926-4.
ieee: W. Kummer, R. Shigemoto, and R. Haberberger, “Smooth muscle cells are the
site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic
nerve,” Neuroscience Letters, vol. 259, no. 2. Elsevier, pp. 119–122, 1999.
ista: Kummer W, Shigemoto R, Haberberger R. 1999. Smooth muscle cells are the site
of neurokinin-1 receptor localization in the arterial supply of the rat sciatic
nerve. Neuroscience Letters. 259(2), 119–122.
mla: Kummer, Wolfgang, et al. “Smooth Muscle Cells Are the Site of Neurokinin-1
Receptor Localization in the Arterial Supply of the Rat Sciatic Nerve.” Neuroscience
Letters, vol. 259, no. 2, Elsevier, 1999, pp. 119–22, doi:10.1016/S0304-3940(98)00926-4.
short: W. Kummer, R. Shigemoto, R. Haberberger, Neuroscience Letters 259 (1999)
119–122.
date_created: 2018-12-11T11:58:33Z
date_published: 1999-01-08T00:00:00Z
date_updated: 2023-03-27T10:11:02Z
day: '08'
doi: 10.1016/S0304-3940(98)00926-4
extern: '1'
external_id:
pmid:
- '10025572'
intvolume: ' 259'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 119 - 122
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4307'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Smooth muscle cells are the site of neurokinin-1 receptor localization in the
arterial supply of the rat sciatic nerve
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 259
year: '1999'
...
---
_id: '2594'
abstract:
- lang: eng
text: Substance P receptor (i.e. NK1)-like immunoreactive (SPR-LI) neurons were
observed in the newborn and adult human spinal cord. Substance P receptor-like
immunoreactive neuronal cell bodies were seen most frequently in lamina I, and
were scattered throughout the remaining laminae of the dorsal horn and the area
around the central canal. Some neurons in the intermediolateral nucleus also showed
weak immunoreactivity. The pattern of distribution of SPR-LI neurons in the adult
spinal cord was essentially the same as that in the newborn spinal cord. However,
SPR-LI neurons cell bodies were seen much more frequently in the newborn than
in the adult dorsal horn, especially in lamina II.
acknowledgement: This work was supported in part by Grants-in-Aid from the National
Natural Science Foundation of China (39600045) and the Ministry of Education, Science,
Sports and Culture of Japan (08279106, 09480211, 10164225, 10680701).
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Heng
full_name: Zheng, Heng
last_name: Zheng
- first_name: Dian
full_name: Wang, Dian
last_name: Wang
- first_name: Jun
full_name: Xu, Jun
last_name: Xu
- first_name: Liang
full_name: Gong, Liang
last_name: Gong
- first_name: Yan
full_name: Lü, Yan
last_name: Lü
- first_name: Bing
full_name: Qin, Bing
last_name: Qin
- first_name: Juan
full_name: Shi, Juan
last_name: Shi
- first_name: Hua
full_name: Li, Hua
last_name: Li
- first_name: Ji
full_name: Li, Ji
last_name: Li
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Zheng H, Wang D, et al. The distribution of substance P receptor (NK1)-like
immunoreactive neurons in the newborn and adult human spinal cord. Neuroscience
Letters. 1999;266(2):133-136. doi:10.1016/S0304-3940(99)00283-9
apa: Ding, Y., Zheng, H., Wang, D., Xu, J., Gong, L., Lü, Y., … Mizuno, N. (1999).
The distribution of substance P receptor (NK1)-like immunoreactive neurons in
the newborn and adult human spinal cord. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/S0304-3940(99)00283-9
chicago: Ding, Yu, Heng Zheng, Dian Wang, Jun Xu, Liang Gong, Yan Lü, Bing Qin,
et al. “The Distribution of Substance P Receptor (NK1)-like Immunoreactive Neurons
in the Newborn and Adult Human Spinal Cord.” Neuroscience Letters. Elsevier,
1999. https://doi.org/10.1016/S0304-3940(99)00283-9.
ieee: Y. Ding et al., “The distribution of substance P receptor (NK1)-like
immunoreactive neurons in the newborn and adult human spinal cord,” Neuroscience
Letters, vol. 266, no. 2. Elsevier, pp. 133–136, 1999.
ista: Ding Y, Zheng H, Wang D, Xu J, Gong L, Lü Y, Qin B, Shi J, Li H, Li J, Shigemoto
R, Kaneko T, Mizuno N. 1999. The distribution of substance P receptor (NK1)-like
immunoreactive neurons in the newborn and adult human spinal cord. Neuroscience
Letters. 266(2), 133–136.
mla: Ding, Yu, et al. “The Distribution of Substance P Receptor (NK1)-like Immunoreactive
Neurons in the Newborn and Adult Human Spinal Cord.” Neuroscience Letters,
vol. 266, no. 2, Elsevier, 1999, pp. 133–36, doi:10.1016/S0304-3940(99)00283-9.
short: Y. Ding, H. Zheng, D. Wang, J. Xu, L. Gong, Y. Lü, B. Qin, J. Shi, H. Li,
J. Li, R. Shigemoto, T. Kaneko, N. Mizuno, Neuroscience Letters 266 (1999) 133–136.
date_created: 2018-12-11T11:58:34Z
date_published: 1999-05-07T00:00:00Z
date_updated: 2022-09-13T10:05:26Z
day: '07'
doi: 10.1016/S0304-3940(99)00283-9
extern: '1'
external_id:
pmid:
- '10353345 '
intvolume: ' 266'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 133 - 136
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4304'
quality_controlled: '1'
status: public
title: The distribution of substance P receptor (NK1)-like immunoreactive neurons
in the newborn and adult human spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 266
year: '1999'
...
---
_id: '2575'
abstract:
- lang: eng
text: It was examined electron microscopically in the rat if a metabotropic glutamate
receptor, mGluR7, might be localized in axon terminals of nociceptive, primary
afferent fibers in laminae I and II of the spinal dorsal horn. Nociceptive nature
of axon terminals showing mGluR7-like immunoreactivity (mGluR7-LI) was indicated
by binding to the isolectin I-B4 from Griffonia simplicifolia (I-B4), or by substance
P-like immunoreactivity (SP-LI). Axon terminals labeled with immunogold particles
indicating mGluR7-LI were usually filled with round synaptic vesicles and were
in asymmetric synaptic contact with dendritic or somatic profiles; occasionally
they contained pleomorphic vesicles and were in symmetric synaptic contact with
somatic profiles in lamina II. The double-labeling studies revealed that most
of axon terminals with I-B4 labeling as well as a small population of axon terminals
with SP-LI, showed mGluR7-LI. About one-third or much smaller population of axon
terminals with mGluR7-LI in laminae I and II were labeled, respectively, with
I-B4 or SP-LI; these were in asymmetric synaptic contact with dendritic profiles.
acknowledgement: We are grateful for photographic help of Mr. Akira Uesugi. We also
express our gratitude for the support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sohzaburo
Hayashi, Mizuho Katsurada, Hitoshi Kawai, Yutaka Kitani, Toshihiko Kuroda, Keiko
Kumagai, Hiroshi Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Gonpei Niwa,
Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki,
Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in part
by Grant-in-Aid from Ministry of Education, Science, Culture and Sports of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: He
full_name: Li, He
last_name: Li
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat. Neuroscience Letters. 1997;223(3):153-156.
doi:10.1016/S0304-3940(97)13429-2'
apa: 'Li, H., Ohishi, H., Kinoshita, A., Shigemoto, R., Nomura, S., & Mizuno,
N. (1997). Localization of a metabotropic glutamate receptor, mGluR7, in axon
terminals of presumed nociceptive, primary afferent fibers in the superficial
layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/S0304-3940(97)13429-2'
chicago: 'Li, He, Hitoshi Ohishi, Ayae Kinoshita, Ryuichi Shigemoto, Sakashi Nomura,
and Noboru Mizuno. “Localization of a Metabotropic Glutamate Receptor, MGluR7,
in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial
Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience
Letters. Elsevier, 1997. https://doi.org/10.1016/S0304-3940(97)13429-2.'
ieee: 'H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, and N. Mizuno, “Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat,” Neuroscience Letters, vol. 223,
no. 3. Elsevier, pp. 153–156, 1997.'
ista: 'Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. 1997. Localization
of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive,
primary afferent fibers in the superficial layers of the spinal dorsal horn: An
electron microscope study in the rat. Neuroscience Letters. 223(3), 153–156.'
mla: 'Li, He, et al. “Localization of a Metabotropic Glutamate Receptor, MGluR7,
in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial
Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience
Letters, vol. 223, no. 3, Elsevier, 1997, pp. 153–56, doi:10.1016/S0304-3940(97)13429-2.'
short: H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience
Letters 223 (1997) 153–156.
date_created: 2018-12-11T11:58:28Z
date_published: 1997-02-28T00:00:00Z
date_updated: 2022-08-22T13:06:30Z
day: '28'
doi: 10.1016/S0304-3940(97)13429-2
extern: '1'
external_id:
pmid:
- '9080455'
intvolume: ' 223'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 153 - 156
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4322'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals
of presumed nociceptive, primary afferent fibers in the superficial layers of the
spinal dorsal horn: An electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 223
year: '1997'
...
---
_id: '2562'
abstract:
- lang: eng
text: A monoclonal antibody against a metabotropic glutamate receptor, mGluR2, was
produced by using a glutathione S-transferase (GST) fusion protein containing
an N-terminal sequence of rat mGluR2. Intense mGluR2-like immunoreactivity (mGluR2-LI)
was seen mainly in neuropil of the cerebral cortical regions, hippocampus, olfactory
bulb, some diencephalic nuclei, dorsal cochlear nucleus and cerebellar cortex.
In the cerebellar cortex, mGluR2-LI was seen only in Golgi cells. In Ammon's hem,
mGluR2-LI was marked in the stratum lucidum of CA3 and the stratum lacunosum-moleculare
of CA1-CA3, but not detected in the stratum pyramidale. The results indicate that
mGluR2 is located not only presynaptically but also postsynaptically.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Pre- and postsynaptic
localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An
immunohistochemical study with a monoclonal antibody. Neuroscience Letters.
1996;202(3):197-200. doi:10.1016/0304-3940(95)12248-6'
apa: 'Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno,
N. (1996). Pre- and postsynaptic localization of a metabotropic glutamate receptor,
mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody.
Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12248-6'
chicago: 'Neki, Akio, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Pre- and Postsynaptic Localization of a Metabotropic
Glutamate Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with
a Monoclonal Antibody.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12248-6.'
ieee: 'A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2,
in the rat brain: An immunohistochemical study with a monoclonal antibody,” Neuroscience
Letters, vol. 202, no. 3. Elsevier, pp. 197–200, 1996.'
ista: 'Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Pre-
and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in
the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience
Letters. 202(3), 197–200.'
mla: 'Neki, Akio, et al. “Pre- and Postsynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with a Monoclonal
Antibody.” Neuroscience Letters, vol. 202, no. 3, Elsevier, 1996, pp. 197–200,
doi:10.1016/0304-3940(95)12248-6.'
short: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience
Letters 202 (1996) 197–200.
date_created: 2018-12-11T11:58:24Z
date_published: 1996-01-05T00:00:00Z
date_updated: 2022-08-12T12:04:18Z
day: '05'
doi: 10.1016/0304-3940(95)12248-6
extern: '1'
external_id:
pmid:
- '8848265'
intvolume: ' 202'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 197 - 200
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4335'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2,
in the rat brain: An immunohistochemical study with a monoclonal antibody'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 202
year: '1996'
...
---
_id: '2565'
abstract:
- lang: eng
text: Immunoreactivity for the metabotropic glutamate receptor 7 (mGluR7) and that
for phosphate-activated glutaminase (PAG) were examined in the trigeminal (TG),
dorsal root (DRG), nodose (NG), superior cervical, celiac, and pelvic ganglia
of the rat. Virtually all neuronal cell bodies showed mGluR7-like immunoreactivity
(mGluR7-LI) in these ganglia. On the other hand, PAG-like immunoreactivity (PAG)
was seen in almost all neuronal cell bodies in the TG, DRG and NG, but not in
the other ganglia. Co-existence of mGluR7- and PAG-LI in the TG, DRG and NG was
confirmed by a double-immunofluorescence immunohistochemical method. The results
indicate that virtually all sensory ganglion neurons are glutamatergic and equipped
with mGluR7.
acknowledgement: The authors are grateful for the support of Dr. Kajitaro Morita and
photographic help of Mr. Akira Uesugi. This work was supported in part by Grant-in-Aid
from the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Ohishi H, Kaneko T, et al. Immunohistochemical localization of a metabotropic
glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference
to the presence in glutamatergic ganglion neurons. Neuroscience Letters.
1996;204(1-2):9-12. doi:10.1016/0304-3940(95)12299-0
apa: Li, J., Ohishi, H., Kaneko, T., Shigemoto, R., Neki, A., Nakanishi, S., &
Mizuno, N. (1996). Immunohistochemical localization of a metabotropic glutamate
receptor, mGluR7, in ganglion neurons of the rat; with special reference to the
presence in glutamatergic ganglion neurons. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/0304-3940(95)12299-0
chicago: Li, Jin, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Akio Neki,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of a
Metabotropic Glutamate Receptor, MGluR7, in Ganglion Neurons of the Rat; with
Special Reference to the Presence in Glutamatergic Ganglion Neurons.” Neuroscience
Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12299-0.
ieee: J. Li et al., “Immunohistochemical localization of a metabotropic glutamate
receptor, mGluR7, in ganglion neurons of the rat; with special reference to the
presence in glutamatergic ganglion neurons,” Neuroscience Letters, vol.
204, no. 1–2. Elsevier, pp. 9–12, 1996.
ista: Li J, Ohishi H, Kaneko T, Shigemoto R, Neki A, Nakanishi S, Mizuno N. 1996.
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7,
in ganglion neurons of the rat; with special reference to the presence in glutamatergic
ganglion neurons. Neuroscience Letters. 204(1–2), 9–12.
mla: Li, Jin, et al. “Immunohistochemical Localization of a Metabotropic Glutamate
Receptor, MGluR7, in Ganglion Neurons of the Rat; with Special Reference to the
Presence in Glutamatergic Ganglion Neurons.” Neuroscience Letters, vol.
204, no. 1–2, Elsevier, 1996, pp. 9–12, doi:10.1016/0304-3940(95)12299-0.
short: J. Li, H. Ohishi, T. Kaneko, R. Shigemoto, A. Neki, S. Nakanishi, N. Mizuno,
Neuroscience Letters 204 (1996) 9–12.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-02-02T00:00:00Z
date_updated: 2022-08-12T09:29:03Z
day: '02'
doi: 10.1016/0304-3940(95)12299-0
extern: '1'
external_id:
pmid:
- '8929965 '
intvolume: ' 204'
issue: 1-2
language:
- iso: eng
month: '02'
oa_version: None
page: 9 - 12
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4333'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7,
in ganglion neurons of the rat; with special reference to the presence in glutamatergic
ganglion neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 204
year: '1996'
...
---
_id: '2566'
abstract:
- lang: eng
text: The present study indicated presynaptic localization of a metabotropic glutamate
receptor, mGluR8, in projection neurons of the main olfactory bulb of rat. An
antibody was produced by using a peptide corresponding to C-terminal 23 amino
acids of mouse mGluR8. It was confirmed that the C-terminal 23 amino acids of
rat mGluR8 were the same as those of mouse mGluR8 except for one, and that the
antibody specifically recognized mGluR8 in the rat rhinencephalon. In layer Ia
of the piriform cortex (a target area of projection fibers from the main olfactory
bulb), mGluR8-like immunoreactivity (mGluR8-LI) was reduced after transection
of the lateral olfactory tract, and mGluR8-LI was observed in axon terminals which
were filled with round synaptic vesicles and made asymmetric synapses with dendritic
spines.
acknowledgement: 'We are grateful to Mr. Akira Uesugi for photographic help, and to
Dr. Toshikazu Fukui, Dainippon Pharmaceutical Co. Ltd. [k)r technical assistance. '
article_processing_charge: No
article_type: original
author:
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Kinoshita A, Ohishi H, Neki A, et al. Presynaptic localization of a metabotropic
glutamate receptor, mGluR8, in the rhinencephalic areas: A light and electron
microscope study in the rat. Neuroscience Letters. 1996;207(1):61-64. doi:10.1016/0304-3940(96)12489-7'
apa: 'Kinoshita, A., Ohishi, H., Neki, A., Nomura, S., Shigemoto, R., Takada, M.,
… Mizuno, N. (1996). Presynaptic localization of a metabotropic glutamate receptor,
mGluR8, in the rhinencephalic areas: A light and electron microscope study in
the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12489-7'
chicago: 'Kinoshita, Ayae, Hitoshi Ohishi, Akio Neki, Sakashi Nomura, Ryuichi Shigemoto,
Masahiko Takada, Shigetada Nakanishi, and Noboru Mizuno. “Presynaptic Localization
of a Metabotropic Glutamate Receptor, MGluR8, in the Rhinencephalic Areas: A Light
and Electron Microscope Study in the Rat.” Neuroscience Letters. Elsevier,
1996. https://doi.org/10.1016/0304-3940(96)12489-7.'
ieee: 'A. Kinoshita et al., “Presynaptic localization of a metabotropic glutamate
receptor, mGluR8, in the rhinencephalic areas: A light and electron microscope
study in the rat,” Neuroscience Letters, vol. 207, no. 1. Elsevier, pp.
61–64, 1996.'
ista: 'Kinoshita A, Ohishi H, Neki A, Nomura S, Shigemoto R, Takada M, Nakanishi
S, Mizuno N. 1996. Presynaptic localization of a metabotropic glutamate receptor,
mGluR8, in the rhinencephalic areas: A light and electron microscope study in
the rat. Neuroscience Letters. 207(1), 61–64.'
mla: 'Kinoshita, Ayae, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR8, in the Rhinencephalic Areas: A Light and Electron Microscope
Study in the Rat.” Neuroscience Letters, vol. 207, no. 1, Elsevier, 1996,
pp. 61–64, doi:10.1016/0304-3940(96)12489-7.'
short: A. Kinoshita, H. Ohishi, A. Neki, S. Nomura, R. Shigemoto, M. Takada, S.
Nakanishi, N. Mizuno, Neuroscience Letters 207 (1996) 61–64.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-03-22T00:00:00Z
date_updated: 2022-08-12T09:24:06Z
day: '22'
doi: 10.1016/0304-3940(96)12489-7
extern: '1'
external_id:
pmid:
- '8710211 '
intvolume: ' 207'
issue: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 61 - 64
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4332'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in
the rhinencephalic areas: A light and electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 207
year: '1996'
...
---
_id: '2568'
abstract:
- lang: eng
text: Localization of a metabotropic glutamate receptor, mGluR4a, was immunohistochemically
examined in the rat cerebellum with an antibody, which was produced by using a
synthetic peptide corresponding to a C-terminal sequence of rat mGluR4a. Marked
mGluR4a-like immunoreactivity (mGluRLta-LI) was seen in neuropil of the molecular
layer of the cerebellar cortex. Electron microscopically, mGluR4a-LI was observed
in many axon terminals in the molecular layer. These axon terminals showing mGluR4a-LI
were filled with round synaptic vesicles and were in asymmetric synaptic contacts
most frequently with dendritic spines. The results indicate that mGluR4a are located
presynaptically in the parallel fibers arising from the granule cells in the cerebellar
cortex.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Kinoshita A, Ohishi H, Nomura S, Shigemoto R, Nakanishi S, Mizuno N. Presynaptic
localization of a metabotropic glutamate receptor, mGluR4a, in the cerebellar
cortex: A light and electron microscope study in the rat. Neuroscience Letters.
1996;207(3):199-202. doi:10.1016/0304-3940(96)12519-2'
apa: 'Kinoshita, A., Ohishi, H., Nomura, S., Shigemoto, R., Nakanishi, S., &
Mizuno, N. (1996). Presynaptic localization of a metabotropic glutamate receptor,
mGluR4a, in the cerebellar cortex: A light and electron microscope study in the
rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12519-2'
chicago: 'Kinoshita, Ayae, Hitoshi Ohishi, Sakashi Nomura, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR4a, in the Cerebellar Cortex: A Light and Electron Microscope Study
in the Rat.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(96)12519-2.'
ieee: 'A. Kinoshita, H. Ohishi, S. Nomura, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the
cerebellar cortex: A light and electron microscope study in the rat,” Neuroscience
Letters, vol. 207, no. 3. Elsevier, pp. 199–202, 1996.'
ista: 'Kinoshita A, Ohishi H, Nomura S, Shigemoto R, Nakanishi S, Mizuno N. 1996.
Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the
cerebellar cortex: A light and electron microscope study in the rat. Neuroscience
Letters. 207(3), 199–202.'
mla: 'Kinoshita, Ayae, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR4a, in the Cerebellar Cortex: A Light and Electron Microscope Study
in the Rat.” Neuroscience Letters, vol. 207, no. 3, Elsevier, 1996, pp.
199–202, doi:10.1016/0304-3940(96)12519-2.'
short: A. Kinoshita, H. Ohishi, S. Nomura, R. Shigemoto, S. Nakanishi, N. Mizuno,
Neuroscience Letters 207 (1996) 199–202.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-04-05T00:00:00Z
date_updated: 2022-08-12T09:06:18Z
day: '05'
doi: 10.1016/0304-3940(96)12519-2
extern: '1'
external_id:
pmid:
- '8728484'
intvolume: ' 207'
issue: '3'
language:
- iso: eng
month: '04'
oa_version: None
page: 199 - 202
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4331'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in
the cerebellar cortex: A light and electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 207
year: '1996'
...
---
_id: '2569'
abstract:
- lang: eng
text: Morphological substrates for interactions between γ-aminobutyric acid (GABA)
and substance P upon neurons expressing substance Preceptor (SPR) in the nucleus
of the solitary tract (NST) were investigated by immunocytochemical electron microscopy.
In the NST of the rat, many GABA-like immunoreactive axon terminals were in symmetric
synaptic contacts with dendritic profiles; they were observed on nearly a half
of the SPR-like immunoreactive dendritic profiles in the medial part of the caudal
half of the NST.
acknowledgement: 'The authors thank Prof. Hui-Min Li for his critical reading of the
manuscript and his excellent suggestions. We are also grateful to Ms. Miao-Li Zhang
for her assistance in the electron microscopic technique and photography and to
Mr. Akira Uesugi for photographic help. This work was supported in part by the Grant
(39370240) from the National Natural Science Foundation of China. '
article_processing_charge: No
article_type: original
author:
- first_name: Hong
full_name: Jia, Hong
last_name: Jia
- first_name: Bai
full_name: Wang, Bai
last_name: Wang
- first_name: Zhi
full_name: Rao, Zhi
last_name: Rao
- first_name: Ji
full_name: Shi, Ji
last_name: Shi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Jia H, Wang B, Rao Z, et al. GABAergic synapses upon neurons expressing substance
P receptors in the nucleus of the solitary tract: An immunocytochemical electron
microscope study in the rat. Neuroscience Letters. 1996;210(1):49-52. doi:10.1016/0304-3940(96)12654-9'
apa: 'Jia, H., Wang, B., Rao, Z., Shi, J., Shigemoto, R., Kaneko, T., & Mizuno,
N. (1996). GABAergic synapses upon neurons expressing substance P receptors in
the nucleus of the solitary tract: An immunocytochemical electron microscope study
in the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12654-9'
chicago: 'Jia, Hong, Bai Wang, Zhi Rao, Ji Shi, Ryuichi Shigemoto, Takeshi Kaneko,
and Noboru Mizuno. “GABAergic Synapses upon Neurons Expressing Substance P Receptors
in the Nucleus of the Solitary Tract: An Immunocytochemical Electron Microscope
Study in the Rat.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(96)12654-9.'
ieee: 'H. Jia et al., “GABAergic synapses upon neurons expressing substance
P receptors in the nucleus of the solitary tract: An immunocytochemical electron
microscope study in the rat,” Neuroscience Letters, vol. 210, no. 1. Elsevier,
pp. 49–52, 1996.'
ista: 'Jia H, Wang B, Rao Z, Shi J, Shigemoto R, Kaneko T, Mizuno N. 1996. GABAergic
synapses upon neurons expressing substance P receptors in the nucleus of the solitary
tract: An immunocytochemical electron microscope study in the rat. Neuroscience
Letters. 210(1), 49–52.'
mla: 'Jia, Hong, et al. “GABAergic Synapses upon Neurons Expressing Substance P
Receptors in the Nucleus of the Solitary Tract: An Immunocytochemical Electron
Microscope Study in the Rat.” Neuroscience Letters, vol. 210, no. 1, Elsevier,
1996, pp. 49–52, doi:10.1016/0304-3940(96)12654-9.'
short: H. Jia, B. Wang, Z. Rao, J. Shi, R. Shigemoto, T. Kaneko, N. Mizuno, Neuroscience
Letters 210 (1996) 49–52.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-05-24T00:00:00Z
date_updated: 2022-08-12T08:18:55Z
day: '24'
doi: 10.1016/0304-3940(96)12654-9
extern: '1'
external_id:
pmid:
- '8762189'
intvolume: ' 210'
issue: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 49 - 52
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4329'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'GABAergic synapses upon neurons expressing substance P receptors in the nucleus
of the solitary tract: An immunocytochemical electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 210
year: '1996'
...
---
_id: '2560'
abstract:
- lang: eng
text: Chemical irritation of the urinary bladder with formalin in the rat induced
c-fos protein-like immunoreactivity in more than 80% of substance P receptor-like
immunoreactive (SPR-LI) neurons of the dorsal commissural nucleus, sacral parasympathetic
nucleus and lamina I in the 6th lumbar and 1st sacral cord segments. These neurons
with SPR-LI may receive noxious information from the urinary bladder through the
primary afferent fibers with substance P.
article_processing_charge: No
article_type: original
author:
- first_name: Yan
full_name: Lü, Yan
last_name: Lü
- first_name: Shan
full_name: Jin, Shan
last_name: Jin
- first_name: Tian
full_name: Xu, Tian
last_name: Xu
- first_name: Bing
full_name: Qin, Bing
last_name: Qin
- first_name: Ji
full_name: Li, Ji
last_name: Li
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Lü Y, Jin S, Xu T, et al. Expression of c-fos protein in substance P receptor-like
immunoreactive neurons in response to noxious stimuli on the urinary bladder:
an observation in the lumbosacral cord segments of the rat. Neuroscience Letters.
1995;198(2):139-142. doi:10.1016/0304-3940(95)11991-5'
apa: 'Lü, Y., Jin, S., Xu, T., Qin, B., Li, J., Ding, Y., … Mizuno, N. (1995). Expression
of c-fos protein in substance P receptor-like immunoreactive neurons in response
to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord
segments of the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)11991-5'
chicago: 'Lü, Yan, Shan Jin, Tian Xu, Bing Qin, Ji Li, Yu Ding, Ryuichi Shigemoto,
and Noboru Mizuno. “Expression of C-Fos Protein in Substance P Receptor-like Immunoreactive
Neurons in Response to Noxious Stimuli on the Urinary Bladder: An Observation
in the Lumbosacral Cord Segments of the Rat.” Neuroscience Letters. Elsevier,
1995. https://doi.org/10.1016/0304-3940(95)11991-5.'
ieee: 'Y. Lü et al., “Expression of c-fos protein in substance P receptor-like
immunoreactive neurons in response to noxious stimuli on the urinary bladder:
an observation in the lumbosacral cord segments of the rat,” Neuroscience Letters,
vol. 198, no. 2. Elsevier, pp. 139–142, 1995.'
ista: 'Lü Y, Jin S, Xu T, Qin B, Li J, Ding Y, Shigemoto R, Mizuno N. 1995. Expression
of c-fos protein in substance P receptor-like immunoreactive neurons in response
to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord
segments of the rat. Neuroscience Letters. 198(2), 139–142.'
mla: 'Lü, Yan, et al. “Expression of C-Fos Protein in Substance P Receptor-like
Immunoreactive Neurons in Response to Noxious Stimuli on the Urinary Bladder:
An Observation in the Lumbosacral Cord Segments of the Rat.” Neuroscience Letters,
vol. 198, no. 2, Elsevier, 1995, pp. 139–42, doi:10.1016/0304-3940(95)11991-5.'
short: Y. Lü, S. Jin, T. Xu, B. Qin, J. Li, Y. Ding, R. Shigemoto, N. Mizuno, Neuroscience
Letters 198 (1995) 139–142.
date_created: 2018-12-11T11:58:23Z
date_published: 1995-09-29T00:00:00Z
date_updated: 2022-06-28T12:54:14Z
day: '29'
doi: 10.1016/0304-3940(95)11991-5
extern: '1'
external_id:
pmid:
- '8592640'
intvolume: ' 198'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394095119915?via%3Dihub
month: '09'
oa_version: None
page: 139 - 142
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4338'
quality_controlled: '1'
status: public
title: 'Expression of c-fos protein in substance P receptor-like immunoreactive neurons
in response to noxious stimuli on the urinary bladder: an observation in the lumbosacral
cord segments of the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 198
year: '1995'
...
---
_id: '2561'
abstract:
- lang: eng
text: An antibody which recognizes specifically a metabotropic glutamate receptor,
mGluR7, was produced by using a trpE fusion protein containing a C-terminal sequence
of rat mGluR7. Neuropil in laminae I and II of the dorsal horn of the rat, as
well as many neuronal cell bodies in the dorsal root ganglion, showed mGluR7-like
immunoreactivity; the immunoreactivity in neuropil was seen in axon terminals,
which were filled with round synaptic vesicles and constituted axodendritic and
axosomatic asymmetric synapses. The mGluR7-like immunoreactivity in laminae I
and II in the dorsal horn was reduced after dorsal rhizotomy. The results indicate
that some axon terminals of the primary afferent fibers to laminae I and II of
the dorsal horn are provided with mGluR7.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Ohishi H, Nomura S, Ding Y, et al. Presynaptic localization of a metabotropic
glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical
study in the rat. Neuroscience Letters. 1995;202(1-2):85-88. doi:10.1016/0304-3940(95)12207-9'
apa: 'Ohishi, H., Nomura, S., Ding, Y., Shigemoto, R., Wada, E., Kinoshita, A.,
… Mizuno, N. (1995). Presynaptic localization of a metabotropic glutamate receptor,
mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat.
Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12207-9'
chicago: 'Ohishi, Hitoshi, Sakashi Nomura, Yu Ding, Ryuichi Shigemoto, Eiki Wada,
Ayae Kinoshita, Jin Li, Akio Neki, Shigetada Nakanishi, and Noboru Mizuno. “Presynaptic
Localization of a Metabotropic Glutamate Receptor, MGluR7, in the Primary Afferent
Neurons: An Immunohistochemical Study in the Rat.” Neuroscience Letters.
Elsevier, 1995. https://doi.org/10.1016/0304-3940(95)12207-9.'
ieee: 'H. Ohishi et al., “Presynaptic localization of a metabotropic glutamate
receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study
in the rat,” Neuroscience Letters, vol. 202, no. 1–2. Elsevier, pp. 85–88,
1995.'
ista: 'Ohishi H, Nomura S, Ding Y, Shigemoto R, Wada E, Kinoshita A, Li J, Neki
A, Nakanishi S, Mizuno N. 1995. Presynaptic localization of a metabotropic glutamate
receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study
in the rat. Neuroscience Letters. 202(1–2), 85–88.'
mla: 'Ohishi, Hitoshi, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR7, in the Primary Afferent Neurons: An Immunohistochemical Study
in the Rat.” Neuroscience Letters, vol. 202, no. 1–2, Elsevier, 1995, pp.
85–88, doi:10.1016/0304-3940(95)12207-9.'
short: H. Ohishi, S. Nomura, Y. Ding, R. Shigemoto, E. Wada, A. Kinoshita, J. Li,
A. Neki, S. Nakanishi, N. Mizuno, Neuroscience Letters 202 (1995) 85–88.
date_created: 2018-12-11T11:58:24Z
date_published: 1995-12-01T00:00:00Z
date_updated: 2022-06-28T12:44:57Z
day: '01'
doi: 10.1016/0304-3940(95)12207-9
extern: '1'
external_id:
pmid:
- '8787837'
intvolume: ' 202'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394095122079?via%3Dihub
month: '12'
oa_version: None
page: 85 - 88
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4337'
quality_controlled: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in
the primary afferent neurons: An immunohistochemical study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 202
year: '1995'
...
---
_id: '2551'
abstract:
- lang: eng
text: Expression patterns of mRNAs of l-AP4-sensitive metabotropic glutamate receptors
(mGluR4, mGluR6, mGluR7) in the rat retina were examined by northern blot analysis
and in situ hybridization histochemistry. Expression patterns of mGluR4 and mGluR7
mRNAs were quite different from that of mGluR6 mRNA which was expressed at the
outer part of the inner nuclear layer. The mGluR4 mRNA was expressed on the cell
bodies of the ganglion cells, but not in the inner or outer nuclear layer. The
expression of mGluR7 mRNA was observed throughout the entire region of the inner
nuclear layer and on the cell bodies of the ganglion cells.
acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged.
This work has been supported by research grants from the Ministry of Education,
Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Akazawa C, Ohishi H, Nakajima Y, et al. Expression of mRNAs of l-AP4-sensitive
metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience
Letters. 1994;171(1-2):52-54. doi:10.1016/0304-3940(94)90602-5
apa: Akazawa, C., Ohishi, H., Nakajima, Y., Okamoto, N., Shigemoto, R., Nakanishi,
S., & Mizuno, N. (1994). Expression of mRNAs of l-AP4-sensitive metabotropic
glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/0304-3940(94)90602-5
chicago: Akazawa, Chihiro, Hitoshi Ohishi, Yoshiaki Nakajima, Naoyuki Okamoto, Ryuichi
Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Expression of MRNAs of L-AP4-Sensitive
Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.”
Neuroscience Letters. Elsevier, 1994. https://doi.org/10.1016/0304-3940(94)90602-5.
ieee: C. Akazawa et al., “Expression of mRNAs of l-AP4-sensitive metabotropic
glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina,” Neuroscience
Letters, vol. 171, no. 1–2. Elsevier, pp. 52–54, 1994.
ista: Akazawa C, Ohishi H, Nakajima Y, Okamoto N, Shigemoto R, Nakanishi S, Mizuno
N. 1994. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors
(mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience Letters. 171(1–2), 52–54.
mla: Akazawa, Chihiro, et al. “Expression of MRNAs of L-AP4-Sensitive Metabotropic
Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” Neuroscience
Letters, vol. 171, no. 1–2, Elsevier, 1994, pp. 52–54, doi:10.1016/0304-3940(94)90602-5.
short: C. Akazawa, H. Ohishi, Y. Nakajima, N. Okamoto, R. Shigemoto, S. Nakanishi,
N. Mizuno, Neuroscience Letters 171 (1994) 52–54.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-04-25T00:00:00Z
date_updated: 2022-06-08T14:02:11Z
day: '25'
doi: 10.1016/0304-3940(94)90602-5
extern: '1'
external_id:
pmid:
- '8084499'
intvolume: ' 171'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394094906025?via%3Dihub
month: '04'
oa_version: None
page: 52 - 54
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4346'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4,
mGluR6, mGluR7) in the rat retina
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 171
year: '1994'
...
---
_id: '2552'
abstract:
- lang: eng
text: The superficial layers of the superior colliculus (SC) have been known to
contain many axons showing substance P-like immunoreactivity (SP-LI). We, therefore,
immunohistochemically examined the distribution of SP receptor (SPR) in the superficial
layers of the SC in the rat by using a specific antibody against SPR. The majority
of SC neurons with SPR-LI were distributed in the zonal and the superficial gray
layers, the rest of them were in the optic layer. Electron microscopy revealed
that SPR-immunoreaction products in SC neurons were distributed not only in postsynaptic
sites, but also in non-synaptic regions of perikaryal and dendritic profiles.
acknowledgement: The authors are grateful for photographic help of Mr. Akira Uesugi.
article_processing_charge: No
article_type: original
author:
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kazuo
full_name: Itoh, Kazuo
last_name: Itoh
- first_name: Akira
full_name: Konishi, Akira
last_name: Konishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat. Neuroscience Letters. 1994;166(2):135-138.
doi:10.1016/0304-3940(94)90469-3
apa: Ogawa Meguro, R., Shigemoto, R., Itoh, K., Konishi, A., & Mizuno, N. (1994).
Immunohistochemical localization of substance P receptor in the superior colliculus.
A light and electron microscope study in the rat. Neuroscience Letters.
Elsevier. https://doi.org/10.1016/0304-3940(94)90469-3
chicago: Ogawa Meguro, Reiko, Ryuichi Shigemoto, Kazuo Itoh, Akira Konishi, and
Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the
Superior Colliculus. A Light and Electron Microscope Study in the Rat.” Neuroscience
Letters. Elsevier, 1994. https://doi.org/10.1016/0304-3940(94)90469-3.
ieee: R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, and N. Mizuno, “Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat,” Neuroscience Letters, vol. 166, no. 2. Elsevier,
pp. 135–138, 1994.
ista: Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. 1994. Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat. Neuroscience Letters. 166(2), 135–138.
mla: Ogawa Meguro, Reiko, et al. “Immunohistochemical Localization of Substance
P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in
the Rat.” Neuroscience Letters, vol. 166, no. 2, Elsevier, 1994, pp. 135–38,
doi:10.1016/0304-3940(94)90469-3.
short: R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, N. Mizuno, Neuroscience
Letters 166 (1994) 135–138.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-01-31T00:00:00Z
date_updated: 2022-06-08T14:37:30Z
day: '31'
doi: 10.1016/0304-3940(94)90469-3
extern: '1'
external_id:
pmid:
- '8177489'
intvolume: ' 166'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394094904693?via%3Dihub
month: '01'
oa_version: None
page: 135 - 138
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4347'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of substance P receptor in the superior colliculus.
A light and electron microscope study in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 166
year: '1994'
...
---
_id: '2541'
abstract:
- lang: eng
text: A trp E fusion protein containing a C-terminal portion of the rat substance
P receptor (SPR) was expressed in bacteria and used to produce an antibody. The
antibody specifically reacted with SPR expressed in a mammalian cell line and
rat striatum. Light and electron microscope analyses of the rat striatum revealed
intense SPR-like immunoreactivity in neuronal somata and dendrites. These immunoreactive
neurons constituted ∼ 3% of the total population of striatal neurons; they were
putative interneurons of large and medium-sized aspiny types.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshifumi
full_name: Nakaya, Yoshifumi
last_name: Nakaya
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Nakaya Y, Nomura S, et al. Immunocytochemical localization of
rat substance P receptor in the striatum. Neuroscience Letters. 1993;153(2):157-160.
doi:10.1016/0304-3940(93)90311-8
apa: Shigemoto, R., Nakaya, Y., Nomura, S., Ogawa Meguro, R., Ohishi, H., Kaneko,
T., … Mizuno, N. (1993). Immunocytochemical localization of rat substance P receptor
in the striatum. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(93)90311-8
chicago: Shigemoto, Ryuichi, Yoshifumi Nakaya, Sakashi Nomura, Reiko Ogawa Meguro,
Hitoshi Ohishi, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunocytochemical
Localization of Rat Substance P Receptor in the Striatum.” Neuroscience Letters.
Elsevier, 1993. https://doi.org/10.1016/0304-3940(93)90311-8.
ieee: R. Shigemoto et al., “Immunocytochemical localization of rat substance
P receptor in the striatum,” Neuroscience Letters, vol. 153, no. 2. Elsevier,
pp. 157–160, 1993.
ista: Shigemoto R, Nakaya Y, Nomura S, Ogawa Meguro R, Ohishi H, Kaneko T, Nakanishi
S, Mizuno N. 1993. Immunocytochemical localization of rat substance P receptor
in the striatum. Neuroscience Letters. 153(2), 157–160.
mla: Shigemoto, Ryuichi, et al. “Immunocytochemical Localization of Rat Substance
P Receptor in the Striatum.” Neuroscience Letters, vol. 153, no. 2, Elsevier,
1993, pp. 157–60, doi:10.1016/0304-3940(93)90311-8.
short: R. Shigemoto, Y. Nakaya, S. Nomura, R. Ogawa Meguro, H. Ohishi, T. Kaneko,
S. Nakanishi, N. Mizuno, Neuroscience Letters 153 (1993) 157–160.
date_created: 2018-12-11T11:58:17Z
date_published: 1993-04-30T00:00:00Z
date_updated: 2022-03-31T12:10:05Z
day: '30'
doi: 10.1016/0304-3940(93)90311-8
extern: '1'
external_id:
pmid:
- '8392153 '
intvolume: ' 153'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394093903118?via%3Dihub
month: '04'
oa_version: None
page: 157 - 160
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4357'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunocytochemical localization of rat substance P receptor in the striatum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 153
year: '1993'
...
---
_id: '2542'
abstract:
- lang: eng
text: A trpE-fusion protein containing a C-terminal sequence of a rat metabotropic
glutamate receptor, mGluR5, was used to produce an antibody. On immunoblot, the
antibody specifically reacted with mGluR5 expressed in mammalian cells and rat
brain. Immunohistochemical analysis revealed intense mGluR5-like immunoreactivity
(LI) in the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, cerebral
cortex, hippocampus, lateral septum, striatum, nucleus accumbens, inferior colliculus,
and spinal trigeminal nuclei. The distribution pattern of mGluR5-LI corresponds
very well with that of mGluR5 mRNA. Electron microscope analysis of the striatum
revealed dense accumulation of immunoreaction products in dendrites which were
often provided with asymmetrical synapses. These results suggest that mGluR5 is
predominantly located in postsynaptic elements.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. Immunohistochemical
localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neuroscience
Letters. 1993;163(1):53-57. doi:10.1016/0304-3940(93)90227-C
apa: Shigemoto, R., Nomura, S., Ohishi, H., Sugihara, H., Nakanishi, S., & Mizuno,
N. (1993). Immunohistochemical localization of a metabotropic glutamate receptor,
mGluR5, in the rat brain. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(93)90227-C
chicago: Shigemoto, Ryuichi, Sakashi Nomura, Hitoshi Ohishi, Hidemitsu Sugihara,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of a
Metabotropic Glutamate Receptor, MGluR5, in the Rat Brain.” Neuroscience Letters.
Elsevier, 1993. https://doi.org/10.1016/0304-3940(93)90227-C.
ieee: R. Shigemoto, S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi, and N. Mizuno,
“Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5,
in the rat brain,” Neuroscience Letters, vol. 163, no. 1. Elsevier, pp.
53–57, 1993.
ista: Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. 1993.
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5,
in the rat brain. Neuroscience Letters. 163(1), 53–57.
mla: Shigemoto, Ryuichi, et al. “Immunohistochemical Localization of a Metabotropic
Glutamate Receptor, MGluR5, in the Rat Brain.” Neuroscience Letters, vol.
163, no. 1, Elsevier, 1993, pp. 53–57, doi:10.1016/0304-3940(93)90227-C.
short: R. Shigemoto, S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi, N. Mizuno,
Neuroscience Letters 163 (1993) 53–57.
date_created: 2018-12-11T11:58:17Z
date_published: 1993-11-26T00:00:00Z
date_updated: 2022-03-31T10:21:52Z
day: '26'
doi: 10.1016/0304-3940(93)90227-C
extern: '1'
external_id:
pmid:
- '8295733'
intvolume: ' 163'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030439409390227C?via%3Dihub
month: '11'
oa_version: None
page: 53 - 57
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4356'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5,
in the rat brain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 163
year: '1993'
...
---
_id: '2531'
abstract:
- lang: eng
text: The distribution of NMDA receptor (NMDAR1) on neurons in the peripheral ganglia
was examined in the adult rat by in situ hybridization. NMDAR1 mRNA was expressed
in all neurons in the sensory and autonomic ganglia examined; in the dorsal root,
trigeminal, nodose, superior cervical, and sphenopalatine ganglia. Possible roles
of the NMDA receptor on the sensory and autonomic ganglion neurons are discussed.
acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged.
This work has been supported by research grants from the Ministry of Education,
Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. Expression of the mRNA for the
rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience
Letters. 1992;144(1-2):229-232. doi:10.1016/0304-3940(92)90756-W
apa: Shigemoto, R., Ohishi, H., Nakanishi, S., & Mizuno, N. (1992). Expression
of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion
neurons. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(92)90756-W
chicago: Shigemoto, Ryuichi, Hitoshi Ohishi, Shigetada Nakanishi, and Noboru Mizuno.
“Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and
Autonomic Ganglion Neurons.” Neuroscience Letters. Elsevier, 1992. https://doi.org/10.1016/0304-3940(92)90756-W.
ieee: R. Shigemoto, H. Ohishi, S. Nakanishi, and N. Mizuno, “Expression of the mRNA
for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons,”
Neuroscience Letters, vol. 144, no. 1–2. Elsevier, pp. 229–232, 1992.
ista: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. 1992. Expression of the mRNA
for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons.
Neuroscience Letters. 144(1–2), 229–232.
mla: Shigemoto, Ryuichi, et al. “Expression of the MRNA for the Rat NMDA Receptor
(NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” Neuroscience Letters,
vol. 144, no. 1–2, Elsevier, 1992, pp. 229–32, doi:10.1016/0304-3940(92)90756-W.
short: R. Shigemoto, H. Ohishi, S. Nakanishi, N. Mizuno, Neuroscience Letters 144
(1992) 229–232.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-09-14T00:00:00Z
date_updated: 2022-03-18T13:15:02Z
day: '14'
doi: 10.1016/0304-3940(92)90756-W
extern: '1'
external_id:
pmid:
- '1436707'
intvolume: ' 144'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030439409290756W
month: '09'
oa_version: None
page: 229 - 232
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4368'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and
autonomic ganglion neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 144
year: '1992'
...
---
_id: '2523'
abstract:
- lang: eng
text: Injection of large amounts of a mixture of horseradish peroxidase and wheat
germ agglutinin-horseradish peroxidase conjugate into the upper cervical segments
of the spinal cord in the Japanese monkey (Macaca fuscata) led to the retrograde
labeling of a small number of neuronal cell bodies within the rostral part of
the subthalamic nucleus of Luys. Direct projection from the subthalamic nucleus
to the spinal cord appeared to be much less prominent in the Japanese monkey than
in the cat and rat.
acknowledgement: The photographic help of Mr Akira Uesugi and Mr Kenichl Uesugi, and
the support of the Niwa Medical Research Foundation are gratefully acknowledged.
This work has also been supported in part by Grants-ln-Aid for General Scientific
Research Nos 59480095 and 62480098 from the Ministry of Education, Science and Culture
of Japan
article_processing_charge: No
article_type: original
author:
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Teizo
full_name: Ueyama, Teizo
last_name: Ueyama
- first_name: Kazuo
full_name: Itoh, Kazuo
last_name: Itoh
- first_name: Takahiro
full_name: Satoda, Takahiro
last_name: Satoda
- first_name: Takashi
full_name: Tashiro, Takashi
last_name: Tashiro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. Direct projections
from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey.
Neuroscience Letters. 1988;89(1):13-18. doi:10.1016/0304-3940(88)90473-9
apa: Mizuno, N., Ueyama, T., Itoh, K., Satoda, T., Tashiro, T., & Shigemoto,
R. (1988). Direct projections from the subthalamic nucleus of Luys to the spinal
cord in the Japanese monkey. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(88)90473-9
chicago: Mizuno, Noboru, Teizo Ueyama, Kazuo Itoh, Takahiro Satoda, Takashi Tashiro,
and Ryuichi Shigemoto. “Direct Projections from the Subthalamic Nucleus of Luys
to the Spinal Cord in the Japanese Monkey.” Neuroscience Letters. Elsevier,
1988. https://doi.org/10.1016/0304-3940(88)90473-9.
ieee: N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, and R. Shigemoto, “Direct
projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese
monkey,” Neuroscience Letters, vol. 89, no. 1. Elsevier, pp. 13–18, 1988.
ista: Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. 1988. Direct
projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese
monkey. Neuroscience Letters. 89(1), 13–18.
mla: Mizuno, Noboru, et al. “Direct Projections from the Subthalamic Nucleus of
Luys to the Spinal Cord in the Japanese Monkey.” Neuroscience Letters,
vol. 89, no. 1, Elsevier, 1988, pp. 13–18, doi:10.1016/0304-3940(88)90473-9.
short: N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, R. Shigemoto, Neuroscience
Letters 89 (1988) 13–18.
date_created: 2018-12-11T11:58:10Z
date_published: 1988-06-17T00:00:00Z
date_updated: 2022-02-08T15:20:07Z
day: '17'
doi: 10.1016/0304-3940(88)90473-9
extern: '1'
external_id:
pmid:
- '2456494'
intvolume: ' 89'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394088904739?via%3Dihub
month: '06'
oa_version: None
page: 13 - 18
pmid: 1
publication: Neuroscience Letters
publication_identifier:
eissn:
- 1872-7972
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4377'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Direct projections from the subthalamic nucleus of Luys to the spinal cord
in the Japanese monkey
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 89
year: '1988'
...