---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3488'
abstract:
- lang: eng
text: We have examined gating and pharmacological characteristics of somatic K+
channels in fast-spiking interneurons and regularly spiking principal neurons
of hippocampal slices. In nucleated patches isolated from basket cells of the
dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive
to tetraethylammonium (TEA) and 4-aminopyridine (4- AP) (half-maximal inhibitory
concentrations <0.1 mM) predominated, contributing an average of 58% to the
total K+ current in these cells. By contrast, in pyramidal neurons of the CA1
region a rapidly inactivating A- type K+ current component that was TEA-resistant
prevailed, contributing 61% to the total K+ current. Both types of neurons also
showed small amounts of the K+ current component mainly found in the other type
of neuron and, in addition, a slow delayed rectifier K+ current component with
intermediate properties (sow inactivation, intermediate sensitivity to TEA). Single-cell
RT-PCR analysis of mRNA revealed that Kv3 (Kv3.1, Kv3.2) subunit transcripts were
expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal
neurons. In contrast, Kv4 (Kv4.2, Kv4.3) subunit mRNAs were present in 87% of
pyramidal neurons but only in 55% of interneurons. Selective block of fast delayed
rectifier K+ channels, presumably assembled from Kv3 subunits, by 4-AP reduced
substantially the action potential frequency in interneurons. These results indicate
that the differential expression of Kv3 and Kv4 subunits shapes the action potential
phenotypes of principal neurons and interneurons in the cortex.
acknowledgement: Supported by German Israeli Foundation Grant I 0352–073.01/94 to
P.J. and Deutsche Forschungsgemeinschaft Grant Mo 432/3–1 to H.M. We thank Drs.
L. Y. Jan, D. McKinnon, O. Pongs, L. Salkoff, S. H. Snyder, and J. S. Trimmer for
providing plasmids, Dr. D. J. Surmeier for sharing unpublished data, and Drs. J.
Bischofberger and J. R. P. Geiger for critically reading this manuscript. M.M. and
J.H.S. contributed equally to this work.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Jobst
full_name: Schultz, Jobst
last_name: Schultz
- first_name: Heimo
full_name: Ehmke, Heimo
last_name: Ehmke
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. Functional and molecular
differences between voltage-gated K+ channels of fast-spiking interneurons and
pyramidal neurons of rat hippocampus. Journal of Neuroscience. 1998;18(20):8111-8125.
doi:10.1523/JNEUROSCI.18-20-08111.1998
apa: Martina, M., Schultz, J., Ehmke, H., Monyer, H., & Jonas, P. M. (1998).
Functional and molecular differences between voltage-gated K+ channels of fast-spiking
interneurons and pyramidal neurons of rat hippocampus. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998
chicago: Martina, Marco, Jobst Schultz, Heimo Ehmke, Hannah Monyer, and Peter M
Jonas. “Functional and Molecular Differences between Voltage-Gated K+ Channels
of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1998. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998.
ieee: M. Martina, J. Schultz, H. Ehmke, H. Monyer, and P. M. Jonas, “Functional
and molecular differences between voltage-gated K+ channels of fast-spiking interneurons
and pyramidal neurons of rat hippocampus,” Journal of Neuroscience, vol.
18, no. 20. Society for Neuroscience, pp. 8111–8125, 1998.
ista: Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. 1998. Functional and molecular
differences between voltage-gated K+ channels of fast-spiking interneurons and
pyramidal neurons of rat hippocampus. Journal of Neuroscience. 18(20), 8111–8125.
mla: Martina, Marco, et al. “Functional and Molecular Differences between Voltage-Gated
K+ Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.”
Journal of Neuroscience, vol. 18, no. 20, Society for Neuroscience, 1998,
pp. 8111–25, doi:10.1523/JNEUROSCI.18-20-08111.1998.
short: M. Martina, J. Schultz, H. Ehmke, H. Monyer, P.M. Jonas, Journal of Neuroscience
18 (1998) 8111–8125.
date_created: 2018-12-11T12:03:35Z
date_published: 1998-10-15T00:00:00Z
date_updated: 2022-08-29T14:20:39Z
day: '15'
doi: 10.1523/JNEUROSCI.18-20-08111.1998
extern: '1'
external_id:
pmid:
- '9763458'
intvolume: ' 18'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792860/
month: '10'
oa: 1
oa_version: None
page: 8111 - 8125
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional and molecular differences between voltage-gated K+ channels of fast-spiking
interneurons and pyramidal neurons of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '1998'
...
---
_id: '2582'
abstract:
- lang: eng
text: 'Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization
of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies
for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning
of the three major hippocampal pathways: the perforant path, mossy fiber, and
Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a,
mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic
elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to
postsynaptic elements. The medial perforant path was strongly immunoreactive for
mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path
was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The
messy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer
collateral was labeled only for mGluR7a. Electron microscopy further revealed
the spatial segregation of group II and group III mGluRs within presynaptic elements.
Immunolabeling for the group III receptors was predominantly observed in presynaptic
active zones of asymmetrical and symmetrical synapses, whereas that for the group
II receptor (mGluR2) was found in preterminal rather than terminal portions of
axons. Target cell-specific segregation of receptors, first reported for mGluR7a
(Shigemoto et al., 1996), was also apparent for the other group III mGluRs, suggesting
that transmitter release is differentially regulated by 2-amino- 4-phosphonobutyrate-sensitive
mGluRs in individual synapses on single axons according to the identity of postsynaptic
neurons.'
acknowledgement: This work was supported by research grants from the Inamori Foundation
and the Ministry of Education, Science, Sports and Culture of Japan. We thank Peter
Somogyi for helpful discussion, David Roberts for technical assistance, and Akira
Uesugi for photographic assistance. We are grateful to Atsu Aiba, David Hampson,
John Roder, and Herman van der Putten for providing us with mGluR1-, mGluR4-, mGluR5-,
and mGluR7-deficient mice, respectively, and to Corrado Corti and Francesco Ferraguti
for sharing rat mGluR8 cDNA and unpublished results.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization
of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal
of Neuroscience. 1997;17(19):7503-7522. doi:10.1523/JNEUROSCI.17-19-07503.1997
apa: Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M.,
… Mizuno, N. (1997). Differential presynaptic localization of metabotropic glutamate
receptor subtypes in the rat hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
chicago: Shigemoto, Ryuichi, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi
Ohishi, Masahiko Takada, Peter Flor, et al. “Differential Presynaptic Localization
of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997.
ieee: R. Shigemoto et al., “Differential presynaptic localization of metabotropic
glutamate receptor subtypes in the rat hippocampus,” Journal of Neuroscience,
vol. 17, no. 19. Society for Neuroscience, pp. 7503–7522, 1997.
ista: Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor P, Neki
A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of
metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience.
17(19), 7503–7522.
mla: Shigemoto, Ryuichi, et al. “Differential Presynaptic Localization of Metabotropic
Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal of Neuroscience,
vol. 17, no. 19, Society for Neuroscience, 1997, pp. 7503–22, doi:10.1523/JNEUROSCI.17-19-07503.1997.
short: R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P.
Flor, A. Neki, T. Abe, S. Nakanishi, N. Mizuno, Journal of Neuroscience 17 (1997)
7503–7522.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T11:32:01Z
day: '01'
doi: 10.1523/JNEUROSCI.17-19-07503.1997
extern: '1'
external_id:
pmid:
- '9295396'
intvolume: ' 17'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573434/
month: '10'
oa: 1
oa_version: Published Version
page: 7503 - 7522
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential presynaptic localization of metabotropic glutamate receptor subtypes
in the rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3482'
abstract:
- lang: eng
text: AMPA- and NMDA-type glutamate receptors (AMPARs and NMDARs) mediate excitatory
synoptic transmission in the basal ganglia and may contribute to excitotoxic injury.
We investigated the functional properties of AMPARs and NMDARs expressed by six
main types of basal ganglia neurons in acute rat brain slices (principal neurons
and cholinergic interneurons of striatum, GABAergic and dopaminergic neurons of
substantia nigra, globus pallidus neurons, and subthalamic nucleus neurons) using
fast application of glutamate to nucleated and outside-out membrane patches, AMPARs
in different types of basal ganglia neurons were functionally distinct. Those
expressed in striatal principal neurons exhibited the slowest gating (desensitization
time constant τ = 11.5 msec, 1 mM glutamate, 22°C), whereas those in striatal
cholinergic interneurons showed the fastest gating (desensitization time constant
τ = 3.6 msec). The lowest Ca2+ permeability of AMPARs was observed in nigral dopaminergic
neurons (P(CA)/P(NA) = 0.10), whereas the highest Ca2+ permeability was found
in subthalamic nucleus neurons (P(Ca)/P(Na) = 1.17). NMDARs of different types
of basal ganglia neurons were less variable in their functional properties; those
expressed in nigral dopaminergic neurons exhibited the slowest gating (deactivation
time constant of predominant fast component τ1 150 msec, 100 μM glutamate), and
those of globus pallidus neurons showed the fastest gating (τ1 = 67 msec). The
Mg2+ block of NMDARs was similar; the average chord conductance ratio g(+60mv)/g(+40mV)
was 0.18-0.22 in 100 μM external Mg2+. Hence, AMPARs expressed in different types
of basal ganglia neurons are markedly diverse, whereas NMDARs are less variable
in functional properties that are relevant for excitatory synoptic transmission
and neuronal vulnerability.
acknowledgement: "This work was supported by Deutsche Forschungsgemeinschaft Grant
BE1859 to T.B. and SFB505/C5 to P.J. We thank Mrs. B. Plessow-Freudenberg for help
with the immunocytochemistry, Dr. M. Ha¨usser for advice concerning the \r\n reparation
of midbrain slices, and Drs. J. Bischofberger, G. B. Landwehrmeyer, and M. Martina
for critically reading this manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Götz, Thomas
last_name: Götz
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
- first_name: Thomas
full_name: Berger, Thomas
last_name: Berger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Götz T, Kraushaar U, Geiger J, Lubke J, Berger T, Jonas PM. Functional properties
of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons.
Journal of Neuroscience. 1997;17(1):204-215. doi:10.1523/JNEUROSCI.17-01-00204.1997
apa: Götz, T., Kraushaar, U., Geiger, J., Lubke, J., Berger, T., & Jonas, P.
M. (1997). Functional properties of AMPA and NMDA receptors expressed in identified
types of basal ganglia neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997
chicago: Götz, Thomas, Udo Kraushaar, Jörg Geiger, Joachim Lubke, Thomas Berger,
and Peter M Jonas. “Functional Properties of AMPA and NMDA Receptors Expressed
in Identified Types of Basal Ganglia Neurons.” Journal of Neuroscience.
Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997.
ieee: T. Götz, U. Kraushaar, J. Geiger, J. Lubke, T. Berger, and P. M. Jonas, “Functional
properties of AMPA and NMDA receptors expressed in identified types of basal ganglia
neurons,” Journal of Neuroscience, vol. 17, no. 1. Society for Neuroscience,
pp. 204–215, 1997.
ista: Götz T, Kraushaar U, Geiger J, Lubke J, Berger T, Jonas PM. 1997. Functional
properties of AMPA and NMDA receptors expressed in identified types of basal ganglia
neurons. Journal of Neuroscience. 17(1), 204–215.
mla: Götz, Thomas, et al. “Functional Properties of AMPA and NMDA Receptors Expressed
in Identified Types of Basal Ganglia Neurons.” Journal of Neuroscience,
vol. 17, no. 1, Society for Neuroscience, 1997, pp. 204–15, doi:10.1523/JNEUROSCI.17-01-00204.1997.
short: T. Götz, U. Kraushaar, J. Geiger, J. Lubke, T. Berger, P.M. Jonas, Journal
of Neuroscience 17 (1997) 204–215.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-22T08:48:45Z
day: '01'
doi: 10.1523/JNEUROSCI.17-01-00204.1997
extern: '1'
external_id:
pmid:
- '8987749'
intvolume: ' 17'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793708/
month: '01'
oa: 1
oa_version: Published Version
page: 204 - 215
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2905'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional properties of AMPA and NMDA receptors expressed in identified types
of basal ganglia neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3483'
abstract:
- lang: eng
text: 'The main excitatory pathway of the hippocampal formation is controlled by
a network of morphologically distinct populations of GABAergic interneurons. Here
we describe a novel type of GABAergic interneuron located in the outer molecular
layer (OML) of the rat dentate gyrus with a long- range forward projection from
the dentate gyrus to the subiculum across the hippocampal fissure, OML interneurons
were recorded in hippocampal slices by using the whole-cell patch-clamp configuration.
During recording, cells were filled with biocytin for subsequent light and electron
microscopic analysis. Neurons projecting to the subiculum were distributed throughout
the entire OML. They had round or ovoid somata and a multipolar dendritic morphology.
Two axonal domains could be distinguished: an extensive, tangential distribution
within the OML and a long-range vertical and tangential projection to layer 1
and stratum pyramidale of the subiculum. Symmetric synaptic contacts were established
by these interneurons on dendritic shafts in the OML and subiculum. OML interneurons
were characterized physiologically by short action potential duration and marked
afterhyperpolarization that followed the spike. On sustained current injection,
they generated high- frequency (up to 130 Hz, 34°C) trains of action potentials
with only little adaptation. In situ hybridization and single-call RT-PCR analysis
for GAD67 mRNA confirmed the GABAergic nature of OML interneurons. GABAergic interneurons
in the OML projecting to the subiculum connect the input and output regions of
the hippocampus. Hence, they could mediate long-range feed- forward inhibition
and may participate in an oscillating cross-regional interneuron network that
may synchronize the activity of spatially distributed principal neurons in the
dentate gyrus and the subiculum.'
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (SFB
505/A3 and Leibniz program to M.F., SFB 505/C5 to P.J., and DFG 432/3 to H.M.) We
thank Drs. H. Scharfman, M. Häusser, and I. Vida for critically reading an earlier
version of this manuscript. We are also grateful to B. Joch, S. Nestel, M. Winter,
and U. Amtmann for excellent technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Katya
full_name: Ceranik, Katya
last_name: Ceranik
- first_name: Roland
full_name: Bender, Roland
last_name: Bender
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
citation:
ama: Ceranik K, Bender R, Geiger J, et al. A novel type of GABAergic interneuron
connecting the input and the output regions of the hippocampus. Journal of
Neuroscience. 1997;17(14):5380-5394. doi:10.1523/JNEUROSCI.17-14-05380.1997
apa: Ceranik, K., Bender, R., Geiger, J., Monyer, H., Jonas, P. M., Frotscher, M.,
& Lubke, J. (1997). A novel type of GABAergic interneuron connecting the input
and the output regions of the hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997
chicago: Ceranik, Katya, Roland Bender, Jörg Geiger, Hannah Monyer, Peter M Jonas,
Michael Frotscher, and Joachim Lubke. “A Novel Type of GABAergic Interneuron Connecting
the Input and the Output Regions of the Hippocampus.” Journal of Neuroscience.
Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997.
ieee: K. Ceranik et al., “A novel type of GABAergic interneuron connecting
the input and the output regions of the hippocampus.,” Journal of Neuroscience,
vol. 17, no. 14. Society for Neuroscience, pp. 5380–5394, 1997.
ista: Ceranik K, Bender R, Geiger J, Monyer H, Jonas PM, Frotscher M, Lubke J. 1997.
A novel type of GABAergic interneuron connecting the input and the output regions
of the hippocampus. Journal of Neuroscience. 17(14), 5380–5394.
mla: Ceranik, Katya, et al. “A Novel Type of GABAergic Interneuron Connecting the
Input and the Output Regions of the Hippocampus.” Journal of Neuroscience,
vol. 17, no. 14, Society for Neuroscience, 1997, pp. 5380–94, doi:10.1523/JNEUROSCI.17-14-05380.1997.
short: K. Ceranik, R. Bender, J. Geiger, H. Monyer, P.M. Jonas, M. Frotscher, J.
Lubke, Journal of Neuroscience 17 (1997) 5380–5394.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-07-15T00:00:00Z
date_updated: 2022-08-22T08:18:54Z
day: '15'
doi: 10.1523/JNEUROSCI.17-14-05380.1997
extern: '1'
external_id:
pmid:
- '9204922'
intvolume: ' 17'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793821/
month: '07'
oa: 1
oa_version: Published Version
page: 5380 - 5394
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2904'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A novel type of GABAergic interneuron connecting the input and the output regions
of the hippocampus.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3476'
abstract:
- lang: eng
text: Tight-seal whole-cell recordings were made from cleaned somata of CA3 pyramidal
cells deep in hippocampal slices from 19–21-d-old rats. The cells were filled
with biocytin, and their voltage responses to short current pulses were recorded.
After washout of initial sag, responses scaled linearly with injected current
and were stable over time. The dendritic and axonal arbors of four cells were
reconstructed and measured using light microscopy. Dendritic spines and axonal
boutons were counted and the additional membrane area was incorporated into the
relevant segments. The morphology of each neuron was converted into a detailed
branching cable model by assuming values for specific membrane capacitance Cm
and resistance Rm, and cytoplasmic resistivity Ri. These parameters were optimized
for each cell by directly matching the model's response to that of the real cell
by means of a modified weighted least-squares fitting procedure. By comparing
the deviations between model and experimental responses to control noise recordings,
approximate 95% confidence intervals were established for each parameter. If a
somatic shunt was allowed, a wide range of possible Rm values produced acceptable
fits. With zero shunt, Cm was 0.7–0.8 microFcm-2, Ri was 170–340 omega cm, and
Rm ranged between 120 and 200 k omega cm2. The electrotonic lengths of the basal
and oblique dendrites were 0.2–0.3 space constants, and those of the apical tufts
were 0.4–0.7 space constants. The steady-state electrical geometry of these cells
was therefore compact; average dendritic tip/soma relative synaptic efficacies
were > 93% for the basal and oblique dendrites, and > 81% for the tufts.
With fast transient synaptic inputs, however, the models produced a wide range
of postsynaptic potential shapes and marked filtering of voltage-clamp currents.
acknowledgement: 'logy Training Fellowship. A.L. was supported by a Royal Society
Fellowship. The Oxford part of the collaboration was funded by a Wellcome Trust
Programme Grant, the Heidelberg part by the Max-Planck Gesellschaft. We are grateful
to Sir David Cox for his comments on the statistics, to K. Stratford, M. Hausser,
D. Flitney, M. O’Neill, S. Gough, G. Stuart, N. Spruston, P. Stem, and K. Bauer
for their help and useful discussions, and to M. Kaiser for technical assistance. '
article_processing_charge: No
article_type: original
author:
- first_name: Guy
full_name: Major, Guy
last_name: Major
- first_name: Alan
full_name: Larkman, Alan
last_name: Larkman
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Julian
full_name: Jack, Julian
last_name: Jack
citation:
ama: Major G, Larkman A, Jonas PM, Sakmann B, Jack J. Detailed passive cable models
of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. Journal
of Neuroscience. 1994;14(8):4613-4638. doi:10.1523/JNEUROSCI.14-08-04613.1994
apa: Major, G., Larkman, A., Jonas, P. M., Sakmann, B., & Jack, J. (1994). Detailed
passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal
slices. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.14-08-04613.1994
chicago: Major, Guy, Alan Larkman, Peter M Jonas, Bert Sakmann, and Julian Jack.
“Detailed Passive Cable Models of Whole-Cell Recorded CA3 Pyramidal Neurons in
Rat Hippocampal Slices.” Journal of Neuroscience. Society for Neuroscience,
1994. https://doi.org/10.1523/JNEUROSCI.14-08-04613.1994.
ieee: G. Major, A. Larkman, P. M. Jonas, B. Sakmann, and J. Jack, “Detailed passive
cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices,”
Journal of Neuroscience, vol. 14, no. 8. Society for Neuroscience, pp.
4613–4638, 1994.
ista: Major G, Larkman A, Jonas PM, Sakmann B, Jack J. 1994. Detailed passive cable
models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices.
Journal of Neuroscience. 14(8), 4613–4638.
mla: Major, Guy, et al. “Detailed Passive Cable Models of Whole-Cell Recorded CA3
Pyramidal Neurons in Rat Hippocampal Slices.” Journal of Neuroscience,
vol. 14, no. 8, Society for Neuroscience, 1994, pp. 4613–38, doi:10.1523/JNEUROSCI.14-08-04613.1994.
short: G. Major, A. Larkman, P.M. Jonas, B. Sakmann, J. Jack, Journal of Neuroscience
14 (1994) 4613–4638.
date_created: 2018-12-11T12:03:32Z
date_published: 1994-08-01T00:00:00Z
date_updated: 2022-06-03T09:36:43Z
day: '01'
doi: 10.1523/JNEUROSCI.14-08-04613.1994
extern: '1'
external_id:
pmid:
- '8046439 '
intvolume: ' 14'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://europepmc.org/article/med/8046439
month: '08'
oa: 1
oa_version: Published Version
page: 4613 - 4638
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2911'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons
in rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 14
year: '1994'
...
---
_id: '2537'
abstract:
- lang: eng
text: 'The metabotropic glutamate receptors are coupled to intracellular signal
transduction via G-proteins and consist of a family of at least five different
subtypes, termed mGluR1-mGluR5. We studied the signal transduction mechanism and
pharmacological characteristics of the rat mGluR3 and mGluR4 subtypes in Chinese
hamster ovary cells permanently expressing the cloned receptors. Both mGluR3 and
mGluR4 inhibit the forskolin-stimulated accumulation of intracellular cAMP formation
in response to agonist interaction. Consistent with the high degree of sequence
similarity to mGluR2, mGluR3 closely resembles mGluR2 in its agonist selectivity;
the potency rank order of agonists is L-glutamate > trans-1-aminocyclopentane-
1,3-dicarboxylate > ibotenate > quisqualate. mGluR4 is totally different
in its agonist specificity from any other member of the metabotropic receptors.
This receptor potently reacts with L-2-amino-4-phosphonobutyrate(L-AP4) in a stereo-selective
manner and moderately responds to L-serine-O-phosphate. mGluR4 thus corresponds
well to the putative L-AP4 receptor characterized from brain preparations. Blot
and in situ hybridization analyses indicated that both mRNAs are widely distributed
in the rat brain. mGluR3 mRNA is highly expressed in neuronal cells of the cerebral
cortex and the caudate- putamen, and in granule cells of the hippocampal dentate
gyrus. The expression pattern of mGluR4 mRNA is more restricted, and this expression
is prominent in the cerebellum, olfactory bulb, and thalamus. Furthermore, the
mGluR3 mRNA, unlike the other mRNAs for the metabotropic receptors, is highly
expressed in glial cells throughout the brain regions. The metabotropic glutamate
receptor subtypes can thus be classified into three subgroups according to the
similarity in their amino acid sequences, signal transduction, and agonist selectivity:
mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4. The mRNAs for the individual receptor
subtypes, however, show overlapping but distinct patterns of expression in the
rat CNS.'
acknowledgement: 'We are grateful to Mr. Akira Uesugi for photographic assistance.
This work was supported in part by research grants from the Ministry of Education,
Science and Culture of Japan, the Ministry of Health and Welfare of Japan, the Uehara
Memorial Foundation, and the Semi Life Science Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Yasuto
full_name: Tanabe, Yasuto
last_name: Tanabe
- first_name: Akinori
full_name: Nomura, Akinori
last_name: Nomura
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. Signal transduction,
pharmacological properties, and expression patterns of two rat metabotropic glutamate
receptors, mGluR3 and mGluR4. Journal of Neuroscience. 1993;13(4):1372-1378.
doi:10.1523/JNEUROSCI.13-04-01372.1993
apa: Tanabe, Y., Nomura, A., Masu, M., Shigemoto, R., Mizuno, N., & Nakanishi,
S. (1993). Signal transduction, pharmacological properties, and expression patterns
of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. Journal of
Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993
chicago: Tanabe, Yasuto, Akinori Nomura, Masayuki Masu, Ryuichi Shigemoto, Noboru
Mizuno, and Shigetada Nakanishi. “Signal Transduction, Pharmacological Properties,
and Expression Patterns of Two Rat Metabotropic Glutamate Receptors, MGluR3 and
MGluR4.” Journal of Neuroscience. Society for Neuroscience, 1993. https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993.
ieee: Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, and S. Nakanishi,
“Signal transduction, pharmacological properties, and expression patterns of two
rat metabotropic glutamate receptors, mGluR3 and mGluR4,” Journal of Neuroscience,
vol. 13, no. 4. Society for Neuroscience, pp. 1372–1378, 1993.
ista: Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. 1993. Signal
transduction, pharmacological properties, and expression patterns of two rat metabotropic
glutamate receptors, mGluR3 and mGluR4. Journal of Neuroscience. 13(4), 1372–1378.
mla: Tanabe, Yasuto, et al. “Signal Transduction, Pharmacological Properties, and
Expression Patterns of Two Rat Metabotropic Glutamate Receptors, MGluR3 and MGluR4.”
Journal of Neuroscience, vol. 13, no. 4, Society for Neuroscience, 1993,
pp. 1372–78, doi:10.1523/JNEUROSCI.13-04-01372.1993.
short: Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal
of Neuroscience 13 (1993) 1372–1378.
date_created: 2018-12-11T11:58:15Z
date_published: 1993-04-01T00:00:00Z
date_updated: 2022-03-31T14:49:42Z
day: '01'
doi: 10.1523/JNEUROSCI.13-04-01372.1993
extern: '1'
external_id:
pmid:
- '8463825'
intvolume: ' 13'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/8463825/
month: '04'
oa: 1
oa_version: Published Version
page: 1372 - 1378
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4361'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Signal transduction, pharmacological properties, and expression patterns of
two rat metabotropic glutamate receptors, mGluR3 and mGluR4
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1993'
...