---
_id: '4273'
abstract:
- lang: eng
  text: We review the various factors that limit adaptation by natural selection.
    Recent discussion of constraints on selection and, conversely, of the factors
    that enhance 'evolvability', have concentrated on the kinds of variation that
    can be produced. Here, we emphasise that adaptation depends on how the various
    evolutionary processes shape variation in populations. We survey the limits that
    population genetics places on adaptive evolution, and discuss the relationship
    between disparate literatures. BioEssays 22:1075-1084, 2000. (C) 2000 John Wiley
    and Sons, Inc.
acknowledgement: We thank Brian Charlesworth, Toby Johnson, and two anonymous referees
  for helpful discussions and criticism of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Linda
  full_name: Partridge, Linda
  last_name: Partridge
citation:
  ama: Barton NH, Partridge L. Limits to natural selection. <i>BioEssays</i>. 2000;22(12):1075-1084.
    doi:<a href="https://doi.org/10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M">10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M</a>
  apa: Barton, N. H., &#38; Partridge, L. (2000). Limits to natural selection. <i>BioEssays</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M">https://doi.org/10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M</a>
  chicago: Barton, Nicholas H, and Linda Partridge. “Limits to Natural Selection.”
    <i>BioEssays</i>. Wiley-Blackwell, 2000. <a href="https://doi.org/10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M">https://doi.org/10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M</a>.
  ieee: N. H. Barton and L. Partridge, “Limits to natural selection,” <i>BioEssays</i>,
    vol. 22, no. 12. Wiley-Blackwell, pp. 1075–1084, 2000.
  ista: Barton NH, Partridge L. 2000. Limits to natural selection. BioEssays. 22(12),
    1075–1084.
  mla: Barton, Nicholas H., and Linda Partridge. “Limits to Natural Selection.” <i>BioEssays</i>,
    vol. 22, no. 12, Wiley-Blackwell, 2000, pp. 1075–84, doi:<a href="https://doi.org/10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M">10.1002/1521-1878(200012)22:12&#38;lt;1075::AID-BIES5&#38;gt;3.0.CO;2-M</a>.
  short: N.H. Barton, L. Partridge, BioEssays 22 (2000) 1075–1084.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-04-19T09:49:52Z
day: '01'
doi: 10.1002/1521-1878(200012)22:12&lt;1075::AID-BIES5&gt;3.0.CO;2-M
extern: '1'
external_id:
  pmid:
  - '11084623'
intvolume: '        22'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 1075 - 1084
pmid: 1
publication: BioEssays
publication_identifier:
  issn:
  - 0265-9247
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1818'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Limits to natural selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2000'
...