---
_id: '1146'
abstract:
- lang: eng
  text: 'Aim: The present study was to compare the effects of nicotinic acid and nicotinamide
    on the plasma methyl donors, choline and betaine. Methods: Thirty adult subjects
    were randomly divided into three groups of equal size, and orally received purified
    water (C group), nicotinic acid (300 mg, NA group) or nicotinamide (300 mg, NM
    group). Plasma nicotinamide, N 1-methylnicotinamide, homocysteine, betaine and
    choline levels before and 1.5-h and 3-h post-dosing, plasma normetanephrine and
    metanephrine concentrations at 3-h post-dosing, and the urinary excretion of N
    1-methyl-2-pyridone-5-carboxamide during the test period were examined. Results:
    The level of 3-h plasma nicotinamide, N 1-methylnicotinamide, homocysteine, the
    urinary excretion of N 1-methyl-2-pyridone-5-carboxamide and pulse pressure (PP)
    in the NM group was 221%, 3972%, 61%, 1728% and 21.2% higher than that of the
    control group (P < 0.01, except homocysteine and PP P < 0.05), while the
    3-h plasma betaine, normetanephrine and metanephrine level in the NM group was
    24.4%, 9.4% and 11.7% lower (P < 0.05, except betaine P < 0.01), without
    significant difference in choline levels. Similar but less pronounced changes
    were observed in the NA group, with a lower level of 3-h plasma N 1-methylnicotinamide
    (1.90 ± 0.20 μmol/l vs. 3.62 ± 0.27 μmol/l, P < 0.01) and homocysteine (12.85
    ± 1.39 μmol/l vs. 18.08 ± 1.02 μmol/l, P < 0.05) but a higher level of betaine
    (27.44 ± 0.71 μmol/l vs. 23.52 ± 0.61 μmol/l, P < 0.05) than that of the NM
    group. Conclusion: The degradation of nicotinamide consumes more betaine than
    that of nicotinic acid at identical doses. This difference should be taken into
    consideration in niacin fortification. © 2016 Elsevier Ltd and European Society
    for Clinical Nutrition and Metabolism.'
acknowledgement: We thank all the participants for their contribution to this study
  and volunteers from the Nursing School of Dalian University for their supporting
  to collect blood and urine samples of the participants. We also thank Dr. Yasunori
  Takayama from National Institute for Physiological Sciences of Japan for his kind
  help.
article_processing_charge: No
author:
- first_name: Wuping
  full_name: Sun, Wuping
  last_name: Sun
- first_name: Ming-Zhu
  full_name: Zhai, Ming-Zhu
  id: 34009CFA-F248-11E8-B48F-1D18A9856A87
  last_name: Zhai
- first_name: Da
  full_name: Li, Da
  last_name: Li
- first_name: Yiming
  full_name: Zhou, Yiming
  last_name: Zhou
- first_name: Nana
  full_name: Chen, Nana
  last_name: Chen
- first_name: Ming
  full_name: Guo, Ming
  last_name: Guo
- first_name: Shisheng
  full_name: Zhou, Shisheng
  last_name: Zhou
citation:
  ama: Sun W, Zhai M-Z, Li D, et al. Comparison of the effects of nicotinic acid and
    nicotinamide degradation on plasma betaine and choline levels. <i>Clinical Nutrition</i>.
    2017;36(4):1136-1142. doi:<a href="https://doi.org/10.1016/j.clnu.2016.07.016">10.1016/j.clnu.2016.07.016</a>
  apa: Sun, W., Zhai, M.-Z., Li, D., Zhou, Y., Chen, N., Guo, M., &#38; Zhou, S. (2017).
    Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma
    betaine and choline levels. <i>Clinical Nutrition</i>. Elsevier. <a href="https://doi.org/10.1016/j.clnu.2016.07.016">https://doi.org/10.1016/j.clnu.2016.07.016</a>
  chicago: Sun, Wuping, Ming-Zhu Zhai, Da Li, Yiming Zhou, Nana Chen, Ming Guo, and
    Shisheng Zhou. “Comparison of the Effects of Nicotinic Acid and Nicotinamide Degradation
    on Plasma Betaine and Choline Levels.” <i>Clinical Nutrition</i>. Elsevier, 2017.
    <a href="https://doi.org/10.1016/j.clnu.2016.07.016">https://doi.org/10.1016/j.clnu.2016.07.016</a>.
  ieee: W. Sun <i>et al.</i>, “Comparison of the effects of nicotinic acid and nicotinamide
    degradation on plasma betaine and choline levels,” <i>Clinical Nutrition</i>,
    vol. 36, no. 4. Elsevier, pp. 1136–1142, 2017.
  ista: Sun W, Zhai M-Z, Li D, Zhou Y, Chen N, Guo M, Zhou S. 2017. Comparison of
    the effects of nicotinic acid and nicotinamide degradation on plasma betaine and
    choline levels. Clinical Nutrition. 36(4), 1136–1142.
  mla: Sun, Wuping, et al. “Comparison of the Effects of Nicotinic Acid and Nicotinamide
    Degradation on Plasma Betaine and Choline Levels.” <i>Clinical Nutrition</i>,
    vol. 36, no. 4, Elsevier, 2017, pp. 1136–42, doi:<a href="https://doi.org/10.1016/j.clnu.2016.07.016">10.1016/j.clnu.2016.07.016</a>.
  short: W. Sun, M.-Z. Zhai, D. Li, Y. Zhou, N. Chen, M. Guo, S. Zhou, Clinical Nutrition
    36 (2017) 1136–1142.
date_created: 2018-12-11T11:50:24Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2023-10-16T11:09:39Z
day: '01'
department:
- _id: RySh
doi: 10.1016/j.clnu.2016.07.016
intvolume: '        36'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: None
page: 1136-1142
publication: Clinical Nutrition
publication_identifier:
  issn:
  - 0261-5614
publication_status: published
publisher: Elsevier
publist_id: '6212'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of the effects of nicotinic acid and nicotinamide degradation on
  plasma betaine and choline levels
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2017'
...