---
_id: '6167'
abstract:
- lang: eng
  text: The tra-1 gene is the terminal regulator in the sex determination pathway
    in C. elegans, directing all aspects of somatic sexual differentiation. Recessive
    loss-of-function (lf) mutations in tra-1 masculinize XX animals (normally somatically
    female), while dominant gain-of-function mutations feminize XO animals (normally
    male). Most tra-1 (lf) mutations can be fitted into a simple allelic series of
    somatic masculinization, but a small number of lf alleles do not fit into this
    series. Here we show that three of these mutations are associated with DNA rearrangements
    5' to the coding region. One allele is an inversion that may be subject to a position
    effect. We also report the isolation of a new class of tra-1 alleles that are
    responsive to mutations in the smg system of RNA surveillance. We show that two
    of these express RNAs of aberrant size. We suggest that the smg-sensitive mutations
    may identify a carboxy-terminal domain required for negative regulation of tra-1
    activity.
author:
- first_name: David
  full_name: Zarkower, David
  last_name: Zarkower
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Rachel
  full_name: Aronoff, Rachel
  last_name: Aronoff
- first_name: Jonathan
  full_name: Hodgkin, Jonathan
  last_name: Hodgkin
citation:
  ama: Zarkower D, de Bono M, Aronoff R, Hodgkin J. Regulatory rearrangements and
    smg-sensitive allels of the C. elegans sex-determining gene tra-1. <i>Developmental
    Genetics</i>. 1994;15(3):240-250. doi:<a href="https://doi.org/10.1002/dvg.1020150306">10.1002/dvg.1020150306</a>
  apa: Zarkower, D., de Bono, M., Aronoff, R., &#38; Hodgkin, J. (1994). Regulatory
    rearrangements and smg-sensitive allels of the C. elegans sex-determining gene
    tra-1. <i>Developmental Genetics</i>. Wiley. <a href="https://doi.org/10.1002/dvg.1020150306">https://doi.org/10.1002/dvg.1020150306</a>
  chicago: Zarkower, David, Mario de Bono, Rachel Aronoff, and Jonathan Hodgkin. “Regulatory
    Rearrangements and Smg-Sensitive Allels of the C. Elegans Sex-Determining Gene
    Tra-1.” <i>Developmental Genetics</i>. Wiley, 1994. <a href="https://doi.org/10.1002/dvg.1020150306">https://doi.org/10.1002/dvg.1020150306</a>.
  ieee: D. Zarkower, M. de Bono, R. Aronoff, and J. Hodgkin, “Regulatory rearrangements
    and smg-sensitive allels of the C. elegans sex-determining gene tra-1,” <i>Developmental
    Genetics</i>, vol. 15, no. 3. Wiley, pp. 240–250, 1994.
  ista: Zarkower D, de Bono M, Aronoff R, Hodgkin J. 1994. Regulatory rearrangements
    and smg-sensitive allels of the C. elegans sex-determining gene tra-1. Developmental
    Genetics. 15(3), 240–250.
  mla: Zarkower, David, et al. “Regulatory Rearrangements and Smg-Sensitive Allels
    of the C. Elegans Sex-Determining Gene Tra-1.” <i>Developmental Genetics</i>,
    vol. 15, no. 3, Wiley, 1994, pp. 240–50, doi:<a href="https://doi.org/10.1002/dvg.1020150306">10.1002/dvg.1020150306</a>.
  short: D. Zarkower, M. de Bono, R. Aronoff, J. Hodgkin, Developmental Genetics 15
    (1994) 240–250.
date_created: 2019-03-22T08:38:41Z
date_published: 1994-01-13T00:00:00Z
date_updated: 2021-01-12T08:06:30Z
day: '13'
doi: 10.1002/dvg.1020150306
extern: '1'
external_id:
  pmid:
  - '7520378'
intvolume: '        15'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 240-250
pmid: 1
publication: Developmental Genetics
publication_identifier:
  issn:
  - 0192-253X
  - 1520-6408
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining
  gene tra-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '1994'
...